TN2217 |
Sophoflavescenol
|
216450-65-6
|
99.65%
|
|
Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...
|
TN3410 |
Anatabine
|
581-49-7
|
98%
|
|
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
|
TN4865 |
Putraflavone
|
23624-21-7
|
98%
|
|
Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
|
TN2131 |
Questin
|
3774-64-9
|
98%
|
|
Questin is an antimicrobial agent derived from Aspergillus florescens with an antimicrobial activity profile that inhibits V. harveyi, V. anguillarum, V. cholera...
|
TN1332 |
7-O-Methylaloeresin A
|
329361-25-3
|
98%
|
|
7-O-Methylaloeresin A shows significant antioxidant activity, it also has moderate inhibitory active on BACE.
|
T10292 |
AM-6494
|
1874232-80-0
|
98%
|
|
AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).
|
T10450 |
BACE1-IN-1
|
1310347-50-2
|
98%
|
|
BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).
|
TN1434 |
Bavachromene
|
41743-38-8
|
98%
|
|
Bavachromene exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro.
|
T8306 |
Epiberberine chloride
|
889665-86-5
|
98%
|
|
Epiberberine chloride (Epiberberine (chloride)) is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BA...
|
T10452 |
BACE1-IN-4
|
2361157-92-6
|
98%
|
|
BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.
|
T12429 |
PF-06751979
|
1818339-66-0
|
98%
|
|
PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
|
TQ0238 |
Lanabecestat
|
1383982-64-6
|
98%
|
|
Lanabecestat (AZD3293) is a highly potent and highly permeable, orally active BACE1 inhibitor (Ki: 0.4 nM) that crosses the blood-brain barrier, Lanabecestat can...
|
T14338 |
Atabecestat
|
1200493-78-2
|
98%
|
|
Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust an...
|
TN4399 |
Kushenol C
|
99119-73-0
|
98%
|
|
Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)....
|
T10453 |
BACE1-IN-5
|
2581114-83-0
|
98%
|
|
BACE1-IN-5 (Compound 15), a potent β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, demonstrates significant efficacy with an IC50 of 9.1 nM...
|
T10451 |
BACE1-IN-2
|
1352416-78-4
|
98%
|
|
BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).
|
T6058 |
LY2886721
|
1262036-50-9
|
99.94%
|
|
LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.
|
T6772 |
AZD3839 free base
|
1227163-84-9
|
99.93%
|
|
AZD3839 free base is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.
|
T4398 |
LX2343
|
333745-53-2
|
99.92%
|
|
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343...
|
TN1343 |
8-Geranyloxypsoralen
|
7437-55-0
|
99.87%
|
|
8-Geranyloxypsoralen inhibits α2-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it can induce vasorelaxation on rat arter...
|