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3
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Cat No. | Product Name | Synonyms | Targets |
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T4067 | VLX1570 | DUB | |
VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14. | |||
T14852 | C527 | DUB | |
C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM). | |||
T11111 | DUB-IN-2 | DUB | |
Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor. | |||
T11110 | DUB-IN-1 | DUB | |
DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs). | |||
T11112 | DUB-IN-3 | DUB | |
DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM. | |||
T9122 | XL177A | DUB | |
XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism. | |||
T36682 | USP30 inhibitor 18 | DUB | |
USP30 inhibitor 18 is a selective USP30 inhibitor with an IC50 of 0.02 μM. USP30 inhibitor 18 increases protein ubiquitination and accelerates mitophagy[1]. [1]. Arthur F Kluge, et al. Novel highly selective inhibitors o... | |||
T15729 | LDN-91946 | DUB | |
LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM). | |||
T15604 | IU1-47 | DUB | |
IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 μM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20 μM). | |||
T15464 | HBX 19818 | DUB | |
HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM). | |||
T3555 | ML364 | DUB | |
ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer. | |||
T12024 | MF-094 | DUB | |
MF-094 is a potent and selective inhibitor of USP30 (IC50 of 120 nM). | |||
T11209 | EOAI3402143 | DUB | |
EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis. EOAI3402143 phenocopies the FAS induction and apoptotic sensitization of Usp5 knockdown and fully blocks melanoma tumor growth. | |||
T9375 | IU1-248 | DUB | |
IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1]. | |||
T5461 | GNE-6640 | DUB | |
GNE-6640 is a non-covalent inhibitor targeting ubiquitin specific peptidase 7 (USP7), exhibiting IC50 values of 0.75 μM for full-length USP7, 0.43 μM for the USP7 catalytic domain, 20.3 μM for full-length USP43, and 0.23... | |||
T13268 | USP7-IN-1 | DUB | |
USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM). | |||
T2424 | P 22077 | P22077 | DUB |
P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47. | |||
T1757 | ML-323 | ML323 | DUB |
ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay (IC50: 76 nM) and in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) (IC50: 174 nM 820 nM)and monoubiquitinated PCNA (Ub-PCNA) (I... | |||
T6107 | IU1 | DUB , Autophagy | |
IU1(IC50=4.7 μ M), a reversible, specific human USP14 proteasome inhibitor, can penetrate the cell. | |||
T1924 | LDN-57444 | LDN57444 | Apoptosis , DUB |
LDN-57444 is a reversible, competitive proteasome Uch-L1 inhibitor(IC50=0.88 μM) . | |||
T11464 | GRL0617 | SARS-CoV , DUB | |
GRL0617 is a selective and competitive SARS-CoVPLpro and deubiquitinase noncovalent inhibitor(IC50 : 0.6 μM, Ki : 0.49 μM). | |||
T8553 | BC-1471 | Others | |
BC-1471 is a STAM-binding protein (STAMBP) deubiquitinase inhibitor. BC-1471 inhibits inflammasome activity of NALP7 (NACHT, LRR and PYD domains-containing protein 7) [1]. | |||
T6300 | Degrasyn | WP1130 | Apoptosis , JAK , Bcr-Abl , DUB , Autophagy |
Degrasyn (WP1130) (WP1130), a specific deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor, also inhibits Bcr/Abl, which is a JAK2 transducer (without affecting 20S proteasome) and activator of transcri... | |||
T4634 | GNE-6776 | GEN6776 | DUB |
GNE-6776 is a selective USP7 inhibitor. | |||
T9217 | USP7-IN-8 | GNE-6776 | DUB |
Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. USP7-IN-8 (GNE-6776) has anticancer effects. | |||
T8464 | RA-9 | Apoptosis , DUB | |
RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity. RA-9 selectively induces apoptosis in ovarian cancer cell lines. | |||
T7678 | SJB2-043 | DUB | |
SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM). | |||
T6925 | P005091 | P5091 | DUB |
P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM. | |||
T4338 | USP7/USP47 inhibitor | USP7/47 inhibitor-1 | DUB |
USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively. | |||
T1932 | B-AP15 | NSC 687852 | Apoptosis , DUB |
B-AP15 (NSC-687852)(NSC-687852) is a selective inhibitor of the deubiquitinating enzymes Usp14 and UCHL5 of the 26S proteasome. It blocks the deubiquitinating activity of the 26S proteasome. | |||
T6697 | TCID | UCH-L3 Inhibitor | DUB |
TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1. | |||
T7685 | USP25/28 inhibitor AZ1 | AZ1 | DUB |
USP25/28 inhibitor AZ1 (AZ1) (AZ1) is an inhibitor of ubiquitin specific protease (USP) 25/28 | |||
T21527 | HBX 41108 | HBX-41108 | DUB , p53 |
HBX 41108 (HBX-41108) is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBX 41108 inhibited deubiquitination of p53 mediated by USP7 in a dose-dependent manner with an IC50 of 0.8μM. | |||
T3951 | NSC632839 | F6,Ubiquitin Isopeptidase Inhibitor II | DUB |
NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2 (EC50: 9.8±1.8 μM). | |||
T1862 | PR-619 | PR 619,2,6-Diamino-3,5-dithiocyanopyridine | Apoptosis , DUB , Autophagy |
PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs). | |||
T1902 | BAY 11-7082 | BAY 11-7821 | Apoptosis , Others , IκB/IKK , DUB , Autophagy |
BAY 11-7082 (BAY 11-7821) is an NF-κB inhibitor that inhibits TNFα-induced IκBα phosphorylation (IC50=10 μM). BAY 11-7082 is also an inhibitor of the ubiquitin-specific proteases USP7 and USP21 (IC50=0.19/0.96 μM). | |||
T3088 | N-Ethylmaleimide | 1-Ethyl-1H-pyrrole-2,5-dione,Ethylmaleimide,NEM | Cysteine Protease , DUB |
N-Ethylmaleimide (NEM) is a sulfhydryl reagent that is widely used in experimental biochemical studies. | |||
T3089 | 6-Thioguanine | 6-TG,2-Amino-6-purinethiol,2-Amino-6-mercaptopurine,Thioguanine | Apoptosis , DNA Methyltransferase , SARS-CoV , Endogenous Metabolite , DUB , Autophagy |
6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | |||
T71092 | Proteasome-IN-3 | ||
Proteasome-IN-3 is an inhibitor of proteasome-associated DUBs. | |||
T69690 | XL-188 | ||
XL-188 is a highly potent and selective inhibitor of USP7. XL188 inhibited USP7 catalytic domain and full-length enzyme with IC50 values of 193 and 90 nM, respectively. XL188 Promotes USP7-Dependent Loss of HDM2 and Inc... | |||
T79672 | DUB-IN-7 | ||
DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1]. |
Cat No. | Product Name | Species | Expression System |
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TMPY-02522 | OTUB2 Protein, Human, Recombinant (His) | Human | E. coli |
Otubain 2 (OTUB2) is a member of DUBs that belong to the ovarian tumour (OTU) superfamily of proteins which consists of a five-stranded β-sheet sandwiched in between a small helical amino-terminal region consisting of α1... | |||
TMPY-03011 | USP46 Protein, Human, Mouse, Recombinant | Human,Mouse | Baculovirus-Insect Cells |
USP46 belongs to the peptidase C19 family, USP12/USP46 subfamily. Deubiquitinating enzymes (DUBs) are a large group of proteases which are also commonly referred to as deubiquitinating peptidases, deubiquitinating isopep... | |||
TMPY-02974 | USP46 Protein, Human, Mouse, Recombinant (SUMO) | Human,Mouse | Baculovirus-Insect Cells |
USP46 belongs to the peptidase C19 family, USP12/USP46 subfamily. Deubiquitinating enzymes (DUBs) are a large group of proteases which are also commonly referred to as deubiquitinating peptidases, deubiquitinating isopep... |
Cat No. | Product Name | ||
---|---|---|---|
L8600 | Ubiquitination Compound Library | 214 compounds | |
A unique collection of 214 ubiquitination related small chemicals can be used for high throughput and high content screening; |