pentacyclic

Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretroviral, antimalarial, and anti-inflammatory properties, as well as a more recently discovered potential as an anticancer agent, by inhibition of topoisomerase.

Ursolic acid (Prunol) is a natural product, a pentacyclic triterpene carboxylic acid extracted from Rhododendron caprifolium. Ursolic acid has anti-tumor, anti-inflammatory, anti-bacterial and hypoglycemic activities.

Resistomycin (Geliomycin), a pentacyclic polyketide antibiotic, exhibits potent anticancer properties by triggering apoptosis.

Tingenone is a pentacyclic triterpene. It induces peripheral antinociception due to opioidergic activation.

Alpha-Boswellic acid (α-Boswellic acid) is a pentacyclic triterpenoid natural product extracted from frankincense, exhibiting anticonvulsant and anticancer effects, and in animals, it prevents and reduces Alzheimer's disease markers, making it valuable for Alzheimer's disease research.

Madecassoside (Asiaticoside A) is a pentacyclic triterpene extracted from Centella asitica (L.) with anti-inflammatory, anti-oxidative and anti-aging activities.

Isoasiaticoside, a pentacyclic triterpene saponin derived from Centella asiatica, exhibits potential neuroprotective effects in the 6-OHDA-induced PC12 cell model [1].

Friedelinol is a pentacyclic trierpene plant as the free acid or the aglycone for many saponins. Friedelinol can rearrange to the isomer, ursolic acid, or be oxidized to taraxasterol and amyrin.

Terminolic acid (2α,6β,23-trihydroxyl oleanolic acid) is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum, can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and IL-6, and enhance anti-inflammatory cytokines by binding to IL-4 receptor binding sites. It also exhibits moderate antibacterial activity.

Arnidiol, a pentacyclic triterpene isolated from Barleria Longiflora Linn, exhibits anti-inflammatory activity, notably inhibiting 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice.

Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-mediated intrinsic and death receptor-induced extrinsic pathways.

18α-Oleanolic acid is a naturally occurring pentacyclic triterpenic acid that can be extracted from plants .

Eupenifeldin, a pentacyclic bistropolone isolated from Eupenicillium brefeldianum ATCC 74184, exhibits cytotoxic activity against the HCT-116 cell line and holds potential for leukemia research [1].

Centellasaponin A (compound 10), a pentacyclic triterpene saponin, has been isolated from the methanolic extract of Centella asiatica [1].

Ilexgenin A is a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr

Licoricesaponin G2, a pentacyclic triterpenoid derived from Glycyrrhiza aspera, can be used to differentiate crude liquorice from honey-processed liquorice.

Alpha-Hederin (Tauroside E) is a water-soluble pentacyclic triterpenoid saponin found in the seeds of Nigella sativa, with hemolytic and apoptotic properties.

Waltonitone is a natural ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill.

Fusarisetin A, a pentacyclic fungal metabolite, acts as an acinar morphogenesis inhibitor.

Ursonic Acid (TOS-BB-0966) belongs to the family of Ursane Triterpenes whose structure is based on the pentacyclic ursane skeleton. It has potential as HIV-1 Protease Inhibitor.

Bellericagenin A, a pentacyclic triterpenoid acid, is isolated from the bark of Terminalia bellerica. This compound exhibits antimicrobial activity and has a high affinity for alcohol dehydrogenase (ADH), suggesting potential for ameliorating alcoholic liver damage.

18α-Glycyrrhetinic acid (Enoxolone) is an inhibitor of NF-kB and an activator of the proteasome, and functions as a longevity-promoting and anti-aggregation factor in multicellular organisms. It induces apoptosis.