Home Tools
Log in
Cart

DNA Alkylator/Crosslinker

Cat No. product name
T1798 RITA RITA(NSC 652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 i...
T1178 Temozolomide Temozolomide is a DNA alkylating agent interfering with DNA replication.
T17212 VAL-083 VAL-083 is an alkylating compound that creates N7 methylation on DNA. It also has antitumor activity.
T17159 Treosulfan Treosulfan is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
T4459 PK11000 PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53.
T1250 Thio-TEPA Thiotepa is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
T0707 Cyclophosphamide hydrate Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer.
T1488 Procarbazine hydrochloride Procarbazine Hydrochloride is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cyt...
T4368 Miriplatin Miriplatin (SM-11355) is a platinum complex used in TACE that has promise for the therapy of hepatocellular carcinoma (HCC).
T0975 Chlorambucil Chlorambucil is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, result...
T1241 Altretamine Altretamine is an alkylating agent with antineoplastic activity.
T1601 Lomustine Lomustine is an alkylating agent of value against both hematologic malignancies and solid tumors.
T6798 Tretazicar CB1954(Tretazicar), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and co-substrate ...
T4570 Pipobroman Pipobroman is an anti-cancer drug that probably acts as an alkylating agent. Pipobroman has well documented clinical activity in polycythemia vera (PV) and essen...
T4558 Trioxsalen Trioxsalen is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation ...
T7221 Satraplatin Satraplatin is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against...
T0095 Bendamustine hydrochloride Bendamustine hydrochloride (IC50 of 50 μM) is an alkylating agent associated with DNA damage.
T8380 Bendamustine Bendamustine for the treatment of Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia
T1564 Cisplatin Cisplatin, a DNA-crosslinking agent, is able to suppress DNA synthesis by conforming DNA adducts in cancer cells.
T0923 Busulfan Busulfan is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood,...
T0164 Oxaliplatin Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.
T4350 Palifosfamide Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to...
T1055 Ifosfamide Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide is a synthetic analog of the nitrogen mus...
T4169 N-Nitroso-N-methylurea N-Nitroso-N-methylurea is a nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.
T5017 Nimustine Hydrochloride Nimustine has been used in trials studying the treatment of Glioblastoma.
T1507 Streptozocin Streptozotocin is an antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animal...
T3091 Carmustine Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent.
T1058 Carboplatin Carboplatin is an organoplatinum compound that possesses antineoplastic activity.
T8554 KCC-07 KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD...
RITA
T1798
RITA(NSC 652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 i...
Temozolomide
T1178
Temozolomide is a DNA alkylating agent interfering with DNA replication.
VAL-083
T17212
VAL-083 is an alkylating compound that creates N7 methylation on DNA. It also has antitumor activity.
Treosulfan
T17159
Treosulfan is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
PK11000
T4459
PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53.
Thio-TEPA
T1250
Thiotepa is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
Cyclophosphamide hydrate
T0707
Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer.
Procarbazine hydrochloride
T1488
Procarbazine Hydrochloride is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cyt...
Miriplatin
T4368
Miriplatin (SM-11355) is a platinum complex used in TACE that has promise for the therapy of hepatocellular carcinoma (HCC).
Chlorambucil
T0975
Chlorambucil is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, result...
Altretamine
T1241
Altretamine is an alkylating agent with antineoplastic activity.
Lomustine
T1601
Lomustine is an alkylating agent of value against both hematologic malignancies and solid tumors.
Tretazicar
T6798
CB1954(Tretazicar), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and co-substrate ...
Pipobroman
T4570
Pipobroman is an anti-cancer drug that probably acts as an alkylating agent. Pipobroman has well documented clinical activity in polycythemia vera (PV) and essen...
Trioxsalen
T4558
Trioxsalen is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation ...
Satraplatin
T7221
Satraplatin is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against...
Bendamustine hydrochloride
T0095
Bendamustine hydrochloride (IC50 of 50 μM) is an alkylating agent associated with DNA damage.
Bendamustine
T8380
Bendamustine for the treatment of Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia
Cisplatin
T1564
Cisplatin, a DNA-crosslinking agent, is able to suppress DNA synthesis by conforming DNA adducts in cancer cells.
Busulfan
T0923
Busulfan is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood,...
Oxaliplatin
T0164
Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.
Palifosfamide
T4350
Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to...
Ifosfamide
T1055
Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide is a synthetic analog of the nitrogen mus...
N-Nitroso-N-methylurea
T4169
N-Nitroso-N-methylurea is a nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.
Nimustine Hydrochloride
T5017
Nimustine has been used in trials studying the treatment of Glioblastoma.
Streptozocin
T1507
Streptozotocin is an antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animal...
Carmustine
T3091
Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent.
Carboplatin
T1058
Carboplatin is an organoplatinum compound that possesses antineoplastic activity.
KCC-07
T8554
KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD...