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Metabolism IDO

IDO

Aminopeptidases are enzymes that catalyze the cleavage of amino acids from the amino terminus (N-terminus) of proteins or peptides (exopeptidases).They are widely distributed throughout the animal and plant kingdoms and are found in many subcellular organelles, in cytosol, and as membrane components. Aminopeptidases are used in essential cellular functions. Many, but not all, of these peptidases are zinc metalloenzymes.Some aminopeptidases are monomeric, and others are assemblies of relatively high mass (50 kDa) subunits. cDNA sequences are available for several aminopeptidases and a crystal structure of the open state of human endoplasmic reticulum Aminopeptidase 1 ERAP1 is presented here. Amino acid sequences determined directly or deduced from cDNAs indicate some amino acid sequence homologies in organisms as diverse as Escherichia coli and mammals, particularly in catalytically important residues or in residues involved in metal ion binding.
Cat No. product name
T1806 NLG919 NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor.
T2647 INCB024360 analogue IDO-IN-2 is an effective IDO1 inhibitor(IC50=10 nM).
T3548 Epacadostat Epacadostat is an oral-available inhibitor of indoleamine 2,3-dioxygenase (IDO1), increasing the proliferation and activation of various immune cells and reduc...
T4142 DO-IN-2 IDO-IN-2 is an IDO inhibitor extracted from patent WO/2015031295 A1, compound example 1.
T6407 Beta-Lapachone Beta-Lapachone is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.
T6543 Indoximod Indoximod is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades...
T4307 PF-06840003 PF-06840003 is a specific and oral active IDO-1 inhibitor.
T5S0053 Coptisine 1. Coptisine treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2,3-dioxygenase . 2. Coptisine treats myoca...
T4532 Linrodostat BMS-986205 is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
TQ0071 Navoximod Navoximod (NLG-​919, GDC-0919) is a potent indoleamine-(2,3)-dioxygenase (IDO) pathway inhibitor (Ki/EC50: 7 nM/75 nM).
T5S0056 Coptisine chloride 1. Coptisine chloride can be absorbed across intestinal epithelial cells, and completely absorbed compounds.
T8214 Flemiphilippinin D Kushenol E is a class of flavonoids isolated from Sophora flavescens. It is a non-competitive IDO1 inhibitor (IC50: 7.7 µM, Ki: 9.5 µM), has anti-tumor ac...
T11614 IDO-IN-11 IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).
T11615 IDO-IN-12 IDO-IN-12 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.
T11617 IDO-IN-3 IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 290 nM. 
T11619 IDO-IN-5 IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor, has an IC50 of 1-10 μM. 
T11620 IDO-IN-6 IDO-IN-6 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.
T11621 IDO-IN-8 IDO-IN-8  is an indoleamine 2,3-dioxygenase (IDO) inhibitor , has an IC50 of 1-10 μM. 
T11622 IDO-IN-9 IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).
T11624 IDO1-IN-2 IDO1-IN-2 has anti-cancer activity. IDO1-IN-2  is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. 
T11626 IACS-8968 IACS-8968  is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively. 
T11627 IACS-8968 R-entiomer IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively. IACS-8968  is the R-enantiomer of IACS-8968.
T11628 IACS-8968 S-entiomer IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively. IACS-8968  is the S-enantiomer of IACS-8968.
T11901 IDO1-IN-5 IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1. 
NLG919
T1806CAS 1402836-58-1
NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor.
INCB024360 analogue
T2647CAS 914471-09-3
IDO-IN-2 is an effective IDO1 inhibitor(IC50=10 nM).
Epacadostat
T3548CAS 1204669-58-8
Epacadostat is an oral-available inhibitor of indoleamine 2,3-dioxygenase (IDO1), increasing the proliferation and activation of various immune cells and reduc...
DO-IN-2
T4142CAS 1668565-74-9
IDO-IN-2 is an IDO inhibitor extracted from patent WO/2015031295 A1, compound example 1.
Beta-Lapachone
T6407CAS 4707-32-8
Beta-Lapachone is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.
Indoximod
T6543CAS 110117-83-4
Indoximod is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades...
PF-06840003
T4307CAS 198474-05-4
PF-06840003 is a specific and oral active IDO-1 inhibitor.
Coptisine
T5S0053CAS 3486-66-6
1. Coptisine treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2,3-dioxygenase . 2. Coptisine treats myoca...
Linrodostat
T4532CAS 1923833-60-6
BMS-986205 is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
Navoximod
TQ0071CAS 1402837-78-8
Navoximod (NLG-​919, GDC-0919) is a potent indoleamine-(2,3)-dioxygenase (IDO) pathway inhibitor (Ki/EC50: 7 nM/75 nM).
Coptisine chloride
T5S0056CAS 6020-18-4
1. Coptisine chloride can be absorbed across intestinal epithelial cells, and completely absorbed compounds.
Flemiphilippinin D
T8214CAS 99119-72-9
Kushenol E is a class of flavonoids isolated from Sophora flavescens. It is a non-competitive IDO1 inhibitor (IC50: 7.7 µM, Ki: 9.5 µM), has anti-tumor ac...
IDO-IN-11
T11614CAS 1888378-32-2
IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).
IDO-IN-12
T11615CAS 1888341-29-4
IDO-IN-12 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.
IDO-IN-3
T11617CAS 2070018-30-1
IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 290 nM. 
IDO-IN-5
T11619CAS 1402837-79-9
IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor, has an IC50 of 1-10 μM. 
IDO-IN-6
T11620CAS 1402837-76-6
IDO-IN-6 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.
IDO-IN-8
T11621CAS 1402837-77-7
IDO-IN-8  is an indoleamine 2,3-dioxygenase (IDO) inhibitor , has an IC50 of 1-10 μM. 
IDO-IN-9
T11622CAS 1888378-12-8
IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).
IDO1-IN-2
T11624CAS 2346614-58-0
IDO1-IN-2 has anti-cancer activity. IDO1-IN-2  is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. 
IACS-8968
T11626CAS 2144425-14-7
IACS-8968  is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively. 
IACS-8968 R-entiomer
T11627CAS 2239305-67-8
IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively. IACS-8968  is the R-enantiomer of IACS-8968.
IACS-8968 S-entiomer
T11628CAS 2239305-70-3
IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively. IACS-8968  is the S-enantiomer of IACS-8968.
IDO1-IN-5
T11901CAS 2166616-75-5
IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.