PKM

Pyruvate kinase isozymes M1/M2 (PKM1/M2), also known as pyruvate kinase muscle isozyme (PKM), pyruvate kinase type K, cytosolic thyroid hormone-binding protein (CTHBP), thyroid hormone-binding protein 1 (THBP1), or opa-interacting protein 3 (OIP3), is an enzyme that in humans is encoded by the PKM2 gene.PKM2 is an isoenzyme of the glycolytic enzyme pyruvate kinase. Depending upon the different metabolic functions of the tissues, different isoenzymes of pyruvate kinase are expressed. PKM2 is expressed in some differentiated tissues, such as lung, fat tissue, retina, and pancreatic islets, as well as in all cells with a high rate of nucleic acid synthesis, such as normal proliferating cells, embryonic cells, and especially tumor cells.

Cat No.	product name
T4170	PKM2 inhibitor	PKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
T4223	Mitapivat	Mitapivat, also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.
T6744	Methylbenactyzine Bromide	Dimethadione is an anticonvulsant that is the active metabolite of trimethadione.
T6816	DASA58	DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.
T1125	(+)-Shikonin	Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pa...
T7214	ML265	ML265 is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation and size in...
T8363	DL-Serine	DL-Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.

Cat No.

product name

T4170

PKM2 inhibitor

PKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.

T4223

Mitapivat

Mitapivat, also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.

T6744

Methylbenactyzine Bromide

Dimethadione is an anticonvulsant that is the active metabolite of trimethadione.

T6816

DASA58

DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.

T1125

(+)-Shikonin

Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pa...

T7214

ML265

ML265 is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation and size in...

T8363

DL-Serine

DL-Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.