hepcidin

Hepcidin antagonist-1 is an iron-modulating antagonist.Hepcidin antagonist-1 can be used to study metabolic disorders such as iron-deficiency diseases and anemia.

Hepcidin-20 (human), a peptide characterized by its histidine content, cysteine-rich composition, and β-sheet structure, exhibits antifungal properties. Furthermore, it effectively inhibits biofilm formation and disrupts the metabolism of bacterial cells in both polysaccharide intercellular adhesin (PIA)-positive and PIA-negative strains [1] [2] [3].

Hepcidin-1 (mouse) is a peptide hormone that regulates iron balance, elevates mRNA for TRAP, cathepsin K, and MMP-9, and promotes TRAP-5b protein secretion. This compound also reduces FPN1 protein levels and boosts intracellular iron, ultimately aiding in osteoclast differentiation [1].

Seabream hepcidin, an antimicrobial peptide, exhibits antibacterial (V. anguillarum), antifungal (S. cerevisiae), and antiviral activities against hemorrhagic septicemia virus [1].

Hepcidin-1 (mouse) TFA, an endogenous peptide hormone, regulates iron homeostasis by upregulating mRNA levels of TRAP, cathepsin K, and MMP-9, enhancing TRAP-5b protein secretion, and downregulating FPN1 protein levels, thereby increasing intracellular iron. It also promotes osteoclast differentiation [1].

Hepcidin-25 (human), an iron metabolism modulator, exhibits both anti-inflammatory and antibacterial activity through the modulation of iron-mediated oxidant injury [1].

Hepcidin-25 (human) acetate is an iron metabolism modulator with anti-inflammatory and antibacterial effects, acting through the modulation of iron-mediated oxidant injury [1].

Bass hepcidin exhibits antimicrobial activity against Escherichia coli [1].

Guanosine 5'-diphosphate (GDP) as Potential Iron Mobilizer, Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway.

Guanosine 5'-diphosphate disodium salt (5'-GDP-Na2) is a nucleoside diphosphate, is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulating the interleukin-6 (IL-6)/stat-3 pathway.

ERRγ agonist-2 is a potent and selective ERRγ inverse agonist with a Kd value of 6.5 μM, inhibiting the expression of hepcidin, fibrinogen, and gluconeogenic genes. ERRγ agonist-2 exhibits antimicrobial, anti-coagulant, and antidiabetic activities [1].

Palsucibep pegol is an engineered protein that specifically binds to human lipocalin-2. It also targets hepcidin [1].

DS28120313 is an oral inhibitor of hepcidin production (IC50: 0.093 μM).

Sulfonyl quinoxaline 1 is an inhibitor of RhoG-hepcidin uptake.

Guanosine 5'-diphosphate (GDP) sodium is a nucleoside diphosphate known for activating the adenosine 5'-triphosphate-sensitive K+ channel, serving as a potential iron mobilizer by inhibiting the hepcidin-ferroportin interaction, and modulating the interleukin-6 (IL-6) stat-3 pathway. It is utilized in research on inflammation-related conditions, including anemia of inflammation (AI).