HENA is a novel activator of large conductance, voltage- and Ca2+-gated K+ (BK) channels.

Perphenazine (Trilafon) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.

6-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-1H-pyridine-3,4-dicarbonitrile is a biologically active compound, which is utilized for research in the fields of chemistry and life sciences.

Orphenadrine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist that inhibits clonal HERG channels in a concentration-dependent manner, producing an IC of 0.85 μM in HEK cells.Orphenadrine is an antagonist of central and peripheral muscarinic receptors. Attenuation is blocked by mutations in pore residues Y652 or F656. Orphenadrine has antispasmodic, analgesic, and anticholinergic activity and protects against glutamatergic neurotoxicity in vitro and in vivo.Orphenadrine has inhibitory effects on sodium channels and can be used in the treatment of Parkinson's disease.

Acetophenazine is an anxiolytic compound that is used in the study of depression.

Anemarrhenasaponin Ia ((2S,3R,4S,5S,6R)-2-{[(2R,3R,4S,5R,6R)-4,5-dihydroxy-2-{[(1R,3R,4R,7S,9S,12S,13S,16S,18R)-3-hydroxy-6-methoxy-7,9,13-trimethyl-6-(3-methylbutyl)-5-oxapentacyclo[10.8.0.02,?.0?,?.013,1?]icosan-16-yl]oxy}-6-(hydroxymethyl)oxan-3-yl]oxy}-6-(hydroxymethyl)oxan), an useful anti-inflammation reagent, is isolated from Anemarrhenae rhizome. Anemarrhenasaponin Ia inhibits the generation of N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide.

Phenamacril (JS39919) is acyanoacrylate fungicide, has powerful inhibition against Fusarium species, especially to Fusarium graminearum. Phenamacril is a specific Fusarium myosin I inhibitor.

cis-1-(3-Chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride (Quaternium-15 cis-form) is an antimicrobial agent used in cosmetics as a cosmetic preservative and antistatic agent.cis-1-(3-Chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride is an oral teratogen, but not a dermal teratogen, and has been dosed in rats at doses exceeding the expected cumulative exposures for cosmetics.

Asperphenamate is a fungal metabolite of Aspergillus flatiipes. The IC50s for T47D cells, MDA-MB-231 cells, and HL-60 cells are 92.3 μM, 96.5 μM, and 97.9 μM. Asperphenamate shows an anticancer effect.

Perphenazine dihydrochloride is an orally active and potent dopamine receptor and histamine-1 receptor antagonist that inhibits D2, D3, and 5-HT2A.Perphenazine dihydrochloride inhibits the proliferation of cancer cells and induces apoptosis, and has been used in studies of schizophrenia and endometrial cancer.

1H-benzo[d][1,2,3]triazol-1-yl 8-methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylate is a useful organic compound for research related to life sciences and the catalog number is T72065.

Phenacetin (Acetophenetidin) is a phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the market.

Fluphenazine dihydrochloride (Prolixin) is an inhibitor of phenothiazine-class D1DR and D2DR; In studies, Fluphenazine can be used to probe the effects and metabolic process of this commonly used dopamine antagonist.

o-Phenanthroline monohydrate (1, 10-Phenanthroline monohydrate) is an inhibitor of metallopeptidases, inhibits zinc-dependent hydrolysis of Fa-Gly-Leu-NH2 by B. subtilis neutral protease and B. thermoproteolyticus thermolysin.

2-Hydroxy-4,7-dimethoxy-9,10-dihydrophenanthrene, isolated from the stem of Dendrobium nobile [1], is a natural product.

5,7-Dimethoxy-2,3-phenanthrenediol exhibits estrogenic activity by promoting the proliferation of MCF-7 cells and enhancing the expression of ERβ within this cell line [1].

Methylenephenanthrene is a biochemical substance.

Flufenazine is an antipsychotic drug. It is used to treat chronic mental illnesses such as schizophrenia. Flufenazine works by blocking postsynaptic dopamine D2 receptors in the limbic system, cortical system, and basal ganglia. This prevents the effects

3,5-Dimethoxy-2,7-phenanthrenediol (compound 2), extracted from Combretum laxum roots, exhibits cytotoxicity against various human cancer cell lines, including 786-0, MCF-7, and NCI/ADR-RES, with corresponding IC50 values of 73.26 μM, 118.40 μM, and 83.99 μM. Additionally, this phenanthrene compound demonstrates free radical scavenging activity, presenting an IC50 of 20.4 μM [1].

(R)-2-Isopropyl-8,8,8a-trimethyl-6,7,8,8a-tetrahydrophenanthrene-3,4-diol (compound 48), a catechol compound, participates in the bioinspired synthesis of rearranged abietane diterpenes, which are associated with pygmaeocins [1].

Dichlorphenamide-13C6is intended for use as an internal standard for the quantification of dichlorphenamide by GC- or LC-MS. Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively).1It lowers intraocular pressure in rabbits when 50 μl of a 10% solution is applied topically to the eye.2Dichlorphenamide rescues the potassium deficiency and prevents insulin-induced paralysis in a rat model of familial hypokalemic periodic paralysis when administered at a dose of 5.6 mg/kg per day for ten days.3Formulations containing dichlorphenamide have been used in the treatment of glaucoma and primary periodic paralysis.

Anemarrhena B is a natural product for research related to life sciences. The catalog number is TN3413 and the CAS number is 1627521-95-2.

Diphenamid is a chemical compound from the group of acetamides and a herbicide. The effect is based on the inhibition of acetyl-CoA carboxylase.

Anemarrhenasaponin III is a natural product

2,3,4,6,7-Pentamethoxy-9,10-dihydrophenanthrene, an active compound, can be isolated from Bulbophyllum vaginatum [1].

(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3), a palmitate derivative, is extracted from the root of Salvia miltiorrhiza. Compound 3 exhibits anti-cancer properties, demonstrating half-maximal cytotoxic concentrations (DC50s) of 25.5 μg/mL against HeLa, 37.5 μg/mL against HepG2, and 30.2 μg/mL against OVCAR-3 human cancer cell lines [1].

Phenamil is an irreversible inhibitor of amiloride-sensitive Na channels; derivative of amiloride, synergizing bone formation with BMP2 and inhibits BMP2 induced cyst-like bone formation.

Phenanthrene, decafluoro- is a biochemical.

Phenazolam is an analytical reference standard categorized as a benzodiazepine. [1] This product is intended for research and forensic applications.

(R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-7,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid is a useful organic compound for research related to life sciences and the catalog number is T64669.

5,10-Di(naphthalen-2-yl)-5,10-dihydrophenazine is a useful organic compound for research related to life sciences and the catalog number is T64604.

Phenacaine (Holocaine), a local anesthetic, suppresses the calmodulin-dependent activation of erythrocyte Ca2+-ATPase and inhibits cyclic nucleotide phosphodiesterases in the brain and heart, as evidenced by studies [1] [2].

Lichenase (endo-1,3:1,4-β-D-Glucanase), an endo-(1-3),(1-4)-β-D-glucan 4-glucanohydrolase, efficiently solubilizes β-glucans from cereal grains, producing gluco-oligosaccharides (GOS). This enzyme is pivotal for the degradation of cell wall polysaccharides [1] [2].

Saphenamycin is an antibiotic from a strain of Streptomyces.

Trehalose 6-behenate is a Th1/Th17 skewing vaccine adjuvant.

Tetrasodium,4-(1,10-phenanthrolin-4-yl)benzenesulfonate,ruthenium((II)) is a useful organic compound for research related to life sciences and the catalog number is T67328.

o-Phenanthroline (1,10-Phenanthroline) , a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells.o-Phenanthroline protects mammalian cells from hydrogen peroxide-induced gene mutation and morphological transformation.

Methophenazine diethanesulfonate is a Calmodulin antagonist.

2-Methoxy-1,6-dimethyl-5-vinyl-9,10-dihydrophenanthren-7-ol is a natural product for research related to life sciences. The catalog number is TN5697 and the CAS number is 2266586-31-4.

Phenanthridinium, 3-amino-8-(3-(3-(((aminoiminomethyl)hydrazono)methyl)phenyl)-1-triazenyl)-5-ethyl-6-phenyl-, chloride, monohydrochloride is a bioactive chemical.

3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride is a useful organic compound for research related to life sciences and the catalog number is T65076.

(1R,4aS,10aR)-methyl 7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylate is a natural product for research related to life sciences. The catalog number is T67200 and the CAS number is 1235-74-1.

6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine . It inhibits protein folding activity of the ribosome (PFAR) when used at a concentration of 150 μM. 6A-8tFP directly competes with protein substrates for the ribosomal active site.

Phenazopyridine hydrochloride (Pyridium) is used orally as a urinary tract analgesic. Side effects of phenazopyridine hydrochloride administration can include nausea, interference with the oxygen-carrying capacity of red blood cells (methemoglobinemia), hemolytic anemia as well as renal and hepatic toxicity. It is reasonably anticipated to be a human carcinogen.

Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19). At 10 μM, sulfaphenazole has been shown to inhibit endothelium-derived hyperpolarizing factor synthase, a CYP450 isozyme in the porcine coronary artery homologous to CYP2C8/9 that generates reactive oxygen species in coronary endothelial cells and modulates vascular tone and homeostasis.

(R)-Methyl 4-((3R,5S,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate is a useful organic compound for research related to life sciences. The catalog number is T66656 and the CAS number is 10538-59-7.

Phenanthriplatin, also known as cis-[Pt(NH3)2-(phenanthridine)Cl]NO3, is a new drug candidate. It belongs to a family of platinum(II)-based agents which includes cisplatin, oxaliplatin and carboplatin. Phenanthriplatin Acts As a Covalent Poison of Topoiso

Phenazopyridine is commonly utilized as a local analgesic to mitigate pain, irritation, discomfort, or urgency resulting from urinary tract infections, surgical procedures, or injuries affecting the urinary tract [1].

Perphenazine-d4 is a deuterated compound of Perphenazine. Perphenazine has a CAS number of 58-39-9. Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.

N'-Phenacylpiperazineinnuchenenolide C is a useful organic compound for research related to life sciences and the catalog number is T131470.