Alantolactone (Inula camphor)(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing the signal transducer and activator of transcription 3 (STAT3) signaling pathway.

Bilobalide ((-)-Bilobalide), a bioactive from Gingko Biloba, is active on hypoxia-induced alterations.

Patchouli alcohol (Patchoulol) is a sesquiterpene alcohol found in patchouli oil. It has antibacterial, antifungal, and antiviral actions. Patchouli alcohol also suppresses inflammation induced by lipopolysaccharide in vivo. Topical application of patchouli alcohol accelerates recovery from ultraviolet irradiation-induced skin damage through antioxidant and anti-inflammatory effects.

Illudin M is a cytotoxic sesquiterpene from the fungus O. illudens that alkylates DNA. It has a cytotoxicity of 6-100 nM against HL-60 human leukemia cells.Illudin M has anticancer activity and is a pre-drug for the synthesis of anticancer compounds.

Ainsliadimer A, a sesquiterpene lactone dimer from Ainsliaea macrocephala, has antitumour activity and induces cell death in various cancer cells.

(E,E)-Farnesol ((2E,6E)-Farnesol) is a sesquiterpene acyclic alcohol produced by bacteria, protozoa, fungi, plants, and animals. (E,E)-Farnesol promotes vasodilation.

Nerolidol acetate is a natural sesquiterpene with anti-cancer, anti-inflammatory, antibacterial and anti-insect activities. Nerolidol acetate can inhibit parasite activity and inhibit schistosomiasis, nematodes, malaria, etc. Nerolidol acetate protects cells from oxidative damage to lipids, proteins and DNA, and has a protective effect on mouse hippocampal nerve cells.

Sclareolide (Norambreinolide) is a sesquiterpene lactone natural product derived from various plant sources including Salvia yosgadensis, Salvia sclarea, and cigar tobacco. It is a close analog of Sclareol, a plant antifungal compound.

Ledol is a sesquiterpene alcohol from Renealmia chrysotrycha.

Versicolactone B, a sesquiterpene extracted from Viola yedoensis, exhibits anti-complement activity affecting both the classical and alternative pathways [1].

Ejaponine A (Compound 1), an insecticidal sesquiterpene ester derived from Euonymus japonicus, exhibits potent activity against Mythimna separata, with an LD50 of 89.2 μg/g. It is employed for the control of this pest species [1].

17(13→14)-Abeo-ent-3S*,13S*,16-trihydroxystrob-8(15)-ene is a sesquiterpene lactone of natural origin that exhibits anti-inflammatory properties [1].

Gochnatiolide A, a dimeric sesquiterpene isolated from Ainsliaea henryi, demonstrates antiproliferative properties against various cell lines, including kidney, melanoma, ovarian-resistant, and glioma [1] [2].

Santalene is a fragrance sesquiterpene that is responsible for the fragrance of sandalwood oil.

Helenalin is a selective inhibitor of transcription factor NF-κB by direct targeting of p65. It is an anti-inflammatory sesquiterpene lactone compound with alkylating activity. Through its ability to target the cysteine sulfhydryl groups in the p65 subunit of NF-κB, helenalin effectively inhibits its DNA binding.

Shizukanolide, a sesquiterpene lactone extracted from Chloranthus japonicus (Chloranthaceae), has a dehydro derivative that exhibits moderate antifungal activity [1].

Madolin U, a germacrane sesquiterpene, has been isolated from the herb Viola yedoensis [1].

Kissoone C (compound 3), a sesquiterpene with a three-membered ring structure, has been isolated from valerian root. This compound has been found to promote nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells [1].

Shizukaol G, a dimeric sesquiterpene, can be isolated from the roots of Chloranthus japonicus [1].

trans-Nerolidol is a sesquiterpene alcohol isolated from the above-ground parts of the Saharan Valerian plant with antifungal activity. trans-Nerolidol inhibits cell proliferation in a dose-dependent manner, and induces cell cycle arrest in the G1 phase.

Longiborneol is a sesquiterpene alcohol.

Illudin S (ILS) is a fungal sesquiterpene secondary metabolite with potent genotoxic and cytotoxic properties.

Angulatin K, a sesquiterpene polyol ester naturally occurring in the root bark of Celastrus angulatus [1], exhibits anti-cancer properties effective against a variety of solid tumors, including renal, breast, and lung.

Celangulatin D (Compound 2), a sesquiterpene polyol ester with insecticidal properties, is derived from the root bark of Celastrus angulatus. It exhibits efficacy against armyworms and has potential applications in both insecticidal and anti-tumor research [1].

Phaeocaulisin E (Compound 5), a guaiane-type sesquiterpene, inhibits LPS-induced NO production in RAW 264.7 macrophages, exhibiting an IC50 value of 10.3 µM [1].

(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one is a sesquiterpene lactone featuring a complex bicyclic structure [1].

(4S)-10-Nor-calamenen-10-one (Compound 15), an eudesmane sesquiterpene sourced from Alpinia oxyphylla [1], amplifies LPS-induced nitric oxide (NO) production in microglial cells.

(-)-Cedrene (Alpha-Cedrene) is a sesquiterpene from cedar oil that has anti-leukemia, antibacterial and anti-obesity properties.

Agarsenone, a juniperine sesquiterpene, is derived from the resin of Commiphora erythraea.

β-Patchoulene, a tricyclic sesquiterpene extracted from Pogostemon cablin (patchouli oil), has potential therapeutic applications in the treatment of inflammatory diseases [1].

Transilin, a sesquiterpene lactone, can be isolated from the entire Lepisorus contortus (Christ) Ching plant [1].

Kissoone A (compound 1), a sesquiterpene featuring a three-membered ring structure, has been isolated from valerian root [1].

Samarcandin is a natural sesquiterpene-coumarin that is isolated from F. assa-foetida.

Metachromin X, a sesquiterpene quinone, halts the cell cycle of HeLa/Fucci2 cells at the S/G2/M phase [1].

Juniper camphor, a sesquiterpene compound, is isolated from the high-boiling fraction of camphor blue oil [1].

Wallichoside, a sesquiterpene isolated from Pteris wallichiana [1], is a chemical compound with specified properties.

Aristolan-1(10)-en-9-ol, a sesquiterpene, is derivable from the Laurencia similis species [1].

Britannilactone (Desacetylinulicin) is a sesquiterpene from Inula britannica with anti-inflammatory and anti-tumor activity.Britannilactone has been associated with this antimelanotic activity and can be used in studies of skin whitening.

Curzerene, a sesquiterpene compound derived from the rhizome of Curculigo orchioides Gaertn, possesses potent anti-cancer properties. It is known to induce apoptosis in cells[1] and also suppress the expression of glutathione S-transferase A1 (GSTA1) mRNA and protein.

(1(10)E,2R*,4R*)-2-Methoxy-8,12-epoxygermacra-1(10),7,11-trien-6-one ([(1(10)E,2R,4R)]-2-Methoxy-8,12-epoxygemacra-1(10),7,11-trien-6-one) is a sesquiterpene from turmeric.

Cyperotundone is a natural product from Cyperus rotundus

Cedrene (AI3-51328), a type sesquiterpene compound derived from Xylaria guizhouensis NJAU4742, promotes lateral root formation in plants and acts through growth hormone transport and signaling.

Bisabolene (FEMA 3331) is a sesquiterpene extracted from oregano and other aromatic plants. It is a potential anticancer agent and studies have shown that it can induce apoptosis in the A549 cancer cell line.

Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.

8-epi-Helenalin, a sesquiterpene lactone with anti-tumor properties, is derived from Inula britannica L. var. chinensis (Rupr.) Reg. It demonstrates cytotoxic activity against a range of cancer cell lines, with ED50 values of 12.2 μM for HL-60, 53.8 μM for A549, 9.1 μM for MCF7, 8.7 μM for HCT-15, 18.7 μM for SK-OV-3, and 8.3 μM for Malme-3M, indicating its potential for anti-tumor research [1].

Thujopsene, a sesquiterpene found in T. dolabrata, exhibits a wide range of biological activities. It inhibits Na+/K+-ATPase and cytochrome P450 (CYP) isoform CYP2B6 with IC50 values of 25.9 µg/ml and Ki of 0.8 µM, respectively. Additionally, thujopsene demonstrates antimicrobial efficacy against both Gram-positive and Gram-negative bacteria, such as S. aureus, M. luteus, and S. typhimurium, with MICs ranging from 25-50 µg/ml. It also suppresses antigen-induced β-hexosaminidase release in IgE-sensitized RBL-2H3 mast cells (IC50= 25.1 µM) and shows cytotoxicity against A549 non-small cell lung cancer cells with an LC50 of 35.27 µg/ml. Furthermore, thujopsene causes mortality in mites D. farinae and T. putrescentiae, with LC50s of 9.82 and 10.92 µg/cm2, respectively.

Telekin, a eudesmane-type sesquiterpene lactone compound isolated from Chinese folk medicine Carpesium divaricatum, has been reported to strongly inhibit the proliferation of cancer cells

Granilin (Graniline)e is a natural product.

Wilfordinine D is a natural sesquiterpene alkaloid.

8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, exhibits anti-LIMK1 activity and inhibits cell motility [1].