MT Receptor

Melatonin receptors are G protein-coupled receptors (GPCR) which bind melatonin. Three types of melatonin receptors have been cloned. The MT1 (or Mel1A or MTNR1A) and MT2 (or Mel1B or MTNR1B) receptor subtypes are present in humans and other mammals, while an additional melatonin receptor subtype MT3 (or Mel1C or MTNR1C) has been identified in amphibia and birds. The receptors are crucial in the signal cascade of melatonin. In the field of chronobiology, melatonin has been found to be a key player in the synchrony of biological clocks. Melatonin secretion by the pineal gland has circadian rhythmicity regulated by the suprachiasmatic nucleus (SCN) found in the brain. The SCN functions as the timing regulator for melatonin; melatonin then follows a feedback loop to decrease SCN neuronal firing. The receptors MT1 and MT2 control this process. Melatonin receptors are found throughout the body in places such as the brain, the retina of the eye, the cardiovascular system, the liver and gallbladder, the colon, the skin, the kidneys, and many others.

Cat. No.	Product name	CAS No.	Purity
T60523	Agomelatine hydrochloride	1176316-99-6	98%
T60523	Agomelatine hydrochloride (S-20098 hydrochloride) is a specific MT1 and MT2 receptor agonist with Ki of 0.1 nM for CHO-hMT1, 0.06 nM for HEK-hMT1, 0.12 nM for CH...
T1463	Ramelteon	196597-26-9	98%
T1463	Ramelteon is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist.
T16834	S26131	296280-56-3	98%
T16834	S26131 is an effective and selective MT1 melatoninergic ligand (Ki: 0.5 and 112 nM for MT1 and MT2, respectively). S26131 behaves as an MT1 and MT2 antagonist.
T14042	4-P-PDOT	134865-74-0	98%
T14042	4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist.
T2O2728	Glycine	56-40-6	98%
T2O2728	Glycine is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neu...
T15795	Luzindole	117946-91-5	98%
T15795	Luzindole is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Luz...
T9193	ACH-000143	2225836-30-4	98%
T9193	ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.
T3495	Tasimelteon	609799-22-6	98%
T3495	Tasimelteon is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals.
T34081	Piromelatine	946846-83-9	98%
T34081	Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibito...