Tyrosine Kinases

A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell. It functions as an "on" or "off" switch in many cellular functions. Tyrosine kinases are a subclass of protein kinase.The phosphate group is attached to the amino acid tyrosine on the protein. Tyrosine kinases are a subgroup of the larger class of protein kinases that attach phosphate groups to other amino acids (serine and threonine). Phosphorylation of proteins by kinases is an important mechanism in communicating signals within a cell (signal transduction) and regulating cellular activity, such as cell division.

Cat. No.	Product name	CAS No.	Purity
T14669	BMS-066	914946-88-6	98%
T14669	BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.
T15605	JAK/HDAC-IN-1	2284621-75-4	98%
T15605	JAK/HDAC-IN-1 is an effective JAK2/HDAC dual inhibitor (IC50s: 4 and 2 nM for JAK2 and HDAC). It also shows antiproliferative and proapoptotic activities in seve...
T13233	Tyk2-IN-3	1779493-12-7	98%
T13233	Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM).
T6104	Cerdulatinib hydrochloride	1369761-01-2	98%
T6104	Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and S...
TN1096	Ginsenoside Ra1	83459-41-0	98%
TN1096	Ginsenoside Ra1 is a component from ginseng. Ginsenoside Ra1 shows significant inhibitory effects on protein tyrosine kinase (PTK) activation induced by hypoxia/...
T6294	NVP-BSK805 2HCl (1092499-93-8(free base))	T6294	98%
T6294	NVP-BSK805 2HCl(IC50=0.5 nM), a specific and effective ATP-competitive JAK2 inhibitor, is more than 20-fold specificity over JAK1, JAK3 and TYK2.
TQ0010	Brepocitinib	1883299-62-4	98%
TQ0010	PF-06700841 is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). It also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).
T13564	AZ7550	1421373-99-0	98%
T13564	AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T60094	SU 4981	186610-88-8	100%
T60094	SU 4981 is an inhibitor of VEGFR and a modulator of tyrosine kinase activity.
T6266	PP2	172889-27-9	95.65%
T6266	PP2 is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2.
T4511	ST271	106392-48-7	97.97%
T4511	ST271 is an effective protein tyrosine kinase (PTK) inhibitor.
T1181	Gefitinib	184475-35-2	98%
T1181	Gefitinib is an EGFR tyrosine kinase inhibitor and can inhibit Tyr1173, Tyr992, Tyr1173 and Tyr992 (IC50s: 37/37/26/57 nM).
T7101	Tyrphostin AG30	122520-79-0	98%
T7101	Tyrphostin AG30 (AG30) is a potent protein tyrosine kinases (PTK) inhibitor.
TN1440	Beta-Hydroxyisovalerylshikonin	7415-78-3	98.16%
TN1440	Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in ...
T6380	AMG 900	945595-80-2	98.4%
T6380	AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases ...
T8697	ZAP-180013	873080-25-2	98.63%
T8697	ZAP-180013 is an inhibitor of zeta-chain-associated protein kinase 70 (ZAP70,IC50 : 1.8 μM).
T3080	Pyridone 6	457081-03-7	98.74%
T3080	Pyridone 6(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM); displaying signi...
T6343	Geldanamycin	30562-34-6	98.83%
T6343	Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.
T1929	Filgotinib	1206161-97-8	99.09%
T1929	GLPG0634(filgotinib) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.
T6914	Oclacitinib maleate	1640292-55-2	99.17%
T6914	Oclacitinib is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM, which...