ABC

The ATP-binding cassette transporters (ABC transporters) are a transport system superfamily that is one of the largest and possibly one of the oldest gene families. It is represented in all extant phyla, from prokaryotes to humans. ABC transporters often consist of multiple subunits, one or two of which are transmembrane proteins and one or two of which are membrane-associated AAA ATPases. The ATPase subunits utilize the energy of adenosine triphosphate (ATP) binding and hydrolysis to provide the energy needed for the translocation of substrates across membranes, either for uptake or for export of the substrate.

Cat. No.	Product name	CAS No.	Purity
T16122	MMAF sodium	1799706-65-2	98%
T16122	MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective ...
TQ0186	Ko 143	461054-93-3	98%
TQ0186	Ko 143 is a selective inhibitor of ATP-binding cassette sub-family G member 2 (ABCG2; BCRP).
T0055L	Glafenine Hydrochloride	65513-72-6	98%
T0055L	Glafenine Hydrochloride is an anti-inflammatory agent.
T0490	Chlorpropamide	94-20-2	98%
T0490	Chlorpropamide is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification.
T9587	CCTA-1523	1616271-41-0	98%
T9587	CCTA-1523 is an efflux function of ABCG2 inhibitor. CCTA-1523 selectively reverses ABCG2-mediated MDR in cancer cells.
T0974	Novobiocin Sodium	1476-53-5	98%
T0974	Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveu...
T18975	DIDS sodium salt	67483-13-0	98%
T18975	DIDS sodium salt is a dual inhibitor of ABCA1 and VDAC1.
T20003	Acridone	578-95-0	98%
T20003	Acridone is an organic compound based on the acridine skeleton. Acridone could induce cell apoptosis, inhibited ABCG2 (ATP-binding cassette sub-family G member 2...
T1603	Glipizide	29094-61-9	98%
T1603	Glipizide is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
T0128	Vigabatrin	60643-86-9	98%
T0128	Vigabatrin, an analogue of gamma-aminobutyric acid, is an irreversible inhibitor of 4-aminobutyrate Transaminase responsible for the catabolism of γ-aminobutyric...
T8165	Erythrodiol	545-48-2	98%
T8165	Erythrodiol, an olive oil component, promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein.
T9601	Tepotinib hydrochloride(1 : x)	1103508-80-0	98%
T9601	Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 s...
T1050	Prazosin hydrochloride	19237-84-4	98%
T1050	Prazosin Hydrochloride reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not complete...
T0254	Probucol	23288-49-5	98%
T0254	Probucol, an anti-hyperlipidemic drug, can lower the level of cholesterol in the bloodstream by increasing the LDL catabolic rate.
T2590	Vismodegib	879085-55-9	98%
T2590	Vismodegib is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).
T17072	Thiethylperazine dimaleate	1179-69-7	98%
T17072	Thiethylperazine dimaleate is an antagonist of the D2 receptor and H1 receptor. Thiethylperazine dimaleate is an activator of ABCC1 and possesses antimicrobial, ...
T15355	Fumitremorgin C	118974-02-0	98%
T15355	Fumitremorgin C is a potent and selective inhibitor of ABCG2/BRCP.
TN3150	6,8-Diprenylnaringenin	68236-11-3	98%
TN3150	6,8-Diprenylnaringenin is a natural product from hop Humulus lupulus. 6,8-Diprenylnaringenin is a breast cancer resistance protein(BCRP) inhibitor with some estr...
TN1804	Isosilybin A	142796-21-2	98%
TN1804	Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC5...
TN7124	5-Hydroxy-2′,3,4′,7-tetramethoxyflavone	19056-75-8	98%
TN7124	5-Hydroxy-2′,3,4′,7-tetramethoxyflavone shows weak ABCG2 inhibitory potency with IC50s of 3.27 and 3.89 µM in the Hoechst 33342 and pheophorbide A assays.