T28904 |
T521
|
891020-54-5
|
98%
|
|
T521 is a selective inhibitor of the PBD of Plk1 and shows no inhibitory effect on Plk2 and Plk3.
|
T16559 |
Poloxime
|
17302-61-3
|
98%
|
|
Poloxime is a hydrolysis product of poloxin and is a non-ATP-competitive Plk1 inhibitor. It also has moderate Plk1 inhibitory activity.
|
TN3247 |
7-O-Prenylscopoletin
|
13544-37-1
|
98%
|
|
7-O-Prenylscopoletin and cedrelopsin show high antiproliferative activities against cancer cell lines.
|
T21678 |
3MB-PP1
|
956025-83-5
|
98%
|
|
3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor. In cells expressing analog-sensitive Plk1 alleles, 3MB-PP1 blocks mitotic progression...
|
T6217 |
LFM-A13
|
244240-24-2
|
98%
|
|
LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and...
|
T6070 |
ON-01910
|
1225497-78-8
|
98%
|
|
ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. ...
|
T6283 |
Wortmannin
|
19545-26-7
|
98%
|
|
Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and poten...
|
T8912 |
5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE
|
17899-49-9
|
98%
|
|
5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE targets PLK1.
|
T15454 |
GW843682X
|
660868-91-7
|
98%
|
|
GW843682X is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).
|
T17008 |
TC-S 7005
|
1082739-92-1
|
98%
|
|
TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).
|
T16560 |
Poloxin
|
321688-88-4
|
98%
|
|
Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).
|
T6338 |
PHA-680632
|
398493-79-3
|
98%
|
|
PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGF...
|
T2271 |
SBE13 Hydrochloride
|
1052532-15-6
|
98%
|
|
SBE13 hydrochloride is an effective and specific PLK1 inhibitor (IC50: 0.2 nM); no inhibition om Aurora A kinase, Plk2/3.
|
T6282 |
GSK461364
|
929095-18-1
|
98%
|
|
GSK461364(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2/3.
|
T14927 |
Centrinone
|
1798871-30-3
|
98%
|
|
Centrinone (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).
|
T19664 |
ON1231320
|
1312471-39-8
|
98%
|
|
ON1231320 is a Polo-like kinase 2 (PLK2) inhibitor.
|
T22288 |
(1E)-CFI-400437 dihydrochloride
|
1247000-76-5
|
98%
|
|
CFI-400437 dihydrochloride is a selective and potent polo-like kinase 4 (PLK4) inhibitor.
|
T1839 |
Mps1-IN-2
|
1228817-38-6
|
98%
|
|
Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.
|
T6019 |
Volasertib
|
755038-65-4
|
98%
|
|
Volasertib (BI-6727) is a potent inhibitor of PLK1 (IC50: 0.87 nM), inducing mitotic arrest and apoptosis. It also inhibits PLK2/PLK3 (IC50s: 5/56 nM).
|
T7200 |
TAK-960
|
1137868-52-0
|
98%
|
|
TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.
|