DYRK

Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) are conserved serine/threonine kinases. DYRKs have been implicated in cell survival, proliferation and differentiation, and in the pathology of Down Syndrome and Alzheimer's disease.

Cat. No.	Product name	CAS No.	Purity
T11132	DYRKs-IN-1	1387090-01-8	98%
T11132	DYRKs-IN-1 has antitumor activity. DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 9 nM and 5 ...
T11133	DYRKs-IN-2	1386980-04-6	98%
T11133	DYRKs-IN-2 has antitumor activity. DYRKs-IN-2 is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively.
T4636	Protein kinase inhibitors 1	1365986-44-2	98%
T4636	Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.
TQ0111	LDN-192960	184582-62-5	null%
TQ0111	LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).
T14364	AZ-Dyrk1B-33	1679330-37-0	99.99%
T14364	AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.
T11960	MBM-55	2083622-09-5	99.98%
T11960	MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing...
T72039	CLK1-IN-3	2922550-28-3	99.79%
T72039	Clk1-in-3 is a + selective and highly potent sexual Clk1 inhibitor with an IC50 of 5 nM and 300 pairs higher affinity than Dyrk1A. CLK1-IN-3 also showed highly e...
T22012	7BIO	916440-85-2	99.77%
T22012	7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kin...
T2431	ID-8	147591-46-6	99.77%
T2431	ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.
T61360	ARN25068	2649882-80-2	99.71%
T61360	ARN25068 is a potent inhibitor of GSK-3β, FYN, and DYRK1A protein kinases, exerting its activity in the sub-micromolar range. This compound effectively addresses...
T6257	AZ191	1594092-37-1	99.65%
T6257	AZ191（IC50 of 17 nM） is an effective and specific DYRK1B inhibitor. The specificity of AZ191 for DYRK1B is about 5- and 110-fold greater over DYRK1A and DYRK2, r...
T15422	GSK-626616	1025821-33-3	99.48%
T15422	GSK-626616 is a potent and orally bioavailable DYRK3 inhibitor (IC50: 0.7 nM). It inhibits other members of the DYRK family with similar potency. GSK-626616 is a...
T2811	Harmine hydrochloride	343-27-1	99.45%
T2811	Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus.
T11447	GNF4877	2041073-22-5	99.11%
T11447	GNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6 nM and 16 nM). It leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and in...
T2670	ML167	1285702-20-6	98.85%
T2670	ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.
T10827	CK2/ERK8-IN-1	1085822-09-8	98.82%
T10827	CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds t...
T24152	HTH-01-091	2000209-42-5	98.40%
T24152	HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK...
T15204	EHT 1610	1425945-60-3	98.27%
T15204	EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively. EHT 1610 has an inhibitory effect on ...
T15579	INDY	1169755-45-6	98.15%
T15579	INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.
T23186	ProINDY	719277-30-2	97.19%
T23186	ProINDY (Pro-indy) is a potent DYRK inhibitor that activates NFAT for the study of Down syndrome.