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NADPH-oxidase

NADPH oxidase (nicotinamide adenine dinucleotide phosphate oxidase) is a membrane-bound enzyme complex that faces the extracellular space. It can be found in the plasma membrane as well as in the membranes of phagosomes used by neutrophil white blood cells to engulf microorganisms.
Cat No. product name
T8408 GKT136901 GKT136901 is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite
T8107 GLX351322 GLX351322 is NADPH Oxidase 4 Inhibitor with IC50 of 5 μM.
T6099 Setanaxib GKT137831 is a potent, specific dual NADPH oxidase (NOX1/4) inhibitor.
T10353 APX-115 free base APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox...
TJS1779 Protosappanin A Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inflammat...
T0679 Ketoconazole Ketoconazole, a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
T35393 Gp91ds-tat gp91ds-tat是一种NADPH氧化酶(NADPH oxidase)的肽抑制剂,由与人类免疫缺陷病毒-tat肽相连的gp91phox序列组成。tat序列促进了这种肽进入细胞。
TN1645 Flavokawain C Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle...
TN2036 Paeonilactone B Paeonilactone B is a natural product from Paeonia albiflora.
TN2126 Quercetin-3-O-glucose-6''-acetate Quercetin-3-O-glucose-6''-acetate 是 NADPH 氧化酶的抑制剂。 Quercetin-3-O-glucose-6''-acetate 具有抗氧化活性。
TN1542 Cycloheterophyllin Cycloheterophyllin has an antioxidant effect, it is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be u...
TN1503 Cistanoside F Cistanoside F shows vasorelaxant, and antioxidative effects, it shows a strong free radical scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical a...
TN1208 2-Amino-3-carboxy-1,4-naphthoquinone 2-Amino-3-carboxy-1,4-naphthoquinone is a novel growth stimulator for bifidobacteria, it affects the end-product profile of bifidobacteria through the mediated o...
TMA1570 Sappanone A Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 ...
TMA0033 5'-Demethylaquillochin 5'-Demethylaquillochin and its isomer from the dichloromethane extract of E. cavaleriei have potential as chemopreventive agents through induction of detoxificat...
T10354 APX-115 APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectiv...
TN5278 Zederone Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads t...
TN5243 Vitexilactone Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse trans...
TP1886L1 NoxA1ds acetate(1435893-78-9 free base) NoxA1ds acetate is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 : 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxida...
TN5156 Totaradiol Totaradiol shows antioxidant activity, it can inhibit linoleic acid autoxidation but not generation of superoxide anion. Totaradiol exhibits cytotoxic activity a...
TN5050 Sprengerinin C Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can st...
TN4889 (R)-Reticuline (R)-Reticuline is the biosynthetic precursor of the morphinan alkaloids.
TN4905 Rehmannic acid Rehmannic acid and oleanolic acetate inhibit succinoxidase activity. Both Rehmannic acid and Icterogenin are potent uncouplers, abolishing the phosphate uptake, ...
TN4800 Pisatin Pisatin is an isoflavonoid phytoalexin synthesized by pea (Pisum sativum L.).
TN2766 2'-Hydroxydaidzein 2'-Hydroxygenistein is an isoflavonoid phytoalexin, it suppresses chemical mediators in inflammatory cells, may have value in treatment and prevention of central...
TN3112 5-Heneicosylresorcinol 5-Heneicosylresorcinol shows inhibitory effects on the release of β-hexosaminidase from RBL-2H3 cells, it also prevents triglyceride accumulation in 3T3-L1 cells...
TN3069 4beta-Carboxy-19-nortotarol 4 beta-Carboxy-19-nortotarol can inhibit microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ ...
TN3627 Chalepensin Chalepensin behaves as an energy transfer inhibitor at low concentration, it inhibits multiple P450s and that epoxidation activity is crucial for the potential d...
TN3469 Aucuparin Aucuparin is a phytoalexin, it shows significant scavenging activity by the ABTS and FRAP assays. Aucuparin exhibits potent inhibitory activity against fMLP-indu...
TN3294 8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate 8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes.
TN3300 8alpha-Tigloyloxyhirsutinolide 13-O-acetate 8alpha-Tigloyloxyhirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes. 8alpha-Tigloyloxyhirsutinolide 13-O-acetate has ...
TN4635 Neoechinulin A Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the ...
TN4317 Isopedicin Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA thr...
TN4227 Horminone Horminone has antimicrobial activity, it can inhibit the protein synthesis in several types of bacteria; it can inhibit the in vitro growth of Trypanosoma cruzi,...
T22990 ML-090 ML-090 是 NOX1 特异性抑制剂 (IC50 = 90 nM),对 NOX1 的特异性高于 NOX2、NOX3、NOX4(所有 IC50 > 10 μM)100倍。
GKT136901
T8408
GKT136901 is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite
GLX351322
T8107
GLX351322 is NADPH Oxidase 4 Inhibitor with IC50 of 5 μM.
Setanaxib
T6099
GKT137831 is a potent, specific dual NADPH oxidase (NOX1/4) inhibitor.
APX-115 free base
T10353
APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, an...
Protosappanin A
TJS1779
Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infla...
Ketoconazole
T0679
Ketoconazole, a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
gp91ds-tat
T35393
Flavokawain C
TN1645
Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycl...
Paeonilactone B
TN2036
Paeonilactone B is a natural product from Paeonia albiflora.
Quercetin-3-O-glucose-6''-acetate
TN2126
Quercetin-3-O-glucose-6''-acetate 是 NADPH 氧化酶的抑制剂。 Quercetin-3-O-glucose-6''-acetate 具有抗氧化活性。
Cycloheterophyllin
TN1542
Cycloheterophyllin has an antioxidant effect, it is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be u...
Cistanoside F
TN1503
Cistanoside F shows vasorelaxant, and antioxidative effects, it shows a strong free radical scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical a...
2-Amino-3-carboxy-1,4-naphthoquinone
TN1208
2-Amino-3-carboxy-1,4-naphthoquinone is a novel growth stimulator for bifidobacteria, it affects the end-product profile of bifidobacteria through the mediated o...
Sappanone A
TMA1570
Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 ...
5'-Demethylaquillochin
TMA0033
5'-Demethylaquillochin and its isomer from the dichloromethane extract of E. cavaleriei have potential as chemopreventive agents through induction of detoxificat...
APX-115
T10354
APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 eff...
Zederone
TN5278
Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads t...
Vitexilactone
TN5243
Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse trans...
NoxA1ds acetate(1435893-78-9 free base)
TP1886L1
NoxA1ds acetate is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 : 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxida...
Totaradiol
TN5156
Totaradiol shows antioxidant activity, it can inhibit linoleic acid autoxidation but not generation of superoxide anion. Totaradiol exhibits cytotoxic activity a...
Sprengerinin C
TN5050
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can st...
(R)-Reticuline
TN4889
(R)-Reticuline is the biosynthetic precursor of the morphinan alkaloids.
Rehmannic acid
TN4905
Rehmannic acid and oleanolic acetate inhibit succinoxidase activity. Both Rehmannic acid and Icterogenin are potent uncouplers, abolishing the phosphate uptake, ...
Pisatin
TN4800
Pisatin is an isoflavonoid phytoalexin synthesized by pea (Pisum sativum L.).
2'-Hydroxydaidzein
TN2766
2'-Hydroxygenistein is an isoflavonoid phytoalexin, it suppresses chemical mediators in inflammatory cells, may have value in treatment and prevention of central...
5-Heneicosylresorcinol
TN3112
5-Heneicosylresorcinol shows inhibitory effects on the release of β-hexosaminidase from RBL-2H3 cells, it also prevents triglyceride accumulation in 3T3-L1 cell...
4beta-Carboxy-19-nortotarol
TN3069
4 beta-Carboxy-19-nortotarol can inhibit microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ ...
Chalepensin
TN3627
Chalepensin behaves as an energy transfer inhibitor at low concentration, it inhibits multiple P450s and that epoxidation activity is crucial for the potential d...
Aucuparin
TN3469
Aucuparin is a phytoalexin, it shows significant scavenging activity by the ABTS and FRAP assays. Aucuparin exhibits potent inhibitory activity against fMLP-indu...
8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate
TN3294
8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes.
8alpha-Tigloyloxyhirsutinolide 13-O-acetate
TN3300
8alpha-Tigloyloxyhirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes. 8alpha-Tigloyloxyhirsutinolide 13-O-acetate has ...
Neoechinulin A
TN4635
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block th...
Isopedicin
TN4317
Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA thr...
Horminone
TN4227
Horminone has antimicrobial activity, it can inhibit the protein synthesis in several types of bacteria; it can inhibit the in vitro growth of Trypanosoma cruzi,...
ML-090
T22990
ML-090 是 NOX1 特异性抑制剂 (IC50 = 90 nM),对 NOX1 的特异性高于 NOX2、NOX3、NOX4(所有 IC50 > 10 μM)100倍。