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Cat No. | Product Name | Synonyms | Targets |
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T11878 | LRRK2 inhibitor 1 | LRRK2 , CDK | |
LRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 nM.LRRK2 inhibitor 1 inhibits DCLK1 kinase with an IC50 value of 2.61 nM. | |||
T2246 | LRRK2-IN-1 | Apoptosis , LRRK2 , CDK | |
LRRK2-IN-1 is an effective and selective LRRK2 inhibitor. | |||
T63620 | LRRK2-IN-3 | ||
LRRK2-IN-3 is a potent, selective, orally active LRRK2 inhibitor that crosses the blood-brain barrier with an IC50 value of 0.6 nM in hPBMCs. LRRK2-IN-3 can be used to study Parkinson's disease. | |||
T63824 | LRRK2-IN-2 | ||
LRRK2-IN-2 is a selective, potent, and orally active LRRK2 inhibitor (IC50: 0.6 nM) that crosses the blood-brain barrier. LRRK2-IN-2 can be used to study Parkinson's disease. | |||
T63621 | LRRK2-IN-4 | ||
LRRK2-IN-4 is a potent, selective, orally active, leucine-rich repeat kinase 2 (LRRK2) inhibitor that crosses the blood-brain barrier with an IC50 value of 2.6 nM. LRRK2-IN-3 has shown investigational potential in Parkin... | |||
T62871 | LRRK2-IN-6 | ||
LRRK2-IN-6 (compound 22) is an orally active, selective leucine-rich repeat protein kinase 2 gene (LRRK2) inhibitor with blood-brain barrier permeability that inhibits GS LRRK2 (IC50: 4.6 μM) and WT LRRK2 (IC50: 49 μM). ... | |||
T63057 | LRRK2-IN-5 | ||
LRRK2-IN-5 (compound 25) is an oral active, blood-brain barrier penetrating, selective leucine-rich repeat protein kinase 2 (LRRK2) inhibitor, which is effective for GS LRRK2 (IC50: 1.2 μM) and WT LRRK2 (IC50:16 μM) had ... | |||
T79746 | LRRK2-IN-10 | LRRK2 | |
LRRK2-IN-10 (compound 34) is a potent, mutation-selective, brain-penetrant inhibitor targeting G2019S-LRRK2 kinase with IC50 values of 11 nM for G2019S-LRRK2 pS935 and 5.2 nM for G2019S-LRRK2 pS1292. It holds promise for... | |||
T73176 | LRRK2-IN-7 | ||
LRRK2-IN-7 is a potent LRRK2 kinase inhibitor that demonstrates high selectivity and central nervous system (CNS) penetration, possessing an IC50 value of 0.9 nM. It exhibits more than 1000-fold selectivity against a bro... | |||
T72421 | LRRK2/NUAK1/TYK2-IN-1 | ||
LRRK2/NUAK1/TYK2-IN-1 (compound 226) exhibits inhibitory activity against LRRK2 (Wt), LRRK2 (G2019), TYK2, and NUAK1, demonstrating IC50 values below 10 nM. This compound is useful for research into autoimmune diseases. | |||
T7155 | JH-II-127 | LRRK2 | |
JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, respectively), | |||
T7729 | PF-06454589 | LRRK2 | |
PF-06454589 is a potent inhibitor of LRRK2. | |||
T1770 | GNE-9605 | LRRK2 | |
GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM). | |||
T2022 | CZC-54252 | CZC54252,CZC 54252 | LRRK2 |
CZC-54252 is a potent inhibitor of LRRK2. | |||
T5139 | CZC-25146 hydrochloride | LRRK2 | |
CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively. | |||
T39202 | CZC-54252 hydrochloride | LRRK2 | |
CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human... | |||
T3053 | CZC-25146 | CHEMBL2397014 | LRRK2 |
CZC-25146 (CHEMBL2397014) is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G2019S LRRK2, respectively. | |||
T16115 | MLi-2 | LRRK2 | |
MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a ce... | |||
T2050 | PF-06447475 | LRRK2 | |
PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively. | |||
T39972 | EB-42486 | LRRK2 | |
EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM. | |||
T1945 | GNE-7915 | GNE7915 | LRRK2 |
GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor. | |||
T16512 | PFE-360 | PF-06685360 | LRRK2 |
PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo). | |||
T6031 | GNE0877 | GNE 0877,GNE-0877 | LRRK2 |
GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM). | |||
T6176 | IKK 16 | IKK Inhibitor VII,IKK-16,IKK16 | IκB/IKK , LRRK2 |
IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. | |||
T2240 | GSK2578215A | Mitophagy , LRRK2 , Autophagy | |
GSK2578215A is a potent and selective LRRK2 kinase inhibitor. | |||
T7196 | HG-10-102-01 | LRRK2 | |
HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM). | |||
T5184 | ERK5-IN-1 | ERK | |
ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM). | |||
T6057 | URMC-099 | ROCK , MLK , VEGFR , SGK , DNA Alkylation , Trk receptor , c-Met/HGFR , LRRK2 , MEK , IGF-1R , Syk , Bcr-Abl , CDK , Src , Aurora Kinase , Autophagy | |
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM). | |||
T2014 | CCG-1423 | CCG1423 | LRRK2 , Rho , Ras |
CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription. | |||
T74638 | XL01126 | ||
XL01126, a potent degrader of LRRK2, exhibits DC50 values of 14 nM (G2019S LRRK2) and 32 nM (WT LRRK2), respectively. It has the ability to cross the blood-brain barrier, making it a viable degrader probe for Parkinson’s... | |||
T34706 | SRI-29132 | SRI29132,SRI 29132,TPZ-11,TPZ 11,TPZ11 | |
SRI-29132 is potent; highly permeant of the blood-brain barrier; and selective for LRRK2 kinase activity, therefore effective in attenuating pro-inflammatory responses in macrophages and in rescuing neurite retraction ph... | |||
T15557 | IKK 16 hydrochloride | Others | |
IKK 16 hydrochloride is a selective IKK2, IKK complex, and IKK1 IκB kinase (IKK) inhibitor (IC50s: 40 nM, 70 nM and 200 nM, respectively). IKK16 inhibits leucine-rich repeat kinase-2 (LRRK2; IC50: 50 nM). | |||
T70338 | Lu AF58786 | ||
Lu AF58786 is a novel potent and selective inhibitor of LRRK2, inhibiting LRRK2 WT, the overactive variant G2019S, and the resistant mutant A2016T56 at 12 nM, 19 nM and 93 nM, respectively. | |||
T73846 | PF-06456384 trihydrochloride | ||
PF-06447475 trihydrochloride is a potent, selective LRRK2 kinase inhibitor that demonstrates excellent brain penetration, exhibiting IC50 values of 3 nM for wild-type LRRK2 and 11 nM for G2019S LRRK2 variants. It holds p... | |||
T83737 | LRRKtide TFA | Moesin (550-564),Membrane-organizing Extension Spike Protein (550-564) | |
LRRKtide, a peptide substrate for leucine-rich repeat kinase 2 (LRRK2)—an enzyme often mutated in Parkinson's disease patients—corresponds to amino acids 550-564 of the membrane-organizing extension spike protein (moesin... | |||
T70363 | PF-06371900 | ||
PF-06371900 is a potent and highly selective inhibitor of leucine-rich repeat kinase 2 (LRRK2). | |||
T72640 | GNE-7915 tosylate | ||
GNE-7915 tosylate is a potent, selective, and brain-penetrant LRRK2 inhibitor, boasting an IC50 value of 9 nM. | |||
T79351 | JH-XII-03-02 | PROTACs | |
JH-XII-03-02 is a potent and selective leucine-rich repeat kinase 2 (LRRK2) proteolysis targeting chimera (PROTAC) degrader, utilized in Parkinson's Disease (PD) research [1]. | |||
T81785 | MK-1468 | LRRK2 | |
MK-1468, a highly selective and brain-penetrant LRRK2 inhibitor, exhibits an IC50 of 0.8 nM and is utilized in the study of Parkinson's disease [1]. | |||
T61527 | GSK2646264 | ||
GSK2646264 (Compound 44) is a highly effective and specific inhibitor of spleen tyrosine kinase (SYK) with a pIC50 of 7.1. In addition to targeting SYK, GSK2646264 also inhibits several other kinases, including LCK, LRRK... | |||
T72999 | PF-06455943 | ||
PF-06455943, a leucine rich repeat kinase 2 (LRRK2) inhibitor, exhibits an inhibition concentration (IC50) value of 3 nM and also functions as a PET radioligand. It is utilized in the research of ADME/neuro PK characteri... | |||
T5428 | BIX 02565 | LRRK2 , S6 Kinase | |
BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM). |
Cat No. | Product Name | Species | Expression System |
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TMPH-02873 | RAB10 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bou... |