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MT Receptor

Melatonin receptors are G protein-coupled receptors (GPCR) which bind melatonin. Three types of melatonin receptors have been cloned. The MT1 (or Mel1A or MTNR1A) and MT2 (or Mel1B or MTNR1B) receptor subtypes are present in humans and other mammals, while an additional melatonin receptor subtype MT3 (or Mel1C or MTNR1C) has been identified in amphibia and birds. The receptors are crucial in the signal cascade of melatonin. In the field of chronobiology, melatonin has been found to be a key player in the synchrony of biological clocks. Melatonin secretion by the pineal gland has circadian rhythmicity regulated by the suprachiasmatic nucleus (SCN) found in the brain. The SCN functions as the timing regulator for melatonin; melatonin then follows a feedback loop to decrease SCN neuronal firing. The receptors MT1 and MT2 control this process. Melatonin receptors are found throughout the body in places such as the brain, the retina of the eye, the cardiovascular system, the liver and gallbladder, the colon, the skin, the kidneys, and many others.
Cat. No. Product name CAS No. Purity Chemical Structure
T60523 Agomelatine hydrochloride 1176316-99-6 98%
Agomelatine hydrochloride (S-20098 hydrochloride) is a specific MT1 and MT2 receptor agonist with Ki of 0.1 nM for CHO-hMT1, 0.06 nM for HEK-hMT1, 0.12 nM for CH...
T1463 Ramelteon 196597-26-9 98%
Ramelteon is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist.
T16834 S26131 296280-56-3 98%
S26131 is an effective and selective MT1 melatoninergic ligand (Ki: 0.5 and 112 nM for MT1 and MT2, respectively). S26131 behaves as an MT1 and MT2 antagonist.
T14042 4-P-PDOT 134865-74-0 98%
4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist.
T2O2728 Glycine 56-40-6 98%
Glycine is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neu...
T15795 Luzindole 117946-91-5 98%
Luzindole is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Luz...
T9193 ACH-000143 2225836-30-4 98%
ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.
T3495 Tasimelteon 609799-22-6 98%
Tasimelteon is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals.
T34081 Piromelatine 946846-83-9 98%
Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibito...
Agomelatine hydrochloride
T60523
Agomelatine hydrochloride (S-20098 hydrochloride) is a specific MT1 and MT2 receptor agonist with Ki of 0.1 nM for CHO-hMT1, 0.06 nM for HEK-hMT1, 0.12 nM for CH...
Ramelteon
T1463
Ramelteon is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist.
S26131
T16834
S26131 is an effective and selective MT1 melatoninergic ligand (Ki: 0.5 and 112 nM for MT1 and MT2, respectively). S26131 behaves as an MT1 and MT2 antagonist.
4-P-PDOT
T14042
4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist.
glycine
T2O2728
Glycine is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neu...
Luzindole
T15795
Luzindole is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Luz...
ACH-000143
T9193
ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.
Tasimelteon
T3495
Tasimelteon is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals.
Piromelatine
T34081
Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibito...