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Neuroscience BACE

BACE

Beta-secretase 1 (BACE1), also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1, membrane-associated aspartic protease 2, memapsin-2, aspartyl protease 2, and ASP2, is an enzyme that in humans is encoded by the BACE1 gene. Expression of BACE1 is observed mainly in neurons.BACE1 is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells: in mice the expression of BACE1 is high in the postnatal stages, when myelination occurs.
Cat No. product name
T2639 LY2811376 LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectiv...
T3394 Timosaponin BII Timosaponin BII has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activity, can inhibit the up-...
T4115 Auraptene Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neur...
T6058 LY2886721 LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.
T6772 AZD3839 AZD3839 is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.
T7011 Verubecestat Verubecestat (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.
T4398 LX2343 LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. L...
TQ0238 Lanabecestat Lanabecestat (AZD3293) is a highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor (Ki: 0.4 nM).
T5S2361 Epiberberine 1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK...
T2759 Loganin Loganin, an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed poten...
T8179 Aloeresin D Aloeresin D, a natural chromone glycoside, inhibits β-Secretase (BACE1) activity (IC50: 39 μM).
T8306 Epiberberine (chloride) Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.0...
TN1332 7-O-Methylaloeresin A 7-O-Methylaloeresin A shows significant antioxidant activity, it also has moderate inhibitory active on BACE.
TN1343 8-Geranyloxypsoralen 8-Geranyloxypsoralen inhibits α²-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it can induce vasorelaxation on rat a...
TN1434 Bavachromene Bavachromene exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro.
TN1305 6-Ethoxydihydrosanguinarine 6-Ethoxydihydrosanguinarine shows human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibitory activity, with IC50 valu...
TN1774 Isobavachromene Isobavachromene is an inhibitor of NADH-Ubiquinone oxidoreductase and ornithine decarboxylase. Isobavachromene has antifungal activity.
TN1799 Isorubrofusarin 10-gentiobioside Isorubrofusarin 10-gentiobioside shows promising inhibitory activity against AChE/BACE1.
T12188 NB-360 NB-360 is orally bioavailable and brain penetrable dual inhibitor of BACE1/BACE2 with IC50 of mouse and human BACE1=5 nM; BACE2=6 nM).
T12429 PF-06751979 PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
T14338 Atabecestat Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust ...
T10292 AM-6494 AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).
T10450 BACE1-IN-1 BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).
T10451 BACE1-IN-2 BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).
T10452 BACE1-IN-4 BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.
T10453 BACE1-IN-5 BACE1-IN-5 is a BACE1 inhibitor (IC50: 9.1 nM) and also inhibits cellular amyloid-β (Aβ; IC50: 0.82 nM). BACE1-IN-5 has medicinal chemistry that improves hERG...
TN3410 Anatabine Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheim...
TN4399 Kushenol C Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)...
TN4865 Putraflavone Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
LY2811376
T2639CAS 1194044-20-6
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectiv...
Timosaponin BII
T3394CAS 136656-07-0
Timosaponin BII has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activity, can inhibit the up-...
Auraptene
T4115CAS 495-02-3
Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neur...
LY2886721
T6058CAS 1262036-50-9
LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.
AZD3839
T6772CAS 1227163-84-9
AZD3839 is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.
Verubecestat
T7011CAS 1286770-55-5
Verubecestat (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.
LX2343
T4398CAS 333745-53-2
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. L...
Lanabecestat
TQ0238CAS 1383982-64-6
Lanabecestat (AZD3293) is a highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor (Ki: 0.4 nM).
Epiberberine
T5S2361CAS 6873-09-2
1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK...
Loganin
T2759CAS 18524-94-2
Loganin, an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed poten...
Aloeresin D
T8179CAS 105317-67-7
Aloeresin D, a natural chromone glycoside, inhibits β-Secretase (BACE1) activity (IC50: 39 μM).
Epiberberine (chloride)
T8306CAS 889665-86-5
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.0...
7-O-Methylaloeresin A
TN1332CAS 329361-25-3
7-O-Methylaloeresin A shows significant antioxidant activity, it also has moderate inhibitory active on BACE.
8-Geranyloxypsoralen
TN1343CAS 7437-55-0
8-Geranyloxypsoralen inhibits α²-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it can induce vasorelaxation on rat a...
Bavachromene
TN1434CAS 41743-38-8
Bavachromene exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro.
6-Ethoxydihydrosanguinarine
TN1305CAS 28342-31-6
6-Ethoxydihydrosanguinarine shows human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibitory activity, with IC50 valu...
Isobavachromene
TN1774CAS 52801-22-6
Isobavachromene is an inhibitor of NADH-Ubiquinone oxidoreductase and ornithine decarboxylase. Isobavachromene has antifungal activity.
Isorubrofusarin 10-gentiobioside
TN1799CAS 200127-93-1
Isorubrofusarin 10-gentiobioside shows promising inhibitory activity against AChE/BACE1.
NB-360
T12188CAS 1262857-73-7
NB-360 is orally bioavailable and brain penetrable dual inhibitor of BACE1/BACE2 with IC50 of mouse and human BACE1=5 nM; BACE2=6 nM).
PF-06751979
T12429CAS 1818339-66-0
PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
Atabecestat
T14338CAS 1200493-78-2
Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust ...
AM-6494
T10292CAS 1874232-80-0
AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).
BACE1-IN-1
T10450CAS 1310347-50-2
BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).
BACE1-IN-2
T10451CAS 1352416-78-4
BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).
BACE1-IN-4
T10452CAS 2361157-92-6
BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.
BACE1-IN-5
T10453CAS
BACE1-IN-5 is a BACE1 inhibitor (IC50: 9.1 nM) and also inhibits cellular amyloid-β (Aβ; IC50: 0.82 nM). BACE1-IN-5 has medicinal chemistry that improves hERG...
Anatabine
TN3410CAS 581-49-7
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheim...
Kushenol C
TN4399CAS 99119-73-0
Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)...
Putraflavone
TN4865CAS 23624-21-7
Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.