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DNA Alkylation

DNA alkylation refers to the addition of alkyl groups to specific bases, resulting in alkylation products such as O2‐alkylthymine, O4‐alkylthymine, O6‐methylguanine and O6‐ethylguanine, which cause DNA mutations.
Cat. No. Product name CAS No. Purity Chemical Structure
T21297 Miriplatin hydrate 250159-48-9 98%
Miriplatin hydrate (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC). Miriplatin hydrate is a...
T11056 DLK-IN-1 1620574-24-4 98%
DLK-IN-1 is a selective oral active inhibitor of bisleucine zipper kinase (DLK, MAP3K12) with Ki of 3 nM. DLK-IN-1 is active in the Alzheimer's disease model, re...
T19300 Duocarmycin Analog 372954-15-9 98%
Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin.
T15771 Lobaplatin 135558-11-1 98%
Lobaplatin (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent which shows...
T11440 GNE-8505 1620573-48-9 98%
GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).
T12813L Seco-Duocarmycin SA 144667-38-9 98%
Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin.
T11120 Duocarmycin TM 157922-77-5 98%
Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.
T9985 Methyl methanesulfonate 66-27-3 98%
Methyl methanesulfonate is a DNA alkylator that modifies adenine (3-methyladenine) and guanine (7-methyladenine) respectively, resulting in base mismatch and rep...
T17212 VAL-083 23261-20-3
VAL-083 is an alkylating compound that creates N7 methylation on DNA. It also has antitumor activity.
T4350 Palifosfamide 31645-39-3 97%
Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to...
T7221 Satraplatin 129580-63-8 98%
Satraplatin is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against...
T7539 O6-Benzylguanine 19916-73-5 98%
O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
T17159 Treosulfan 299-75-2 98%
Treosulfan is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
T1250 Thio-TEPA 52-24-4 99.07%
Thiotepa is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
T6057 URMC-099 1229582-33-5 99.32%
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
T3707 GNE-3511 1496581-76-0 99.37%
GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.
T1507 Streptozocin 18883-66-4 99.56%
Streptozotocin is an antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animal...
T0975 Chlorambucil 305-03-3 99.58%
Chlorambucil is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, result...
T2495 Lomeguatrib 192441-08-0 99.62%
Lomeguatrib, a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
T6798 Tretazicar 21919-05-1 99.7%
CB1954(Tretazicar), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and co-substrate ...
Miriplatin hydrate
T21297
Miriplatin hydrate (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC). Miriplatin hydrate is a...
DLK-IN-1
T11056
DLK-IN-1 is a selective oral active inhibitor of bisleucine zipper kinase (DLK, MAP3K12) with Ki of 3 nM. DLK-IN-1 is active in the Alzheimer's disease model, re...
Duocarmycin Analog
T19300
Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin.
Lobaplatin
T15771
Lobaplatin (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent which shows...
GNE-8505
T11440
GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).
Seco-Duocarmycin SA
T12813L
Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin.
Duocarmycin TM
T11120
Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.
Methyl methanesulfonate
T9985
Methyl methanesulfonate is a DNA alkylator that modifies adenine (3-methyladenine) and guanine (7-methyladenine) respectively, resulting in base mismatch and rep...
VAL-083
T17212
VAL-083 is an alkylating compound that creates N7 methylation on DNA. It also has antitumor activity.
Palifosfamide
T4350
Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to...
Satraplatin
T7221
Satraplatin is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against...
O6-Benzylguanine
T7539
O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
Treosulfan
T17159
Treosulfan is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
Thio-TEPA
T1250
Thiotepa is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
URMC-099
T6057
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
GNE-3511
T3707
GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.
Streptozocin
T1507
Streptozotocin is an antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animal...
Chlorambucil
T0975
Chlorambucil is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, result...
Lomeguatrib
T2495
Lomeguatrib, a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
Tretazicar
T6798
CB1954(Tretazicar), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and co-substrate ...
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