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IDO

Aminopeptidases are enzymes that catalyze the cleavage of amino acids from the amino terminus (N-terminus) of proteins or peptides (exopeptidases).They are widely distributed throughout the animal and plant kingdoms and are found in many subcellular organelles, in cytosol, and as membrane components. Aminopeptidases are used in essential cellular functions. Many, but not all, of these peptidases are zinc metalloenzymes.Some aminopeptidases are monomeric, and others are assemblies of relatively high mass (50 kDa) subunits. cDNA sequences are available for several aminopeptidases and a crystal structure of the open state of human endoplasmic reticulum Aminopeptidase 1 ERAP1 is presented here. Amino acid sequences determined directly or deduced from cDNAs indicate some amino acid sequence homologies in organisms as diverse as Escherichia coli and mammals, particularly in catalytically important residues or in residues involved in metal ion binding.
Cat No. product name
T10199 GNF-PF-3777 GNF-PF-3777 (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).
T4307 PF-06840003 PF-06840003 is a specific and oral active IDO-1 inhibitor.
T6407 β-Lapachone Beta-Lapachone is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.
T4532 Linrodostat BMS-986205 is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.
T11901 IDO1-IN-5 IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.
T8214 Kushenol E Kushenol E is a class of flavonoids isolated from Sophora flavescens. It is a non-competitive IDO1 inhibitor (IC50: 7.7 μM, Ki: 9.5 μM), has anti-tumor activity....
T3548 Epacadostat Epacadostat is an oral-available inhibitor of indoleamine 2, 3-dioxygenase (IDO1), increasing the proliferation and activation of various immune cells and reduci...
T11616 IDO-IN-13 IDO-IN-13 is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).
T2647 IDO5L IDO-IN-2 is an effective IDO1 inhibitor(IC50=10 nM).
T9164 BMS-986242 BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.
T20513 IDO1-IN-1 IDO1-IN-1 is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
T11617 IDO-IN-3 IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 290 nM).
T11615 IDO-IN-12 IDO-IN-12 是吲哚胺 2,3-双加氧酶抑制剂。
T11614 IDO-IN-11 IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).
T11622 IDO-IN-9 IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).
T11621 IDO-IN-8 IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T11620 IDO-IN-6 IDO-IN-6 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.
T11619 IDO-IN-5 IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T11628 IACS-8968 S-enantiomer IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
T11627 IACS-8968 R-enantiomer IACS-8968 R-enantiomer is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
T11626 IACS-8968 IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
T11624 IDO1-IN-2 IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.
GNF-PF-3777
T10199
GNF-PF-3777 (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).
PF-06840003
T4307
PF-06840003 is a specific and oral active IDO-1 inhibitor.
β-Lapachone
T6407
Beta-Lapachone is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.
Linrodostat
T4532
BMS-986205 is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.
IDO1-IN-5
T11901
IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.
Kushenol E
T8214
Kushenol E is a class of flavonoids isolated from Sophora flavescens. It is a non-competitive IDO1 inhibitor (IC50: 7.7 μM, Ki: 9.5 μM), has anti-tumor activit...
Epacadostat
T3548
Epacadostat is an oral-available inhibitor of indoleamine 2, 3-dioxygenase (IDO1), increasing the proliferation and activation of various immune cells and reduci...
IDO-IN-13
T11616
IDO-IN-13 is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).
IDO5L
T2647
IDO-IN-2 is an effective IDO1 inhibitor(IC50=10 nM).
BMS-986242
T9164
BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.
IDO1-IN-1
T20513
IDO1-IN-1 is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
IDO-IN-3
T11617
IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 290 nM).
IDO-IN-12
T11615
IDO-IN-12 是吲哚胺 2,3-双加氧酶抑制剂。
IDO-IN-11
T11614
IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).
IDO-IN-9
T11622
IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).
IDO-IN-8
T11621
IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
IDO-IN-6
T11620
IDO-IN-6 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.
IDO-IN-5
T11619
IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
IACS-8968 S-enantiomer
T11628
IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
IACS-8968 R-enantiomer
T11627
IACS-8968 R-enantiomer is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
IACS-8968
T11626
IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
IDO1-IN-2
T11624
IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.