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DYRK

Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) are conserved serine/threonine kinases. DYRKs have been implicated in cell survival, proliferation and differentiation, and in the pathology of Down Syndrome and Alzheimer's disease.
Cat. No. Product name CAS No. Purity Chemical Structure
T15204 EHT 1610 1425945-60-3 98%
EHT 1610 is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively. EHT 1610 has an inhibitory effect on leukemia, r...
T11133 DYRKs-IN-2 1386980-04-6 98%
DYRKs-IN-2 has antitumor activity. DYRKs-IN-2 is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively.
T11132 DYRKs-IN-1 1387090-01-8 98%
DYRKs-IN-1 has antitumor activity. DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 9 nM and 5 ...
T4636 Protein kinase inhibitors 1 1365986-44-2 98%
Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.
T40187 GNF2133 2561414-56-8 98%
GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.
T14364 AZ-Dyrk1B-33 1679330-37-0 98%
AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor. With an IC50 of 7 nM[1].
T14980 CLK-IN-T3 2109805-56-1 98%
CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.
T11447 GNF4877 2041073-22-5
GNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6 nM and 16 nM). It leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and in...
T10827 CK2/ERK8-IN-1 1085822-09-8 98.02%
CK2/ERK8-IN-1 is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1,...
T15579 INDY 1169755-45-6 98.15%
INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.
T2670 ML167 1285702-20-6 98.85%
ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.
TQ0111 LDN-192960 184582-62-5 99.32%
LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).
T2811 Harmine hydrochloride 343-27-1 99.45%
Harmine hydrochloride is extracted from Peganum Harmala Genus.
T15422 GSK-626616 1025821-33-3 99.48%
GSK-626616 is a potent and orally bioavailable DYRK3 inhibitor (IC50: 0.7 nM). It inhibits other members of the DYRK family with similar potency. GSK-626616 is a...
T6257 AZ191 1594092-37-1 99.65%
AZ191(IC50 of 17 nM) is an effective and specific DYRK1B inhibitor. The specificity of AZ191 for DYRK1B is about 5- and 110-fold greater over DYRK1A and DYRK2, r...
T2431 ID-8 147591-46-6 99.77%
ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.
T22012 7BIO 916440-85-2 99.77%
7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kin...
T1711 Harmine 442-51-3 99.92%
Harmine is an alkaloid isolated from seeds of Peganum harmala.
T11960 MBM-55 2083622-09-5 99.98%
MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing...
EHT 1610
T15204
EHT 1610 is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively. EHT 1610 has an inhibitory effect on leukemia, r...
DYRKs-IN-2
T11133
DYRKs-IN-2 has antitumor activity. DYRKs-IN-2 is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively.
DYRKs-IN-1
T11132
DYRKs-IN-1 has antitumor activity. DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 9 nM and 5 ...
Protein kinase inhibitors 1
T4636
Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.
GNF2133
T40187
GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.
AZ-Dyrk1B-33
T14364
AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor. With an IC50 of 7 nM[1].
CLK-IN-T3
T14980
CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.
GNF4877
T11447
GNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6 nM and 16 nM). It leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and in...
CK2/ERK8-IN-1
T10827
CK2/ERK8-IN-1 is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1,...
INDY
T15579
INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.
ML167
T2670
ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.
LDN-192960
TQ0111
LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).
Harmine hydrochloride
T2811
Harmine hydrochloride is extracted from Peganum Harmala Genus.
GSK-626616
T15422
GSK-626616 is a potent and orally bioavailable DYRK3 inhibitor (IC50: 0.7 nM). It inhibits other members of the DYRK family with similar potency. GSK-626616 is a...
AZ191
T6257
AZ191(IC50 of 17 nM) is an effective and specific DYRK1B inhibitor. The specificity of AZ191 for DYRK1B is about 5- and 110-fold greater over DYRK1A and DYRK2, r...
ID-8
T2431
ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.
7BIO
T22012
7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kin...
Harmine
T1711
Harmine is an alkaloid isolated from seeds of Peganum harmala.
MBM-55
T11960
MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing...