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Immunology / Inflammation MALT

MALT

MALT1 is a paracaspase, which is related to the caspase (cysteine-aspartic proteases) family of proteases but cleaves after Arg residues instead of Asp. MALT1 cleavage activity is linked to the pathogenesis of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL), a chemoresistant form of DLBCL. MALT1 is a unique paracaspase protein that transduces aberrant oncogenic signaling in ABC-DLBCL. MALT1 represents a potentially important therapeutic target for ABC-DLBCL and MALT lymphoma. MALT1 small molecule inhibitors might be useful chemical tools for studying MALT1 biology and treating MALT1-addicted tumors.
Cat No. product name
T2350 MI 2 (MALT1 inhibitor) MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.
T16077 MIR96-IN-1 MIR96-IN-1 selectively inhibits biogenesis of microRNA-96, upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells.
T16132 MRE3008F20 MRE3008F20 is a highly effective and selective antagonist of adenosine A3 receptor (AA3R). MRE3008F20 also inhibits agonist-induced cAMP elevation in resting T ...
T16133 MRK-560 MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.
MI 2 (MALT1 inhibitor)
T2350CAS 1047953-91-2
MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.
MIR96-IN-1
T16077CAS 1311982-88-3
MIR96-IN-1 selectively inhibits biogenesis of microRNA-96, upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells.
MRE3008F20
T16132CAS 252979-43-4
MRE3008F20 is a highly effective and selective antagonist of adenosine A3 receptor (AA3R). MRE3008F20 also inhibits agonist-induced cAMP elevation in resting T ...
MRK-560
T16133CAS 677772-84-8
MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.