T2639 |
LY2811376 |
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectiv...
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T3394 |
Timosaponin BII |
Timosaponin BII has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activity, can inhibit the up-...
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T4115 |
Auraptene |
Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neur...
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T6058 |
LY2886721 |
LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease. |
T6772 |
AZD3839 |
AZD3839 is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1. |
T7011 |
Verubecestat |
Verubecestat (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor. |
T4398 |
LX2343 |
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. L...
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TQ0238 |
Lanabecestat |
Lanabecestat (AZD3293) is a highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor (Ki: 0.4 nM). |
T5S2361 |
Epiberberine |
1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK...
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T2759 |
Loganin |
Loganin, an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed poten...
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T8179 |
Aloeresin D |
Aloeresin D, a natural chromone glycoside, inhibits β-Secretase (BACE1) activity (IC50: 39 μM). |
T8306 |
Epiberberine (chloride) |
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.0...
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TN1332 |
7-O-Methylaloeresin A |
7-O-Methylaloeresin A shows significant antioxidant activity, it also has moderate inhibitory active on BACE. |
TN1343 |
8-Geranyloxypsoralen |
8-Geranyloxypsoralen inhibits α²-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it can induce vasorelaxation on rat a...
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TN1434 |
Bavachromene |
Bavachromene exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro. |
TN1305 |
6-Ethoxydihydrosanguinarine |
6-Ethoxydihydrosanguinarine shows human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibitory activity, with IC50 valu...
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TN1774 |
Isobavachromene |
Isobavachromene is an inhibitor of NADH-Ubiquinone oxidoreductase and ornithine decarboxylase. Isobavachromene has antifungal activity. |
TN1799 |
Isorubrofusarin 10-gentiobioside |
Isorubrofusarin 10-gentiobioside shows promising inhibitory activity against AChE/BACE1. |
T12188 |
NB-360 |
NB-360 is orally bioavailable and brain penetrable dual inhibitor of BACE1/BACE2 with IC50 of mouse and human BACE1=5 nM; BACE2=6 nM). |
T12429 |
PF-06751979 |
PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay). |
T14338 |
Atabecestat |
Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust ...
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T10292 |
AM-6494 |
AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM). |
T10450 |
BACE1-IN-1 |
BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2). |
T10451 |
BACE1-IN-2 |
BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM). |
T10452 |
BACE1-IN-4 |
BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2. |
T10453 |
BACE1-IN-5 |
BACE1-IN-5 is a BACE1 inhibitor (IC50: 9.1 nM) and also inhibits cellular amyloid-β (Aβ; IC50: 0.82 nM). BACE1-IN-5 has medicinal chemistry that improves hERG...
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TN3410 |
Anatabine |
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheim...
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TN4399 |
Kushenol C |
Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)...
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TN4865 |
Putraflavone |
Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging. |