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MT Receptor

Melatonin receptors are G protein-coupled receptors (GPCR) which bind melatonin. Three types of melatonin receptors have been cloned. The MT1 (or Mel1A or MTNR1A) and MT2 (or Mel1B or MTNR1B) receptor subtypes are present in humans and other mammals, while an additional melatonin receptor subtype MT3 (or Mel1C or MTNR1C) has been identified in amphibia and birds. The receptors are crucial in the signal cascade of melatonin. In the field of chronobiology, melatonin has been found to be a key player in the synchrony of biological clocks. Melatonin secretion by the pineal gland has circadian rhythmicity regulated by the suprachiasmatic nucleus (SCN) found in the brain. The SCN functions as the timing regulator for melatonin; melatonin then follows a feedback loop to decrease SCN neuronal firing. The receptors MT1 and MT2 control this process. Melatonin receptors are found throughout the body in places such as the brain, the retina of the eye, the cardiovascular system, the liver and gallbladder, the colon, the skin, the kidneys, and many others.
Cat No. product name
T1463 Ramelteon Ramelteon is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist.
T14042 4-P-PDOT 4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist.
T16834 S26131 S26131 is an effective and selective MT1 melatoninergic ligand (Ki: 0.5 and 112 nM for MT1 and MT2, respectively). S26131 behaves as an MT1 and MT2 antagonist.
T9193 ACH-000143 ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.
T15795 Luzindole Luzindole is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Luz...
T2O2728 Glycine Glycine is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neu...
T3495 Tasimelteon Tasimelteon is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals.
Ramelteon
T1463
Ramelteon is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist.
4-P-PDOT
T14042
4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist.
S26131
T16834
S26131 is an effective and selective MT1 melatoninergic ligand (Ki: 0.5 and 112 nM for MT1 and MT2, respectively). S26131 behaves as an MT1 and MT2 antagonist.
ACH-000143
T9193
ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.
Luzindole
T15795
Luzindole is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Luz...
glycine
T2O2728
Glycine is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neu...
Tasimelteon
T3495
Tasimelteon is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals.