Galectin

Galectins are a class of proteins that bind specifically to β-galactoside sugars, such as N-acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation. They are also termed S-type lectins due to their dependency on disulphide bonds for stability and carbohydrate binding. There have been about 15 galectins discovered in mammals, encoded by the LGALS genes, which are numbered in a consecutive manner. Only galectin-1, -2, -3, -4, -7, -7B, -8, -9, -9B, 9C, -10, -12, -13, -14, and -16 have been identified in humans. Galectin-5 and -6 are found in rodents, whereas galectin-11 and -15 are uniquely found in sheep and goats. Members of the galectin family have also been discovered in other mammals, birds, amphibians, fish, nematodes, sponges, and some fungi. Unlike the majority of lectins they are not membrane bound, but soluble proteins with both intra- and extracellular functions. They have distinct but overlapping distributions[2] but found primarily in the cytosol, nucleus, extracellular matrix or in circulation. Although many galectins must be secreted, they do not have a typical signal peptide required for classical secretion. The mechanism and reason for this non-classical secretion pathway is unknown.

Cat. No.	Product name	CAS No.	Purity
T79380	Galectin-3/galectin-8-IN-1		98%
Galectin-3/galectin-8-IN-1 (Compound 53) serves as a dual inhibitor of the Galectin-3 and galectin-8 C-terminal domains, exhibiting dissociation constants (Kd) o...
T79381	Galectin-3/galectin-8-IN-2		98%
Galectin-3/galectin-8-IN-2 (Compound 57) is a dual inhibitor targeting the C-terminal domains of Galectin-3 and galectin-8, exhibiting dissociation constants (Kd...
T82605	DB21, Galectin-1 Antagonist	1623027-80-4	98%
DB21, Galectin-1 Antagonist, is a peptidomimetic conjugated with dibenzofuran, serving as an allosteric inhibitor of galectin-1 (GAL1) interactions with glycans ...
T74538	Galectin-3 antagonist 2	2921603-02-1	98%
Galectin-3, a β-galactoside-specific carbohydrate recognition protein (lectin), facilitates the migration of B-cell precursor acute lymphoblastic leukemia (BCP-A...
T38074	Thiodigalactoside	51555-87-4	99.74%
Thiodigalactoside (TDG), a non-metabolizable disaccharide, serves as an orally active, potent galectin (GAL) inhibitor, exhibiting Kd values of 24 μM and 49 μM f...
T5121	TD139	1450824-22-2	99.48%
TD139 is an inhaled galectin-3 inhibitor (Kd: 14 nM).
T16413	OTX008	286936-40-1	98.77%
OTX008 (PTX008) is a selective galectin-1 inhibitor.
T15372	GB1107	1978336-61-6	98.33%
GB1107 is an effective and selective Galectin-3 inhibitor with a Kd of 37 nM.
T11346L	G3-C12 acetate(848301-94-0 free base)	T11346L	98%
G3-C12 acetate shows anticancer activity. is a galectin-3 binding peptide, with Kd of 88 nM.

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T79380

Galectin-3/galectin-8-IN-1

98%

Galectin-3/galectin-8-IN-1 (Compound 53) serves as a dual inhibitor of the Galectin-3 and galectin-8 C-terminal domains, exhibiting dissociation constants (Kd) o...

T79381

Galectin-3/galectin-8-IN-2

98%

Galectin-3/galectin-8-IN-2 (Compound 57) is a dual inhibitor targeting the C-terminal domains of Galectin-3 and galectin-8, exhibiting dissociation constants (Kd...

T82605

DB21, Galectin-1 Antagonist

1623027-80-4

98%

DB21, Galectin-1 Antagonist, is a peptidomimetic conjugated with dibenzofuran, serving as an allosteric inhibitor of galectin-1 (GAL1) interactions with glycans ...

T74538

Galectin-3 antagonist 2

2921603-02-1

98%

Galectin-3, a β-galactoside-specific carbohydrate recognition protein (lectin), facilitates the migration of B-cell precursor acute lymphoblastic leukemia (BCP-A...

T38074

Thiodigalactoside

51555-87-4

99.74%

Thiodigalactoside (TDG), a non-metabolizable disaccharide, serves as an orally active, potent galectin (GAL) inhibitor, exhibiting Kd values of 24 μM and 49 μM f...

T5121

TD139

1450824-22-2

99.48%