chalcone

Chalcone (Cinnamophenone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.

2,2'-Dihydroxy chalcone is a potent inhibitor of β-glucuronidase (IC50=1.6±0.2 μM) and lysozyme (IC50=1.4±0.2 μM) release from rat neutrophils stimulated with fMLP/CB.2,2'-Dihydroxy chalcone has inhibitory activity against Escherichia coli, Shigella fowleri, Staphylococcus albicans and Staphylococcus aureus.

2-Hydroxy-3-methoxy chalcone has anticancer activity and inhibits colon cancer.

Eriodictyol chalcone has anti-plasmodial effects on P. falciparum growth.

Pinostrobin chalcone, a chalcone analog isolated from the leguminous plant, Mucuna pruriens, exhibits anticancer activity with an IC50 value of 20.42±2.23 μg/mL against MDA-MB-231 and 22.51±0.42 μg/mL against the HT-29 colon cancer cell line.

Naringenin chalcone (Isosalipurpol) has antiallergic activity Naringenin chalcone suppresses asthmatic symptoms by inhibiting Th2 cytokine production from CD4 T cells. Naringenin chalcone is a potent tomato flavonoid that improves adipocyte metabolic functions and exerts insulin-sensitizing effects by activating an adiponectin-related pathway. Naringenin chalcone exhibits anti-inflammatory properties by inhibiting the production of proinflammatory cytokines in the interaction between adipocytes and macrophages, may be useful for ameliorating the inflammatory changes in obese adipose tissue.

trans-Chalcone (Chalkone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.

Pinocembrin chalcone is an inhibitor of tyrosinase with antimutagenic effects. Pinocembrin chalcone can be used in studies about the prevention of gastric ulcers.

Naringenin chalcone is a natural product isolated from the stem of the plant Machaerium isadelphum (Fabaceae).Naringenin chalcone has anti-inflammatory activity.

Butein (2’,3,4,4’-tetrahydroxy Chalcone), a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR.

(E)-Cardamonin (Alpinetin chalcone) is a chalconoid that has been isolated from several plants including Alpinia katsumadai and Alpinia conchigera. It is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM. It has received growing attention from the scientific community due to the expectations toward its benefits to human health.

Licochalcone A is a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch with obvious anti-cancer effects.

4,4'-Dimethoxychalcone (4,4-Dimethoxychalcone) is a natural product.

2'-Hydroxy-3,4-dimethoxychalcone, a chalcone compound isolated from the roots of Sophora japonica, has antioxidant activity and inhibited the intracellular survival of Lactobacillus donovani Parasite EC.50 Values ranged between 0.39 and 0.41 μg/mL, which can be used in the study of diabetes, treatment of schistosomiasis, malaria and other infections.

2',4,4',6'-Tetramethoxychalcone (2',4,4',6'-TETRAMETHOXY) is a natural product.

2'-Hydroxychalcone is a drug synthesis intermediate for the synthesis of flavonoids. 2'-Hydroxychalcone loaded in nanoemulsion showed fungicidal activity against Coccidioides parapsilosis in Danio rerio model.2'-Hydroxychalcone induced cytotoxicity through oxidative stress in lipid-loaded Hepg2 cells.2'-Hydroxychalcone inhibited the induction of ICAM-1, VCAM-α, tumor necrosis factor-α, and tumor necrosis factor-alpha as determined by reverse transcription-polymerase chain reaction determined by tumor necrosis factor-alpha induces steady-state transcript levels of ICAM-1, VCAM-1, and E-selectin, and therefore may interfere with the transcription of their genes.

4-METHOXYCHALCONE (2-(4-Methoxybenzal)Acetophenone) is a natural compound that enhanced adipocyte differentiation,

Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. Licochalcone D has cardioprotective potential against myocardial is

4'-Hydroxy-2,4-dimethoxychalcone is a naturally occurring chalcone derivative from the herbal resin of the red geranium Dragon's Blood.4'-Hydroxy-2,4-dimethoxychalcone possesses a wide range of biological activities including anti-malarial, anti-bacterial, anti-fungal, and anti-protozoa activity.

2',3'-Dihydroxy-4',6'-dimethoxychalcone (compound 1) possesses the capacity to inhibit Amyloid β-protein (Aβ42) fibrillization and aggregation, demonstrating oral activity with detectable presence in the brain [1].

α,β-Dihydro-4,6-dihydroxy-2-methoxy-3-methylchalcone (compound 7), a natural product, can be isolated from the Dragon's blood of Daemonorops draco [1].

6'-Hydroxy-3,4,2',3',4'-pentamethoxychalcone is an alkenylphenol from Piper obliquum with antiinflammatory and antibacterial activities.

2',4'-Dihydroxy-3',6'-dimethoxydihydrochalcone is a natural product for research related to life sciences. The catalog number is TN2715 and the CAS number is 54299-52-4.

2',6'-Dihydroxy-4,4'-dimethoxychalcone is a natural product for research related to life sciences. The catalog number is TN2735 and the CAS number is 20621-49-2.

Morachalcone A displays significant tyrosinase inhibitory activity (IC50, 0.013 uM); it also exerts strong pancreatic lipase inhibition with IC 50 value of 6.2 uM. Morachalcone A exhibits neuroprotective effects on HT22-immortalized hippocampal cells agai

4'-Methoxychalcone with a variety of pharmacological activities, such as anti-tumor and anti-inflammatory activities.

2',6'-Dihydroxy 4'-methoxydihydrochalcone is a natural product for research related to life sciences. The catalog number is TN2737 and the CAS number is 35241-55-5.

Licoagrochalcone B is a flavonoid isolated from Patrinia villosa.

2',3',4'-Trimethoxyacetophenone is a raw material for the preparation of chalcone compounds with anti-inflammatory activity.

4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activity

Isobavachalcone (Corylifolinin) is a chalcone constituent of Angelica keiskei, has potent anti-inflammatory activity, possible can ameliorate neuronal injury in brain diseases associated with inflammation.

2'-Hydroxy-3',4',6'-trimethoxychalcone is a natural product for research related to life sciences. The catalog number is TN6377 and the CAS number is 91856-16-5.

Licoagrochalcone C, a flavonoid compound, demonstrates potent inhibitory effects on NF-κB transcription and significantly reduces LPS-induced NO production, showcasing its bioactive properties [1] [2].

2,4-Dihydroxy-4,6-dimethoxydihydrochalcone is a natural product for research related to life sciences. The catalog number is TN2718 and the CAS number is 75679-58-2.

2,4,4'-Trihydroxydihydrochalcone is a natural product from Dracaena draco.

4',2-Dihydroxy-4,6-dimethoxydihydrochalcone, an estrogen agonist, exhibits a significant binding affinity for the estrogen receptor in bovine uterine tissue, with an IC50 value of 15 μM.

Xinjiachalcone A is a natural product isolated from Glycyrrhiza inflata Batalin. Xinjiachalcone A shows both a low MIC and a strong bactericidal activity against H. pylori(MIC : 12.5 to 50 µM, seventeen H. pylori strains).

3-Deoxysappanchalcone is an effective HO-1 inducer at the translational level.

2-Hydroxychalcone (2-(2-Hydroxybenzal)Acetophenone) can be used as antiparasitic hit compounds when Methoxylated.It can inhibit invasion of triple negative breast cancer cells.

3,2'-Dihydroxy-4,4'-dimethoxychalcone is a natural product for research related to life sciences. The catalog number is TN2854 and the CAS number is 2567-65-9.

2',4'-Dihydroxy-2,3',6'-trimethoxychalcone is a natural product of Scutellaria, Lamiaceae. The catalog number is TN2713 and the CAS number is 100079-39-8. 2',4'-Dihydroxy-2,3',6'-trimethoxychalcone can be used as a reference standard.

Hesperidin methylchalcone is the Citrus original products with powerful antioxidant activity. It can suppresse experimental gout arthritis in mice by inhibiting NF-κB activation.

4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.

3,4-Dimethoxychalcone is a natural product found in the flowers of Arrabidaea brachypoda.

Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.

Neohesperidin Dihydrochalcone (Neohesperidin DC) is an artificial sweetener derived from citrus.

4,2'-Dihydroxy-4'-methoxychalcone shows allergy-preventive effects.

Bavachalcone is a major bioactive compounds isolated from Psoralea corylifolia L. it may be useful as a therapeutic drug for bone resorption-associated diseases.Bavachalcone can protect the endothelial function by increasing AMPK activity and MnSOD expression and reducing mitochondrial oxidative stress.

1. Licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (murine bladder cancer cell line) tumor model. 2. LCB and Licochalcone D(LCD) significantly reduce

Broussochalcone A, an antioxidant and Xanthine Oxidase inhibitor (IC 50 =2.21 μM), exhibits free radical scavenging activity. It prevents iron-induced lipid peroxidation and nitric oxide synthesis in lipopolysaccharide (LPS)-activated macrophages. Additionally, Broussochalcone A triggers apoptosis in human renal carcinoma cells by elevating ROS levels and activating FOXO3 signaling pathways.