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Lipase

A carboxypeptidase is a protease enzyme that hydrolyzes (cleaves) a peptide bond at the carboxy-terminal (C-terminal) end of a protein or peptide. This is in contrast to an aminopeptidases, which cleave peptide bonds at the N-terminus of proteins. Humans, animals, bacteria and plants contain several types of carboxypeptidases that have diverse functions ranging from catabolism to protein maturation.
Cat. No. Product name CAS No. Purity Chemical Structure
T11939 MAGL-IN-1 2324160-91-8 98%
MAGL-IN-1 is a selective and potent monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 80 nM.
T16496 PF-06795071 2075629-81-9 98%
PF-06795071 is an effective and selective covalent inhibitor of MAGL (IC50: 3 nM).
T1875 Atglistatin 1469924-27-3 98%
Atglistatin is a highly effective, specific and competitive ATGL inhibitor with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, and no toxicity when the...
T5353 ABX-1431 1446817-84-0 98%
ABX-1431 is a selective and orally available CNS-penetrant monoacylglycerol lipase (MAGL/MGLL) inhibitor (IC50: 14 nM).
T2338 JZL195 1210004-12-8 98%
JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
T2249 XEN445 1515856-92-4 98%
XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.
T9374 AA38-3 65815-76-1 98%
AA38-3 inhibites three SHs (ABHD6, ABHD11, and FAAH)
T2966 Beta-Sitosterol 83-46-5 98%
β-Sitosterol has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. β-Sitosterol, a m...
T3591 URB602 565460-15-3 98%
URB602 is a specific monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL (IC50: 28±4 μM) through a noncompetitive mechanism.
T27703 JZP-361 1680193-80-9 98%
JZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6. JZP-361 disp...
T1846 Y-320 288250-47-5 98%
Y-320 is a new phenylpyrazoleanilide immunomodulator.
T15614 JJKK 048 1515855-97-6 98%
JJKK 048 is a potent and selective MAGL inhibitor.
T15632 JW 642 1416133-89-5 98%
JW 642 is an effective inhibitor of monoacylglycerol lipase (MAGL) (IC50: 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, r...
T15635 JZP-430 1672691-74-5 98%
JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM). It also shows ~230-fold selectivity over fatty...
T41160 Lalistat 2 1234569-09-5 98%
Lalistat 2 is a selective inhibitor of lysosomal acid lipase with IC50 of 152 nM and exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein...
T28165 NF-1819 1881244-28-5 98%
NF-1819 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. NF-1819 alleviates symptoms in a MS model in vivo and exhi...
T5737 Euphol 514-47-6 98%
Euphol, an alcohol tetracyclic triterpene, has a wide range of pharmacological properties and is considered to have anti-inflammatory action.
T5815 MJN110 1438416-21-7 98%
Cravatt Reagent is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110 Produces Opioid-Sparing Effects in a Mouse Neurop...
T6554 JZL 184 1101854-58-3 98%
JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.
T11199 Endothelial lipase inhibitor-1 1466427-02-0 98%
Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM.
MAGL-IN-1
T11939
MAGL-IN-1 is a selective and potent monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 80 nM.
PF-06795071
T16496
PF-06795071 is an effective and selective covalent inhibitor of MAGL (IC50: 3 nM).
Atglistatin
T1875
Atglistatin is a highly effective, specific and competitive ATGL inhibitor with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, and no toxicity when the...
ABX-1431
T5353
ABX-1431 is a selective and orally available CNS-penetrant monoacylglycerol lipase (MAGL/MGLL) inhibitor (IC50: 14 nM).
JZL195
T2338
JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
XEN445
T2249
XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.
AA38-3
T9374
AA38-3 inhibites three SHs (ABHD6, ABHD11, and FAAH)
Beta-Sitosterol
T2966
β-Sitosterol has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. β-Sitosterol, a m...
URB602
T3591
URB602 is a specific monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL (IC50: 28±4 μM) through a noncompetitive mechanism.
JZP-361
T27703
JZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6. JZP-361 disp...
Y-320
T1846
Y-320 is a new phenylpyrazoleanilide immunomodulator.
JJKK 048
T15614
JJKK 048 is a potent and selective MAGL inhibitor.
JW 642
T15632
JW 642 is an effective inhibitor of monoacylglycerol lipase (MAGL) (IC50: 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, r...
JZP-430
T15635
JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM). It also shows ~230-fold selectivity over fatty...
Lalistat 2
T41160
Lalistat 2 is a selective inhibitor of lysosomal acid lipase with IC50 of 152 nM and exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein...
NF-1819
T28165
NF-1819 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. NF-1819 alleviates symptoms in a MS model in vivo and exhi...
euphol
T5737
Euphol, an alcohol tetracyclic triterpene, has a wide range of pharmacological properties and is considered to have anti-inflammatory action.
MJN110
T5815
Cravatt Reagent is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110 Produces Opioid-Sparing Effects in a Mouse Neurop...
JZL 184
T6554
JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.
Endothelial lipase inhibitor-1
T11199
Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM.
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