Wee1

Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe. Wee1 has a molecular mass of 96 kDa and is a key regulator of cell cycle progression. It influences cell size by inhibiting the entry into mitosis, through inhibiting Cdk1. Wee1 has homologues in many other organisms, including mammals.

Cat. No.	Product name	CAS No.	Purity
T60889	RP-6306	2719793-90-3	98%
RP-6306 is a potent, selective and orally active PKMYT1 inhibitor (IC50= 14 nM). RP-6306 exhibits a high degree of selectivity for PKMYT1 over other kinases in c...
T9864	Debio-0123	2243882-74-6	98%
Debio-0123 is a potent Wee1 inhibitor with an IC50 value of 0.8 nM. Debio-0123 inhibits phospho-CDC2. Debio-0123 abrogates the G2 check point, increasing sensiti...
T8916	WEE1-IN-3	2272976-28-8	98.61%
JUN76288 is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.
T9643	ZN-c3	2376146-48-2	98.97%
ZN-c3 is a potent and selective Wee1 inhibitor with balanced potency, ADME, and pharmacokinetic properties.
T2077	Adavosertib	955365-80-7	99.58%
MK-1775 is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.
T6931	PD0166285	185039-89-8	99.59%
PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T60889

RP-6306

2719793-90-3

98%

RP-6306 is a potent, selective and orally active PKMYT1 inhibitor (IC50= 14 nM). RP-6306 exhibits a high degree of selectivity for PKMYT1 over other kinases in c...

T9864

Debio-0123

2243882-74-6

98%

Debio-0123 is a potent Wee1 inhibitor with an IC50 value of 0.8 nM. Debio-0123 inhibits phospho-CDC2. Debio-0123 abrogates the G2 check point, increasing sensiti...

T8916

WEE1-IN-3

2272976-28-8

98.61%

JUN76288 is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.

T9643

ZN-c3

2376146-48-2

98.97%

ZN-c3 is a potent and selective Wee1 inhibitor with balanced potency, ADME, and pharmacokinetic properties.

T2077

Adavosertib

955365-80-7

99.58%

MK-1775 is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.

T6931

PD0166285

185039-89-8

99.59%

PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.