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Search Result

Search Results for " neuroprotection "

Targets

Dopamine Receptor Arrestin

43

Compounds

11

Natural Products

6

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T8423 ML417 Dopamine Receptor , Arrestin
ML417 is a selective and brain penetrant agonist of D3 Dopamine (EC50 : 38 nM).
T8887 2'MeO6MF GABA Receptor
2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors.It offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response...
T21551 2-hexyl-4-Pentynoic Acid HDAC
2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.
T7644 DPN Diarylpropionitrile Apoptosis , Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Autophagy
DPN (Diarylpropionitrile) is an selective agonist of estrogen receptor β (ERβ) .
T1476 Pramipexole SND 919 Dopamine Receptor
Pramipexole (SND 919) is a selective dopamine receptor agonist used in the therapy of Parkinson disease. Pramipexole therapy is associated with a low rate of transient serum enzyme elevations during treatment but has not...
T3198L PRE-084 hydrochloride Sigma receptor
PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).
T1057 Azilsartan TAK-536 RAAS
Azilsartan (TAK-536) is an Angiotensin 2 Receptor Blocker. The mechanism of action of azilsartan is as an Angiotensin 2 Type 1 Receptor Antagonist. The physiologic effect of azilsartan is by means of Decreased Blood Pres...
T6540 Ibuprofen Lysine Neoprofen COX
Ibuprofen Lysine (Neoprofen) is a non-steroidal anti-inflammatory drug.
T1394 Ibuprofen Brufen,(±)-Ibuprofe,Motrin,Advil COX
Ibuprofen (Advil) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resu...
T8505 SC-236 Sc 236 Apoptosis , COX , PPAR
SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively).
T0334 Rosiglitazone BRL49653 Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidinedione insulin sensitizer.
T2226 Pergolide mesylate Pergolide mesylate salt,LY127809,Pergolide methanesulfonate Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
Pergolide mesylate salt(LY127809) is a long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some markets due to potential for HEART VALVE DISEASES.
T6951 Pramipexole dihydrochloride hydrate Pramipexole 2HCl Monohydrate,Mirapex Dopamine Receptor
Pramipexole dihydrochloride hydrate (Mirapex) is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and su...
T6646 Rosiglitazone hydrochloride BRL-49653 HCl,Rosiglitazone HCl Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
T9956 VK-28 Mitochondrial Metabolism , Lipid
VK-28 is a brain permeable iron chelator with neuroprotection. VK-28 inhibits basal as well as iron-induced mitochondrial lipid peroxidation.
T27748L KRP-199 sodium KRP-199 sodium(221164-28-9 Free base) GluR
KRP-199 sodium sodium is highly potent and selective for AMPA-R in vitro and exhibits good neuroprotection in vivo.
T22900 L-701252 L-701,252 NMDAR
L-701252, a potent glycine site NMDA receptor antagonist, exhibits an inhibition concentration (IC50) of 420 nM. Additionally, it offers marginal neuroprotection against global cerebral ischemia.
T10212 A2AR-agonist-1 N-(2-(1H-Indol-3-yl)ethyl)adenosine Others , Adenosine Receptor
A2AR-agonist-1 (N-(2-(1H-Indol-3-yl)ethyl)adenosine) is a potent A2AR and ENT1 agonist (Ki: 4.39 and 3.47 for A2AR and ENT1. It targets the Adenosine A2A Receptor and Adenosine Transporter for Neuroprotection.
T21757 BRL 52537 hydrochloride Opioid Receptor
BRL 52537 hydrochloride is a selective and specific KOR agonist which has been implicated in neuroprotection from ischemic neuronal injury[1]. It is used for research into potential treatments for stroke and heart attack...
T76863 Elezanumab AE12-1Y-QL,ABT-555 TGF-beta/Smad
Elezanumab(ABT-555) is a potent human anti-RGMa monoclonal antibody.Elezanumab exerts its inhibitory effect on RGMa-mediated BMP signaling through the SMAD1/5/8 pathway, with an IC50 of approximately 97 pM.Elezanumab pro...
TP1079 (Arg)9 TFA (143413-47-2 free base) Nona-L-arginine (TFA),(Arg)9 TFA,Peptide R9 (TFA) Others
(Arg)9 TFA (Peptide R9 TFA) is a cell-penetrating peptide. (Arg)9 TFA (Nona-L-arginine TFA) exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model.
T1993 J-147 J147 Epigenetic Reader Domain , Dopamine Receptor , Monoamine Oxidase
J-147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative and a potent neurogenic and neuroprotective drug candidate...
T23736 AND-302 AND 302
AND-302 is a potent agent of anticonvulsant. It also has in vitro neuroprotection.
T28117 MSN-50 MSN50,MSN 50
MSN-50, an inhibitor of Bax and Bak oligomerization, inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection.
T24529 Neuroprotectant-7 Neuroprotectant7
Neuroprotectant-7 is a neuroprotectant for Alzheimer's disease. It displays significant neuroprotection and antioxidative properties. It also can cross the blood-brain barrier.
T28894 SZV558 SZV 558,SZV-558
SZV558 is a potent inhibitor of both human and rodent MAO-B. SZV558 is safe in high doses with no hERG and mutagenic activities and demonstrated neuroprotection in an in vivo chronic model of PD.
T16292 NFPS Thrombin
NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion. NFPS is a selective and non-competitive glycine transporter-1 (GlyT1) inhibitor (IC50s: 2.8 nM a...
T21470 Davunetide AL-208,AL 208,AL 108,AL-108
Davunetide is an eight amino acid peptide (NAPVSIPQ) with potent neuroprotection in vitro and in vivo. Davunetide has been shown to enhance functional daily behaviors in schizophrenia patients and to increase memory scor...
T24787 SGE-201
SGE-201 is an allosteric modulator of N-methyl-D-aspartate receptors. SGE-201 also unmasked differences among the blockers in neuronal networks - measured either by suppression of activity in multi-electrode arrays or by...
T41058 Nelonemdaz potassium Neu2000potassium,Salfaprodil
Nelonemdaz potassium (also known as Salfaprodil) is a potent NR2B-selective and uncompetitive antagonist of N-methyl-D-aspartate (NMDA). This compound exhibits remarkable neuroprotection against cell death induced by bot...
T35889 PB2
PB2, a tris(2-carboxyethyl)phosphine (TCEP) analogue, enhances the survival of retinal ganglion cells (RGCs) following axotomy in vitro. Even at nanomolar and picomolar concentrations, PB2 demonstrates pronounced efficac...
T78681 ITH12711 Phosphatase
ITH12711, a PP2A ligand, can traverse the blood-brain barrier (BBB) and exerts neuroprotection by restoring PP2A-phosphatase activity [1].
T75408 Batroxobin
Batroxobin (DF-521), a venom derived from the Bothrops atrox moojeni snake, facilitates thrombolysis, inhibits thrombus reformation, and offers neuroprotection. It holds research potential for treating cerebral venous th...
T16797 RPR104632 NMDAR
RPR104632 is a novel and potent antagonist located at the NMDA glycine site with neuroprotective activity.
T60695 DPQ
DPQ is a potent inhibitor of PARP-1 that can be used in neuroprotection research. DPQ reduce the PARP activation induced by N-methyl-d-aspartate (NMDA), restoring ATP to near control levels as well as significantly atten...
T80210 TAT-GluN2BCTM DAPK
TAT-GluN2BCTM is a membrane-permeable peptide that selectively targets active DAPK1 (Death-associated protein kinase 1) for lysosomal degradation, thereby protecting neurons against oxidative stress and NMDAR-mediated ex...
T78094 Eglumegad hydrochloride LY354740 hydrochloride,Eglumetad hydrochloride
Eglumegad (LY354740) hydrochloride is a potent, selective agonist for group II (mGlu2/3) receptors, exhibiting IC50 values of 5 nM for mGlu2 and 24 nM for mGlu3 receptors when transfected into human cells. This compound ...
T83963 Z-DEVD-FMK Caspase-3 Inhibitor
Z-DEVD-FMK, a Caspase-3 Inhibitor, is an irreversible, cell-permeable inhibitor of caspase-3/CPP32 that impedes tumor cell apoptosis. In vivo studies show it offers neuroprotection in rat hippocampi post-seizures and con...
T62743 AChE-IN-10
AChE-IN-10 (Compound 24r) is a potent inhibitor of AChE with an IC50 value of 2.4 nM. AChE-IN-10 decreases amyloid aggregation in the presence of AChE. AChE-IN-10 exhibited a potent inhibitory effect on AChE, reducing ta...
T79569 AChE/Aβ-IN-1
AChE/Aβ-IN-1 (compound 32) is a potent, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 86 nM and an NMDA receptor antagonist targeting the GluN1-1b/GluN2B subunit combination with an IC50 of 3.876 μM...
T73989 Tirilazad
Tirilazad, a nonglucocorticoid 21-aminosteroid, serves to inhibit lipid peroxidation. It mitigates the effects of trauma-induced brain or spinal cord injury, as well as damage resulting from stroke, ischemia, and reperfu...
T13976 (Arg)9 Peptide R9,Nona-L-arginine Others
(Arg)9 (Nona-L-arginine;Peptide R9) is a cell-penetrating peptide,and exhibits neuroprotective activity(IC50 of 0.78 μM, in the glutamic acid model).
T64672 Colivelin TFA
Colivelin (sequence SALLRSIPAPAGASRLLLLTGEIDLP) is composed of activity-dependent neurotrophic factor (ADNF) C-terminally fused to AGA-(C8R)HNG17, a potent HN derivative. It works as a neuroprotective peptide and activat...

Compounds

ML417
T8423
Synonym:
Target: Dopamine Receptor, Arrestin
2'MeO6MF
T8887
Synonym:
Target: GABA Receptor
2-hexyl-4-Pentynoic Acid
T21551
Synonym:
Target: HDAC
DPN
T7644
Synonym: Diarylpropionitrile
Target: Apoptosis, Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Autophagy
Pramipexole
T1476
Synonym: SND 919
Target: Dopamine Receptor
PRE-084 hydrochloride
T3198L
Synonym:
Target: Sigma receptor
Azilsartan
T1057
Synonym: TAK-536
Target: RAAS
Ibuprofen Lysine
T6540
Synonym: Neoprofen
Target: COX
Ibuprofen
T1394
Synonym: Brufen,(±)-Ibuprofe,Motrin,Advil
Target: COX
SC-236
T8505
Synonym: Sc 236
Target: Apoptosis, COX, PPAR
Rosiglitazone
T0334
Synonym: BRL49653
Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy
Pergolide mesylate
T2226
Synonym: Pergolide mesylate salt,LY127809,Pergolide methanesulfonate
Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor
Pramipexole dihydrochloride hydrate
T6951
Synonym: Pramipexole 2HCl Monohydrate,Mirapex
Target: Dopamine Receptor
Rosiglitazone hydrochloride
T6646
Synonym: BRL-49653 HCl,Rosiglitazone HCl
Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy
VK-28
T9956
Synonym:
Target: Mitochondrial Metabolism, Lipid
KRP-199 sodium
T27748L
Synonym: KRP-199 sodium(221164-28-9 Free base)
Target: GluR
L-701252
T22900
Synonym: L-701,252
Target: NMDAR
A2AR-agonist-1
T10212
Synonym: N-(2-(1H-Indol-3-yl)ethyl)adenosine
Target: Others, Adenosine Receptor
BRL 52537 hydrochloride
T21757
Synonym:
Target: Opioid Receptor
Elezanumab
T76863
Synonym: AE12-1Y-QL,ABT-555
Target: TGF-beta/Smad
(Arg)9 TFA (143413-47-2 free base)
TP1079
Synonym: Nona-L-arginine (TFA),(Arg)9 TFA,Peptide R9 (TFA)
Target: Others
J-147
T1993
Synonym: J147
Target: Epigenetic Reader Domain, Dopamine Receptor, Monoamine Oxidase
AND-302
T23736
Synonym: AND 302
Target:
MSN-50
T28117
Synonym: MSN50,MSN 50
Target:
Neuroprotectant-7
T24529
Synonym: Neuroprotectant7
Target:
SZV558
T28894
Synonym: SZV 558,SZV-558
Target:
NFPS
T16292
Synonym:
Target: Thrombin
Davunetide
T21470
Synonym: AL-208,AL 208,AL 108,AL-108
Target:
SGE-201
T24787
Synonym:
Target:
Nelonemdaz potassium
T41058
Synonym: Neu2000potassium,Salfaprodil
Target:
PB2
T35889
Synonym:
Target:
ITH12711
T78681
Synonym:
Target: Phosphatase
Batroxobin
T75408
Synonym:
Target:
RPR104632
T16797
Synonym:
Target: NMDAR
DPQ
T60695
Synonym:
Target:
TAT-GluN2BCTM
T80210
Synonym:
Target: DAPK
Eglumegad hydrochloride
T78094
Synonym: LY354740 hydrochloride,Eglumetad hydrochloride
Target:
Z-DEVD-FMK Caspase-3 Inhibitor
T83963
Synonym:
Target:
AChE-IN-10
T62743
Synonym:
Target:
AChE/Aβ-IN-1
T79569
Synonym:
Target:
Tirilazad
T73989
Synonym:
Target:
(Arg)9
T13976
Synonym: Peptide R9,Nona-L-arginine
Target: Others
Colivelin TFA
T64672
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T2919 Sesamin Fagarol,Fsesamin Others
Sesamin (Fsesamin) is a lignan extracted from Sesamum indicum L.
T0683 Mevastatin Compactin,ML236B Apoptosis , Antibacterial , Antibiotic , HMG-CoA Reductase , Autophagy , Lipid
Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials.
T4024 Norharmane 2-Azacarbazole,2,9-Diazafluorene,β-Carboline DNA , Endogenous Metabolite , Monoamine Oxidase
Norharmane (β-Carboline) is a natural β-carboline first isolated from plants of the Zygophyllaceae family.
T0883 Tramiprosate Homotaurine,3-Amino-1-propanesulfonic acid,Alzhemed Beta Amyloid , GABA Receptor
Tramiprosate (Alzhemed) is an orally active, blood-brain-barrier-crossing, naturally occurring amino acid found in a variety of red seaweeds that binds soluble Aβ and maintains it in a non-protofibrillar form.It is a GAB...
T2163 Dihydrocapsaicin CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide Others , TRP/TRPV Channel
Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an...
T2961 Notoginsenoside R1 Sanqi glucoside R1,Sanchinoside R1 Apoptosis , ERK , Beta Amyloid
Notoginsenoside R1 (Sanchinoside R1) has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.
T2879 Fisetin TNF , Sirtuin , PPAR
Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidant, anticancer, neuroprotection effects.
T6S1587 Notoginsenoside R2 20(S)-Notoginsenoside R2,Ginsenoside Ng-R2 Others , Nrf2
Notoginsenoside R2 (20(S)-Notoginsenoside R2) has neuroprotection against 6-OHDA-induced neurotoxicity, is associated with Notoginsenoside R2-mediated P90RSK and Nrf2 activation through MEK1/2-ERK1/2 pathways.
T6S0721 Orientin Lutexin,Luteolin-8-glucoside Others
1. Orientin (Luteolin-8-glucoside) may be regarded as a candidate therapeutic agent for treatment of vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway. 2. Orientin protects vascular barrier int...
T2808 Bilobalide (-)-Bilobalide Apoptosis , Endogenous Metabolite , Autophagy
Bilobalide ((-)-Bilobalide), a bioactive from Gingko Biloba, is active on hypoxia-induced alterations.
TN5639 Rocaglaol Ferrugin,Aglaiastatin A
Rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its G2/M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylatio...

Natural Products

Sesamin
T2919
Synonym: Fagarol,Fsesamin
Target: Others
Mevastatin
T0683
Synonym: Compactin,ML236B
Target: Apoptosis, Antibacterial, Antibiotic, HMG-CoA Reductase, Autophagy, Lipid
Norharmane
T4024
Synonym: 2-Azacarbazole,2,9-Diazafluorene,β-Carboline
Target: DNA, Endogenous Metabolite, Monoamine Oxidase
Tramiprosate
T0883
Synonym: Homotaurine,3-Amino-1-propanesulfonic acid,Alzhemed
Target: Beta Amyloid, GABA Receptor
Dihydrocapsaicin
T2163
Synonym: CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide
Target: Others, TRP/TRPV Channel
Notoginsenoside R1
T2961
Synonym: Sanqi glucoside R1,Sanchinoside R1
Target: Apoptosis, ERK, Beta Amyloid
Fisetin
T2879
Synonym:
Target: TNF, Sirtuin, PPAR
Notoginsenoside R2
T6S1587
Synonym: 20(S)-Notoginsenoside R2,Ginsenoside Ng-R2
Target: Others, Nrf2
Orientin
T6S0721
Synonym: Lutexin,Luteolin-8-glucoside
Target: Others
Bilobalide
T2808
Synonym: (-)-Bilobalide
Target: Apoptosis, Endogenous Metabolite, Autophagy
Rocaglaol
TN5639
Synonym: Ferrugin,Aglaiastatin A
Target:

Recombinant Proteins

Species：
Human (3)
Mouse (3)
Expression System：
Baculovirus-Insect Cells (2)
HEK293 (2)
E. coli (1)
E.coli (1)
Tag：
His (2)
His,GST (2)
N-terminal 6xHis-SUMO-tagged (1)
Tag Free (1)
Cat No. Product Name Species Expression System
TMPY-04384 Src Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C...
TMPJ-01469 NGF Protein, Human, Recombinant (E. colli) Mouse E.coli
NGF is the first member discovered in the Neurotrophin family, which includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These proteins belong to the cysteine-knot family ...
TMPH-01761 Neuroglobin Protein, Human, Recombinant (His & SUMO) Human E. coli
Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhi...
TMPY-04434 Src Protein, Mouse, Recombinant (His & GST) Mouse Baculovirus-Insect Cells
Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C...
TMPY-00719 CNDP1 Protein, Human, Recombinant (His) Human HEK293
CNDP1, also known as carnosine dipeptidase 1, glutamate carboxypeptidase-like protein 2 (CPGL-2) or carnosinase 1 (CN1), is a member of the M20 metalloprotease family. The CNDP1 gene contains trinucleotide (CTG) repeat l...
TMPY-02733 CNDP1 Protein, Mouse, Recombinant (His) Mouse HEK293
CNDP1, also known as carnosine dipeptidase 1, glutamate carboxypeptidase-like protein 2 (CPGL-2) or carnosinase 1 (CN1), is a member of the M20 metalloprotease family. The CNDP1 gene contains trinucleotide (CTG) repeat l...
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