isodon

Isodonal shows abilities to inhibit K562 cells camparable to that of cisplatin.

Oridonin (NSC-250682) is a diterpenoid isolated from Rabdosia rubescens with anti-tumor, anti-bacterial and anti-inflammatory effects. It acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2.

1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expression of X-linked inhibitor of apoptosis protein. 3. Glaucocalyxin A inhibits Akt phosphorylation, suppresses proliferation, and promotes apoptosis in a dose-dependent manner, but not in normal glial cells. 4. Glaucocalyxin A inhibits collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GPⅥ pathway. 5. Glaucocalyxin A could potentially be developed as an antiplatelet and antithrombotic agent, can inhibit platelet p-selectin secretion and integrin activation by convulxin, is a GPVI selective ligand.

Kamebanin, a natural diterpenoid, has antibacterial activity. It also shows efficient cytotoxic activity against HeLa and HL-60 cells.

Lophanthoidin E is a kind of natural product derived from the herbs of Rabdosia lophanthoides.

Maoyerabdosin is a kind of natural product derived from the herbs of Isodon.

Sculponeatin N may have protective effects on the lipid peroxidation-damaged live cells.

Sculponeatin A is a natural product from Rabdosia amethystoides.

Lophanthoidin F is a kind of natural product derived from the herbs of Rabdosia lophanthoides.

Lophanthoidin B is a natural product isolated from the herbs of Rabdosia lophanthoides.

Bulleyanin shows strong inhibition of mouse ehrlich ascites carcinoma (ECA), mouse sarcoma S-180, and mouse liver ascites.

Lasiodonin is a natural product isolated from the leaves of Isodon parvifolius.

Sculponeatin O may have protective effects on the lipid peroxidation-damaged live cells.

Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.

Rosthornin A is a kind of natural product derived from the herbs of Rabdosia rosthornii.

Maoecrystal B is a diterpenoid isolated from the leaves of Isodon eriocalyx var.

Trichorabdal A shows a very strong in vitro antibacterial activity against Helicobacter pylori.

D-alpha-Tocopherol acetate (Vitamin E Acetate) is hydrolyzed to d-alpha-tocopherol (VE) and absorbed in the small intestine.

Xerophilusin G is a natural product of Isodon, Lamiaceae. The catalog number is TMA1742 and the CAS number is 304642-94-2. Xerophilusin G can be used as a reference standard.

Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p65 proteins to down-regulate COX-2 expression .

Liangshanin A is a natural product for research related to life sciences. The catalog number is TN4432 and the CAS number is 122717-54-8.

Sculponeatic acid is a natural product of Isodon, Lamiaceae. The catalog number is TN4969 and the CAS number is 1169806-02-3. Sculponeatic acid can be used as a reference standard.

16-Kaurene-2,6,15-triol is a natural product for research related to life sciences. The catalog number is TN2647 and the CAS number is 53452-32-7.

12E,14-Labdadien-20,8beta-olide is a natural product from Isodon yuennanensis.

6-epi-Augustifolin is a natural product for research related to life sciences. The catalog number is TN3164 and the CAS number is 369390-94-3.

Augustifolin is a natural product for research related to life sciences. The catalog number is TN3470 and the CAS number is 66548-01-4.

Serrin A shows weak to moderate cytotoxic activities (IC50<10 uM) against two human cancer cell lines.

Trichokaurin is a natural product of Isodon, Lamiaceae. The catalog number is TN5172 and the CAS number is 23811-50-9. Trichokaurin can be used as a reference standard.

Sculponeatin K is a natural product of Isodon, Lamiaceae. The catalog number is TN4971 and the CAS number is 477529-70-7. Sculponeatin K can be used as a reference standard.

Macrocalyxin C is extracted from the stems and leaves of Isodon albopilosus.

ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the cleavage of caspase-3 and the proteolytic degradation of poly (ADP-ribose) polymerase (PARP).

Rabdosin B shows cytotoxic activity against three human tumour HepG2, GLC-82 and HL-60 cell lines, it induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner. Rabdosin B at higher concentrations inhibits root growth by affecting

Rabdoternin F is a natural product from Rabdosia ternifolia.

Excisanin B shows inhibitory effects on LPS-induced production of nitric oxide in murine macrophage RAW264.7 cells.

Effusanin B shows antibacterial activity. It exhibits DNA-damaging activity in assay which employes DNA-repair deficient (RAD 52Y) and repair proficient (RAD +) yeast strains.

Carpalasionin is a natural product from Rabdosia lasiocarpa.

Xerophilusin A, an ent-kaurane diterpenoid, is extractable from the aerial parts of Isodon enanderianus [1].

Epinodosin induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner.Epinodosin has a biphasic, dose-dependent effect on root growth and a strong inhibitory effect on root hair development in Lactuca sativa L. seedlings.

Effusanin A has antibacterial activity. It exhibits DNA-damaging activity in assay which employed DNA-repair deficient (RAD 52Y) and repair proficient (RAD +) yeast strains. Effusanin A shows inhibitory effects on DU145 cells with IC50 value of 3.16 micro

Acetylsventenic acid is a natural product from Rabdosia excisa.

Sventenic acid is a natural product of Isodon, Lamiaceae. The catalog number is TN5081 and the CAS number is 126778-79-8. Sventenic acid can be used as a reference standard.

Odonicin is a kind of natural product derived from the herbs of Rabdosia longituba.

Inflexuside A, an abietane diterpenoid isolated from the aerial parts of Isodon inflexus, and Inflexuside B significantly inhibit lipopolysaccharide (LPS)-activated NO production (NO Synthase) in RAW264.7 macrophages [1].

ent-7alpha,9-Dihydroxy-15-oxokaur-16-en-19,6bet-olide is a natural product for research related to life sciences. The catalog number is TN3954 and the CAS number is 59885-89-1.

Nodosin has anti-inflammatory function of Nodosin via inhibition of IL-2. Nodosin perfusion provides a potential protective effect through inducing HO-1 expression to attenuate ischemia/reperfusion injury in liver transplantation.

Dl-alpha-tocopheryl acetate is a dietary supplement.

1. Kamebakaurin (Kamebakaurine) has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stress. 2. Kamebakaurin inhibits the expression of hypoxia-inducible factor-1α and its target genes to confer antitumor activity. 3. Kamebakaurin has anti-cancer and anti-inflammatory activities through direct inhibition of DNA-binding activity of nuclear factor-kappa B (NF-κB) p50.4. Kamebakaurin has anti-neuroinflammatory activity via inhibition of c-Jun NH -terminal kinase and p38 mitogen-activated protein kinase pathway in activated microglial cells.

Inflexuside B, an abietane diterpenoid derived from the aerial parts of Isodon inflexus, effectively inhibits lipopolysaccharide (LPS)-activated NO Synthase in RAW264.7 macrophages [1].

Longikaurin E ((-)-Longikaurin E) is a therapeutic agent for pancreatic cancer. It is isolated from Isodon adenolomus.

Glycerol 1-(26-hydroxyhexacosanoate) has weak activities antiplasmodial