14
1
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T73098 | BACE2-IN-1 | ||
BACE2-IN-1, a potent BACE2 inhibitor characterized by its exceptional selectivity and a Ki value of 1.6 nM, is utilized in the investigation of Type 2 Diabetes. | |||
T6058 | LY2886721 | Beta-Secretase , BACE | |
LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease. | |||
T7011 | Verubecestat | MK-8931 | Beta-Secretase , BACE |
Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor. | |||
T12188 | NB-360 | BACE | |
NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cat... | |||
T6772 | AZD3839 free base | AZD3839 | Beta-Secretase , BACE |
AZD3839 free base is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1. | |||
T2639 | LY2811376 | Beta Amyloid , Beta-Secretase , BACE | |
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition... | |||
T10292 | AM-6494 | BACE | |
AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM). | |||
T10450 | BACE1-IN-1 | BACE | |
BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2). | |||
T10452 | BACE1-IN-4 | BACE | |
BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2. | |||
T62573 | AMG-8718 | ||
AMG-8718 is a selective, orally active and potent BACE1 inhibitor that acts on both BACE1 (IC50: 0.0007 μM) and BACE2 (IC50: 0.005 μM). AMG-8718 significantly reduces CSF and Aβ40 levels in the brain. | |||
T61956 | BACE1/2-IN-1 | ||
BACE1/2-IN-1 (compound 34) is an effective BACE1 and BACE2 inhibitor with IC50 of 0.01 and 0.0053 μM, respectively. BACE1/2-IN-1 has lower Pgp efflux ratio and improved passive permeability. The metabolic stability of BA... | |||
T37661 | LY 2886721 Hydrochloride | ||
Potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin a... | |||
T12429 | PF-06751979 | BACE | |
PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay). | |||
T13434 | β-Secretase Inhibitor IV | Others | |
β-Secretase Inhibitor IV is a potent, cell-active inhibitor of BACE-1(IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively). |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03065 | BACE2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is th... |