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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T7527 | Frentizole | Beta Amyloid | |
Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction | |||
T3259 | FPS-ZM1 | Beta Amyloid , advanced glycation end products | |
FPS-ZM1 is a high-affinity RAGE specific inhibitor that blocks Aβ binding to the V domain of RAGE. | |||
T22694 | CRANAD 2 | Others | |
CRANAD-2 is a difluoroboron-derivatized curcumins as near-infrared probe for in vivo detection of amyloid-beta deposits. Upon interacting with Abeta aggregates, CRANAD-2 undergoes a range of changes, which include a 70-f... | |||
T12532 | PQM130 | Beta Amyloid | |
PQM130 is a neuroprotective compound ,and is a potential anti-AD drug. | |||
TP1856 | Colivelin | Beta Amyloid , STAT | |
Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN). | |||
T7905 | PBD-150 | Beta Amyloid | |
PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM) | |||
T5447 | Anle138b | Beta Amyloid , Others | |
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease | |||
T7490 | ARN2966 | Beta Amyloid | |
ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion. | |||
T21825 | TAE-1 | Beta Amyloid , AChE | |
TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively. | |||
T4364 | Aftin-4 | Aftin 4,Aftin4 | Beta Amyloid , Gamma-secretase |
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus... | |||
T21890 | JLK6 | Gamma-secretase | |
JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling | |||
T14199 | ALZ-801 | Valiltramiprosate | Beta Amyloid |
ALZ-801 is an orally available, valine-conjugated prodrug of tramiprosate. ALZ-801 is an advanced and markedly improved candidate for the treatment of Alzheimer's disease. ALZ-801 is a potent and orally available small-m... | |||
T4398 | LX2343 | Beta Amyloid , Beta-Secretase , BACE , PI3K , Autophagy | |
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance. | |||
T11043 | Dihydroergocristine mesylate | DHEC (mesylate) | Beta Amyloid |
Dihydroergocristine mesylate (DHEC (mesylate))(DHEC mesylate) is the methanesulfonic acid salt of dihydroergocristine. It has been used as the for the symptomatic treatment of mental deterioration associated with cerebro... | |||
T6125 | Semagacestat | LY450139 | Beta Amyloid , Gamma-secretase |
Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM). | |||
TQ0026 | MDR-1339 | DWK-1339 | Beta Amyloid , Gamma-secretase |
MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation. | |||
T2507 | Azeliragon | TTP488 | Beta Amyloid , advanced glycation end products |
Azeliragon (TTP488) is an antagonist at the Receptor for Advanced Glycation End products; is evaluated as a potential treatment for patients with mild-to-moderate Alzheimer_acute_s disease (AD). | |||
T6202 | DAPT | LY-374973,GSI-IX | Apoptosis , Beta Amyloid , Gamma-secretase , Autophagy |
DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces cell differentiation, autophagy and apoptosis. | |||
T6708 | Tolcapone | Tasmar,Ro 40-7592 | Apoptosis , Beta Amyloid , Transferase |
Tolcapone (Ro 40-7592) is a catechol-O-methyltransferase inhibitor used in the therapy of Parkinson disease as adjunctive therapy in combination with levodopa and carbidopa. | |||
T4422 | Edonerpic maleate | T-817MA,T-817 maleate | Beta Amyloid |
Edonerpic maleate (T-817 maleate) is a neurotrophic agent which can inhibit amyloid-β peptides (Aβ). | |||
T29856 | Aleplasinin | PAZ 417,PAZ417,PAZ-417 | PAI-1 |
Aleplasinin (PAZ 417) is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolytic system. Aleplasinin can be used in Alzheimer's disease studies... | |||
T63208L | Aβ-IN-1 TFA | Aβ-IN-1 TFA(2766509-32-2 Free base) | |
Aβ-IN-1 TFA inhibits and reverses different types of protein aggregation. | |||
T6562 | Latrepirdine dihydrochloride | Dimebolin dihydrochloride,Latrepirdine,Latrepirdine 2HCl,Dimebolin | Beta Amyloid , 5-HT Receptor , Adrenergic Receptor , GluR , Autophagy , Histamine Receptor |
Latrepirdine dihydrochloride (Dimebolin dihydrochloride) is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug. | |||
T9713 | δ-secretase inhibitor 11 | Beta Amyloid , Caspase | |
δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment. | |||
T39781 | Aβ/tau aggregation-IN-1 | ||
Aβ/tau aggregation-IN-1 is a potent inhibitor of Aβ 1-42 β-sheet formation and tau aggregation. It exhibits K D values of 160 μM and 337 μM with Aβ 1-42 and tau, respectively. Additionally, Aβ/tau aggregation-IN-1 can pe... | |||
T14284 | β-Amyloid (25-35) | β-Amyloid peptide(25-35),Aβ25-35,Amyloid beta-peptide(25-35) | Beta Amyloid |
β-Amyloid (25-35) (Aβ25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide. Which has shown neurotoxic activities in cultured cells. | |||
T19011 | Hoechst 34580 | HOE 34580 | Beta Amyloid |
Hoechst 34580 (HOE 34580), a cell-permeable fluorescent dye, is used for staining DNA and nuclei. | |||
T7562 | β-Amyloid (31-35) | β-Amyloid 31-35(TFA),β-Amyloid 31-35 | Beta Amyloid |
β-Amyloid (31-35) (β-Amyloid 31-35) is the shortest sequence of native Amyloid-β peptide. | |||
T7003 | Leucomethylene blue mesylate | TRx0237 mesylate,TRx0237 (LMTX) mesylate,Methylene blue leuco base mesylate salt,Leucomethylene Blue Dimesylate | Beta Amyloid , Microtubule Associated |
Leucomethylene blue mesylate (TRx0237 mesylate) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. | |||
TP1007 | β-Amyloid (1-42), human | β-Amyloid (1-42), human,Amyloid β-Peptide (1-42) human | Beta Amyloid |
Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. | |||
T0348 | Labetalol hydrochloride | Sch-15719W,AH-5158 hydrochloride,Labetalol HCl | Adrenergic Receptor |
Labetalol hydrochloride (Sch-15719W), a salicylamide derivative, is a non-cardioselective blocker of β-adrenergic receptors and α1-adrenergic receptors. | |||
T5642 | Tegatrabetan | BC2059 | Wnt/beta-catenin |
Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity. | |||
T20570 | Labetalol | Apo-Labetalol,Albetol,Trandate,Dilevalol,Normodyne | Adrenergic Receptor |
Labetalol (Apo-Labetalol) is a mixed alpha/beta-adrenergic antagonist.It is used to treat high blood pressure. It can be given by mouth for long term hypertension management or intravenously in severe hypertensive situat... | |||
T2480 | Apabetalone | RVX-208,RVX000222 | Epigenetic Reader Domain , HIV Protease |
Apabetalone (RVX000222) , an effective BET bromodomain inhibitor, has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disease. | |||
T35326 | Labetalone hydrochloride | Labetalone hydrochloride,Benzoic amide | Others |
Labetalone hydrochloride (Benzoic amide) is an impurity of Labetalol. Labetalol is an orally active adrenoceptor blocking drug, Labetalol is a competitive antagonist at both alpha- and beta-adrenoceptor sites | |||
T22932L | LPYFD-NH2 acetate | LPYFD-NH2 acetate (700361-48-4 free base) | Beta Amyloid |
LPYFD-NH2 acetate shows some inhibitory effect on the aggregation of Abeta(1-42). | |||
T77054 | Lecanemab | BAN-2401 | Beta Amyloid |
Lecanemab (BAN-2401) is an IgG1 monoclonal antibody targeting soluble aggregated β-amyloid (Abeta) with activity against oligomers, protofibrils, and insoluble protofibrils, and may be useful in the study of Alzheimer's ... | |||
T37621 | Ezeprogind disulfate | Beta Amyloid | |
Ezeprogind disulfate is a neurotrophic inducer. Ezeprogind disulfate targets all causes of neurodegeneration including Abeta protein or tau protein. Ezeprogind disulfate can be used for the research of neurological disor... | |||
T31801 | Florbetapir F-18 | ||
Florbetapir F-18 is a PET agent for Abeta plaques. | |||
T76666 | β-Amyloid peptide(16-20) | ||
β-Amyloid peptide(16-20) is a amino acid sequences (KLVFF) of Amyloid-β (Abeta). β-Amyloid peptide(16-20) is an effective inhibitor of Abeta fibril formation, with RG-/-GR-NH 2 residues added at N- and C-terminal ends to... | |||
T80701 | β Amyloid (1-16) rat | ||
β-Amyloid (1-16) rat is a fragment of the metal-binding domain of the amyloid beta (Abeta) peptide. It contains three amino acid substitutions that distinguish it from its human counterpart, conferring reduced susceptibi... | |||
T80700 | β Amyloid(17-28) human | ||
β-Amyloid(17-28) human is a fragment of the β-amyloid peptide (Abeta) associated with Alzheimer's disease (AD), promoting the aggregation of the full-length β-Amyloid40 into toxic aggregates [1]. This lipid-induced amylo... | |||
TP1673 | β-Amyloid (11-22) | β-Amyloid 11-22 | |
β-Amyloid (11-22) is a peptide fragment of β-Amyloid.Beta-amyloid peptide (Abeta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be the cause of Alzheimer’s Disease (AD). A... | |||
T40701 | Ezeprogind | AZP-2006 | |
Ezeprogind (AZP-2006) is an orally active neurotrophic inducer that effectively addresses the underlying factors contributing to neurodegeneration, with a broad scope extending beyond the conventional targets like Abeta ... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN6919 | Methyl tridecanoate | Beta Amyloid , AChE | |
Methyl tridecanoate is a natural product. | |||
T2212 | Geniposide | Beta Amyloid , Influenza Virus | |
Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activity. Geniposide has been shown to regulate Nrf2 translocation... | |||
T3914 | Saikosaponin C | Beta Amyloid , Caspase | |
Saikosaponin C efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation. | |||
T8012 | Scyllo-Inositol | Scyllitol | Beta Amyloid , Endogenous Metabolite |
Scyllo-Inositol (Scyllitol) is one of the inositol stereoisomers, rare in the nature, and expected as a promising disease-modifying therapeutic agent for Alzheimer's disease. | |||
T4S0350 | Licochalcone B | Beta Amyloid , Others | |
1. Licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (murine bladder cancer cell line) tumor model. 2. LCB and Licoc... | |||
TMS1461 | Qingyangshengenin B | Otophylloside B | Beta Amyloid |
Qingyangshengenin B (Otophylloside B) is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mR... | |||
T0795 | Rutin | Quercetin 3-O-rutinoside,Rutoside | Beta Amyloid , Prostaglandin Receptor , Autophagy |
Rutin (Quercetin 3-O-rutinoside), a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and anticarcinogenic properties. | |||
T6S1918 | Schisantherin B | Gomisin-B,Wuweizi ester-B,Schizantherin-B | Beta Amyloid , Others |
1. Schisantherin B (Schizantherin-B) shows good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis. | |||
T22417 | Rutin hydrate | Rutoside,Sophorin,Quercetin-3-O-rutinoside | Beta Amyloid , Others , Autophagy |
Rutin hydrate (Sophorin), a kind of glycoside, widely exists in many plants including citrus fruit. | |||
T0883 | Tramiprosate | Homotaurine,3-Amino-1-propanesulfonic acid,Alzhemed | Beta Amyloid , GABA Receptor |
Tramiprosate (Alzhemed) is an orally active, blood-brain-barrier-crossing, naturally occurring amino acid found in a variety of red seaweeds that binds soluble Aβ and maintains it in a non-protofibrillar form.It is a GAB... | |||
T1686 | Hematoxylin | Hydroxybrazilin,Natural Black 1,Haematoxylin | Beta Amyloid , Others |
Hematoxylin (Natural Black 1) is a dye obtained from the heartwood of logwood (Haematoxylon campechianum Linn., Leguminosae) used as a stain in microscopy and in the manufacture of ink. | |||
T2872 | Ginsenoside Re | Ginsenoside B2,Panaxoside Re,Chikusetsusaponin Ivc,Sanchinoside Re | Beta Amyloid , NF-κB , Endogenous Metabolite , JNK |
Ginsenoside Re (Ginsenoside B2) may have properties that inhibit or prevent the growth of tumors. | |||
T2961 | Notoginsenoside R1 | Sanqi glucoside R1,Sanchinoside R1 | Apoptosis , ERK , Beta Amyloid |
Notoginsenoside R1 (Sanchinoside R1) has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties. | |||
T2777 | Ginsenoside Rg1 | Sanchinoside C1,Panaxoside Rg1,Sanchinoside Rg1,Panaxoside A,Ginsenoside A2 | Apoptosis , Beta Amyloid , NF-κB |
Ginsenoside Rg1 (Panaxoside Rg1) is a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spatial learning and increase hippocampal synaptophysin level i... | |||
T2873 | Ginsenoside Rg2 | Chikusetsusaponin I,Panaxoside Rg2,Prosapogenin C2,(20S)Ginsenoside Rg2 | Beta Amyloid , GSK-3 , NF-κB |
Ginsenoside Rg2 (Chikusetsusaponin I) is one of the major active components of ginseng, act as an NF-κB inhibitor. | |||
T3402 | 20(S)-Ginsenoside Rg3 | 20(S)-Ginsenoside-Rg3,Rg3,20S-Ginsenoside Rg3,Ginsenoside Rg3,S-Ginsenoside Rg3 | EGFR , Beta Amyloid , Potassium Channel , NF-κB , COX , Sodium Channel , Endogenous Metabolite |
20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhibits the proliferation of human umbilical vein endothelial c... | |||
TN1653 | Fustin | ERK , Beta Amyloid , AChR | |
Fustin is the phytogenic flavanol component of the plant Rhus verniciflua Stokes. Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death. | |||
T14305 | Apicidin | OSI 2040 | Apoptosis , HDAC , Autophagy |
Apicidin (OSI 2040) is a histone deacetylase (HDAC) inhibitor with antiparasitic activity and antiproliferative activity.Apicidin attenuates memory deficits, inhibits cell growth and proliferation, and induces apoptosis ... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00851 | IDE Protein, Human, Recombinant (His) | Human | Human Cells |
Insulin-Degrading Enzyme (IDE) is a secreted enzyme that belongs to the peptidase M16 family. IDE is a large zinc-binding protease and cleaves multiple short polypeptides that vary considerably in sequence. IDE plays a r... | |||
TMPY-00668 | APP/Protease nexin-II Protein, Human, Recombinant (hFc) | Human | HEK293 |
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can... | |||
TMPY-03884 | Beta-amyloid 39/Beta-APP39 Protein, Human, Recombinant (aa 672-710, His & GST) | Human | E. coli |
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can... | |||
TMPY-03885 | Beta-amyloid 38/Beta-APP38 Protein, Human, Recombinant (aa 672-709, His & GST) | Human | E. coli |
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can... | |||
TMPY-02110 | Beta-amyloid 40/Beta-APP40 Protein, Human, Recombinant (His & GST) | Human | E. coli |
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can... | |||
TMPY-02221 | Beta-amyloid 42/Beta-APP42 Protein, Human, Recombinant (His & GST) | Human | E. coli |
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can... | |||
TMPY-02393 | Thimet Oligopeptidase/THOP1 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
THOP1, also known as Thimet oligopeptidase 1, Thimet oligopeptidase, EC 3.4.24.15, or EP24.15, is a zinc(II) endopeptidase implicated in the processing of numerous physiological peptides. As an intracellular enzyme, high... | |||
TMPY-00752 | BACE1 Protein, Human, Recombinant (His) | Human | HEK293 |
Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c... | |||
TMPY-00651 | BACE1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c... | |||
TMPY-00678 | BACE1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c... | |||
TMPY-00652 | BACE1 Protein, Human, Recombinant | Human | HEK293 |
Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c... | |||
TMPY-04555 | GRK5 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
G protein-coupled receptor kinase 5, also known as G protein-coupled receptor kinase GRK5 and GRK5, is a member of the protein kinase superfamily, AGC Ser/Thr protein kinase family, and GPRK subfamily. GRKs specifically ... |