T22256 |
C-Kit-IN-5-1
|
1003311-62-3
|
98%
|
|
c-Kit-IN-5-1 (AMG-25) is a novel selective and potent c-Kit inhibitor.
|
T80558 |
Anti-Mouse CD117 Antibody
|
|
98%
|
|
Anti-Mouse CD117 Antibody, a rat-derived IgG2b isotype, acts as an inhibitor specific to the mouse CD117 antigen.
|
TQ0080 |
SU14813 maleate
|
849643-15-8
|
98%
|
|
SU14813 maleate is an inhibitor of multi-targeted receptor tyrosine kinases (IC50s: 2, 50, 4, 15 nM for VEGFR1, VEGFR2, PDGFRβ, and KIT).
|
T1925 |
PLX647
|
873786-09-5
|
98%
|
|
PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).
|
T10801 |
CHMFL-ABL/KIT-155
|
2081093-21-0
|
98%
|
|
CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM). It arrests cell cycle progression and induce...
|
T10650 |
C-Kit-IN-2
|
2121515-37-3
|
98%
|
|
c-Kit-IN-2 is a c-KIT inhibitor (IC50: 82 nM), shows superior antiproliferative activities against all the three GIST cell lines, GIST430, GIST882, and GIST48 (G...
|
T6193 |
Dovitinib Dilactic Acid
|
852433-84-2
|
98%
|
|
Dovitinib Dilactic Acid (Dovitinib (TKI-258) Dilactic Acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3...
|
T12145 |
N-Desethyl Sunitinib
|
356068-97-8
|
98%
|
|
N-Desethyl Sunitinib (SU-11662) is a sunitinib metabolite.
|
T14928 |
Agerafenib hydrochloride
|
1227678-26-3
|
98%
|
|
Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).
|
T22303 |
Dasatinib hydrochloride
|
854001-07-3
|
99.98%
|
|
Dasatinib hydrochloride (BMS-354825 HCl) (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent ant...
|
T6091 |
CP-673451
|
343787-29-1
|
99.93%
|
|
CP-673451 is a specific inhibitor of PDGFRα/β (IC50: 10/1 nM) with antiangiogenic and antitumor activity and the selectivity is higher 450-fold than other angiog...
|
T2609 |
Masitinib
|
790299-79-5
|
99.91%
|
|
Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 200...
|
T1448L |
Dasatinib monohydrate
|
863127-77-9
|
99.89%
|
|
Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib mon...
|
T1448 |
Dasatinib
|
302962-49-8
|
99.89%
|
|
Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and is orally active and ATP-competitive. Dasatinib has antitum...
|
T2341 |
KW-2449
|
1000669-72-6
|
99.89%
|
|
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R...
|
T2586 |
Cabozantinib
|
849217-68-1
|
99.88%
|
|
Cabozantinib (BMS-907351) (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50s: 0.035, 1.3, 4.6, 7 and 11.3 ...
|
T1792 |
Regorafenib
|
755037-03-7
|
99.87%
|
|
Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally active...
|
T0097L |
Pazopanib
|
444731-52-6
|
99.84%
|
|
Pazopanib (GW786034), a small molecule inhibitor, inhibits multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibi...
|
T6196 |
PP1
|
172889-26-8
|
99.82%
|
|
PP1 (AGL 1872), a specific and effective Src inhibitor, is with IC50 for Lck/Fyn is 5 nM/ 6 nM, respectively.
|
T7861 |
Flumatinib mesylate
|
895519-91-2
|
99.82%
|
|
Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.
|