6b-hydroxy dexamethasone

6-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-1H-pyridine-3,4-dicarbonitrile is a biologically active compound, which is utilized for research in the fields of chemistry and life sciences.

2-Hydroxy-6-methoxybenzoic acid (6-Methoxysalicylic acid) may be employed as internal standard for the determination of acetylsalicylic acid (aspirin, ASA) and its major metabolite, salicylic acid (SA),and exhibits significant analgesic effects

4-Hydroxy-6-methylcoumarin (4-HMC) is a naturally occurring phenolic compound, a derivative of coumarin, found in a variety of plants, fungi, and bacteria. It has anti-inflammatory and anti-tumor activity.4-HMC is used as a flavoring agent, preservative and antioxidant in the food industry.

6-Bromo-2-hydroxy-3-methoxybenzaldehyde (NSC-95682) is an inhibitor of IRE-1α with an IC50 value of 0.08 μM.

(+)-6-(2-Hydroxy-3-methoxy-3-methylbutyl is a structural isomer of Ent-toddalolactone, which belongs to the coumarin group.

3-Hydroxy-6-methoxyflavone can be used in combination with antibiotics to treat ESKAPE pathogen infections.

(5R,6E)-5-Hydroxy-1,7-diphenyl-6-hepten-3-one ((5R)-trans-1,7-diphenyl-5-hydroxy-6-hept) possesses antioxidant activity.

6-Hydroxy-DOPA is an allosteric inhibitor of RAD52, it inhibits proliferation of BRCA-deficient cancer cells in vitro and also inhibits APE1.

6β-hydroxy Dexamethasone is a metabolite of dexamethasone that is more hydrophilic than the parent compound. Dexamethasone is metabolized by CYP3A4; therefore, quantification of the dexamethasone metabolites, 6α- and 6β-hydroxy dexamethasone, can be used to determine CYP3A4 enzyme activity in humans., The formation of 6-hydroxy dexamethasone metabolites is species-specific, with hamsters producing the highest amount. In rats, dexamethasone hydroxylation is sex-specific, with male rats producing metabolites in similar ratios to humans and female rats producing fewer hydroxylated metabolites than male rats.

(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one is a sesquiterpene lactone with a complex bicyclic structure [1].

6-Hydroxy Buspirone, an active metabolite of the anxiolytic compound buspirone, is produced via the cytochrome P450 (CYP) isoform CYP3A4. This compound exhibits affinity for the serotonin (5-HT) receptor subtype 5-HT1A, demonstrating efficacy in the rat hippocampus and dorsal raphe with half-maximal effective concentrations (EC50s) of 4 and 1 µM, respectively. Furthermore, 6-Hydroxy Buspirone acts as a potent antagonist against dopamine D2, D3, and D4 receptors with half-maximal inhibitory concentrations (IC50s) of 3.1, 4.9, and 0.85 µM, respectively, and inhibits the organic cation transporters 1 (OCT1), OCT2, and OCT3 in S2 proximal tubule cells expressing human transporters, showcasing a concentration-dependent mechanism.

6'-Hydroxy-3,4,2',3',4'-pentamethoxychalcone is an alkenylphenol from Piper obliquum with antiinflammatory and antibacterial activities.

Methyl 2-(6-acetyl-5-hydroxy-2,3-dihydrobenzofuran-2-yl)propenoate is a natural product from Vernonia cinerea.

4-Hydroxy-3-methoxyphenol 1-O-(6-O-syringoyl)glucoside is a useful organic compound for research related to life sciences and the catalog number is T124850.

5,6,7,4'-tetrahydroxyisoflavone-6,7-di-O-beta-D-glucopyranoside is a natural product

6-Hydroxy-3,4-dihydroquinolin-2(1H)-one is a useful organic compound for research related to life sciences. The catalog number is T67507 and the CAS number is 54197-66-9.

2,2-Dimethyl-6-phenylpyrano[3,4-b]pyran-8-one is a natural product derived from the metabolites of Hypericum revolutum ssp.

5-Hydroxy-canthin-6-one is a natural product for research related to life sciences. The catalog number is TN3122 and the CAS number is 64118-73-6.

Benzyl 2-hydroxy-6-(β-glucosyloxy)benzoate is a natural product for research related to life sciences. The catalog number is TN5679 and the CAS number is 403857-21-6.

6-Hydroxy-5,7,3',4',5'-pentamethoxyflavone is a natural product for research related to life sciences. The catalog number is TN6355 and the CAS number is 29043-06-9.

Nucleoside Derivatives –Fluoro-modified nucleosides, 6-Modified purine nucleosides, 3’-Modified nucleosides

2'-Deoxy-2'-fluoro-b-D-arabino-6-azauridine is a Nucleoside Derivative - 6-Aza-uridine; Fluoro-modified nucleoside; Arabino nucleoside.

B-Raf IN 6 is a potent inhibitor (IC50: 1.7 nM) of the protein kinase B-Raf, which does not bind the secondary target PXR and is resistant to rapid metabolism.B-Raf IN 6 has shown research potential in cancer diseases.

Quercetin 3-O-(6-O-malonyl)-b-D-glucoside is a useful organic compound for research related to life sciences. The catalog number is T123838 and the CAS number is 96862-01-0.

Nucleoside Derivatives - 7-Deaza-8-aza purine nucleosides; Halo-nucleosides; 6-Modified purine nucleosides

6-(4-Hydroxy-3-methylphenyl)-2-methylhept-2-en-4-one is a natural product for research related to life sciences. The catalog number is TN3141 and the CAS number is 949081-05-4.

Compound 17d (hMAO-B-IN-6) is an effective and selective hMAO-B inhibitor, demonstrating an IC 50 of 67.02 nM. It significantly ameliorates cognitive deficits induced by Scopolamine in Alzheimer's disease (AD) mice [1].

6-Formyl-isoophiopogonanone B, a homoisoflavonoid, can be isolated from the species Ophiopogon japonicus [1].

6-Hydroxy-TSU-68, a derivative and metabolite of TSU-68, reflects the compound's self-induced hydroxylation in human liver microsomes [1].

6-Hydroxy Etodolac, a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor etodolac, causes false positives in diazo diagnostic tests for urinary bilirubin.

(S)-5-hydroxy-6-methoxy Duloxetine, an active metabolite of the (S)-duloxetine, functions as a serotonin (5-HT) and norepinephrine reuptake inhibitor. Its formation occurs through the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2D6 via a 5- or 6-hydroxy duloxetine intermediate, followed by a catechol duloxetine intermediate. This compound effectively inhibits the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) across lipid membranes, with inhibition constants (Kis) of 266, 920, and 2,814 nM, respectively, for human transporters.

Benzyl 2-hydroxy-6-methoxybenzoate exhibits potent antifungal activity, demonstrating an IC 50 of 25–26 μg/mL against fungal strains.

Methyl 2-hydroxy-6-methylbenzoate is a useful organic compound for research related to life sciences. The catalog number is T66105 and the CAS number is 33528-09-5.

(2S,3S)-3-Hydroxy-2-(4-methoxyphenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one is a useful organic compound for research related to life sciences. The catalog number is T65968 and the CAS number is 42399-49-5.

5-Hydroxy-1,7-diphenylhept-6-en-3-one is a natural product for research related to life sciences. The catalog number is TN6357 and the CAS number is 155239-30-8.

6-Hydroxy-3,3',4',5,7,8-hexamethoxyflavone is a useful organic compound for research related to life sciences. The catalog number is T125628 and the CAS number is 167416-97-9.

4-Amino-6-bromo-5-cyano-1-(3-deoxy-3-fluoro-b-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine is a useful organic compound for research related to life sciences and the catalog number is TNU1039.

Nucleoside Derivatives - Fluoro-modified nucleoside; Halo-nucleoside

13-Hydroxy-7,14-labdadiene-6-one is a useful organic compound for research related to life sciences and the catalog number is T130143.

1-(b-D-Xylofuranosyl)-6-azauracil is a Nucleoside Derivative - Xylo-nucleoside; 6-Aza-uridine.

Intermediates and Building Blocks - Nucleoside base, Electrophile; Heterocyclic Compounds - Pyridine; Scaffolds and Templates

6-Amino-2,5-dihydro-2-(b-D-ribofuranosyl)-4H-pyrazolo[3,4-d]pyrimidin-4-one is a Nucleoside Derivative - 7-deaza-8-aza purine nucleoside.

6-O-p-Coumaroyl-1,2-di-O-galloyl-b-D-glucopyranose is a useful organic compound for research related to life sciences and the catalog number is T130064.

Nucleoside Derivatives - Xylo-nucleoside; Halo-nucleoside; Scaffolds and Templates

Nucleoside Derivatives - 7-Deaza-8-aza-purine nucleosides,6-Modified purine nucleosides; Scaffolds and Templates

6-Hydroxy Bexarotene, an oxidative metabolite of bexarotene, serves as a high-affinity ligand for retinoid X receptors (RXRs), specifically binding to RXRα, RXRβ, and RXRγ, as well as to the retinoic acid receptor α (RARα) with dissociation constants (Kds) of 3.46, 4.21, 4.83, and 8.17 μM, respectively. It demonstrates selective activation of RXRα, RXRβ, and RXRγ over RARα, RARβ, and RARγ in vitro, with half-maximal effective concentrations (EC50s) of 398, 356, 420, 4,414, 2,121, and 2,043 nM, respectively.

Compound 24, also known as 6-Aldehydoisoophiopogonone B, is a homoisoflavonoid extractable from Ophiopogon japonicus [1].

Ethyl 8-hydroxy-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T66942 and the CAS number is 131666-45-0.