tracer

Tau tracer 2 (Pl-2620) is a specific imaging agent designed to detect and visualize Tau protein aggregates, primarily used for diagnosing neurodegenerative diseases [1].

Tau tracer 1 is a radiopharmaceutical agent designed specifically for visualizing Tau protein aggregates, commonly associated with neurodegenerative diseases. Its primary application lies in the diagnosis of these conditions.

ROS tracer precursor, the synthesis precursor for [18F]ROStrace, serves in the production of ROStrace. This compound is instrumental in disease diagnosis.

p-SCN-Bn-DOTA is a chelator that simultaneously binds radionuclides and links monoclonal antibodies. It is utilized as a tracer for radio-guided surgery and serves in radio-immunoassay studies of tumors.

Rhodamine B (Brilliant Pink B) is used as a tracer dye in water to determine the rate and direction of flow and transport.

JHU 75528 (JHU-75528) is a novel PET tracer with inhibitory effects on CB that can be used to study the cannabinoid system in schizophrenic patients.

FITC-Dextran (MW 60,000-76,000) is a fluorescein isothiocyanate (FITC)-labeled dextran fluorescent probe that is commonly used as a tracer molecule to label and track the action of cells or other biomaterials on semipermeable membranes.

PiB (Pittsburgh Compound-B) is a standard for analysis of 11C-PiB. 11C-PiB is a β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.

GSHtracer is a ratiometric probe designed for the quantification of glutathione (GSH) concentrations. This probe demonstrates a measurable shift in its excitation-emission profile, specifically from 520/580 nm to 430/510 nm, upon binding with GSH.

ABP688 is a non-competitive and selective mGluR5 antagonist(Ki = 1.7 nM). ABP688 can be used as a PET tracer for clinical imaging.

4-Trifluoromethylsalicylic acid-13C6 is 13C-labeled 4-Trifluoromethylsalicylic acid, mainly used as a quantitative tracer in drug development. 4-Trifluoromethylsalicylic acid is also a platelet aggregation inhibitor.

PF-06445974 has good selectivity for PDE4D, excellent brain permeability, and has a high level of specific binding in the cold tracer study.

DCCCyb is an orally bioavailable and selective GlyT1 Inhibitor. DCCCyb demonstrated excellent in vivo occupancy of GlyT1 transporters in rhesus monkeys as determined by the displacement of a PET tracer ligand.

FFN270 hydrochloride, a fluorescent tracer for norepinephrine and vesicular monoamine transporters, features dual resolved absorption/excitation peaks that vary with solvent pH (FFN270 ex: 320 nm or 365 nm, em: 475 nm). It serves as a ratiometric fluorescent pH-sensor, highlighting its utility in monitoring norepinephrine.

Bicisate is usually complex with technetium Tc99m for its usage as a tracer to measure cerebral blood flow with single-photon emission computed tomography (SPECT).

Fluoroethylnormemantine hydrochloride, a Memantine derivative, functions as an antagonist for the N-methyl-D-aspartate (NMDA) receptor. It can also serve as a positron emission tomography (PET) tracer, specifically as [18F]-Fluoroethylnormemantine hydrochloride. Notably, this compound displays a range of effects, including anti-amnesic, neuroprotective, antidepressant-like, and fear-attenuating properties.

MK-6240 is a tau positron emission tomography (PET) tracer for neurofibrillary tangles (NFTs) that exhibits high specificity and selectivity in binding to NFTs.

DOTATATE acetate is a DOTA-binding peptide, a growth inhibitor analog, and a novel PET tracer involved in the assessment of functional imaging of highly differentiated neuroendocrine tumors (NETs).

Fet F-18 is an amino acid analog radiolabeled with fluorine F-18, a positron-emitting isotope, can be used as a tracer in positron emission tomography (PET).

Desmethyl-HD-800 is a PET precursor of preparing radiolabel [11C]HD-800, a high affinity brain penetrant PET tracer for imaging microtubules.

DCFBC F-18 is a radioconjugate containing a low molecular weight tracer, DCFBC, specific for prostate-specific membrane antigen (PSMA) and labeled with the positron-emitting isotope F 18 with potential prostate tumor imaging upon positron emission tomogra

T807 (AV-1451) is a novel tracer of tau positron emission tomography (PET).

Fluoroethylnormemantine, a derivative of Memantine, acts as an N-methyl-D-aspartate (NMDA) receptor antagonist and can function as a positron emission tomography (PET) tracer known as [18F]-fluoroethylnormemantine. This compound displays anti-amnesic, neuroprotective, antidepressant-like, and fear-attenuating properties.

Senecionine n-oxide is a major product of pyrrolizidine nucleic alkaloid biosynthesis in unusual root cultures of Trichoderma lucidum.Senecionine N-oxide (Senecionine oxide) has antitumor activity but induces hepatic sinusoidal obstruction syndrome.Senecionine n-oxide acts as a chelating tracer for N-oxide.

T-808 is a tau tracer which may be used in radiographic labeling of Tau aggregates during Alzheimer's disease.

AZ683 is an effective selective inhibitor of the 3-amino-4-anilinoquinoline CSF1R, demonstrating a high affinity for CSF1R (Ki=8 nM; IC50=6 nM). It also possesses favorable oral bioavailability. [11C]AZ683 can be used as a positron emission tomography (PET) tracer for the colony stimulating factor 1 receptor (CSF1R).

TUG-1609 is a fluorescent tracer of FFA2 with good spectral properties and high affinity.

CP-18 F-18 is a DEVD (the caspase 3 substrate recognition motif) that is an imaging tracer for caspase-3 activity in apoptotic cells.

Nicotelline, also known as Nicotellin, is an alkaloid associated with nicotine and acts as a modest inhibitor of the enzyme human cDNA-expressed cytochrome P-450 2A6 (CYP2A6), which is responsible for coumarin 7-hydroxylation. However, Nicotelline does not show inhibitory effects at a concentration of 300 μM. It serves as a tracer and biomarker for particulate matter (PM) originating from tobacco smoke [1] [2].

JNJ-42259152 F-18 can be used as a Novel Phosphodiesterase 10A PET Tracer.

CXCR4 probe 1 (compound 5) is a potent and specific CXCR4-targeted PET tracer that acts on the CXCR4-specific antagonist TN14003 (IC50: 6.9 nM). It has potential as a CXCR4-specific imaging probe for the diagnosis and prognostic monitoring of inflammatory diseases, CXCR4-positive tumors, and metastatic tumors.

FITC-GW3965, a fluorescence-labeled liver X receptor β (LXRβ) agonist, is derived from GW3965 by substituting its trifluoromethyl group with an amide linkage to FITC. This tracer facilitates the study of LXRβ function [1].

D-Glucose-13C6 (Dextrose-13C6) is an isotopic marker of D-Glucose, which can be used as a metabolic tracer for the study of metabolism-related diseases and metabolic processes of some substances in the body.

4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET tracer used in the diagnosis of neurological diseases.

PSMA-11 (HBED-CC-PSMA) detects prostate cancer recurrence and metastasis by binding to the extracellular structural domain of prostate-specific membrane antigen (PSMA).PSMA-11 is often used as a tracer of PSMA-expressing tumours in positron emission tomography (PET) scanning by intravenous injection of gallium Ga 68-labelled PSMA-11, Glu-urea-Lys(Ahx) molecule targeted and bound PSMA-expressing tumour cells. After internalisation, PSMA-expressing tumour cells could be detected on PET imaging.

Methyl -D9- choline is an isotopically labeled choline tracer.

Biocytin is a classical neuroanatomical tracer commonly used to map brain connectivity. Biocytin is a conjugate of D-biotin and L-lysine, where the carboxylate of D-biotin is coupled with the ϵ-amine of L-lysine via a secondary amide bond.

FAPI-74 is a PET (positron emission tomography) tracer involved in early FAPI-PET imaging.FAPI-74 can be used to study cancerous tumors and degenerative diseases.

THK5351 is a tracer involved in PET imaging for electron emission tomography imaging of Alzheimer's disease and cognitive impairment.

NOTA-FAPI-4 is an analogue of FAPI-4 and a fibroblast activation protein (FAP) inhibitor. NOTA-FAPI-4 is useful in the diagnosis or treatment of a disease characterized by overexpression of fibroblast activation protein (FAP). NOTA-FAPI-4 can be used as a PET tracer for detection of diseases or disorders related to fibroblast activation protein.

DOTA.SA.FAPi TFA is a bifunctional chelator composed of squaric acid (squaric acid) and UAMC1110, integrating the properties of DATA5m and DOTA. It exhibits inhibitory activity against fibroblast activation protein (FAP) with an IC50 of 0.9 nM and targets the prolyl endopeptidase (PREP) with an IC50 of 5.4 μM. After labeling with 68Ga, DOTA.SA.FAPi TFA serves as a PET tracer for cancer research.

C-ABL-IN-5, a selective c-Abl inhibitor, exhibits neuroprotective properties and has favorable characteristics including blood-brain barrier permeability, metabolic stability, and pharmacokinetic profiles. When labeled with [18F] (compound [18F]3), C-ABL-IN-5 serves as a tracer in positron emission tomography (PET) scans to assess disease-modifying effects, particularly in research on neurodegenerative conditions like Parkinson's disease (PD) [1].

JNJ-42259152 is a phosphodiesterase 10A PET tracer.

(18F)LBT 999 is a positron emission tomography (PET) tracer, used for the quantification of the dopamine transporter (DAT) in the healthy rat brain.

Fluoroethyl-l-tyrosine (18F) or 18F-FET is a neuro-oncology PET tracer.

PBB3 is a tau-specific PET tracer.

1,6-Anhydro-D-galactose is a carbohydrate found in liquid smoke flavorings that is used as a tracer of the contribution of biomass burning to total atmospheric particulate matter.

DOTATATE, a DOTA-conjugated peptide, is utilized for its ability to be labeled with radionuclides, facilitating positron emission tomography (PET) imaging and peptide receptor radionuclide therapy (PRRT)[4].