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c-Kit

Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR). Multiple transcript variants encoding different isoforms have been found for this gene.KIT is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. Altered forms of this receptor may be associated with some types of cancer. KIT is a receptor tyrosine kinase type III, which binds to stem cell factor (a substance that causes certain types of cells to grow), also known as "steel factor" or "c-kit ligand".
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T22256 C-Kit-IN-5-1 1003311-62-3 98%
c-Kit-IN-5-1
c-Kit-IN-5-1 (AMG-25) is a novel selective and potent c-Kit inhibitor.
T80558 Anti-Mouse CD117 Antibody 98%
Anti-Mouse CD117 Antibody
Anti-Mouse CD117 Antibody, a rat-derived IgG2b isotype, acts as an inhibitor specific to the mouse CD117 antigen.
TQ0080 SU14813 maleate 849643-15-8 98%
SU14813 maleate
SU14813 maleate is an inhibitor of multi-targeted receptor tyrosine kinases (IC50s: 2, 50, 4, 15 nM for VEGFR1, VEGFR2, PDGFRβ, and KIT).
T1925 PLX647 873786-09-5 98%
PLX647
PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).
T10801 CHMFL-ABL/KIT-155 2081093-21-0 98%
CHMFL-ABL/KIT-155
CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM). It arrests cell cycle progression and induce...
T10650 C-Kit-IN-2 2121515-37-3 98%
c-Kit-IN-2
c-Kit-IN-2 is a c-KIT inhibitor (IC50: 82 nM), shows superior antiproliferative activities against all the three GIST cell lines, GIST430, GIST882, and GIST48 (G...
T6193 Dovitinib Dilactic Acid 852433-84-2 98%
Dovitinib Dilactic Acid
Dovitinib Dilactic Acid (Dovitinib (TKI-258) Dilactic Acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3...
T12145 N-Desethyl Sunitinib 356068-97-8 98%
N-Desethyl Sunitinib
N-Desethyl Sunitinib (SU-11662) is a sunitinib metabolite.
T14928 Agerafenib hydrochloride 1227678-26-3 98%
Agerafenib hydrochloride
Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).
T22303 Dasatinib hydrochloride 854001-07-3 99.98%
Dasatinib hydrochloride
Dasatinib hydrochloride (BMS-354825 HCl) (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent ant...
T6091 CP-673451 343787-29-1 99.93%
CP-673451
CP-673451 is a specific inhibitor of PDGFRα/β (IC50: 10/1 nM) with antiangiogenic and antitumor activity and the selectivity is higher 450-fold than other angiog...
T2609 Masitinib 790299-79-5 99.91%
Masitinib
Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 200...
T1448L Dasatinib monohydrate 863127-77-9 99.89%
Dasatinib monohydrate
Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib mon...
T1448 Dasatinib 302962-49-8 99.89%
Dasatinib
Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and is orally active and ATP-competitive. Dasatinib has antitum...
T2341 KW-2449 1000669-72-6 99.89%
KW-2449
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R...
T2586 Cabozantinib 849217-68-1 99.88%
Cabozantinib
Cabozantinib (BMS-907351) (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50s: 0.035, 1.3, 4.6, 7 and 11.3 ...
T1792 Regorafenib 755037-03-7 99.87%
Regorafenib
Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally active...
T0097L Pazopanib 444731-52-6 99.84%
Pazopanib
Pazopanib (GW786034), a small molecule inhibitor, inhibits multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibi...
T6196 PP1 172889-26-8 99.82%
PP1
PP1 (AGL 1872), a specific and effective Src inhibitor, is with IC50 for Lck/Fyn is 5 nM/ 6 nM, respectively.
T7861 Flumatinib mesylate 895519-91-2 99.82%
Flumatinib mesylate
Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.
c-Kit-IN-5-1
T22256
c-Kit-IN-5-1 (AMG-25) is a novel selective and potent c-Kit inhibitor.
Anti-Mouse CD117 Antibody
T80558
Anti-Mouse CD117 Antibody, a rat-derived IgG2b isotype, acts as an inhibitor specific to the mouse CD117 antigen.
SU14813 maleate
TQ0080
SU14813 maleate is an inhibitor of multi-targeted receptor tyrosine kinases (IC50s: 2, 50, 4, 15 nM for VEGFR1, VEGFR2, PDGFRβ, and KIT).
PLX647
T1925
PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).
CHMFL-ABL/KIT-155
T10801
CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM). It arrests cell cycle progression and induce...
c-Kit-IN-2
T10650
c-Kit-IN-2 is a c-KIT inhibitor (IC50: 82 nM), shows superior antiproliferative activities against all the three GIST cell lines, GIST430, GIST882, and GIST48 (G...
Dovitinib Dilactic Acid
T6193
Dovitinib Dilactic Acid (Dovitinib (TKI-258) Dilactic Acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3...
N-Desethyl Sunitinib
T12145
N-Desethyl Sunitinib (SU-11662) is a sunitinib metabolite.
Agerafenib hydrochloride
T14928
Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).
Dasatinib hydrochloride
T22303
Dasatinib hydrochloride (BMS-354825 HCl) (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent ant...
CP-673451
T6091
CP-673451 is a specific inhibitor of PDGFRα/β (IC50: 10/1 nM) with antiangiogenic and antitumor activity and the selectivity is higher 450-fold than other angiog...
Masitinib
T2609
Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 200...
Dasatinib monohydrate
T1448L
Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib mon...
Dasatinib
T1448
Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and is orally active and ATP-competitive. Dasatinib has antitum...
KW-2449
T2341
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R...
Cabozantinib
T2586
Cabozantinib (BMS-907351) (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50s: 0.035, 1.3, 4.6, 7 and 11.3 ...
Regorafenib
T1792
Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally active...
Pazopanib
T0097L
Pazopanib (GW786034), a small molecule inhibitor, inhibits multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibi...
PP1
T6196
PP1 (AGL 1872), a specific and effective Src inhibitor, is with IC50 for Lck/Fyn is 5 nM/ 6 nM, respectively.
Flumatinib mesylate
T7861
Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.
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