MT Receptor

Melatonin receptors are G protein-coupled receptors (GPCR) which bind melatonin. Three types of melatonin receptors have been cloned. The MT1 (or Mel1A or MTNR1A) and MT2 (or Mel1B or MTNR1B) receptor subtypes are present in humans and other mammals, while an additional melatonin receptor subtype MT3 (or Mel1C or MTNR1C) has been identified in amphibia and birds. The receptors are crucial in the signal cascade of melatonin. In the field of chronobiology, melatonin has been found to be a key player in the synchrony of biological clocks. Melatonin secretion by the pineal gland has circadian rhythmicity regulated by the suprachiasmatic nucleus (SCN) found in the brain. The SCN functions as the timing regulator for melatonin; melatonin then follows a feedback loop to decrease SCN neuronal firing. The receptors MT1 and MT2 control this process. Melatonin receptors are found throughout the body in places such as the brain, the retina of the eye, the cardiovascular system, the liver and gallbladder, the colon, the skin, the kidneys, and many others.

Cat. No.	Product name	CAS No.	Purity
T14042	4-P-PDOT	134865-74-0	98%
4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist.
T9193	ACH-000143	2225836-30-4	98.05%
ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.
T15795	Luzindole	117946-91-5	98.96%
Luzindole is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Luz...
T2O2728	Glycine	56-40-6	99.54%
Glycine is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neu...
T3495	Tasimelteon	609799-22-6	99.93%
Tasimelteon is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals.
T1463	Ramelteon	196597-26-9	99.94%
Ramelteon is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist.
T16834	S26131	296280-56-3	98%
S26131 is an effective and selective MT1 melatoninergic ligand (Ki: 0.5 and 112 nM for MT1 and MT2, respectively). S26131 behaves as an MT1 and MT2 antagonist.

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T14042

4-P-PDOT

134865-74-0

98%

4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist.

T9193

ACH-000143

2225836-30-4

98.05%

ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.

T15795

Luzindole

117946-91-5

98.96%

Luzindole is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Luz...

T2O2728

Glycine

56-40-6

99.54%

Glycine is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neu...

T3495

Tasimelteon

609799-22-6

99.93%

Tasimelteon is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals.

T1463

Ramelteon

196597-26-9

99.94%

Ramelteon is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist.

T16834

S26131

296280-56-3

98%

S26131 is an effective and selective MT1 melatoninergic ligand (Ki: 0.5 and 112 nM for MT1 and MT2, respectively). S26131 behaves as an MT1 and MT2 antagonist.