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NUDIX hydrolase

Nudix hydrolases are a superfamily of hydrolytic enzymes capable of cleaving nucleoside diphosphates linked to x (any moiety), hence their name. The reaction yields nucleoside monophosphate (NMP) plus X-P. Substrates hydrolysed by nudix enzymes comprise a wide range of organic pyrophosphates, including nucleoside di- and triphosphates, dinucleoside and diphosphoinositol polyphosphates, nucleotide sugars and RNA caps, with varying degrees of substrate specificity. Enzymes of the Nudix superfamily are found in all types of organisms, including eukaryotes, bacteria and archaea.
Cat No. product name
T39785L TH5427 TH5427 is a lead NUDT5 inhibitor(MG assay IC50 = 29 nM).
TH5427
T39785L
TH5427 is a lead NUDT5 inhibitor(MG assay IC50 = 29 nM).