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Cat No. | Product Name | Synonyms | Targets |
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T11111 | DUB-IN-2 | DUB | |
Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor. | |||
T11110 | DUB-IN-1 | DUB | |
DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs). | |||
T11112 | DUB-IN-3 | DUB | |
DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM. | |||
T4067 | VLX1570 | DUB | |
VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14. | |||
T14852 | C527 | DUB | |
C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM). | |||
T9122 | XL177A | DUB | |
XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism. | |||
T15604 | IU1-47 | DUB | |
IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 μM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20 μM). | |||
T15464 | HBX 19818 | DUB | |
HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM). | |||
T3555 | ML364 | DUB | |
ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer. | |||
T12024 | MF-094 | DUB | |
MF-094 is a potent and selective inhibitor of USP30 (IC50 of 120 nM). | |||
T36682 | USP30 inhibitor 18 | DUB | |
USP30 inhibitor 18 is a selective USP30 inhibitor with an IC50 of 0.02 μM. USP30 inhibitor 18 increases protein ubiquitination and accelerates mitophagy[1]. [1]. Arthur F Kluge, et al. Novel highly selective inhibitors o... | |||
T11209 | EOAI3402143 | DUB | |
EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis. EOAI3402143 phenocopies the FAS induction and apoptotic sensitization of Usp5 knockdown and fully blocks melanoma tumor growth. | |||
T9375 | IU1-248 | DUB | |
IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1]. | |||
T5461 | GNE-6640 | DUB | |
GNE-6640 is a non-covalent inhibitor targeting ubiquitin specific peptidase 7 (USP7), exhibiting IC50 values of 0.75 μM for full-length USP7, 0.43 μM for the USP7 catalytic domain, 20.3 μM for full-length USP43, and 0.23... | |||
T15729 | LDN-91946 | DUB | |
LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM). | |||
T13268 | USP7-IN-1 | DUB | |
USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM). | |||
T2424 | P 22077 | P22077 | DUB |
P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47. | |||
T1757 | ML-323 | ML323 | DUB |
ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay (IC50: 76 nM) and in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) (IC50: 174 nM 820 nM)and monoubiquitinated PCNA (Ub-PCNA) (I... | |||
T6107 | IU1 | DUB , Autophagy | |
IU1(IC50=4.7 μ M), a reversible, specific human USP14 proteasome inhibitor, can penetrate the cell. | |||
T1924 | LDN-57444 | LDN57444 | Apoptosis , DUB |
LDN-57444 is a reversible, competitive proteasome Uch-L1 inhibitor(IC50=0.88 μM) . | |||
T9884 | EN523 | Others | |
EN523 targets non-catalytic allosteric cysteine C23 in K48 ubiquitin-specific deuquitinase OTUB1. | |||
T11464 | GRL0617 | SARS-CoV , DUB | |
GRL0617 is a selective and competitive SARS-CoVPLpro and deubiquitinase noncovalent inhibitor(IC50 : 0.6 μM, Ki : 0.49 μM). | |||
T8553 | BC-1471 | Others | |
BC-1471 is a STAM-binding protein (STAMBP) deubiquitinase inhibitor. BC-1471 inhibits inflammasome activity of NALP7 (NACHT, LRR and PYD domains-containing protein 7) [1]. | |||
T6300 | Degrasyn | WP1130 | Apoptosis , JAK , Bcr-Abl , DUB , Autophagy |
Degrasyn (WP1130) (WP1130), a specific deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor, also inhibits Bcr/Abl, which is a JAK2 transducer (without affecting 20S proteasome) and activator of transcri... | |||
T4634 | GNE-6776 | GEN6776 | DUB |
GNE-6776 is a selective USP7 inhibitor. | |||
T9217 | USP7-IN-8 | GNE-6776 | DUB |
Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. USP7-IN-8 (GNE-6776) has anticancer effects. | |||
T8464 | RA-9 | Apoptosis , DUB | |
RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity. RA-9 selectively induces apoptosis in ovarian cancer cell lines. | |||
T7678 | SJB2-043 | DUB | |
SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM). | |||
T6925 | P005091 | P5091 | DUB |
P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM. | |||
T4338 | USP7/USP47 inhibitor | USP7/47 inhibitor-1 | DUB |
USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively. | |||
T1932 | B-AP15 | NSC 687852 | Apoptosis , DUB |
B-AP15 (NSC-687852)(NSC-687852) is a selective inhibitor of the deubiquitinating enzymes Usp14 and UCHL5 of the 26S proteasome. It blocks the deubiquitinating activity of the 26S proteasome. | |||
T6697 | TCID | UCH-L3 Inhibitor | DUB |
TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1. | |||
T7685 | USP25/28 inhibitor AZ1 | AZ1 | DUB |
USP25/28 inhibitor AZ1 (AZ1) (AZ1) is an inhibitor of ubiquitin specific protease (USP) 25/28 | |||
T21527 | HBX 41108 | HBX-41108 | DUB , p53 |
HBX 41108 (HBX-41108) is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBX 41108 inhibited deubiquitination of p53 mediated by USP7 in a dose-dependent manner with an IC50 of 0.8μM. | |||
T3951 | NSC632839 | F6,Ubiquitin Isopeptidase Inhibitor II | DUB |
NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2 (EC50: 9.8±1.8 μM). | |||
T1862 | PR-619 | PR 619,2,6-Diamino-3,5-dithiocyanopyridine | Apoptosis , DUB , Autophagy |
PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs). | |||
T1902 | BAY 11-7082 | BAY 11-7821 | Apoptosis , Others , IκB/IKK , DUB , Autophagy |
BAY 11-7082 (BAY 11-7821) is an NF-κB inhibitor that inhibits TNFα-induced IκBα phosphorylation (IC50=10 μM). BAY 11-7082 is also an inhibitor of the ubiquitin-specific proteases USP7 and USP21 (IC50=0.19/0.96 μM). | |||
T3088 | N-Ethylmaleimide | 1-Ethyl-1H-pyrrole-2,5-dione,Ethylmaleimide,NEM | Cysteine Protease , DUB |
N-Ethylmaleimide (NEM) is a sulfhydryl reagent that is widely used in experimental biochemical studies. | |||
T3089 | 6-Thioguanine | 6-TG,2-Amino-6-purinethiol,2-Amino-6-mercaptopurine,Thioguanine | Apoptosis , DNA Methyltransferase , SARS-CoV , Endogenous Metabolite , DUB , Autophagy |
6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | |||
T36970 | STD1T | DUB | |
STD1T is a selective and potent inhibitor of the deubiquitinase USP2a with potential anticancer activity that reduces cell cycle protein D1 protein levels in HCT116 colon and MCF-7 breast cancer cells. | |||
T8706 | STAMBP-IN-1 | Others | |
STAMBP-IN-1 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release after TLR agonism. | |||
T60130 | USP5-IN-1 | DUB | |
USP5-IN-1 (compound 64) is a potent deubiquitinase USP5 inhibitor, which binds to the USP5 ZnF-UBD with a KD of 2.8 μM and is selective over nine proteins containing structurally similar ZnF-UBD domains. USP5-IN-1 inhibi... | |||
T70082 | Pyrithione cadmium | ||
Pyrithione cadmium suppresses tumor growth in vitro and in vivo through inhibition of proteasomal deubiquitinase | |||
T75182 | GK13S | ||
G13KS is a deubiquitinase UCHL1 ligand and inhibitor. G13KS inhibits recombinant and cellular UCHL1. G13KS reduces levels of monoubiquitin in human glioblastoma cells [1] . | |||
T74277 | NJH-2-056 | ||
NJH-2-056 is a deubiquitinase-targeting chimera (DUBTAC) linking the OTUB1 recruiter EN523 to the CFTR chaperone lumacaftor. NJH-2-056 can be used for cystic fibrosis research [1] . | |||
T74276 | LEB-03-153 | ||
LEB-03-153 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through no linker [1] . | |||
T74371 | LEB-03-146 | ||
LEB-03-146, a WEE1 DUBTAC (deubiquitinase-targeting chimera), effectively links AZD1775 (Adavosertib) with the OTUB1 recruiter EN523 via a PEG2 linker. This compound demonstrates considerable WEE1 stabilization in HEP3B ... | |||
T74274 | LEB-03-145 | ||
LEB-03-145 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a C5 alkyl linker [1] . | |||
T74275 | LEB-03-144 | ||
LEB-03-144 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a C3 alkyl linker. LEB-03-144 shows significant WEE1 stabilization in HEP3B hepatoma cance... | |||
T71837 | HBX | ||
HBX is a deubiquitinase inhibitor. It inhibits HAdV type 5 (species C, HAdV-C5) replication and oncogenic transformation through inhibition of the cellular pro-viral factor ubiquitin-specific protease 7 (USP7). HBX also ... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02214 | OTUB1 Protein, Human, Recombinant (His) | Human | E. coli |
Ubiquitin thioesterase OTUB1, also known as Deubiquitinating enzyme OTUB1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Otubain-1, Ubiquitin-specific-processing protease OTUB1, OTUB1 and OTB1, is a cytopla... | |||
TMPY-02522 | OTUB2 Protein, Human, Recombinant (His) | Human | E. coli |
Otubain 2 (OTUB2) is a member of DUBs that belong to the ovarian tumour (OTU) superfamily of proteins which consists of a five-stranded β-sheet sandwiched in between a small helical amino-terminal region consisting of α1... | |||
TMPH-01621 | BRCC3 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes... | |||
TMPH-02285 | USP6 Protein, Human, Recombinant (His & KSI) | Human | E. coli |
Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activit... | |||
TMPH-02640 | ZC3H12A Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angi... |