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DYRK

Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) are conserved serine/threonine kinases. DYRKs have been implicated in cell survival, proliferation and differentiation, and in the pathology of Down Syndrome and Alzheimer's disease.
Cat No. product name
T22012 7BIO 7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kin...
T4636 Protein kinase inhibitors 1 Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.
T2811 Harmine hydrochloride Harmine hydrochloride is extracted from Peganum Harmala Genus.
T1711 Harmine Harmine is an alkaloid isolated from seeds of Peganum harmala.
T11447 GNF4877 GNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6 nM and 16 nM). It leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and in...
T2670 ML167 ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.
T2431 ID-8 ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.
T11133 DYRKs-IN-2 DYRKs-IN-2 has antitumor activity. DYRKs-IN-2 is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively.
T11132 DYRKs-IN-1 DYRKs-IN-1 has antitumor activity. DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 9 nM and 5 ...
TQ0111 LDN-192960 LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).
T6257 AZ191 AZ191(IC50 of 17 nM) is an effective and specific DYRK1B inhibitor. The specificity of AZ191 for DYRK1B is about 5- and 110-fold greater over DYRK1A and DYRK2, r...
T15579 INDY INDY is a ATP-competitive inhibitor of Dyrk1A and Dyrk1B (IC50s: 0.24 μM and 0.23 μM). INDY sharply causes the self-renewal capacity of normal and tumorigenic c...
T14364 AZ-Dyrk1B-33 AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor. With an IC50 of 7 nM[1].
T15422 GSK-626616 GSK-626616 is a potent and orally bioavailable DYRK3 inhibitor (IC50: 0.7 nM). It inhibits other members of the DYRK family with similar potency. GSK-626616 is a...
7BIO
T22012
7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kin...
Protein kinase inhibitors 1
T4636
Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.
Harmine hydrochloride
T2811
Harmine hydrochloride is extracted from Peganum Harmala Genus.
Harmine
T1711
Harmine is an alkaloid isolated from seeds of Peganum harmala.
GNF4877
T11447
GNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6 nM and 16 nM). It leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and i...
ML167
T2670
ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.
ID-8
T2431
ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.
DYRKs-IN-2
T11133
DYRKs-IN-2 has antitumor activity. DYRKs-IN-2 is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively.
DYRKs-IN-1
T11132
DYRKs-IN-1 has antitumor activity. DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 9 nM and 5 ...
LDN-192960
TQ0111
LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).
AZ191
T6257
AZ191(IC50 of 17 nM) is an effective and specific DYRK1B inhibitor. The specificity of AZ191 for DYRK1B is about 5- and 110-fold greater over DYRK1A and DYRK...
INDY
T15579
INDY is a ATP-competitive inhibitor of Dyrk1A and Dyrk1B (IC50s: 0.24 μM and 0.23 μM). INDY sharply causes the self-renewal capacity of normal and tumorigenic...
AZ-Dyrk1B-33
T14364
AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor. With an IC50 of 7 nM[1].
GSK-626616
T15422
GSK-626616 is a potent and orally bioavailable DYRK3 inhibitor (IC50: 0.7 nM). It inhibits other members of the DYRK family with similar potency. GSK-626616 is a...