pentapeptide

Acetyl Pentapeptide-1 acetate is an histone deacetylase inhibitor.

Myristoyl Pentapeptide-17 Acetate is a small peptide. It promotes the delivery of key ingredients, thus effectively promoting the growth of eyelashes, lengthens and thickens the eyelashes, fortifies the hair, and noticeably intensifies eye expression.

Human IgE Pentapeptide HEPP acetate is a pentapeptide that does not produce IgE inhibition in several different systems and is used in the treatment of conjunctivitis.

Pentapeptide-3, a pentapeptide fragment derived from waglerin-1 neurotoxin, is sourced from Temple Viper venom. This compound serves as a competitive antagonist of nicotinic acetylcholine receptors (nAChRs), blocking nerve signals at the post-synaptic membrane. Notably, Pentapeptide-3 exhibits anti-aging properties and is commonly incorporated with other cosmetic peptides for enhanced effects [1] [2].

Pentapeptide-31, a bioactive peptide with anti-aging properties, is utilized as a cosmetic ingredient [1].

Myristoyl Pentapeptide-4 is a bioactive peptide known to promote hair growth and is reported to be used as a cosmetic ingredient [1].

Pentapeptide-4 is a matrikine utilized in anti-wrinkle cosmetics.

Myristoyl Pentapeptide-17 is a small peptide. It promotes the delivery of key ingredients, thus effectively promotes the growth of eyelashes, lengthens and thickens the eyelashes, fortifies the hair and noticeably intensifies eye expression.

Angiotensin pentapeptide is a peptide.

Cholecystokinin pentapeptide is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein.

Tripalmitoyl pentapeptide is a Mitogen from E Coli lipoprotein. It also is a potent macrophage B lymphocyte activator.

Splenopentin diacetate (Splenin pentapeptide (32-36)) is a synthetic immunomodulating peptide and can reproduce the biological activities of splenin and thymic hormone thymopoietin.

Matrixyl Acetate(214047-00-4 free base) (Palmitoyl pentapeptide) is a matrikine used in anti-wrinkle cosmetics.

Hemoregulatory peptide 5b is a synthetic analog of granulocyte chalone which initially identified in extracts of rodent bone marrow and human leukocytes. Monomer inhibits both formations of GM-CFC colonies and cytotoxic drug-induced recruitment of murine

Matrixyl (PAL-Lys-Thr-Thr-Lys-Ser) is a matrikine used in anti-wrinkle cosmetics.

Relamorelin (RM-131), a selective and potent growth hormone-releasing peptide/growth hormone secretagogue receptor (GHSR) agonist, is a potent growth hormone-releasing peptide mimetic with a high affinity for the GHS-1a receptor Relamorelin is a centrally permeable pentapeptide that increases growth hormone levels and accelerates gastric emptying and has potential for studying malignant disease.

GLP-1(32-36)amide acetate is a pentapeptide and derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide acetate could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice.

Nemifitide acetate(173240-15-8 free base) (INN 00835 acetate) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. It is a peptide analog of melanocyte-inhibiting factor (MIF).

Enterostatin, human, mouse, rat acetate is a pentapeptide mainly formed in the intestine by the cleavage of secreted pancreatic procolipase.

Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. Thymopentin (TP5) is an immunomodulator which has been studied for possible use in the treatment of rheumatoid arthritis, AIDS, and other primary immunodeficiencies.

Pheromonotropin (Pseudaletia separata) (Pss-PT), a C-terminal pentapeptide FXPRL-amide pheromone of the armyworm (Pseudaletia separata), is a member of the PK/PBAN family. It induces sex pheromone production in moths while also mediating feeding through intestinal muscle contraction, influencing development processes such as embryonic diapause, pupal diapause, and pupation, and enhancing defense mechanisms against predators [1].

Cyclo(RGDyC), a cyclic pentapeptide, exhibits anti-angiogenic properties and has been investigated in conjunction with liposomal delivery systems for the study of ocular neovascular diseases and cancer [1] [2].

Enterostatin, human, mouse, rat is a pentapeptide that reduces fat intake.

EILDV (human, bovine, rat) is an active pentapeptide analog with a conserved tripeptide sequence LDV across human, bovine, and rat species, utilized in cell adhesion research [1].

The sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK, specifically cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2), which interacts with human IIA phospholipase A2 (hGIIA) to impede its ester bond hydrolyzing function. As part of the esterase superfamily, sPLA2 enzymatically cleaves the sn-2 ester bond in glycerophospholipids, releasing arachidonic acid and lysophospholipids[1].

Cyclo(RGDfK(Mal)), a pentapeptide, enhances the attachment and infiltration of human pluripotent stem cells and is utilized in three-dimensional stem cell culture and expansion [1].

D-{Ala-Ala-Ala-Ala-Ala}, a pentapeptide, serves as an inhibitor of immunological responses [1].

Relamorelin (RM-131) acetate is a pentapeptide ghrelin analog that acts as a selective agonist for the ghrelin/growth hormone secretagogue receptor (GHSR). It exhibits a high affinity for the GHS-1a receptor, with a Ki value of 0.42 nM. Notably, Relamorelin acetate can cross the blood-brain barrier and target the central nervous system. This compound effectively increases growth hormone levels and promotes faster gastric emptying. Due to these properties, Relamorelin acetate holds promise for its potential applications in research related to cachexia, gastroparesis, and gastric/intestinal dysmobility disorders [4] [5].

Phosphorylated p60c-src substrate II is a pentapeptide and a phosphorylated polypeptide form of p60c-src substrate II. Phosphorylation is a critical post-translational modification (post-translationmodification) vital for biological regulatory processes [1].

ADH-1 trifluoroacetate (Exherin trifluoroacetate) is a cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis.

Histatin-3, a 32-amino-acid peptide, exhibits potent antimicrobial activities and serves as a substrate for proprotein convertase 1 (PC1), where it is primarily cleaved at a site carboxy-terminal to Arg25 (HRGYR↓SN). Additionally, it acts as a moderately potent, reversible, and competitive inhibitor of furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an inhibition constant (Ki) estimated at 1.98 μM [1].

GLP-1(32-36)amide TFA, originating from the C-terminal end of the glucoregulatory hormone GLP-1, is a pentapeptide that has demonstrated the ability to mitigate weight gain and regulate glucose metabolism throughout the body in diabetic mice [1] [2].

P60c-src substrate II is a potent pentapeptide substrate for the tyrosine kinase pp60c-src [1].

Relamorelin (RM-131) TFA, a pentapeptide ghrelin analog, acts as a potent and selective agonist for the ghrelin/growth hormone secretagogue receptor (GHSR), with a K_i of 0.42 nM for the GHS-1a receptor. This compound is capable of crossing the blood-brain barrier and effectively increases growth hormone levels while promoting faster gastric emptying. It holds significant research potential for conditions such as cachexia, gastroparesis, and disorders related to gastric/intestinal motility [1] [2] [3] [4] [5].

LPYFD-NH2 TFA, a pentapeptide, exhibits an inhibitory effect on Aβ(1-42) aggregation, indicating its potential utility in Alzheimer’s disease research [1].

Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide, a peptide like melanocyte suppressor factor (MIF) that can cross the blood-brain barrier and has potent antidepressant activity.

YGFGG, C-terminal pentapeptide fragment of the osteogenic growth peptide (OGP), (H-8640), showed the full spectrum of OGP-like bioactivities. It has attracted considerable interest as bone anabolic agent and hematopoietic stimulator.

Enterostatin (human, mouse, rat) TFA, a pentapeptide predominantly synthesized in the intestine from pancreatic procolipase cleavage, effectively decreases fat consumption, body weight, and body fat in vivo [1].

Programmed cell death in bacteria is dependent on a system of cell-to-cell communication termed quorum sensing. Extracellular death factor (EDF) is a linear pentapeptide that communicating cells produce and release, which upon reaching a sufficient concentration activates the cell death pathway in a subset of cells. It is sensitive to extreme pH, high temperatures, and other stressful conditions. At 2.5 ng/ml, EDF has been shown to facilitate mazEF-mediated cell death, significantly reducing population size in E. coli cultures.

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA (compound 1) serves as a high-affinity pentapeptide that binds to the src SH2 domain with an IC 50 value of approximately 1 µM. Additionally, it acts as an inhibitor of src SH3-SH2: phosphoprotein interactions [1].

GLP-1(32-36)amide is a pentapeptide compound derived from the C terminus of the glucoregulatory hormone GLP-1. This compound has shown potential in inhibiting weight gain and regulating glucose metabolism in diabetic mice[1][2].

Knqdk peptide is a synthetic pentapeptide, located in residues 112-116 of bovine K-casein.