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Acetyl-CoA Carboxylase

Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes the irreversible carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT).
Cat No. product name
T14991 CMS-121 CMS-121 is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor with strong neuroprotective, antioxidative, anti-inflammatory, and renoprotective activitie...
T5046 Haloxyfop (±)-Haloxyfop is a herbicide.
T1889 CP-640186 CP-640186 is an isozyme-nonselective Acetyl-CoA carboxylase (ACCase) inhibitor. The IC50s of CP-640186 is 53 nM and 61 nM for rat liver ACC1 and rat skeletal mus...
T7163 PF-05175157 PF 05175157 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 27, 33, 23.5, and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, re...
T7184 Firsocostat ND-630 is an inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits human ACC1 and ACC2 activity (IC50s of 2.1 and 6.1 nM, respectively)
T9209 PF-05221304 PF-05221304 is an orally active, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), a rate-limiting enzymes for fatty acid synthesis.
TQ0243 ND-646 ND-646 is an orally bioavailable and allosteric inhibitor of the ACC enzymes ACC1 and ACC2(IC50s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respective...
T3510 Olumacostat Glasaretil Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC). It has been used in trials studying the treatment of Acne Vulgaris.
T3622 CP-640186 hydrochloride CP-640186 HCl is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM...
T3988 TOFA TOFA is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA).
CMS-121
T14991
CMS-121 is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor with strong neuroprotective, antioxidative, anti-inflammatory, and renoprotective activitie...
Haloxyfop
T5046
(±)-Haloxyfop is a herbicide.
CP-640186
T1889
CP-640186 is an isozyme-nonselective Acetyl-CoA carboxylase (ACCase) inhibitor. The IC50s of CP-640186 is 53 nM and 61 nM for rat liver ACC1 and rat skeletal mus...
PF-05175157
T7163
PF 05175157 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 27, 33, 23.5, and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, re...
Firsocostat
T7184
ND-630 is an inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits human ACC1 and ACC2 activity (IC50s of 2.1 and 6.1 nM, respectively)
PF-05221304
T9209
PF-05221304 is an orally active, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), a rate-limiting enzymes for fatty acid synthesis.
ND-646
TQ0243
ND-646 is an orally bioavailable and allosteric inhibitor of the ACC enzymes ACC1 and ACC2(IC50s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respective...
Olumacostat Glasaretil
T3510
Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC). It has been used in trials studying the treatment of Acne Vulgaris.
CP-640186 hydrochloride
T3622
CP-640186 HCl is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM...
TOFA
T3988
TOFA is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA).