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Immunology/Inflammation

Aryl Hydrocarbon Receptor

Immunology/Inflammation related

NOD-like Receptor (NLR)

Prostaglandin Receptor

Reactive Oxygen Species

Thrombopoietin Receptor

CD73

5′-nucleotidase (5′-NT), also known CD73 (cluster of differentiation 73), is an enzyme that in humans is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine. NT5E (CD73) is a surface enzyme which is expressed on multiple cells. This enzyme mediates the gradual hydrolysis of the autocrine and paracrine danger signals of ATP and ADP to anti-inflammatory adenosine. Immune suppression mediated by adenosinergic pathways is very important for maintaining immune system homeostasis.

Filter HomeSignaling PathwaysImmunology/InflammationCD73

Oleclumab

T766951803176-05-7

Oleclumab (MEDI9447) is a human anti-CD73 monoclonal antibody with anticancer activity that inhibits the extracellular enzyme CD73 nucleic acid exonuclease activity, inhibits the adenosine pathway, and can be used for the study of metastatic desmoplasia-resistant prostate cancer.

$479

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AB-680

T102162105904-82-1

AB-680, a highly potent, reversible, and selective inhibitor of CD73 (an ectonucleotidase, Ki: 4.9 pM for hCD73) with anti-tumor activity, displays >10,000-fold selectivity over related ectonucleotidases CD39.

$115

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MethADP

T120083768-14-7In house

MethADP (Adenosine 5'-(α,β-methylene)diphosphate) is a specific CD73 inhibitor that inhibits the enzyme ecto-5′-nucleotidase (ecto), which has been used in the study of neurological and cardiovascular diseases.

$198

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CD73-IN-3

T88752375815-63-5

CD73-IN-3 (LY-3475070) is a potent and selective CD73 inhibitor with an IC50 of 28 nM, and its use alone or in combination with pembrolizumab is currently being tested in patients with advanced cancer.

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CD73-IN-4

T92102216764-29-1

CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor.

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PSB-12379 ditriethylamine salt

T12569L In house

PSB-12379 ditriethylamine salt, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human).

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Mupadolimab

T767352451856-97-4

Mupadolimab (CPI-006) is a humanized FC-γR binding deficient IgG1 anti-CD73 antibody with potential anticancer activity and activation of CD73POS B cells.

$222

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CD73-IN-1

T107212132396-40-6

CD73-IN-1 is a CD73 inhibitor with anticancer activity.

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Dresbuxelimab

T806032550560-20-6

Dresbuxelimab (AK-119), an IgG-κ monoclonal antibody, selectively targets CD73 and is commonly produced using a Chinese Hamster Ovary (CHO) cell expression system [1].

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ZM522

T2033411454575-38-2

ZM522 is a CD73 inhibitor with an IC50 value of 0.56 μM. It effectively increases interferon-gamma (INF-γ) levels and enhances immune activity by modulating T cell activation. ZM522 holds potential for research in immunology and anti-cancer fields.

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10-14 weeks

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CD73-IN-17

T200431

CD73-IN-17 (compound 19) is an inhibitor of CD73 with an IC50 of 0.1 μM against hCD73. It is applicable in cancer research.

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CD73-IN-16

T200673

CD73-IN-16 (compound 18) acts as an inhibitor of hCD73, exhibiting an IC50 value of 0.28 μM.

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CD73-IN-18

T2006723037968-61-6

CD73-IN-18 (compound 35j) is an orally effective inhibitor of the extracellular 5'-nucleotidase (CD73) enzyme. It can be utilized in anticancer research.