BACE

Beta-secretase 1 (BACE1), also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1, membrane-associated aspartic protease 2, memapsin-2, aspartyl protease 2, and ASP2, is an enzyme that in humans is encoded by the BACE1 gene. Expression of BACE1 is observed mainly in neurons.BACE1 is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells: in mice the expression of BACE1 is high in the postnatal stages, when myelination occurs.

Cat. No.	Product name	CAS No.	Purity
TN1434	Bavachromene	41743-38-8	98%
TN1434	Bavachromene exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro.
T10292	AM-6494	1874232-80-0	98%
T10292	AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).
T10452	BACE1-IN-4	2361157-92-6	98%
T10452	BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.
T8306	Epiberberine chloride	889665-86-5	98%
T8306	Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07...
T10451	BACE1-IN-2	1352416-78-4	98%
T10451	BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).
T10453	BACE1-IN-5	T10453	98%
T10453	BACE1-IN-5 (Compound 15) is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC 50 of 9.1 nM, and also inhibits cellular amyloid-β ...
TN3410	Anatabine	581-49-7	98%
TN3410	Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
TN4399	Kushenol C	99119-73-0	98%
TN4399	Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)....
T12429	PF-06751979	1818339-66-0	98%
T12429	PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
TN4865	Putraflavone	23624-21-7	98%
TN4865	Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
T10450	BACE1-IN-1	1310347-50-2	98%
T10450	BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).
TQ0238	Lanabecestat	1383982-64-6	98%
TQ0238	Lanabecestat (AZD3293) is a highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor (Ki: 0.4 nM).
T14338	Atabecestat	1200493-78-2	98%
T14338	Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust an...
TN1332	7-O-Methylaloeresin A	329361-25-3	98%
TN1332	7-O-Methylaloeresin A shows significant antioxidant activity, it also has moderate inhibitory active on BACE.
T3161L	BACE-IN-1 acetate		98%
T3161L	β-Secretase inhibitor has been used as β-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) inhibitor in BACE1 inhibitor assay. β-Site amyloid precur...
T13253	Umibecestat	1387560-01-1	100%
T13253	Umibecestat is an inhibitor of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, r...
T4115	Auraptene	495-02-3	98%
T4115	Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuro...
T2639	LY2811376	1194044-20-6	99.01%
T2639	LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity...
TN2190	Scoulerine	6451-73-6	99.22%
TN2190	Scoulerine shows significant cytotoxic effects against both two cancer cell lines (Caco-2 and Hep-G2 cancer cells), with IC50 values 6.44 ± 0.87 and 4.57 ± 0.42,...
T12188	NB-360	1262857-73-7	99.25%
T12188	NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent ...