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Cell Cycle/Checkpoint DYRK

DYRK

Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) are conserved serine/threonine kinases. DYRKs have been implicated in cell survival, proliferation and differentiation, and in the pathology of Down Syndrome and Alzheimer's disease.
Cat No. product name
T2431 ID-8 ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.
T2670 ML167 ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.
T6257 AZ191 AZ191(IC50 of 17 nM) is an effective and specific DYRK1B inhibitor. The specificity of AZ191 for DYRK1B is about 5- and 110-fold greater over DYRK1A and DYR...
TQ0111 LDN-192960 LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).
T2811 Harmine hydrochloride Harmine hydrochloride is extracted from Peganum Harmala Genus.
T14364 AZ-Dyrk1B-33 AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor. With an IC50 of 7 nM[1].
T11132 DYRKs-IN-1  DYRKs-IN-1 has antitumor activity. DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 9 nM an...
T11133 DYRKs-IN-2 DYRKs-IN-2 has antitumor activity. DYRKs-IN-2 is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively.
T11447 GNF4877 GNF4877 leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation cells. GNF4877 is a potent DYRK1A ...
T15579 INDY INDY is a potent and ATP-competitive inhibitor of Dyrk1A and Dyrk1B (IC50s: 0.24 μM and 0.23 μM, respectively). INDY sharply causes the self-renewal capacity...
ID-8
T2431CAS 147591-46-6
ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.
ML167
T2670CAS 1285702-20-6
ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.
AZ191
T6257CAS 1594092-37-1
AZ191(IC50 of 17 nM) is an effective and specific DYRK1B inhibitor. The specificity of AZ191 for DYRK1B is about 5- and 110-fold greater over DYRK1A and DYR...
LDN-192960
TQ0111CAS 184582-62-5
LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).
Harmine hydrochloride
T2811CAS 343-27-1
Harmine hydrochloride is extracted from Peganum Harmala Genus.
AZ-Dyrk1B-33
T14364CAS 1679330-37-0
AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor. With an IC50 of 7 nM[1].
DYRKs-IN-1
T11132CAS 1387090-01-8
 DYRKs-IN-1 has antitumor activity. DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 9 nM an...
DYRKs-IN-2
T11133CAS 1386980-04-6
DYRKs-IN-2 has antitumor activity. DYRKs-IN-2 is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively.
GNF4877
T11447CAS 2041073-22-5
GNF4877 leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation cells. GNF4877 is a potent DYRK1A ...
INDY
T15579CAS 1169755-45-6
INDY is a potent and ATP-competitive inhibitor of Dyrk1A and Dyrk1B (IC50s: 0.24 μM and 0.23 μM, respectively). INDY sharply causes the self-renewal capacity...