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Lipase

A carboxypeptidase is a protease enzyme that hydrolyzes (cleaves) a peptide bond at the carboxy-terminal (C-terminal) end of a protein or peptide. This is in contrast to an aminopeptidases, which cleave peptide bonds at the N-terminus of proteins. Humans, animals, bacteria and plants contain several types of carboxypeptidases that have diverse functions ranging from catabolism to protein maturation.
Cat No. product name
T15632 JW 642 JW 642 is an effective inhibitor of monoacylglycerol lipase (MAGL) (IC50: 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, r...
T1846 Y-320 Y-320 is a new phenylpyrazoleanilide immunomodulator.
T2966 Beta-Sitosterol β-Sitosterol has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. β-Sitosterol, a m...
T9687 MAGL-IN-4 MAGL-IN-4 is one of the monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases.
T2338 JZL195 JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
T5737 Euphol Euphol, an alcohol tetracyclic triterpene, has a wide range of pharmacological properties and is considered to have anti-inflammatory action.
T3591 URB602 URB602 is a specific monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL (IC50: 28±4 μM) through a noncompetitive mechanism.
T17260 WWL70 WWL70 is a selective alpha/beta hydrolase domain 6 inhibitors (IC50: 70 nM).
T15635 JZP-430 JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM). It also shows ~230-fold selectivity over fatty...
T9374 AA38-3 AA38-3 inhibites three SHs (ABHD6, ABHD11, and FAAH)
T1875 Atglistatin Atglistatin is a highly effective, specific and competitive ATGL inhibitor with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, and no toxicity when the...
T2249 XEN445 XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.
T11199 Endothelial lipase inhibitor-1 Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM.
T11939 MAGL-IN-1 MAGL-IN-1 is a selective and potent monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 80 nM.
T5353 ABX-1431 ABX-1431 is a selective and orally available CNS-penetrant monoacylglycerol lipase (MAGL/MGLL) inhibitor (IC50: 14 nM).
T5815 MJN110 Cravatt Reagent is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110 Produces Opioid-Sparing Effects in a Mouse Neurop...
T6554 JZL 184 JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.
T4052 KML29 KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It ha...
T16496 PF-06795071 PF-06795071 is an effective and selective covalent inhibitor of MAGL (IC50: 3 nM).
T15614 JJKK 048 JJKK 048 is an ultrapotent and highly selective Monoacylglycerol lipase inhibitor.
JW 642
T15632
JW 642 is an effective inhibitor of monoacylglycerol lipase (MAGL) (IC50: 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, r...
Y-320
T1846
Y-320 is a new phenylpyrazoleanilide immunomodulator.
Beta-Sitosterol
T2966
β-Sitosterol has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. β-Sitosterol, a...
MAGL-IN-4
T9687
MAGL-IN-4 is one of the monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases.
JZL195
T2338
JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
euphol
T5737
Euphol, an alcohol tetracyclic triterpene, has a wide range of pharmacological properties and is considered to have anti-inflammatory action.
URB602
T3591
URB602 is a specific monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL (IC50: 28±4 μM) through a noncompetitive mechanism.
WWL70
T17260
WWL70 is a selective alpha/beta hydrolase domain 6 inhibitors (IC50: 70 nM).
JZP-430
T15635
JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM). It also shows ~230-fold selectivity over fat...
AA38-3
T9374
AA38-3 inhibites three SHs (ABHD6, ABHD11, and FAAH)
Atglistatin
T1875
Atglistatin is a highly effective, specific and competitive ATGL inhibitor with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, and no toxicity when th...
XEN445
T2249
XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.
Endothelial lipase inhibitor-1
T11199
Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM.
MAGL-IN-1
T11939
MAGL-IN-1 is a selective and potent monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 80 nM.
ABX-1431
T5353
ABX-1431 is a selective and orally available CNS-penetrant monoacylglycerol lipase (MAGL/MGLL) inhibitor (IC50: 14 nM).
MJN110
T5815
Cravatt Reagent is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110 Produces Opioid-Sparing Effects in a Mouse Neurop...
JZL 184
T6554
JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.
KML29
T4052
KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It ha...
PF-06795071
T16496
PF-06795071 is an effective and selective covalent inhibitor of MAGL (IC50: 3 nM).
JJKK 048
T15614
JJKK 048 is an ultrapotent and highly selective Monoacylglycerol lipase inhibitor.