T16122 |
MMAF sodium
|
1799706-65-2
|
98%
|
|
MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective ...
|
TQ0186 |
Ko 143
|
461054-93-3
|
98%
|
|
Ko 143 is a selective inhibitor of ATP-binding cassette sub-family G member 2 (ABCG2; BCRP).
|
T0055L |
Glafenine Hydrochloride
|
65513-72-6
|
98%
|
|
Glafenine Hydrochloride is an anti-inflammatory agent.
|
T0490 |
Chlorpropamide
|
94-20-2
|
98%
|
|
Chlorpropamide is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification.
|
T9587 |
CCTA-1523
|
1616271-41-0
|
98%
|
|
CCTA-1523 is an efflux function of ABCG2 inhibitor. CCTA-1523 selectively reverses ABCG2-mediated MDR in cancer cells.
|
T0974 |
Novobiocin Sodium
|
1476-53-5
|
98%
|
|
Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveu...
|
T18975 |
DIDS sodium salt
|
67483-13-0
|
98%
|
|
DIDS sodium salt is a dual inhibitor of ABCA1 and VDAC1.
|
T20003 |
Acridone
|
578-95-0
|
98%
|
|
Acridone is an organic compound based on the acridine skeleton. Acridone could induce cell apoptosis, inhibited ABCG2 (ATP-binding cassette sub-family G member 2...
|
T1603 |
Glipizide
|
29094-61-9
|
98%
|
|
Glipizide is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
|
T0128 |
Vigabatrin
|
60643-86-9
|
98%
|
|
Vigabatrin, an analogue of gamma-aminobutyric acid, is an irreversible inhibitor of 4-aminobutyrate Transaminase responsible for the catabolism of γ-aminobutyric...
|
T8165 |
Erythrodiol
|
545-48-2
|
98%
|
|
Erythrodiol, an olive oil component, promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein.
|
T9601 |
Tepotinib hydrochloride(1 : x)
|
1103508-80-0
|
98%
|
|
Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 s...
|
T1050 |
Prazosin hydrochloride
|
19237-84-4
|
98%
|
|
Prazosin Hydrochloride reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not complete...
|
T0254 |
Probucol
|
23288-49-5
|
98%
|
|
Probucol, an anti-hyperlipidemic drug, can lower the level of cholesterol in the bloodstream by increasing the LDL catabolic rate.
|
T2590 |
Vismodegib
|
879085-55-9
|
98%
|
|
Vismodegib is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).
|
T17072 |
Thiethylperazine dimaleate
|
1179-69-7
|
98%
|
|
Thiethylperazine dimaleate is an antagonist of the D2 receptor and H1 receptor. Thiethylperazine dimaleate is an activator of ABCC1 and possesses antimicrobial, ...
|
T15355 |
Fumitremorgin C
|
118974-02-0
|
98%
|
|
Fumitremorgin C is a potent and selective inhibitor of ABCG2/BRCP.
|
TN3150 |
6,8-Diprenylnaringenin
|
68236-11-3
|
98%
|
|
6,8-Diprenylnaringenin is a natural product from hop Humulus lupulus. 6,8-Diprenylnaringenin is a breast cancer resistance protein(BCRP) inhibitor with some estr...
|
TN1804 |
Isosilybin A
|
142796-21-2
|
98%
|
|
Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC5...
|
TN7124 |
5-Hydroxy-2′,3,4′,7-tetramethoxyflavone
|
19056-75-8
|
98%
|
|
5-Hydroxy-2′,3,4′,7-tetramethoxyflavone shows weak ABCG2 inhibitory potency with IC50s of 3.27 and 3.89 µM in the Hoechst 33342 and pheophorbide A assays.
|