phenothiazine

Phenothiazine (ENT 38) is a class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Phenothiazines antagonize the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain, potentially preventing chemotherapy-induced emesis.

3-Amino-1-(2-chloro-10H-phenothiazin-10-yl)-1-propanone is involved in the synthesis of phenothiazine series compounds.

3-(2',5'-Disulfophenylimino)-3H-phenothiazine is a Bio-reagent, fine chemical.

3-(4'-Carboxyphenyl)imino-3H-phenothiazine is a Bio-reagent, fine chemical.

2-Methoxy Phenothiazine is light yellow or light gray solid.

2-Chlorophenothiazine is used as the intermediate of Chlorpromazine hydrochloride.

PTZ-256 is a phenothiazine derivative with chemical name: 3-(10H-phenothiazin-10-yl)propane-1-amine. PTZ-256 has molecule weight 256, therefore, we call it as PTZ-256.

Zuclopenthixol (cis-Clopenthixol) is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.

Fluphenazine dihydrochloride (Prolixin) is an inhibitor of phenothiazine-class D1DR and D2DR; In studies, Fluphenazine can be used to probe the effects and metabolic process of this commonly used dopamine antagonist.

Prochlorperazine Maleate (Capazine) is a phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS.

Promazine hydrochloride (Romtiazin hydrochloride) is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.

Fluphenazine decanoate is dopamine D2 receptor blocke,and is a long-acting phenothiazine neuroleptic that used to treat schizophrenia.

carfenazine targets the Dopamine receptor and is used for schizophrenia research.

Opromazine hydrochloride belongs to the phenothiazine class of antipsychotics and reduces the activity of dopaminergic pathways by blocking dopamine receptors in the brain. It is mainly used for the treatment of psychiatric disorders such as schizophrenia and psychosis.

PPA-904, a specific phenothiazine photosensitizer, is used in photodynamic therapy (PDT).

Quisultazine is a phenothiazine derivative with no central effects, can be classified as a non anti H2 antisecretory agent.

RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties. It exhibits considerable effectiveness against an EGFR-driven cancer xenograft model. The mechanism behind its efficacy can be attributed to the simultaneous inhibition of PI3K-AKT and RAS-ERK signaling pathways.

Perphenazine (Trilafon) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.

Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic activity. It is a selective antagonist of mycotoxins M1 receptors, exhibiting high (Ki=84 nM, M1 receptors) and low (Ki=1.65 μM, M2 receptors) affinity, with a 20-fold difference. Oxomemazine is an antihistamine and anticholinergic agent used in cough studies[1][2].

Dacemazine is a phenothiazine derivative that acts as a histamine antagonist at the H1 subtype. It was also assessed as a possible anticancer drug.

Levomepromazine HCl is a phenothiazine with pharmacological activity similar to that of both CHLORPROMAZINE and PROMETHAZINE. It has the histamine-antagonist properties of the antihistamines together with CENTRAL NERVOUS SYSTEM effects resembling those of chlorpromazine.

Triflupromazine is a phenothiazine drug used as an antipsychotic and antiemetic.

alpha-Clopenthixol dihydrochloride is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.

ProMazine-d6 hydrochloride is a deuterated compound of ProMazine hydrochloride. ProMazine hydrochloride has a CAS number of 53-60-1. Promazine hydrochloride is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.

Acetophenazine dimaleate is an antipsychotic agent, effective in anxious depression. Acetophenazine dimaleate primarily targets the dopamine D2 receptor.

RTC-30, an optimized phenothiazine compound, possesses potent anti-cancer properties and is formulated with a hydroxylated linker (N) to enhance its oral bioavailability[1].

Clopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.

Perphenazine-d4 is a deuterated compound of Perphenazine. Perphenazine has a CAS number of 58-39-9. Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.

Fonazine mesylate is a phenothiazine drug used for the treatment of migraine. It is a serotonin antagonist and histamine antagonist.

Butaperazine is a typical antipsychotic of the phenothiazine class.

Promethazine is a neuroleptic medication and first-generation antihistamine of the phenothiazine family.

Fluphenazine-d8 Dihydrochloride is a deuterated compound of Fluphenazine Dihydrochloride. Fluphenazine Dihydrochloride has a CAS number of 146-56-5. Fluphenazine dihydrochloride is an inhibitor of phenothiazine-class D1DR and D2DR; In studies, Fluphenazine can be used to probe the effects and metabolic process of this commonly used dopamine antagonist.

Methdilazine Hydrochloride is a first-generation phenothiazine class antihistamine with anticholinergic properties.

Pipotiazine has less sedating and a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics among the different phenothiazine derivatives. However, it produces a high incidence of extra pyramidal reactions. I

Mesoridazine (thioridazine EP impurity B) is a phenothiazine antipsychotic with effects similar to chlorpromazine.

Imiclopazine, a phenothiazine derivative, exhibits sedative, analgesic, antiaggressive, and antiemetic effects.

D54 Naponate is a stored salt form of biologically active phenothiazine, which has good antitumor activity and can be maintained longer in the body.

Butaperazine maleate, a phenothiazine derivative, is an antipsychotic.

Clopenthixol decanoate is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.

Prochlorperazine-d8 is a deuterated compound of Prochlorperazine. Prochlorperazine has a CAS number of 58-38-8. Prochlorperazine is an antipsychotic phenothiazine derivative.

Biperiden (Bipariden) is a muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine.

Forazine (dimethiazide) is a phenothiazine drug used in the treatment of migraine and is a serotonin antagonist and a histamine antagonist.

Oxypertine is an indole-derivative antipsychotic with general properties similar to those of the chlorpromazine and phenothiazine. Oxypertine is used as a treatment for various psychoses including mania, schizophrenia, disturbed behaviour, and severe anx

Fonazine hydrochloride is a phenothiazine drug used for the treatment of migraine. It is a serotonin antagonist and histamine antagonist.