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Metabolism Lipase

Lipase

A carboxypeptidase is a protease enzyme that hydrolyzes (cleaves) a peptide bond at the carboxy-terminal (C-terminal) end of a protein or peptide. This is in contrast to an aminopeptidases, which cleave peptide bonds at the N-terminus of proteins. Humans, animals, bacteria and plants contain several types of carboxypeptidases that have diverse functions ranging from catabolism to protein maturation.
Cat No. product name
T11199 Endothelial lipase inhibitor-1 Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM.
T11939 MAGL-IN-1 MAGL-IN-1 is a selective and potent monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 80 nM.
T15614 JJKK 048 JJKK 048 is an ultrapotent and highly selective Monoacylglycerol lipase inhibitor.
T16496 PF-06795071 PF-06795071 is an effective and selective covalent inhibitor of MAGL (IC50: 3 nM).
T1846 Y320 Y-320 is a new phenylpyrazoleanilide immunomodulator.
T1875 Atglistatin Atglistatin is a highly effective, specific and competitive ATGL inhibitor with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, and no toxicity when...
T2249 XEN445 XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.
T2338 JZL195 JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
T2966 Beta-Sitosterol β-Sitosterol has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. β-Sitosterol, ...
T3591 URB602 URB602 is a specific monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL (IC50: 28±4 μM) through a noncompetitive mechanism.
T4052 KML29 KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It h...
T5353 ABX-1431 ABX-1431 is a selective and orally available CNS-penetrant monoacylglycerol lipase (MAGL/MGLL) inhibitor (IC50: 14 nM).
T5815 Cravatt Reagent Cravatt Reagent is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110 Produces Opioid-Sparing Effects in a Mouse Neuro...
T6554 JZL184 JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.
Endothelial lipase inhibitor-1
T11199CAS 1466427-02-0
Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM.
MAGL-IN-1
T11939CAS 2324160-91-8
MAGL-IN-1 is a selective and potent monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 80 nM.
JJKK 048
T15614CAS 1515855-97-6
JJKK 048 is an ultrapotent and highly selective Monoacylglycerol lipase inhibitor.
PF-06795071
T16496CAS 2075629-81-9
PF-06795071 is an effective and selective covalent inhibitor of MAGL (IC50: 3 nM).
Y320
T1846CAS 288250-47-5
Y-320 is a new phenylpyrazoleanilide immunomodulator.
Atglistatin
T1875CAS 1469924-27-3
Atglistatin is a highly effective, specific and competitive ATGL inhibitor with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, and no toxicity when...
XEN445
T2249CAS 1515856-92-4
XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.
JZL195
T2338CAS 1210004-12-8
JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
Beta-Sitosterol
T2966CAS 83-46-5
β-Sitosterol has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. β-Sitosterol, ...
URB602
T3591CAS 565460-15-3
URB602 is a specific monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL (IC50: 28±4 μM) through a noncompetitive mechanism.
KML29
T4052CAS 1380424-42-9
KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It h...
ABX-1431
T5353CAS 1446817-84-0
ABX-1431 is a selective and orally available CNS-penetrant monoacylglycerol lipase (MAGL/MGLL) inhibitor (IC50: 14 nM).
Cravatt Reagent
T5815CAS 1438416-21-7
Cravatt Reagent is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110 Produces Opioid-Sparing Effects in a Mouse Neuro...
JZL184
T6554CAS 1101854-58-3
JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.