tri 1

TRi-1 is irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy

2,3,5-Tri-O-benzoyl-1-O-acetyl-4-thio-D-ribofuranose is a Carbohydrate.

2,3,5-Tri-O-(p-toluoyl)-1-O-acetyl-4-thio-D-ribofuranose is a Carbohydrate Derivative.

4-Amino-6-bromo-5-cyano-1-(2,3,5-tri-O-benzoyl-b-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine is a Nucleoside Derivative - 7-Deaza-purine nucleoside, 8-Modified-purine nucleoside, Halo-nucleoside; Scaffold and Template.

3,6-Dibromo-1,5-dihydro-1-(2,3,5-tri-O-benzoyl-b-D-ribofuranosyl)-4H-pyrazolo[3,4-d]pyrimidin-4-one is a Nucleoside Derivative - 7-Deaza-8-aza-purine nucleoside; Halo-nucleoside; Scaffold and Template.

6-Amino-4-methoxy-1-(2,3,5-tri-O-benzoyl-b-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a useful organic compound for research related to life sciences and the catalog number is TNU1045.

1-O-Acetyl-2,3,5-tri-O-benzoyl-5(R)-C-methyl-D-ribofuranose is a Carbohydrate Derivative.

Kaempferol 3,4',7-triacetate (3,7,4'-Tri-O-acetylkaempferol) is a natural product of the herbs of Cudrania tricuspidata.

1,2,6-Tri-O-galloyl-β-D-glucose is a chemical compound that can be extracted from the plant Sanguisorba officinalis [1].

3,4,6-Tri-O-benzyl-β-D-mannopyranose 1,2-(methyl orthoacetate) is a synthetic intermediate used in glycosylation reactions. Typically, the methyl orthoester protecting group is first removed by mild acid hydrolysis, producing a glycosyl donor. Removal of the O-benzyl protecting groups is performed late in the synthesis.

1,2,3-Tri-α-linolenoyl glycerol, a polyunsaturated triacylglycerol featuring α-linolenoyl (18:3) side chains at the C-1, C-2, and C-3 positions, serves a key role in lipid research.

1,2,3-Tri-13(E)-docosenoyl glycerol, a triacylglycerol featuring 13(E)-docosenoic acid at the \(sn-1\), \(sn-2\), and \(sn-3\) positions, transiently elevates heart triglyceride levels in weanling rats when administered as 15% of a calcium-deficient diet, with levels returning to baseline after 28 days.

Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH is a chemical linker featuring the TLR4 inhibitor TLR4-IN-C34, known for inhibition of TLR4 in enterocytes and macrophages, thereby diminishing systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis [1].

1,2,3-Tri-11(Z)-eicosenoyl glycerol, a triacylglycerol with 11(Z)-eicosenoic acid at the sn-1,sn-2, and sn-3 positions, serves as an internal standard for quantifying triacylglycerols in seed and olive oils.

Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH, a chemical compound, serves as a linker incorporating TLR4 inhibitor TLR4-IN-C34. This compound effectively inhibits TLR4 in both enterocytes and macrophages, significantly reducing systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis [1].

Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) is a useful organic compound for research related to life sciences. The catalog number is T64630 and the CAS number is 1445085-55-1.

Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH is a chemical linker incorporating the TLR4 inhibitor, TLR4-IN-C34, which suppresses TLR4 activity in enterocytes and macrophages, consequently diminishing systemic inflammation observed in mouse models of endotoxemia and necrotizing enterocolitis [1].

1,2,3-Tri-γ-linolenoyl glycerol, a polyunsaturated triacylglycerol featuring γ-linolenoyl side chains at the C-1, C-2, and C-3 positions, occurs in multiple plant species such as blackcurrant, redcurrant, and borage.

1,2,3-Tri-6(Z)-octadecenoyl glycerol, a triacylglycerol, incorporates 6(Z)-octadecenoic acid (cis-petroselinic acid) into the sn-1, sn-2, and sn-3 positions. This compound is prevalent in plant seed oils.

1,3,5-Tri-O-benzoyl-D-ribofuranose is a Carbohydrate.

1,2,3-Tri-O-acetyl-6-O-benzoyl-5-deoxy-D-ribo-hexofruanose is a useful organic compound for research related to life sciences and the catalog number is TNU1671.

5-(2,3,5-Tri-O-benzyl-beta-D-ribofuranosyl)-2(1H)-pyridinone is a useful organic compound for research related to life sciences and the catalog number is TNU0828.

Methanesulfonato(2-di-t-butylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) dichloromethane adduct is a useful organic compound for research related to life sciences and the catalog number is T67242.

Methanesulfonato(tri-t-butylphosphino)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) is a useful organic compound for research related to life sciences and the catalog number is T67261.

Methanesulfonato(2-di-t-butylphosphino-3,4,5,6-tetramethyl-2',4',6'-tri-i-propylbiphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) is a useful organic compound for research related to life sciences and the catalog number is T67252.

Methanesulfonato(2-di-t-butylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) is a useful organic compound for research related to life sciences and the catalog number is T66570.

BrettPhos Pd G4 is a useful organic compound for research related to life sciences. The catalog number is T64764 and the CAS number is 1599466-83-7.

Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) is a useful organic compound for research related to life sciences. The catalog number is T67240 and the CAS number is 1599466-81-5.

1,3,6-Tri-O-galloyl-beta-D-glucose (1,3,6-Tri-O-galloylglucose) is a phenolic compound in Black Walnut Kernels. It shows anti-inflammatory activity.

2-(Dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1'-biphenyl is a useful organic compound for research related to life sciences. The catalog number is T65998 and the CAS number is 564483-18-7.

Chlorotrianisene (tri-p-anisylchloroethylene) is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), with predominantly estrogenic but also antiestrogenic activities.

b-Casomorphin (1-3) Acetate is a tri-peptide with an opioid effect.

Tri-GalNAc-NHS ester, a LYsosome TArgeting Chimera (LYTAC) and ligand for the asialoglycoprotein receptor (ASGPR), facilitates the degradation of extracellular proteins, including membrane proteins, via the lysosomal targeting receptor expressed on liver cells. This compound is utilized as a protein degrader in LYTAC research [1].

Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride is a cleavable PEG-based linker employed in the synthesis of antibody-drug conjugates (ADCs) and utilized as a PEG-based PROTAC linker for PROTACs synthesis, as documented in references [1] [2].

Tri-GalNAc(OAc)3-Perfluorophenyl is a pentafluorophenyl-modified triantenerrary N-acetylgalactosamine (tri-GalNAc) ligand utilized in the synthesis of GalNAc-lysosome-targeting chimeras (LYTACs). These chimeras facilitate targeted protein degradation through engagement with the asialoglycoprotein receptor [1].

Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane, a PEG-derived PROTAC linker, is employed for PROTAC synthesis[1].

N1,N5,N10-(E)-tri-p-coumaroylspermidine shows free radical-scavenging activity.

3-Acetyldeoxy nivalenol-13C17is intended for use as an internal standard for the quantification of 3-acetyldeoxy nivalenol by GC- or LC-MS. 3-Acetyldeoxy nivalenol is a mycotoxin that has been found inF. graminearum.1In vivo, 3-acetyldeoxy nivalenol (40 mg/kg) induces duodenal and splenic cell necrosis, as well as lethality (LD50= 70 mg/kg) in mice.2 1.Jiao, F., Kawakami, A., and Nakajima, T.Effects of different carbon sources on trichothecene production and Tri gene expression by Fusarium graminearum in liquid cultureFEMS Microbiol.Lett.285(2)212-219(2008) 2.Schiefer, H.B., Nicholson, S., Kasali, O.B., et al.Pathology of acute 3-acetyldeoxynivalenol toxicity in miceCan. J. Comp. Med.49(3)315-318(1985)

Tri-GalNAc(OAc)3 TFA, a triantenerrary N-acetylgalactosamine (tri-GalNAc) ligand, is utilized in the synthesis of GalNAc-lysosome-targeting chimera (GalNAc-LYTAC). This compound facilitates targeted protein degradation by engaging with the asialoglycoprotein receptor [1].

Tri-valine (NSC 35938) is a polypeptide isolated from creatine kinase, β-enolase, triosephosphate isomerase, and glyceraldehyde 3-phosphate dehydrogenase [1].

Tri-GalNAc biotin, a small molecule lysosome targeting degrader, serves as a ligand for the asialoglycoprotein receptor (ASGPR). It promotes the uptake of NeutrAvidin (NA) into liver cells via ASGPR and directs NeutrAvidin to the lysosome for degradation. This compound is applicable in the study of Lysosome Targeting Chimeras (LYTAC) [1].

Cidofovir diphosphate triethylamine, an active intracellular metabolite of Cidofovir, acts as a selective inhibitor of viral DNA polymerases. It exhibits inhibitory constants (K_i) of 6.6 μM for human cytomegalovirus (HCMV) DNA polymerase, 0.86 μM for herpes simplex virus-1 (HSV-1) DNA polymerase, and 1.4 μM for herpes simplex virus-2 (HSV-2) DNA polymerase, demonstrating its efficacy against these viral enzymes [1] [2].

m-C-tri(CH2-PEG1-NHS ester) is a non-cleavable one-unit polyethylene glycol (PEG) linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].

Amino-Tri-(carboxyethoxymethyl)-methane, an ADC linker and PROTAC linker, is a cleavable PEG compound utilized for the synthesis of antibody-drug conjugates (ADCs)[1] and PEG-based PROTACs[2].

Methionylserine (H-MET-SER-OH), a dipeptide composed of methionine and serine, demonstrates effective binding and translocation through the intestinal di/tri-peptide transporter 1 (hPEPT1), possessing a K_m value of 0.2 mM. It also exhibits inhibition of ACE enzyme activity, rendering it useful in hypertension research [1] [2].

Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-spec

Tri-(PEG1-C2-acid) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Tri(Amino-PEG4-amide)-amine is a polyethylene glycol (PEG)-based linker compound utilized for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Tri(Amino-PEG3-amide)-amine is a polyethylene glycol (PEG)-derived linker employed for the synthesis of proteolysis-targeting chimeric molecules (PROTACs)[1].

Tri(Mal-PEG2-amide)-amine is a polyethylene glycol (PEG)-derived linker commonly employed for synthesizing proteolysis-targeting chimeras (PROTACs)[1].