PLK

Polo-like kinase (PLK) is a highly conserved serine/threonine protein kinase with a highly homologous serine/threonine kinase domain at its N-terminus, which regulates PLK activity and subcellular dynamics at the C-terminus and targeted polo-box domain (PBD). There are many PLK family members, and there are four subtypes in the human body, namely PLK1, PLK2, PLK3, and PLK4, which play important roles in the regulation of various phases of the cell cycle.

Cat. No.	Product name	CAS No.	Purity
T28904	T521	891020-54-5	98%
T28904	T521 is a selective inhibitor of the PBD of Plk1 and shows no inhibitory effect on Plk2 and Plk3.
T16559	Poloxime	17302-61-3	98%
T16559	Poloxime is a hydrolysis product of poloxin and is a non-ATP-competitive Plk1 inhibitor. It also has moderate Plk1 inhibitory activity.
TN3247	7-O-Prenylscopoletin	13544-37-1	98%
TN3247	7-O-Prenylscopoletin and cedrelopsin show high antiproliferative activities against cancer cell lines.
T21678	3MB-PP1	956025-83-5	98%
T21678	3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor. In cells expressing analog-sensitive Plk1 alleles, 3MB-PP1 blocks mitotic progression...
T6217	LFM-A13	244240-24-2	98%
T6217	LFM-A13（IC50=2.5 μM）, a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and...
T6070	ON-01910	1225497-78-8	98%
T6070	ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. ...
T6283	Wortmannin	19545-26-7	98%
T6283	Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and poten...
T8912	5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE	17899-49-9	98%
T8912	5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE targets PLK1.
T15454	GW843682X	660868-91-7	98%
T15454	GW843682X is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).
T17008	TC-S 7005	1082739-92-1	98%
T17008	TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).
T16560	Poloxin	321688-88-4	98%
T16560	Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).
T6338	PHA-680632	398493-79-3	98%
T6338	PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGF...
T2271	SBE13 Hydrochloride	1052532-15-6	98%
T2271	SBE13 hydrochloride is an effective and specific PLK1 inhibitor (IC50: 0.2 nM); no inhibition om Aurora A kinase, Plk2/3.
T6282	GSK461364	929095-18-1	98%
T6282	GSK461364(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2/3.
T14927	Centrinone	1798871-30-3	98%
T14927	Centrinone (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).
T19664	ON1231320	1312471-39-8	98%
T19664	ON1231320 is a Polo-like kinase 2 (PLK2) inhibitor.
T22288	(1E)-CFI-400437 dihydrochloride	1247000-76-5	98%
T22288	CFI-400437 dihydrochloride is a selective and potent polo-like kinase 4 (PLK4) inhibitor.
T1839	Mps1-IN-2	1228817-38-6	98%
T1839	Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.
T6019	Volasertib	755038-65-4	98%
T6019	Volasertib (BI-6727) is a potent inhibitor of PLK1 (IC50: 0.87 nM), inducing mitotic arrest and apoptosis. It also inhibits PLK2/PLK3 (IC50s: 5/56 nM).
T7200	TAK-960	1137868-52-0	98%
T7200	TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.