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DNA Alkylation

DNA alkylation refers to the addition of alkyl groups to specific bases, resulting in alkylation products such as O2‐alkylthymine, O4‐alkylthymine, O6‐methylguanine and O6‐ethylguanine, which cause DNA mutations.
Cat No. product name
T17212 VAL-083 VAL-083 is an alkylating compound that creates N7 methylation on DNA. It also has antitumor activity.
T17159 Treosulfan Treosulfan is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
T7539 O6-Benzylguanine O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
T1250 Thio-TEPA Thiotepa is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
T2495 Lomeguatrib Lomeguatrib, a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
T0975 Chlorambucil Chlorambucil is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, result...
T1241 Altretamine Altretamine is an alkylating agent with antineoplastic activity.
T15771 Lobaplatin Lobaplatin (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent which shows...
T1601 Lomustine Lomustine is an alkylating agent of value against both hematologic malignancies and solid tumors.
T6798 Tretazicar CB1954(Tretazicar), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and co-substrate ...
T6057 URMC-099 URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
T7221 Satraplatin Satraplatin is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against...
T0923 Busulfan Busulfan is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood,...
T4350 Palifosfamide Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to...
T11120 Duocarmycin TM Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.
T1507 Streptozocin Streptozotocin is an antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animal...
T3091 Carmustine Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent.
T19300 Duocarmycin Analog Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin.
T12813L Seco-Duocarmycin SA Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin.
T11440 GNE-8505 GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).
T11056 DLK-IN-1 DLK-IN-1 is a selective oral active inhibitor of bisleucine zipper kinase (DLK, MAP3K12) with Ki of 3 nM. DLK-IN-1 is active in the Alzheimer's disease model, re...
T3707 GNE-3511 GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.
T9985 Methyl methanesulfonate Methyl methanesulfonate 是一种DNA烷基化剂,可以分别修饰腺嘌呤(为3-甲基腺嘌呤)和鸟嘌呤(7-甲基腺嘌呤),进而导致碱基错配和复制障碍。
VAL-083
T17212
VAL-083 is an alkylating compound that creates N7 methylation on DNA. It also has antitumor activity.
Treosulfan
T17159
Treosulfan is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
O6-Benzylguanine
T7539
O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
Thio-TEPA
T1250
Thiotepa is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
Lomeguatrib
T2495
Lomeguatrib, a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
Chlorambucil
T0975
Chlorambucil is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, result...
Altretamine
T1241
Altretamine is an alkylating agent with antineoplastic activity.
Lobaplatin
T15771
Lobaplatin (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent which shows...
Lomustine
T1601
Lomustine is an alkylating agent of value against both hematologic malignancies and solid tumors.
Tretazicar
T6798
CB1954(Tretazicar), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and co-substrate ...
URMC-099
T6057
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
Satraplatin
T7221
Satraplatin is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against...
Busulfan
T0923
Busulfan is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood,...
Palifosfamide
T4350
Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to...
Duocarmycin TM
T11120
Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.
Streptozocin
T1507
Streptozotocin is an antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animal...
Carmustine
T3091
Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent.
Duocarmycin Analog
T19300
Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin.
Seco-Duocarmycin SA
T12813L
Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin.
GNE-8505
T11440
GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).
DLK-IN-1
T11056
DLK-IN-1 is a selective oral active inhibitor of bisleucine zipper kinase (DLK, MAP3K12) with Ki of 3 nM. DLK-IN-1 is active in the Alzheimer's disease model, re...
GNE-3511
T3707
GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.
Methyl methanesulfonate
T9985