T23128 |
PD180970
|
287204-45-9
|
98%
|
|
PD180970 is an inhibitor of Bcr-Abl with IC50s of 5 nM, 0.8 nM and 50 nM for the autophosphorylation of p210Bcr-Abl, Src and Kit. PD180970 can be used in studies...
|
TQ0080 |
SU14813 maleate
|
849643-15-8
|
98%
|
|
SU14813 maleate is an inhibitor of multi-targeted receptor tyrosine kinases (IC50s: 2, 50, 4, 15 nM for VEGFR1, VEGFR2, PDGFRβ, and KIT).
|
T13178 |
Toceranib
|
356068-94-5
|
98%
|
|
Toceranib phosphate is an orally active inhibitor of tyrosine kinase (RTK) receptor, and it potently inhibits PDGFR, VEGFR, and Kit(with Kis of 5 and 6 nM for PD...
|
T14928 |
Agerafenib hydrochloride
|
1227678-26-3
|
98%
|
|
Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).
|
T12145 |
N-Desethyl Sunitinib
|
356068-97-8
|
98%
|
|
N-Desethyl Sunitinib is a sunitinib metabolite.
|
T67847 |
Imatinib impurities3
|
404844-11-7
|
98%
|
|
Imatinib impurities3 is a protein kinases inhibitor with IC50 values of 6.95uM, 0.245uM, 0.139uM for ABL1 wt, KIT wt, PDGFRR wt, respectively.
|
T35331 |
Dovitinib (TKI258) Lactate
|
|
98%
|
|
|
T10650 |
C-Kit-IN-2
|
2121515-37-3
|
98%
|
|
c-Kit-IN-2 is a c-KIT inhibitor (IC50: 82 nM), shows superior antiproliferative activities against all the three GIST cell lines, GIST430, GIST882, and GIST48 (G...
|
T1925 |
PLX647
|
873786-09-5
|
98%
|
|
PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).
|
T22256 |
C-Kit-IN-5-1
|
1003311-62-3
|
98%
|
|
AMG-25 is a novel selective and potent c-Kit inhibitor.
|
T10801 |
CHMFL-ABL/KIT-155
|
2081093-21-0
|
98%
|
|
CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM). It arrests cell cycle progression and induce...
|
T6193 |
Dovitinib Dilactic Acid
|
852433-84-2
|
98%
|
|
Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with ...
|
T22303 |
Dasatinib hydrochloride
|
854001-07-3
|
98%
|
|
Dasatinib hydrochloride is a highly ATP competitive, potent, orally active inhibitor of dual Src/Bcr-Abl(with Ki values of 16 pM and 30 pM for Src and Bcr-Abl, r...
|
T10651 |
C-Kit-IN-3
|
2363169-01-9
|
98%
|
|
c-Kit-IN-3 is a selective inhibitor of c-KIT kinase with IC50s of 4 nM and 8 nM for c-Kit (wt) and c-Kit (T670I).
|
TQ0235 |
AC710
|
1351522-04-7
|
98%
|
|
AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).
|
T10803 |
CHMFL-KIT-033
|
2351801-41-5
|
98%
|
|
CHMFL-KIT-033 is an effective and selective c-KIT inhibitor with an IC50 value of 45 nM for c-KIT T670I mutant in gastrointestinal stromal tumors.
|
T11641 |
N-Desmethyl imatinib
|
404844-02-6
|
|
|
N-Desmethyl imatinib is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.
|
T7104 |
Dovitinib lactate
|
692737-80-7
|
100%
|
|
Dovitinib lactate(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).
|
T35570 |
Chiauranib
|
1256349-48-0
|
96.25%
|
|
Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related k...
|
T4191 |
Multi-kinase inhibitor 1
|
778274-97-8
|
98%
|
|
Multi-kinase inhibitor I is a Multi-kinase inhibitor.
|