c-Kit

Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR). Multiple transcript variants encoding different isoforms have been found for this gene.KIT is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. Altered forms of this receptor may be associated with some types of cancer. KIT is a receptor tyrosine kinase type III, which binds to stem cell factor (a substance that causes certain types of cells to grow), also known as "steel factor" or "c-kit ligand".

Cat. No.	Product name	CAS No.	Purity
T23128	PD180970	287204-45-9	98%
T23128	PD180970 is an inhibitor of Bcr-Abl with IC50s of 5 nM, 0.8 nM and 50 nM for the autophosphorylation of p210Bcr-Abl, Src and Kit. PD180970 can be used in studies...
TQ0080	SU14813 maleate	849643-15-8	98%
TQ0080	SU14813 maleate is an inhibitor of multi-targeted receptor tyrosine kinases (IC50s: 2, 50, 4, 15 nM for VEGFR1, VEGFR2, PDGFRβ, and KIT).
T13178	Toceranib	356068-94-5	98%
T13178	Toceranib phosphate is an orally active inhibitor of tyrosine kinase (RTK) receptor, and it potently inhibits PDGFR, VEGFR, and Kit(with Kis of 5 and 6 nM for PD...
T14928	Agerafenib hydrochloride	1227678-26-3	98%
T14928	Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).
T12145	N-Desethyl Sunitinib	356068-97-8	98%
T12145	N-Desethyl Sunitinib is a sunitinib metabolite.
T67847	Imatinib impurities3	404844-11-7	98%
T67847	Imatinib impurities3 is a protein kinases inhibitor with IC50 values of 6.95uM, 0.245uM, 0.139uM for ABL1 wt, KIT wt, PDGFRR wt, respectively.
T35331	Dovitinib (TKI258) Lactate		98%
T35331
T10650	C-Kit-IN-2	2121515-37-3	98%
T10650	c-Kit-IN-2 is a c-KIT inhibitor (IC50: 82 nM), shows superior antiproliferative activities against all the three GIST cell lines, GIST430, GIST882, and GIST48 (G...
T1925	PLX647	873786-09-5	98%
T1925	PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).
T22256	C-Kit-IN-5-1	1003311-62-3	98%
T22256	AMG-25 is a novel selective and potent c-Kit inhibitor.
T10801	CHMFL-ABL/KIT-155	2081093-21-0	98%
T10801	CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM). It arrests cell cycle progression and induce...
T6193	Dovitinib Dilactic Acid	852433-84-2	98%
T6193	Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with ...
T22303	Dasatinib hydrochloride	854001-07-3	98%
T22303	Dasatinib hydrochloride is a highly ATP competitive, potent, orally active inhibitor of dual Src/Bcr-Abl(with Ki values of 16 pM and 30 pM for Src and Bcr-Abl, r...
T10651	C-Kit-IN-3	2363169-01-9	98%
T10651	c-Kit-IN-3 is a selective inhibitor of c-KIT kinase with IC50s of 4 nM and 8 nM for c-Kit (wt) and c-Kit (T670I).
TQ0235	AC710	1351522-04-7	98%
TQ0235	AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).
T10803	CHMFL-KIT-033	2351801-41-5	98%
T10803	CHMFL-KIT-033 is an effective and selective c-KIT inhibitor with an IC50 value of 45 nM for c-KIT T670I mutant in gastrointestinal stromal tumors.
T11641	N-Desmethyl imatinib	404844-02-6
T11641	N-Desmethyl imatinib is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.
T7104	Dovitinib lactate	692737-80-7	100%
T7104	Dovitinib lactate(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).
T35570	Chiauranib	1256349-48-0	96.25%
T35570	Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related k...
T4191	Multi-kinase inhibitor 1	778274-97-8	98%
T4191	Multi-kinase inhibitor I is a Multi-kinase inhibitor.