PKM

Pyruvate kinase isozymes M1/M2 (PKM1/M2), also known as pyruvate kinase muscle isozyme (PKM), pyruvate kinase type K, cytosolic thyroid hormone-binding protein (CTHBP), thyroid hormone-binding protein 1 (THBP1), or opa-interacting protein 3 (OIP3), is an enzyme that in humans is encoded by the PKM2 gene.PKM2 is an isoenzyme of the glycolytic enzyme pyruvate kinase. Depending upon the different metabolic functions of the tissues, different isoenzymes of pyruvate kinase are expressed. PKM2 is expressed in some differentiated tissues, such as lung, fat tissue, retina, and pancreatic islets, as well as in all cells with a high rate of nucleic acid synthesis, such as normal proliferating cells, embryonic cells, and especially tumor cells.

Cat. No.	Product name	CAS No.	Purity
T0745	Disodium monofluorophosphate	10163-15-2
Sodium Monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase, which also irreversibly inhibits phosphorylase phosphatase.
T8363	DL-Serine	302-84-1	98%
DL-Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.
T6816	DASA-58	1203494-49-8	98.99%
DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.
T12499	PKR-IN-2	1628428-01-2	99.17%
PKR-IN-2 is a activator of pyruvate kinase (PKR).
T4223	Mitapivat	1260075-17-9	99.83%
Mitapivat, also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.
T1125	Shikonin	517-89-5	99.9%
Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pathw...
T4170	PKM2-IN-1	94164-88-2	99.9%
PKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
T7214	TEPP-46	1221186-53-3	98.77%
ML265 is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation and size in ...

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T0745

Disodium monofluorophosphate

10163-15-2

Sodium Monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase, which also irreversibly inhibits phosphorylase phosphatase.

T8363

DL-Serine

302-84-1

98%

DL-Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.

T6816

DASA-58

1203494-49-8

98.99%

DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.

T12499

PKR-IN-2

1628428-01-2

99.17%

PKR-IN-2 is a activator of pyruvate kinase (PKR).

T4223

Mitapivat

1260075-17-9

99.83%

Mitapivat, also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.

T1125

Shikonin

517-89-5

99.9%

Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pathw...

T4170

PKM2-IN-1

94164-88-2

99.9%

PKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.

T7214

TEPP-46

1221186-53-3

98.77%

ML265 is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation and size in ...