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Inhibitors Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling
MAPK Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells Tyrosine Kinase/Adaptors Ubiquitination Others
Compound Libraries Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD Drug-like Compound Libraries Fragment Libraries Custom Compound Library
Signaling Pathways Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling
DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK Membrane transporter/Ion channel
Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome
Stem Cells Tyrosine Kinase/Adaptors Ubiquitination
Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries
Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD
Drug-like Compound Libraries Compound Libraries for HTS/HCS
Fragment Libraries General Fragment Libraries Characteristic Fragment Libraries Custom Compound Library

NADPH-oxidase

NADPH oxidase (nicotinamide adenine dinucleotide phosphate oxidase) is a membrane-bound enzyme complex that faces the extracellular space. It can be found in the plasma membrane as well as in the membranes of phagosomes used by neutrophil white blood cells to engulf microorganisms.
Cat. No. Product name CAS No. Purity Chemical Structure
TN5243 Vitexilactone 61263-49-8 98%
Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse trans...
TN4635 Neoechinulin A 51551-29-2 98%
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the ...
TN4905 Rehmannic acid 467-81-2 98%
Rehmannic acid and oleanolic acetate inhibit succinoxidase activity. Both Rehmannic acid and Icterogenin are potent uncouplers, abolishing the phosphate uptake, ...
TN2766 2'-Hydroxydaidzein 7678-85-5 98%
2'-Hydroxygenistein is an isoflavonoid phytoalexin, it suppresses chemical mediators in inflammatory cells, may have value in treatment and prevention of central...
TN1208 2-Amino-3-carboxy-1,4-naphthoquinone 173043-38-4 98%
2-Amino-3-carboxy-1,4-naphthoquinone is the electron transfer mediator, can change glucose metabolism of the homofermentative lactic acid bacteria. 2-Amino-3-car...
TN4227 Horminone 21887-01-4 98%
Horminone has antimicrobial activity, it can inhibit the protein synthesis in several types of bacteria; it can inhibit the in vitro growth of Trypanosoma cruzi,...
TN5050 Sprengerinin C 88861-91-0 98%
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can st...
T35393 Gp91ds-tat 98%
TN4889 (R)-Reticuline 3968-19-2 98%
(R)-Reticuline is the biosynthetic precursor of the morphinan alkaloids.
TN3294 8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate 67667-71-4 98%
8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes.
TN4317 Isopedicin 4431-42-9 98%
Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA thr...
TN3627 Chalepensin 13164-03-9 98%
Chalepensin behaves as an energy transfer inhibitor at low concentration, it inhibits multiple P450s and that epoxidation activity is crucial for the potential d...
T10354 APX-115 1395946-75-4 98%
APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase （Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectiv...
TN3469 Aucuparin 3687-28-3 98%
Aucuparin is a plant antibiotic with anti-inflammatory activity. Aucuparin inhibited pulmonary fibrosis in mouse models induced by bleomycin (BLM). ABTS and FRAP...
TN3069 4beta-Carboxy-19-nortotarol 55102-39-1 98%
4 beta-Carboxy-19-nortotarol can inhibit microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ ...
TMA0033 5'-Demethylaquillochin 305364-91-4 98%
5'-Demethylaquillochin and its isomer from the dichloromethane extract of E. cavaleriei have potential as chemopreventive agents through induction of detoxificat...
TN1503 Cistanoside F 97411-47-7 98%
Cistanoside F shows vasorelaxant, and antioxidative effects, it shows a strong free radical scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical a...
TN2036 Paeonilactone B 98751-78-1 98%
Paeonilactone B is a natural product from Paeonia albiflora.
TN5156 Totaradiol 3772-56-3 98%
Totaradiol shows antioxidant activity, it can inhibit linoleic acid autoxidation but not generation of superoxide anion. Totaradiol exhibits cytotoxic activity a...
TN1645 Flavokawain C 56798-34-6 98%
Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle...
Vitexilactone
TN5243
Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse trans...
Neoechinulin A
TN4635
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the ...
Rehmannic acid
TN4905
Rehmannic acid and oleanolic acetate inhibit succinoxidase activity. Both Rehmannic acid and Icterogenin are potent uncouplers, abolishing the phosphate uptake, ...
2'-Hydroxydaidzein
TN2766
2'-Hydroxygenistein is an isoflavonoid phytoalexin, it suppresses chemical mediators in inflammatory cells, may have value in treatment and prevention of central...
2-Amino-3-carboxy-1,4-naphthoquinone
TN1208
2-Amino-3-carboxy-1,4-naphthoquinone is the electron transfer mediator, can change glucose metabolism of the homofermentative lactic acid bacteria. 2-Amino-3-car...
Horminone
TN4227
Horminone has antimicrobial activity, it can inhibit the protein synthesis in several types of bacteria; it can inhibit the in vitro growth of Trypanosoma cruzi,...
Sprengerinin C
TN5050
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can st...
gp91ds-tat
T35393
(R)-Reticuline
TN4889
(R)-Reticuline is the biosynthetic precursor of the morphinan alkaloids.
8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate
TN3294
8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes.
Isopedicin
TN4317
Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA thr...
Chalepensin
TN3627
Chalepensin behaves as an energy transfer inhibitor at low concentration, it inhibits multiple P450s and that epoxidation activity is crucial for the potential d...
APX-115
T10354
APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase （Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectiv...
Aucuparin
TN3469
Aucuparin is a plant antibiotic with anti-inflammatory activity. Aucuparin inhibited pulmonary fibrosis in mouse models induced by bleomycin (BLM). ABTS and FRAP...
4beta-Carboxy-19-nortotarol
TN3069
4 beta-Carboxy-19-nortotarol can inhibit microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ ...
5'-Demethylaquillochin
TMA0033
5'-Demethylaquillochin and its isomer from the dichloromethane extract of E. cavaleriei have potential as chemopreventive agents through induction of detoxificat...
Cistanoside F
TN1503
Cistanoside F shows vasorelaxant, and antioxidative effects, it shows a strong free radical scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical a...
Paeonilactone B
TN2036
Paeonilactone B is a natural product from Paeonia albiflora.
Totaradiol
TN5156
Totaradiol shows antioxidant activity, it can inhibit linoleic acid autoxidation but not generation of superoxide anion. Totaradiol exhibits cytotoxic activity a...
Flavokawain C
TN1645
Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle...
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