T11939 |
MAGL-IN-1
|
2324160-91-8
|
98%
|
|
MAGL-IN-1 is a selective and potent monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 80 nM.
|
T16496 |
PF-06795071
|
2075629-81-9
|
98%
|
|
PF-06795071 is an effective and selective covalent inhibitor of MAGL (IC50: 3 nM).
|
T1875 |
Atglistatin
|
1469924-27-3
|
98%
|
|
Atglistatin is a highly effective, specific and competitive ATGL inhibitor with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, and no toxicity when the...
|
T5353 |
ABX-1431
|
1446817-84-0
|
98%
|
|
ABX-1431 is a selective and orally available CNS-penetrant monoacylglycerol lipase (MAGL/MGLL) inhibitor (IC50: 14 nM).
|
T2338 |
JZL195
|
1210004-12-8
|
98%
|
|
JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
|
T2249 |
XEN445
|
1515856-92-4
|
98%
|
|
XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.
|
T9374 |
AA38-3
|
65815-76-1
|
98%
|
|
AA38-3 inhibites three SHs (ABHD6, ABHD11, and FAAH)
|
T2966 |
Beta-Sitosterol
|
83-46-5
|
98%
|
|
β-Sitosterol has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. β-Sitosterol, a m...
|
T3591 |
URB602
|
565460-15-3
|
98%
|
|
URB602 is a specific monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL (IC50: 28±4 μM) through a noncompetitive mechanism.
|
T27703 |
JZP-361
|
1680193-80-9
|
98%
|
|
JZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6. JZP-361 disp...
|
T1846 |
Y-320
|
288250-47-5
|
98%
|
|
Y-320 is a new phenylpyrazoleanilide immunomodulator.
|
T15614 |
JJKK 048
|
1515855-97-6
|
98%
|
|
JJKK 048 is a potent and selective MAGL inhibitor.
|
T15632 |
JW 642
|
1416133-89-5
|
98%
|
|
JW 642 is an effective inhibitor of monoacylglycerol lipase (MAGL) (IC50: 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, r...
|
T15635 |
JZP-430
|
1672691-74-5
|
98%
|
|
JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM). It also shows ~230-fold selectivity over fatty...
|
T41160 |
Lalistat 2
|
1234569-09-5
|
98%
|
|
Lalistat 2 is a selective inhibitor of lysosomal acid lipase with IC50 of 152 nM and exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein...
|
T28165 |
NF-1819
|
1881244-28-5
|
98%
|
|
NF-1819 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. NF-1819 alleviates symptoms in a MS model in vivo and exhi...
|
T5737 |
Euphol
|
514-47-6
|
98%
|
|
Euphol, an alcohol tetracyclic triterpene, has a wide range of pharmacological properties and is considered to have anti-inflammatory action.
|
T5815 |
MJN110
|
1438416-21-7
|
98%
|
|
Cravatt Reagent is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110 Produces Opioid-Sparing Effects in a Mouse Neurop...
|
T6554 |
JZL 184
|
1101854-58-3
|
98%
|
|
JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.
|
T11199 |
Endothelial lipase inhibitor-1
|
1466427-02-0
|
98%
|
|
Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM.
|