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Metabolism Lipase

Lipase

A carboxypeptidase is a protease enzyme that hydrolyzes (cleaves) a peptide bond at the carboxy-terminal (C-terminal) end of a protein or peptide. This is in contrast to an aminopeptidases, which cleave peptide bonds at the N-terminus of proteins. Humans, animals, bacteria and plants contain several types of carboxypeptidases that have diverse functions ranging from catabolism to protein maturation.
Cat No. product name
T1846 Y320 Y-320 is a new phenylpyrazoleanilide immunomodulator.
T1875 Atglistatin Atglistatin is a highly effective, specific and competitive ATGL inhibitor with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, and no toxicity when...
T2249 XEN-445 XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.
T2338 JZL195 JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
T2966 Beta-Sitosterol β-Sitosterol has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. β-Sitosterol, ...
T3591 URB602 URB602 is a specific monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL (IC50: 28±4 μM) through a noncompetitive mechanism.
T4052 KML29 KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It h...
T6554 JZL184 JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.
T5353 ABX-1431 ABX-1431 is a selective and orally available CNS-penetrant monoacylglycerol lipase (MAGL/MGLL) inhibitor (IC50: 14 nM).
T5815 Cravatt Reagent Cravatt Reagent is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110 Produces Opioid-Sparing Effects in a Mouse Neuro...
T11199 Endothelial lipase inhibitor-1 Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM. 
T15614 JJKK 048 JJKK 048 is an ultrapotent and highly selective Monoacylglycerol lipase inhibitor.
T16496 PF-06795071 PF-06795071 is an effective and selective covalent inhibitor of MAGL (IC50: 3 nM).
T11939 MAGL-IN-1 MAGL-IN-1 is a selective and potent monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 80 nM. 
Y320
T1846CAS 288250-47-5
Y-320 is a new phenylpyrazoleanilide immunomodulator.
Atglistatin
T1875CAS 1469924-27-3
Atglistatin is a highly effective, specific and competitive ATGL inhibitor with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, and no toxicity when...
XEN-445
T2249CAS 1515856-92-4
XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.
JZL195
T2338CAS 1210004-12-8
JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
Beta-Sitosterol
T2966CAS 83-46-5
β-Sitosterol has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. β-Sitosterol, ...
URB602
T3591CAS 565460-15-3
URB602 is a specific monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL (IC50: 28±4 μM) through a noncompetitive mechanism.
KML29
T4052CAS 1380424-42-9
KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It h...
JZL184
T6554CAS 1101854-58-3
JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.
ABX-1431
T5353CAS 1446817-84-0
ABX-1431 is a selective and orally available CNS-penetrant monoacylglycerol lipase (MAGL/MGLL) inhibitor (IC50: 14 nM).
Cravatt Reagent
T5815CAS 1438416-21-7
Cravatt Reagent is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110 Produces Opioid-Sparing Effects in a Mouse Neuro...
Endothelial lipase inhibitor-1
T11199CAS 1466427-02-0
Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM. 
JJKK 048
T15614CAS 1515855-97-6
JJKK 048 is an ultrapotent and highly selective Monoacylglycerol lipase inhibitor.
PF-06795071
T16496CAS 2075629-81-9
PF-06795071 is an effective and selective covalent inhibitor of MAGL (IC50: 3 nM).
MAGL-IN-1
T11939CAS 2324160-91-8
MAGL-IN-1 is a selective and potent monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 80 nM.