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Membrane transporter/Ion channel ABC

ABC

The ATP-binding cassette transporters (ABC transporters) are a transport system superfamily that is one of the largest and possibly one of the oldest gene families. It is represented in all extant phyla, from prokaryotes to humans. ABC transporters often consist of multiple subunits, one or two of which are transmembrane proteins and one or two of which are membrane-associated AAA ATPases. The ATPase subunits utilize the energy of adenosine triphosphate (ATP) binding and hydrolysis to provide the energy needed for the translocation of substrates across membranes, either for uptake or for export of the substrate.
Cat No. product name
T0055L Glafenine Hydrochloride Glafenine Hydrochloride is an anti-inflammatory agent.
T0128 Vigabatrin Vigabatrin, an analogue of gamma-aminobutyric acid, is an irreversible inhibitor of 4-aminobutyrate transaminase responsible for the catabolism of γ-aminobuty...
T0254 Probucol Probucol, an anti-hyperlipidemic drug, can lower the level of cholesterol in the bloodstream by increasing the LDL catabolic rate.
T0490 Chlorpropamide Chlorpropamide is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification.
T0974 Albamycinsodium Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces nive...
T1050 Prazosin hydrochloride Prazosin Hydrochloride reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not complet...
T1603 Glipizide Glipizide is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
TQ0186 Ko 143 Ko 143 is a selective inhibitor of ATP-binding cassette sub-family G member 2 (ABCG2; BCRP).
T2590 VismodegibHOT Vismodegib is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).
T8165 Erythrodiol Erythrodiol, an olive oil component, promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein.
TN1804 Isosilybin A Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (...
T18975 DIDS sodium salt DIDS sodium salt is a dual inhibitor of ABCA1 and VDAC1.
T16122 MMAF sodium MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective...
T4S2157 Campesterol Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects, it and other plant sterols often decrease LDL cholesterol levels overall. ...
Glafenine Hydrochloride
T0055LCAS 65513-72-6
Glafenine Hydrochloride is an anti-inflammatory agent.
Vigabatrin
T0128CAS 60643-86-9
Vigabatrin, an analogue of gamma-aminobutyric acid, is an irreversible inhibitor of 4-aminobutyrate transaminase responsible for the catabolism of γ-aminobuty...
Probucol
T0254CAS 23288-49-5
Probucol, an anti-hyperlipidemic drug, can lower the level of cholesterol in the bloodstream by increasing the LDL catabolic rate.
Chlorpropamide
T0490CAS 94-20-2
Chlorpropamide is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification.
Albamycinsodium
T0974CAS 1476-53-5
Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces nive...
Prazosin hydrochloride
T1050CAS 19237-84-4
Prazosin Hydrochloride reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not complet...
Glipizide
T1603CAS 29094-61-9
Glipizide is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
Ko 143
TQ0186CAS 461054-93-3
Ko 143 is a selective inhibitor of ATP-binding cassette sub-family G member 2 (ABCG2; BCRP).
Vismodegib HOT
T2590CAS 879085-55-9
Vismodegib is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).
Erythrodiol
T8165CAS 545-48-2
Erythrodiol, an olive oil component, promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein.
Isosilybin A
TN1804CAS 142796-21-2
Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (...
DIDS sodium salt
T18975CAS 67483-13-0
DIDS sodium salt is a dual inhibitor of ABCA1 and VDAC1.
MMAF sodium
T16122CAS 1799706-65-2
MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective...
Campesterol
T4S2157CAS 474-62-4
Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects, it and other plant sterols often decrease LDL cholesterol levels overall. ...