IDO

Aminopeptidases are enzymes that catalyze the cleavage of amino acids from the amino terminus (N-terminus) of proteins or peptides (exopeptidases).They are widely distributed throughout the animal and plant kingdoms and are found in many subcellular organelles, in cytosol, and as membrane components. Aminopeptidases are used in essential cellular functions. Many, but not all, of these peptidases are zinc metalloenzymes.Some aminopeptidases are monomeric, and others are assemblies of relatively high mass (50 kDa) subunits. cDNA sequences are available for several aminopeptidases and a crystal structure of the open state of human endoplasmic reticulum Aminopeptidase 1 ERAP1 is presented here. Amino acid sequences determined directly or deduced from cDNAs indicate some amino acid sequence homologies in organisms as diverse as Escherichia coli and mammals, particularly in catalytically important residues or in residues involved in metal ion binding.

Cat No.	product name
T11614	IDO-IN-11	IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).
T11615	IDO-IN-12	IDO-IN-12 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.
T11617	IDO-IN-3	IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 290 nM).
T11619	IDO-IN-5	IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T11620	IDO-IN-6	IDO-IN-6 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.
T11621	IDO-IN-8	IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T11622	IDO-IN-9	IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).
T11624	IDO1-IN-2	IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.
T11626	IACS-8968	IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
T11627	IACS-8968 R-enantiomer	IACS-8968 R-enantiomer is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
T11628	IACS-8968 S-enantiomer	IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
T11901	IDO1-IN-5	IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.
T1806	NLG919	NLG919 is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor.
T20513	IDO1-IN-1	IDO1-IN-1 is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
T2647	INCB024360 analogue	IDO-IN-2 is an effective IDO1 inhibitor(IC50=10 nM).
T3548	Epacadostat	Epacadostat is an oral-available inhibitor of indoleamine 2, 3-dioxygenase (IDO1), increasing the proliferation and activation of various immune cells and reduc...
T4142	DO-IN-2	IDO-IN-2 is an IDO inhibitor extracted from patent WO/2015031295 A1, compound example 1.
T4307	PF06840003	PF-06840003 is a specific and oral active IDO-1 inhibitor.
T4532	Linrodostat	BMS-986205 is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.
T5S0053	Coptisine	1. Coptisine treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myoc...
T5S0056	Coptisine chloride	1. Coptisine chloride can be absorbed across intestinal epithelial cells, and completely absorbed compounds.
T6407	Beta-Lapachone	Beta-Lapachone is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.
T6543	Indoximod	Indoximod is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2, 3-dioxygenase (IDO), which degrade...
T8214	Flemiphilippinin D	Kushenol E is a class of flavonoids isolated from Sophora flavescens. It is a non-competitive IDO1 inhibitor (IC50: 7.7 µM, Ki: 9.5 µM), has anti-tumor ac...
TQ0071	Navoximod	Navoximod (NLG-919, GDC-0919) is a potent indoleamine-(2,3)-dioxygenase (IDO) pathway inhibitor (Ki/EC50: 7 nM/75 nM).

Cat No.

product name

T11614

IDO-IN-11

IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).

T11615

IDO-IN-12

IDO-IN-12 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.

T11617

IDO-IN-3

IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 290 nM).

T11619

IDO-IN-5

IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).

T11620

IDO-IN-6

IDO-IN-6 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.

T11621

IDO-IN-8

IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).

T11622

IDO-IN-9

IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).

T11624

IDO1-IN-2

IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.

T11626

IACS-8968

IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).

T11627

IACS-8968 R-enantiomer

IACS-8968 R-enantiomer is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).

T11628

IACS-8968 S-enantiomer

IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).

T11901

IDO1-IN-5

IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.

T1806

NLG919

NLG919 is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor.

T20513

IDO1-IN-1

IDO1-IN-1 is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.

T2647

INCB024360 analogue

IDO-IN-2 is an effective IDO1 inhibitor(IC50=10 nM).

T3548

Epacadostat

Epacadostat is an oral-available inhibitor of indoleamine 2, 3-dioxygenase (IDO1), increasing the proliferation and activation of various immune cells and reduc...

T4142

DO-IN-2

IDO-IN-2 is an IDO inhibitor extracted from patent WO/2015031295 A1, compound example 1.

T4307

PF06840003

PF-06840003 is a specific and oral active IDO-1 inhibitor.

T4532

Linrodostat

BMS-986205 is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.

T5S0053

Coptisine

1. Coptisine treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myoc...

T5S0056

Coptisine chloride

1. Coptisine chloride can be absorbed across intestinal epithelial cells, and completely absorbed compounds.

T6407

Beta-Lapachone

Beta-Lapachone is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.

T6543

Indoximod

Indoximod is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2, 3-dioxygenase (IDO), which degrade...

T8214

Flemiphilippinin D

Kushenol E is a class of flavonoids isolated from Sophora flavescens. It is a non-competitive IDO1 inhibitor (IC50: 7.7 µM, Ki: 9.5 µM), has anti-tumor ac...

TQ0071

Navoximod

Navoximod (NLG-919, GDC-0919) is a potent indoleamine-(2,3)-dioxygenase (IDO) pathway inhibitor (Ki/EC50: 7 nM/75 nM).