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DNA Alkylator/Crosslinker

Cat. No. Product name CAS No. Purity Chemical Structure
T22857 Illudin S 1149-99-1 98%
Illudin S (ILS) is a fungal sesquiterpene secondary metabolite with potent genotoxic and cytotoxic properties.
T17212 VAL-083 23261-20-3
VAL-083 is an alkylating compound that creates N7 methylation on DNA. It also has antitumor activity.
T4558 Trioxsalen 3902-71-4 100%
Trioxsalen is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation ...
T4459 PK11000 38275-34-2 100%
PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53.
T1488 Procarbazine hydrochloride 366-70-1 85.01%
Procarbazine Hydrochloride is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cyt...
T4570 Pipobroman 54-91-1 93.01%
Pipobroman is an anti-cancer drug that probably acts as an alkylating agent. Pipobroman has well documented clinical activity in polycythemia vera (PV) and essen...
T4350 Palifosfamide 31645-39-3 97%
Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to...
T8380 Bendamustine 16506-27-7 97.38%
Bendamustine for the treatment of Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia
T7221 Satraplatin 129580-63-8 98%
Satraplatin is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against...
T4368 Miriplatin 141977-79-9 98%
Miriplatin (SM-11355) is a platinum complex used in TACE that has promise for the therapy of hepatocellular carcinoma (HCC).
T0707 Cyclophosphamide hydrate 6055-19-2 98%
Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer.
T17159 Treosulfan 299-75-2 98%
Treosulfan is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
T0095 Bendamustine hydrochloride 3543-75-7 98.03%
Bendamustine hydrochloride (IC50 of 50 μM) is an alkylating agent associated with DNA damage.
T1798 RITA 213261-59-7 98.85%
RITA(NSC 652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 i...
T1250 Thio-TEPA 52-24-4 99.07%
Thiotepa is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
T5017 Nimustine Hydrochloride 55661-38-6 99.2%
Nimustine has been used in trials studying the treatment of Glioblastoma.
T1507 Streptozocin 18883-66-4 99.56%
Streptozotocin is an antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animal...
T0975 Chlorambucil 305-03-3 99.58%
Chlorambucil is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, result...
T1564 Cisplatin 15663-27-1 99.62%
Cisplatin, a DNA-crosslinking agent, is able to suppress DNA synthesis by conforming DNA adducts in cancer cells.
T0164 Oxaliplatin 61825-94-3 99.63%
Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.
Illudin S
T22857
Illudin S (ILS) is a fungal sesquiterpene secondary metabolite with potent genotoxic and cytotoxic properties.
VAL-083
T17212
VAL-083 is an alkylating compound that creates N7 methylation on DNA. It also has antitumor activity.
Trioxsalen
T4558
Trioxsalen is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation ...
PK11000
T4459
PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53.
Procarbazine hydrochloride
T1488
Procarbazine Hydrochloride is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cyt...
Pipobroman
T4570
Pipobroman is an anti-cancer drug that probably acts as an alkylating agent. Pipobroman has well documented clinical activity in polycythemia vera (PV) and essen...
Palifosfamide
T4350
Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to...
Bendamustine
T8380
Bendamustine for the treatment of Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia
Satraplatin
T7221
Satraplatin is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against...
Miriplatin
T4368
Miriplatin (SM-11355) is a platinum complex used in TACE that has promise for the therapy of hepatocellular carcinoma (HCC).
Cyclophosphamide hydrate
T0707
Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer.
Treosulfan
T17159
Treosulfan is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
Bendamustine hydrochloride
T0095
Bendamustine hydrochloride (IC50 of 50 μM) is an alkylating agent associated with DNA damage.
RITA
T1798
RITA(NSC 652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 i...
Thio-TEPA
T1250
Thiotepa is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
Nimustine Hydrochloride
T5017
Nimustine has been used in trials studying the treatment of Glioblastoma.
Streptozocin
T1507
Streptozotocin is an antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animal...
Chlorambucil
T0975
Chlorambucil is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, result...
Cisplatin
T1564
Cisplatin, a DNA-crosslinking agent, is able to suppress DNA synthesis by conforming DNA adducts in cancer cells.
Oxaliplatin
T0164
Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.
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