Shopping Cart

Remove All
Your shopping cart is currently empty

Immunology/Inflammation

Aryl Hydrocarbon Receptor

Immunology/Inflammation related

NOD-like Receptor (NLR)

Prostaglandin Receptor

Reactive Oxygen Species

Thrombopoietin Receptor

CD73

5′-nucleotidase (5′-NT), also known CD73 (cluster of differentiation 73), is an enzyme that in humans is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine. NT5E (CD73) is a surface enzyme which is expressed on multiple cells. This enzyme mediates the gradual hydrolysis of the autocrine and paracrine danger signals of ATP and ADP to anti-inflammatory adenosine. Immune suppression mediated by adenosinergic pathways is very important for maintaining immune system homeostasis.

Filter HomeSignaling PathwaysImmunology/InflammationCD73

AB-680

T102162105904-82-1

AB-680, a highly potent, reversible, and selective inhibitor of CD73 (an ectonucleotidase, Ki: 4.9 pM for hCD73) with anti-tumor activity, displays >10,000-fold selectivity over related ectonucleotidases CD39.

$115

In Stock

Size

QTY

Oleclumab

T766951803176-05-7

Oleclumab (MEDI9447) is a human anti-CD73 monoclonal antibody with anticancer activity that inhibits the extracellular enzyme CD73 nucleic acid exonuclease activity, inhibits the adenosine pathway, and can be used for the study of metastatic desmoplasia-resistant prostate cancer.

$479

In Stock

Size

QTY

MethADP

T120083768-14-7In house

MethADP (Adenosine 5'-(α,β-methylene)diphosphate) is a specific CD73 inhibitor that inhibits the enzyme ecto-5′-nucleotidase (ecto), which has been used in the study of neurological and cardiovascular diseases.

$198

In Stock

Size

QTY

CD73-IN-4

T92102216764-29-1

CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor.

In Stock

Size

QTY

PSB-12379 ditriethylamine salt

T12569L In house

PSB-12379 ditriethylamine salt, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human).

In Stock

Size

QTY

CD73-IN-3

T88752375815-63-5

CD73-IN-3 (LY-3475070) is a potent and selective CD73 inhibitor with an IC50 of 28 nM, and its use alone or in combination with pembrolizumab is currently being tested in patients with advanced cancer.

In Stock

Size

QTY

Mupadolimab

T767352451856-97-4

Mupadolimab (CPI-006) is a humanized FC-γR binding deficient IgG1 anti-CD73 antibody with potential anticancer activity and activation of CD73POS B cells.

$222

In Stock

Size

QTY

CD73-IN-1

T107212132396-40-6

CD73-IN-1 is a CD73 inhibitor with anticancer activity.

In Stock

Size

QTY

Dresbuxelimab

T806032550560-20-6

Dresbuxelimab (AK-119), an IgG-κ monoclonal antibody, selectively targets CD73 and is commonly produced using a Chinese Hamster Ovary (CHO) cell expression system [1].

Inquiry Price

Size

QTY

CD73-IN-17

T200431

CD73-IN-17 (compound 19) is an inhibitor of CD73 with an IC50 of 0.1 μM against hCD73. It is applicable in cancer research.

Inquiry Price

Size

QTY

CD73-IN-18

T2006723037968-61-6

CD73-IN-18 (compound 35j) is an orally effective inhibitor of the extracellular 5'-nucleotidase (CD73) enzyme. It can be utilized in anticancer research.