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DNA Alkylator/Crosslinker

DNA alkylator/crosslinker is a molecule that alkylates or can crosslink DNA. Alkylation is a chemical reaction that entails the transfer of an alkyl group. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion, or a carbene (or their equivalents). Alkylating agents are reagents for effecting alkylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with a class of drugs called alkylating antineoplastic agents.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T3091 Carmustine 154-93-8 99.97%
Carmustine
Carmustine (bis-chloroethylnitrosourea) is a cell-cycle phase nonspecific alkylating antineoplastic agent.
T0164 Oxaliplatin 61825-94-3 99.93%
Oxaliplatin
Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis. Oxaliplatin causes DNA cross-linking damage, preventing DNA replication and transcr...
T8554 KCC-07 315702-75-1 99.93%
KCC-07
KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD...
T1601 Lomustine 13010-47-4 99.86%
Lomustine
Lomustine (NSC-79037) is an alkylating agent of value against both hematologic malignancies and solid tumors.
T0923 Busulfan 55-98-1 99.77%
Busulfan
Busulfan (Busulphan) is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully...
T6798 Tretazicar 21919-05-1 99.7%
Tretazicar
CB1954(Tretazicar (NSC-115829)), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and ...
T0707 Cyclophosphamide hydrate 6055-19-2 99.65%
Cyclophosphamide hydrate
Cyclophosphamide hydrate is a DNA alkylating agent, an inhibitor of DNA synthesis. Cyclophosphamide hydrate has antitumor and immunosuppressive activities.
T0975 Chlorambucil 305-03-3 99.58%
Chlorambucil
Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cyc...
T16871 Semustine 13909-09-6 99.55%
Semustine
Semustine, a DNA alkylating agent, is a cancer chemotherapy compound that is nephrotoxic in patients with malignant melanoma receiving adjuvant chemotherapy for ...
T1564 Cisplatin 15663-27-1 99.54%
Cisplatin
Cisplatin (CDDP) is a DNA cross-linking agent. Cisplatin has antitumor activity and inhibits DNA synthesis by forming DNA adducts in cancer cells. Cisplatin also...
T1058 Carboplatin 41575-94-4 99.43%
Carboplatin
Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor. Carboplatin binds to DNA, inhibits replication and transcription, and induces cell death...
T17159 Treosulfan 299-75-2 99.26%
Treosulfan
Treosulfan (Treosulphan) is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
T5017 Nimustine Hydrochloride 55661-38-6 99.2%
Nimustine Hydrochloride
Nimustine Hydrochloride (Nidran hydrochloride) has been used in trials studying the treatment of Glioblastoma.
T4558 Trioxsalen 3902-71-4 98.96%
Trioxsalen
Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After ph...
T4169 N-Nitroso-N-methylurea 684-93-5 98.78%
N-Nitroso-N-methylurea
N-Nitroso-N-methylurea (Methylnitrosourea) is a nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.
T1178 Temozolomide 85622-93-1 98.43%
Temozolomide
Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity. Temozolomide has antitumor activity and antiangiogenic acti...
T22857 Illudin S 1149-99-1 98.15%
Illudin S
Illudin S (ILS) is a fungal sesquiterpene secondary metabolite with potent genotoxic and cytotoxic properties.
T0095 Bendamustine hydrochloride 3543-75-7 98.03%
Bendamustine hydrochloride
Bendamustine hydrochloride (EP-3101) (IC50 of 50 μM) is an alkylating agent associated with DNA damage.
T4368 Miriplatin 141977-79-9 98%
Miriplatin
Miriplatin (SM-11355) (SM-11355) is a platinum complex used in TACE that has promise for the therapy of hepatocellular carcinoma (HCC).
T1250 Thio-TEPA 52-24-4 98%
Thio-TEPA
Thio-TEPA (Tiofosyl) is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
Carmustine
T3091
Carmustine (bis-chloroethylnitrosourea) is a cell-cycle phase nonspecific alkylating antineoplastic agent.
Oxaliplatin
T0164
Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis. Oxaliplatin causes DNA cross-linking damage, preventing DNA replication and transcr...
KCC-07
T8554
KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD...
Lomustine
T1601
Lomustine (NSC-79037) is an alkylating agent of value against both hematologic malignancies and solid tumors.
Busulfan
T0923
Busulfan (Busulphan) is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully...
Tretazicar
T6798
CB1954(Tretazicar (NSC-115829)), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and ...
Cyclophosphamide hydrate
T0707
Cyclophosphamide hydrate is a DNA alkylating agent, an inhibitor of DNA synthesis. Cyclophosphamide hydrate has antitumor and immunosuppressive activities.
Chlorambucil
T0975
Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cyc...
Semustine
T16871
Semustine, a DNA alkylating agent, is a cancer chemotherapy compound that is nephrotoxic in patients with malignant melanoma receiving adjuvant chemotherapy for ...
Cisplatin
T1564
Cisplatin (CDDP) is a DNA cross-linking agent. Cisplatin has antitumor activity and inhibits DNA synthesis by forming DNA adducts in cancer cells. Cisplatin also...
Carboplatin
T1058
Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor. Carboplatin binds to DNA, inhibits replication and transcription, and induces cell death...
Treosulfan
T17159
Treosulfan (Treosulphan) is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
Nimustine Hydrochloride
T5017
Nimustine Hydrochloride (Nidran hydrochloride) has been used in trials studying the treatment of Glioblastoma.
Trioxsalen
T4558
Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After ph...
N-Nitroso-N-methylurea
T4169
N-Nitroso-N-methylurea (Methylnitrosourea) is a nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.
Temozolomide
T1178
Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity. Temozolomide has antitumor activity and antiangiogenic acti...
Illudin S
T22857
Illudin S (ILS) is a fungal sesquiterpene secondary metabolite with potent genotoxic and cytotoxic properties.
Bendamustine hydrochloride
T0095
Bendamustine hydrochloride (EP-3101) (IC50 of 50 μM) is an alkylating agent associated with DNA damage.
Miriplatin
T4368
Miriplatin (SM-11355) (SM-11355) is a platinum complex used in TACE that has promise for the therapy of hepatocellular carcinoma (HCC).
Thio-TEPA
T1250
Thio-TEPA (Tiofosyl) is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
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TargetMol