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Neprilysin

Neprilysin, also known as membrane metallo-endopeptidase (MME), neutral endopeptidase (NEP), cluster of differentiation 10 (CD10), and common acute lymphoblastic leukemia antigen (CALLA) is an enzyme that in humans is encoded by the MME gene. Neprilysin is a zinc-dependent metalloprotease that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. It also degrades the amyloid beta peptide whose abnormal folding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. Synthesized as a membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to the cell surface.
Cat No. product name
T6627 Phosphoramidon Disodium Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool.
T1176 Racecadotril Racecadotril has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.
T2318 Sacubitril/Valsartan LCZ696 is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure.
T7693 Thiorphan Thiorphan is an neprilysin inhibitor (NEP; IC50 : 0.007 μM).
T19626 LHW090-A7 LHW090-A7 is an neutral endopeptidase (NEP) inhibitor, and an enzyme responsible for the metabolic inactivation of enkephalins.
TQ0106 Sacubitrilat Sacubitrilat (LBQ657) is an effective inhibitor of active neprilysin (NEP).
T4200 Sacubitril hemicalcium salt AHU-377 hemicalcium salt is a potent NEP inhibitor with an IC50 of 5 nM. AHU-377 is a component of the heart failure medicine LCZ696.AHU377 is a prodrug of LBQ65...
T4574 Sacubitril AHU-377 is a potent NEP inhibitor with an IC50 of 5 nM. AHU-377 is a component of the heart failure medicine LCZ696.
Phosphoramidon Disodium
T6627
Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool.
Racecadotril
T1176
Racecadotril has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.
Sacubitril/Valsartan
T2318
LCZ696 is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure.
Thiorphan
T7693
Thiorphan is an neprilysin inhibitor (NEP; IC50 : 0.007 μM).
LHW090-A7
T19626
LHW090-A7 is an neutral endopeptidase (NEP) inhibitor, and an enzyme responsible for the metabolic inactivation of enkephalins.
Sacubitrilat
TQ0106
Sacubitrilat (LBQ657) is an effective inhibitor of active neprilysin (NEP).
Sacubitril hemicalcium salt
T4200
AHU-377 hemicalcium salt is a potent NEP inhibitor with an IC50 of 5 nM. AHU-377 is a component of the heart failure medicine LCZ696.AHU377 is a prodrug of LBQ65...
Sacubitril
T4574
AHU-377 is a potent NEP inhibitor with an IC50 of 5 nM. AHU-377 is a component of the heart failure medicine LCZ696.