Home Tools
Log in
Cart

MALT

MALT1 is a paracaspase, which is related to the caspase (cysteine-aspartic proteases) family of proteases but cleaves after Arg residues instead of Asp. MALT1 cleavage activity is linked to the pathogenesis of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL), a chemoresistant form of DLBCL. MALT1 is a unique paracaspase protein that transduces aberrant oncogenic signaling in ABC-DLBCL. MALT1 represents a potentially important therapeutic target for ABC-DLBCL and MALT lymphoma. MALT1 small molecule inhibitors might be useful chemical tools for studying MALT1 biology and treating MALT1-addicted tumors.
Cat No. product name
T2350 MALT1 inhibitor MI-2 MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.
T9216 MLT-943 MLT-943 is a potent, selective and orally active MALT1 protease inhibitor. [1].
T16077 MIR96-IN-1 MIR96-IN-1 selectively inhibits biogenesis of microRNA-96, upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells.
T16133 MRK-560 MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.
T16132 MRE3008F20 MRE3008F20 is a highly effective and selective antagonist of adenosine A3 receptor (AA3R). MRE3008F20 also inhibits agonist-induced cAMP elevation in resting T l...
MALT1 inhibitor MI-2
T2350
MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.
MLT-943
T9216
MLT-943 is a potent, selective and orally active MALT1 protease inhibitor. [1].
MIR96-IN-1
T16077
MIR96-IN-1 selectively inhibits biogenesis of microRNA-96, upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells.
MRK-560
T16133
MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.
MRE3008F20
T16132
MRE3008F20 is a highly effective and selective antagonist of adenosine A3 receptor (AA3R). MRE3008F20 also inhibits agonist-induced cAMP elevation in resting T l...