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Metabolism

Acetyl-CoA Carboxylase

Amino Acids and Derivatives

Angiotensin-converting Enzyme (ACE)

Endogenous Metabolite

Glutathione Peroxidase

(40)

Glyoxalase

(2)

HIF/HIF Prolyl-Hydroxylase

Indoleamine 2,3-Dioxygenase (IDO)

(33)

Isocitrate Dehydrogenase (IDH)

Mitochondrial Metabolism

(94)

N-Acetylglucosaminyltransferase

Procollagen C Proteinase

(1)

Prolyl Endopeptidase (PREP)

Reactive Oxygen Species

Serine/threonin kinase

(47)

Stearoyl-CoA Desaturase (SCD)

IDO

Indoleamine-pyrrole 2,3-dioxygenase (IDO) is a heme-containing enzyme physiologically expressed in several tissues and cells, such as the small intestine, lungs, female genital tract or placenta.IDO is involved in tryptophan metabolism. It is one of three enzymes that catalyze the first and rate-limiting step in the kynurenine pathway. IDO is an important part of the immune system and plays a part in natural defense against various pathogens. It is produced by the cells in response to inflammation and has an immunosuppressive function because of its ability to limit T-cell function and engage mechanisms of immune tolerance. IDO is part of the malignant transformation process and plays a key role in suppressing the anti-tumor immune response in the body, so inhibiting it could increase the effect of chemotherapy as well as other immunotherapeutic protocols.

Filter HomeSignaling PathwaysMetabolismIDO

Linrodostat

T45321923833-60-6

Linrodostat (BMS-986205) is a selective inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1).

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Epacadostat

T35481204669-58-8

Epacadostat (INCB 024360) is an oral, potent and selective IDO1 inhibitor with IC50 value of 71.8 nM.

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IDO-IN-12

T116151888341-29-4In house

IDO-IN-12 is an inhibitor of indoleamine 2,3-dioxygenase (IDO).

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β-Lapachone

T64074707-32-8

β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.

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PF-06840003

T4307198474-05-4

PF-06840003 (EOS200271) is a specific and orally active IDO-1 inhibitor.

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LY3381916

T119012166616-75-5

LY3381916 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.

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BMS-986242

T91641923844-48-7

BMS-986242 is an orally active, potent, and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor, suitable for cancer research.

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IDO1-IN-1

T20513615-21-4

IDO1-IN-1 (2 HzBTZ) is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.

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IDO1/TDO-IN-4

T60318461424-21-5

IDO1 TDO-IN-4 is a novel dual inhibitor of IDO1 TDO with antidepressant activity, forming hydrogen bonds with IDO1 and π-π stacking interactions with TDO. IDO1 TDO-IN-4 rescues lipopolysaccharide-induced depressive-like behaviors in mice, used for cancer and Alzheimer's disease research.

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IDO-IN-13

T116162291164-02-6

IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).

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GNF-PF-3777

T1019977603-42-0

GNF-PF-3777 (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2) with a Ki of 0.97 μM.

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IDO5L

T2647914471-09-3

IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).

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Kushenol E

T821499119-72-9

Kushenol E (Flemiphilippinin D) is a class of flavonoids isolated from Sophora flavescens. It is a non-competitive IDO1 inhibitor (IC50: 7.7 μM, Ki: 9.5 μM), has anti-tumor activity.