Lipase

A carboxypeptidase is a protease enzyme that hydrolyzes (cleaves) a peptide bond at the carboxy-terminal (C-terminal) end of a protein or peptide. This is in contrast to an aminopeptidases, which cleave peptide bonds at the N-terminus of proteins. Humans, animals, bacteria and plants contain several types of carboxypeptidases that have diverse functions ranging from catabolism to protein maturation.

Cat No.	product name
T15632	JW 642	JW 642 is an effective inhibitor of monoacylglycerol lipase (MAGL) (IC50: 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, r...
T1846	Y-320	Y-320 is a new phenylpyrazoleanilide immunomodulator.
T2966	Beta-Sitosterol	β-Sitosterol has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. β-Sitosterol, a m...
T9687	MAGL-IN-4	MAGL-IN-4 is one of the monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases.
T2338	JZL195	JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
T5737	Euphol	Euphol, an alcohol tetracyclic triterpene, has a wide range of pharmacological properties and is considered to have anti-inflammatory action.
T3591	URB602	URB602 is a specific monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL (IC50: 28±4 μM) through a noncompetitive mechanism.
T17260	WWL70	WWL70 is a selective alpha/beta hydrolase domain 6 inhibitors (IC50: 70 nM).
T15635	JZP-430	JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM). It also shows ~230-fold selectivity over fatty...
T9374	AA38-3	AA38-3 inhibites three SHs (ABHD6, ABHD11, and FAAH)
T1875	Atglistatin	Atglistatin is a highly effective, specific and competitive ATGL inhibitor with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, and no toxicity when the...
T2249	XEN445	XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.
T11199	Endothelial lipase inhibitor-1	Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM.
T11939	MAGL-IN-1	MAGL-IN-1 is a selective and potent monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 80 nM.
T5353	ABX-1431	ABX-1431 is a selective and orally available CNS-penetrant monoacylglycerol lipase (MAGL/MGLL) inhibitor (IC50: 14 nM).
T5815	MJN110	Cravatt Reagent is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110 Produces Opioid-Sparing Effects in a Mouse Neurop...
T6554	JZL 184	JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.
T4052	KML29	KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It ha...
T16496	PF-06795071	PF-06795071 is an effective and selective covalent inhibitor of MAGL (IC50: 3 nM).
T15614	JJKK 048	JJKK 048 is an ultrapotent and highly selective Monoacylglycerol lipase inhibitor.

Cat No.

product name

T15632

JW 642

JW 642 is an effective inhibitor of monoacylglycerol lipase (MAGL) (IC50: 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, r...

T1846

Y-320

Y-320 is a new phenylpyrazoleanilide immunomodulator.

T2966

Beta-Sitosterol

β-Sitosterol has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. β-Sitosterol, a m...

T9687

MAGL-IN-4

MAGL-IN-4 is one of the monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases.

T2338

JZL195

JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.

T5737

Euphol

Euphol, an alcohol tetracyclic triterpene, has a wide range of pharmacological properties and is considered to have anti-inflammatory action.

T3591

URB602

URB602 is a specific monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL (IC50: 28±4 μM) through a noncompetitive mechanism.

T17260

WWL70

WWL70 is a selective alpha/beta hydrolase domain 6 inhibitors (IC50: 70 nM).

T15635

JZP-430

JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM). It also shows ~230-fold selectivity over fatty...

T9374

AA38-3

AA38-3 inhibites three SHs (ABHD6, ABHD11, and FAAH)

T1875

Atglistatin

Atglistatin is a highly effective, specific and competitive ATGL inhibitor with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, and no toxicity when the...

T2249

XEN445

XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.

T11199

Endothelial lipase inhibitor-1

Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM.

T11939

MAGL-IN-1

MAGL-IN-1 is a selective and potent monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 80 nM.

T5353

ABX-1431

ABX-1431 is a selective and orally available CNS-penetrant monoacylglycerol lipase (MAGL/MGLL) inhibitor (IC50: 14 nM).

T5815

MJN110

Cravatt Reagent is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110 Produces Opioid-Sparing Effects in a Mouse Neurop...

T6554

JZL 184

JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.

T4052

KML29

KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It ha...

T16496

PF-06795071

PF-06795071 is an effective and selective covalent inhibitor of MAGL (IC50: 3 nM).

T15614

JJKK 048

JJKK 048 is an ultrapotent and highly selective Monoacylglycerol lipase inhibitor.