T13233 |
Tyk2-IN-3
|
1779493-12-7
|
98%
|
|
Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM).
|
T14669 |
BMS-066
|
914946-88-6
|
98%
|
|
BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.
|
TQ0010 |
Brepocitinib
|
1883299-62-4
|
98%
|
|
PF-06700841 is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). It also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).
|
T15605 |
JAK/HDAC-IN-1
|
2284621-75-4
|
98%
|
|
JAK/HDAC-IN-1 is an effective JAK2/HDAC dual inhibitor (IC50s: 4 and 2 nM for JAK2 and HDAC). It also shows antiproliferative and proapoptotic activities in seve...
|
T6294 |
NVP-BSK805 2HCl (1092499-93-8(free base))
|
T6294
|
98%
|
|
NVP-BSK805 2HCl(IC50=0.5 nM), a specific and effective ATP-competitive JAK2 inhibitor, is more than 20-fold specificity over JAK1, JAK3 and TYK2.
|
T17220 |
Vecabrutinib
|
1510829-06-7
|
98%
|
|
Vecabrutinib is a potent and noncovalent BTK and ITK inhibitor (Kd: 0.3 nM and 2.2 nM, respectively). Vecabrutinib displays an IC50 of 24 nM for ITK.
|
T60094 |
SU 4981
|
186610-88-8
|
98%
|
|
SU 4981 is an inhibitor of VEGFR and a modulator of tyrosine kinase activity.
|
T1506 |
Vidarabine
|
5536-17-4
|
98%
|
|
Vidarabine is a nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA ...
|
T6266 |
PP2
|
172889-27-9
|
98%
|
|
PP2 is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2.
|
T13564 |
AZ7550
|
1421373-99-0
|
98%
|
|
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
|
TN1096 |
Ginsenoside Ra1
|
83459-41-0
|
98%
|
|
Ginsenoside Ra1 is a component from ginseng. Ginsenoside Ra1 shows significant inhibitory effects on protein tyrosine kinase (PTK) activation induced by hypoxia/...
|
T4511 |
ST271
|
106392-48-7
|
98%
|
|
ST271 is an effective protein tyrosine kinase (PTK) inhibitor.
|
T7101 |
Tyrphostin AG30
|
122520-79-0
|
98%
|
|
Tyrphostin AG30 (AG30) is a potent protein tyrosine kinases (PTK) inhibitor.
|
TN1440 |
Beta-Hydroxyisovalerylshikonin
|
7415-78-3
|
98%
|
|
Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in ...
|
T6380 |
AMG 900
|
945595-80-2
|
98%
|
|
AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases ...
|
T73334 |
Larotinib
|
1438072-11-7
|
98%
|
|
Larotinib is an orally active, potent, and broad-spectrum tyrosine kinase inhibitor (TKI) with an IC50 of 0.6 nM for EGFR.
|
T8697 |
ZAP-180013
|
873080-25-2
|
98%
|
|
ZAP-180013 is an inhibitor of zeta-chain-associated protein kinase 70 (ZAP70,IC50 : 1.8 μM).
|
T6933 |
Peficitinib
|
944118-01-8
|
98%
|
|
Peficitinib (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.
|
T3080 |
Pyridone 6
|
457081-03-7
|
98%
|
|
Pyridone 6(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM); displaying signi...
|
T6343 |
Geldanamycin
|
30562-34-6
|
98%
|
|
Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.
|