Lipase

A carboxypeptidase is a protease enzyme that hydrolyzes (cleaves) a peptide bond at the carboxy-terminal (C-terminal) end of a protein or peptide. This is in contrast to an aminopeptidases, which cleave peptide bonds at the N-terminus of proteins. Humans, animals, bacteria and plants contain several types of carboxypeptidases that have diverse functions ranging from catabolism to protein maturation.

Cat No.	product name
T11199	Endothelial lipase inhibitor-1	Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM.
T11939	MAGL-IN-1	MAGL-IN-1 is a selective and potent monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 80 nM.
T15614	JJKK 048	JJKK 048 is an ultrapotent and highly selective Monoacylglycerol lipase inhibitor.
T16496	PF-06795071	PF-06795071 is an effective and selective covalent inhibitor of MAGL (IC50: 3 nM).
T1846	Y320	Y-320 is a new phenylpyrazoleanilide immunomodulator.
T1875	Atglistatin	Atglistatin is a highly effective, specific and competitive ATGL inhibitor with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, and no toxicity when...
T2249	XEN445	XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.
T2338	JZL195	JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
T2966	Beta-Sitosterol	β-Sitosterol has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. β-Sitosterol, ...
T3591	URB602	URB602 is a specific monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL (IC50: 28±4 μM) through a noncompetitive mechanism.
T4052	KML29	KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It h...
T5353	ABX-1431	ABX-1431 is a selective and orally available CNS-penetrant monoacylglycerol lipase (MAGL/MGLL) inhibitor (IC50: 14 nM).
T5815	Cravatt Reagent	Cravatt Reagent is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110 Produces Opioid-Sparing Effects in a Mouse Neuro...
T6554	JZL184	JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.

Cat No.

product name

T11199

Endothelial lipase inhibitor-1

Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM.

T11939

MAGL-IN-1

MAGL-IN-1 is a selective and potent monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 80 nM.

T15614

JJKK 048

JJKK 048 is an ultrapotent and highly selective Monoacylglycerol lipase inhibitor.

T16496

PF-06795071

PF-06795071 is an effective and selective covalent inhibitor of MAGL (IC50: 3 nM).

T1846

Y320

Y-320 is a new phenylpyrazoleanilide immunomodulator.

T1875

Atglistatin

Atglistatin is a highly effective, specific and competitive ATGL inhibitor with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, and no toxicity when...

T2249

XEN445

XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.

T2338

JZL195

JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.

T2966

Beta-Sitosterol

β-Sitosterol has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. β-Sitosterol, ...

T3591

URB602

URB602 is a specific monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL (IC50: 28±4 μM) through a noncompetitive mechanism.

T4052

KML29

KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It h...

T5353

ABX-1431

ABX-1431 is a selective and orally available CNS-penetrant monoacylglycerol lipase (MAGL/MGLL) inhibitor (IC50: 14 nM).

T5815

Cravatt Reagent

Cravatt Reagent is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110 Produces Opioid-Sparing Effects in a Mouse Neuro...

T6554

JZL184

JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.