Bcr-Abl

The Bcr/Abl fusion protein is localized to the cytoplasm and actin cytoskeleton of hematopoietic cells, and has increased and dysregulated tyrosine kinase activity.

Cat. No.	Product name	CAS No.	Purity
T12907	SIAIS178	2376047-73-1	98%
SIAIS178 is a potent and selective degrader of BCR-ABL based on PROTAC technology (IC50 of 24 nM).
T10488	BCR-ABL-IN-1	188260-50-6	98%
BCR-ABL-IN-1 is a BCR-ABL tyrosine kinase inhibitor (pIC50: 6.46) and may be used in the research of chronic myelogenous leukemia.
T22378	Nilotinib hydrochloride	923288-95-3	98%
Nilotinib hydrochloride, the hydrochloride salt form of nilotinib, is an orally bioavailable Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.
T6650	Sabutoclax	1228108-65-3	98%
Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.
T14925	Cenisertib	871357-89-0	98%
Cenisertib is A potent ATP-competitive multi-kinase inhibitor, showing inhibitory effects on the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5, FLT3, as well a...
T10583	Bosutinib D8	T10583	98%
Bosutinib D8 is a deuterium-labeled Bosutinib. Bosutinib (SKI-606) is a dual Src/Abl inhibitor (IC50s: 1.2 nM/1 nM).
T28374	PF-06651481-00	1391063-17-4	98%
PF-06651481-00 is a Bosutinib analog and a Bcr-Abl inhibitor.
T16545	Pivanex	122110-53-6	98%
Pivanex is a derivative of Butyric acid and is an orally active HDAC inhibitor. Pivanex has antimetastic and antiangiogenic properties. Pivanex down-regulates bc...
T7186	CZC-8004	916603-07-1	98%
CZC-8004 is a pan-kinase(ABL kinase) inhibitor and binds a range of tyrosine kinases.
T4618	BGG463	890129-26-7	98%
BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.
T67847	Imatinib impurities3	404844-11-7	98%
Imatinib impurities3 is a protein kinases inhibitor with IC50 values of 6.95uM, 0.245uM, 0.139uM for ABL1 wt, KIT wt, PDGFRR wt, respectively.
T22553	Adaphostin	241127-58-2	98%
This compound is a p210bcr/abl tyrosine kinase inhibitor (IC50 = 14 μM).
T16750	Rigosertib	592542-59-1	98%
Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which...
T6348	NVP-BHG712	940310-85-0	98%
NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and c...
T4191	Multi-kinase inhibitor 1	778274-97-8	98%
Multi-kinase inhibitor I is a Multi-kinase inhibitor.
T2116	AEE788	497839-62-0	98%
AEE788 has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.
T30855	CGP77675	234772-64-6	98%
CGP77675 is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates and autophosphorylat...
T22552L	AD57	1093380-42-7	98%
AD57 is a potent inhibitor of both c-Src and Abl with IC50 of 0.025 μM and 0.041 μM, respectively.
T2094	Danusertib	827318-97-8	98%
Danusertib is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinases, which may ...
T23128	PD180970	287204-45-9	98%
PD180970 is an inhibitor of Bcr-Abl with IC50s of 5 nM, 0.8 nM and 50 nM for the autophosphorylation of p210Bcr-Abl, Src and Kit. PD180970 can be used in studies...

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T12907

SIAIS178

2376047-73-1

98%

SIAIS178 is a potent and selective degrader of BCR-ABL based on PROTAC technology (IC50 of 24 nM).

T10488

BCR-ABL-IN-1

188260-50-6

98%

BCR-ABL-IN-1 is a BCR-ABL tyrosine kinase inhibitor (pIC50: 6.46) and may be used in the research of chronic myelogenous leukemia.

T22378

Nilotinib hydrochloride

923288-95-3

98%

Nilotinib hydrochloride, the hydrochloride salt form of nilotinib, is an orally bioavailable Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.

T6650

Sabutoclax

1228108-65-3

98%

Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.

T14925

Cenisertib

871357-89-0

98%

Cenisertib is A potent ATP-competitive multi-kinase inhibitor, showing inhibitory effects on the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5, FLT3, as well a...

T10583

Bosutinib D8

T10583

98%

Bosutinib D8 is a deuterium-labeled Bosutinib. Bosutinib (SKI-606) is a dual Src/Abl inhibitor (IC50s: 1.2 nM/1 nM).

T28374

PF-06651481-00

1391063-17-4

98%

PF-06651481-00 is a Bosutinib analog and a Bcr-Abl inhibitor.

T16545

Pivanex

122110-53-6

98%

Pivanex is a derivative of Butyric acid and is an orally active HDAC inhibitor. Pivanex has antimetastic and antiangiogenic properties. Pivanex down-regulates bc...

T7186

CZC-8004

916603-07-1

98%

CZC-8004 is a pan-kinase(ABL kinase) inhibitor and binds a range of tyrosine kinases.

T4618

BGG463

890129-26-7

98%

BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.

T67847

Imatinib impurities3

404844-11-7

98%

Imatinib impurities3 is a protein kinases inhibitor with IC50 values of 6.95uM, 0.245uM, 0.139uM for ABL1 wt, KIT wt, PDGFRR wt, respectively.

T22553

Adaphostin

241127-58-2

98%

This compound is a p210bcr/abl tyrosine kinase inhibitor (IC50 = 14 μM).

T16750

Rigosertib

592542-59-1

98%

Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which...

T6348

NVP-BHG712

940310-85-0

98%

NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and c...

T4191

Multi-kinase inhibitor 1

778274-97-8

98%

Multi-kinase inhibitor I is a Multi-kinase inhibitor.

T2116

AEE788

497839-62-0

98%

AEE788 has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.

T30855

CGP77675

234772-64-6

98%

CGP77675 is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates and autophosphorylat...

T22552L

AD57

1093380-42-7

98%

AD57 is a potent inhibitor of both c-Src and Abl with IC50 of 0.025 μM and 0.041 μM, respectively.

T2094

Danusertib

827318-97-8

98%

Danusertib is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinases, which may ...

T23128

PD180970

287204-45-9

98%

PD180970 is an inhibitor of Bcr-Abl with IC50s of 5 nM, 0.8 nM and 50 nM for the autophosphorylation of p210Bcr-Abl, Src and Kit. PD180970 can be used in studies...