glycyrrhiza

Glycyrrhiza flavonol A is a natural product of Glycyrrhiza, Fabaceae. The catalog number is TN4150 and the CAS number is 197304-01-1. Glycyrrhiza flavonol A can be used as a reference standard.

Echinatin (Retrochalcone) disturb the mitochondrial energy transfer reactions and membrane permeability, at a low concentration cause deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria, inhibits DNP-ATPase activity while stimulating range latent ATPase activity. Echinatin has significant antioxidant activities, it shows strong scavenging activity toward the ABTS + radical, it also dose-dependently inhibits LPS induced reactive oxygen species (ROS) production in RAW 264.7 cells and inhibits the production of nitric oxide (NO), interleukin-6 (IL-6) and prostaglandin E2 (PGE2) in LPS-induced macrophage cells.

Dipotassium glycyrrhizinate is an anionic surfactant having anti-allergic and anti-inflammatory activities.

Licochalcone A is a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch with obvious anti-cancer effects.

Diammonium Glycyrrhizinate (Glycyrrhizin) , an extensively used anti-inflammatory agent, is isolated from the licorice root. It is metabolized to glycyrrhetinic acid, which inhibits 11-β-hydroxysteroid dehydrogenase and other enzymes involved in the metabolism of corticosteroids. Therefore, glycyrrhizic acid, the main and sweet component of licorice, has been studied for its ability to cause hypermineralocorticoidism with potassium loss and sodium retention, edema, increased blood pressure, as well as inhibited the renin-angiotensin-aldosterone system.

Isoliquiritigenin (ISL), an anti-tumor flavonoid from the root of Glycyrrhiza glabra, suppresses aldose reductase (IC50=320 nM).

Methyl Glycyrrhizate is a compound derived from licorice and is used as a flavoring agent. Commonly used in cosmetics.

Glycyrrhizic acid (Glycyrrhizin) is a triterpenoid saponinl with anti-tumor and anti-diabetic activities.

18α-Glycyrrhetinic acid (Enoxolone) is an inhibitor of NF-kB and an activator of the proteasome, and functions as a longevity-promoting and anti-aggregation factor in multicellular organisms. It induces apoptosis.

18β-Glycyrrhetinic acid (Enoxolone) is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.

Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. Licochalcone D has cardioprotective potential against myocardial is

Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on metabolic disorders( such as diabetes and hyperglycemia), by modulating glucose metabolism through AMPK in skeletal muscle cells. Glabridin may have potential as a chemopreventive agent against liver Y metastasis, by inhibiting the invasion of human HCC cells.

Liquiritigenin (4',7-Dihydroxyflavanone), a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist.

Neoliquiritin may possess ytotoxiciy and Tumor-specificity.

Macedonoside A (compound 3), a saponin, is isolated from the stolons of Glycyrrhiza lepidota [1].

24-Hydroxy-licorice-saponin A3, an oleanane-type triterpene saponin (OTS), can be isolated from Glycyrrhiza uralensis [1].

Gancaonin M is a natural product from Glycyrrhiza uralensis Fisch.

Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.

Licorisoflavan A shows weak scavenging activity against superoxide anion radical, it and licoricidin have potential for the development of novel host-modulating strategies for the treatment of cytokine and/or MMP-mediated disorders such as periodontitis.L

Glicoricone acts as a partial estrogen antagonist. Glicoricone inhibited the monoamine oxidase with the IC50 values of 6.0 x 10(-5)-1.4 x 10(-4) M.

Licorice glycoside C2 is a oleanane-type triterpene oligoglycoside isolated from Glycyrrhiza uralensis.

Glabrene, Liquiritin apioside, neolicuroside, and 18α²-glycyrrhetic acid are the predominant phenolic derivatives partitioning at the interface and most likely the major contributors to the notable synergistic antioxidant activity when coupled with pea pr

Isoglycycoumarin, a flavonoid derived from the roots of Glycyrrhiza uralensis, serves as a highly selective probe for human cytochrome P450 2A6.

Gancaonin N is a natural product for research related to life sciences. The catalog number is TN4100 and the CAS number is 129145-52-4.

Gancaonin G shows antibacterial effects on the MRSA strains with MIC values of 16 microg/ml, it also shows more moderate antibacterial activity against Streptococcus mutans.

Licoflavonol is a novel natural inhibitor of Salmonella T3SS, could be a promising candidate for novel type of anti-virulence drugs, it exhibits a strong inhibitory effect on the secretion of the SPI-1 effector proteins via regulating the transcription of

4-Methyl-5,6,7,8-tetrahydroquinoline, a tetrahydroquinoline alkaloid, has been isolated from the roots of Glycyrrhiza uralensis Fisch [1].

Glyurallin B, a flavonoid derived from Glycyrrhiza inflata and Glycyrrhiza uralensis (licorice), exhibits ABTS+ radical scavenging activity and lipid peroxidation inhibition, with EC50 values of 11.9 ± 0.58 μM and 15.3 ± 1.26 μM, respectively [1].

Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Isoangustone A dampens mesangial sclerosis associated with inflammation in response to high glucose through hindering TGF-β and NF-κB signaling. Isoangustone A also shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals.

Glyasperin A has cytotoxic properties against P-388 cells, its IC50 values being 6.0 microM.

Glyurallin A possesses an antigenotoxic effect against carcinogenic N-methyl-N-nitrosourea (MNU) for the first time, it is important to prevent DNA damage by N-nitrosamines for cancer chemoprevention.

Glyasperin F has antinociceptive, and anti-inflammatory effects, it could inhibit NO production in RAW 264.7 macrophages to some extent. Glyasperin F displayed cytotoxic effects against the four tested cancer cell lines with IC50values below 85 μM.

Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neuroprotective activities, it has protective effects against chronic diseases

Liconeolignan is extracted from the root of Glycyrrhiza uralensis.

Kanzonol D, a flavonoid derived from the hairy root cultures of Glycyrrhiza glabra [1], exhibits anti-inflammatory and anticancer properties by inhibiting nitric oxide production and suppressing NF-κB activation. It also shows potential in osteoblast differentiation, suggesting its utility in bone diseases.

Kanzonol C has antimicrobial activity, it also shows potent PTP1B inhibitory activity (IC50 value of 0.31-0.97uM). Kanzonol C has chemopreventive activity,it shows the inhibition of matrix metalloproteinase (MMP)-2 secretion from brain tumor-derived glioblastoma cells.

Glycyroside is an isoflavone diglycoside isolated from Glycyrrhiza eurycarpa P. C. Li.

Glabranin has antimicrobial activity, it shows significant activities on DPPH free radical with the IC50 value of 240.20 ug/ml. Glabranin or a derivative thereof could be used to stimulate hair growth. Glabranine exerts a dose-dependent inhibitory effect

Glabrolide is a natural product

Glycyuralin E, a natural product, can be isolated from Glycyrrhiza uralensis [1].

Gancaonin I exhibits anti-BsFtsZ GTPase activities; it also shows significant inhibitory activity against B. subtilis, with a MIC value of 5 uM.

Licoisoflavanone is a natural product from Licorice.

Licopyranocoumarin could as a potent neuroprotective drug via markedly blocked MPP+-induced neuronal PC12D cell death and disappearance of mitochondrial membrane potential, which were mediated by JNK.

Apioglycyrrhizin is a sweet oleanane-type triterpene oligoglycoside; isolated from the roots of Glycyrrhiza inflata.

Eurycarpin A is a natural product of Glycyrrhiza, Fabaceae. The catalog number is TN4043 and the CAS number is 166547-20-2. Eurycarpin A can be used as a reference standard.

6,8-Diprenylorobol possesses weaker anti-H. pylori activity, it may be a useful chemopreventive agent for peptic ulcer or gastric cancer in H. pylori-infected individuals.

Licoisoflavone B is an inhibitor of germ tube growth in the arbuscular mycorrhizal (AM) fungus Gigaspora margarita, it can strongly inhibit germ tube growth at 0.63 ug/disc.

Licofuranocoumarin is a minor flavonoid extracted from Glycyrrhiza uralensis (licorice).

Glycyrrhizin-6'-methylester, a naturally occurring compound, is isolatable from Glycyrrhiza glabra, commonly known as licorice [1].

Uralenol significantly shows the inhibitory activities against the PTP1B enzyme; it also shows inhibitory activities on mushroom tyrosinase using l-tyrosine as substrate( IC50 =49.5 μM). Uralenol shows potent anti-proliferation effects on ER-positive breast cancer MCF-7 cells in vitro.