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Search Result

Search Results for " p2xrs "

Targets

P2X Receptor

27

Compounds

1

Natural Products

Cat No. Product Name Synonyms Targets
T22518 5-BDBD P2X Receptor
5-BDBD is a potent and selective P2X4 receptor antagonist. 5-BDBD inhibits rP2X4R-mediated currents with an IC50 of 0.75 μM. 5-BDBD completely blocked the basal and acute hyperalgesia induced by NTG.
T10207 A 438079 P2X Receptor
A 438079 is a potent, and selective antagonist of P2X7 receptor (pIC50: 6.9).
T3690 A-740003 A 740003 P2X Receptor
A-740003 (A 740003) is an effective and specific P2X7 receptor antagonist (IC50: 18/40 nM, for rat/human). It can reduce nociception in animal models of persistent neuropathic and inflammatory pain, and also reduce neuro...
T3639 A-804598 A 804598 P2X Receptor
A-804598 is a competitive and selective P2X7 receptor antagonist (IC50: 10 nM, rat; 9 nM, mouse; 11 nM, human).
T5513 RO-3 P2X Receptor
RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor
T8946 Indophagolin P2X Receptor , 5-HT Receptor , Autophagy
Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively.
T14385 AZD9056 hydrochloride P2X Receptor
AZD9056 hydrochloride is a P2X7 inhibitor，Which plays a significant role in pain-causing diseases and inflammation.
T9519 Eliapixant BAY 1817080 P2X Receptor
Eliapixant (BAY 1817080) (BAY 1817080) is a potent and selective P2X3 receptor antagonist, with an IC50 of 8 nM. Eliapixant can be used for the research of refractory chronic cough.
T2087 AF-353 Ro-4 P2X Receptor
AF-353 (Ro-4), an effective and orally bioavailable antagonist of the P2X3/P2X2/3 receptor, inhibits human and rat P2X3 (pIC50= 8.0).
T40045 Sivopixant S-600918,Sivopixant P2X Receptor
Sivopixant (S-600918) (S-600918) is a potent and selective antagonist of P2X3 receptor (P2X3 IC 50 =4.2 nM; P2X2/3 IC 50 =1100 nM). Sivopixant shows strong analgesic effect .
T12568 PSB-12062 N-(p-Methylphenylsulfonyl)phenoxazine P2X Receptor
PSB-12062 (N-(p-Methylphenylsulfonyl)phenoxazine) is a potent and selective antagonist of P2X4(IC50 of 1.38 μM for human P2X4).
T4298 JNJ-47965567 JNJ-479655 P2X Receptor
JNJ-47965567 (JNJ-479655) is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for human and rat P2X7, respectively).
T14920 CE-224535 PF-04905428 P2X Receptor
CE-224535 (PF-04905428) is a selective antagonist of P2X7 receptor. CE-224535 can be used in disease-modifying antirheumatic studies.
TQ0002 A-317491 ABT 202 P2X Receptor
A-317491 (ABT 202) is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors.
T9786 Lu AF27139 P2X Receptor
Lu AF27139 is an effective and selective antagonist of P2X7 receptor (IC50s of 12 and 2.4 nM for human and rat, Kis of 22, 54, and 13 nM for mouse, human, and rat, respectively). Lu AF27139 can be used in CNS diseases st...
T2694 KN-62 CaMK , P2X Receptor , Autophagy
KN-62 is a potent and specific Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.
T14366 AZ10606120 dihydrochloride P2X Receptor
AZ10606120 dihydrochloride is a selectable, potent, high-affinity receptor antagonist with K D values of 1.4 and 19 nM at human and rat P2X 7 receptors, respectively. AZ10606120 dihydrochloride inhibits tumor growth and ...
T10466 BAY-1797 P2X Receptor
BAY-1797 is an orally active and selective P2X4 antagonist (IC50: 211 nM against human P2X4) with anti-nociceptive and anti-inflammatory effects. BAY-1797 displays no or very weak activity on the other P2X ion channels.
T14844 BX430 P2X Receptor , Calcium Channel
BX430 is used for chronic pain and cardiovascular disease and it is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC50 of 0.54 μM. BX430 has species specificity.
T9833 Opiranserin hydrochloride P2X Receptor , GlyT , 5-HT Receptor
Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. It shows antagonistic activity on rP2X3 (IC50...
T7805 GW791343 dihydrochloride GW791343 (HCl) P2X Receptor
GW791343 dihydrochloride (GW791343 (HCl)) is a P2X7 allosteric modulator.
T2673 A 438079 hydrochloride A 438079 (hydrochloride),A-438079 hydrochloride,A-438079 HCl P2X Receptor
A 438079 hydrochloride (A-438079 HCl) is a potent and selective P2X7 receptor antagonist with pIC50 of 6.9.
T5099 Gefapixant RO 4926219,AF219,MK-7264 P2X Receptor
Gefapixant (AF219) is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors.
T8333 Aurintricarboxylic acid ATA,NSC-4056,NSC4056,NSC 4056 Apoptosis , P2X Receptor , Influenza Virus , Topoisomerase
Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme.
T16399 Opiranserin P2X Receptor , GlyT , 5-HT Receptor
Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is a dual antagonist of glycine transporter type 2 (GlyT2) an...
T6526 GW791343 trihydrochloride GW791343 3HCl P2X Receptor
GW791343 trihydrochloride (GW791343 3HCl) is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7.
T16564 PPADS tetrasodium P2X Receptor , Na+/Ca2+ Exchanger
PPADS tetrasodiuma is a potent P2X receptor antagonist and inhibitor of the inverse mode of Na/Ca²⁺ exchange in guinea pig airway smooth muscle and is neuroprotective against glutamate/NMDA toxicity.PPADS tetrasodiuma in...

Compounds

5-BDBD
T22518
Synonym:
Target: P2X Receptor
A 438079
T10207
Synonym:
Target: P2X Receptor
A-740003
T3690
Synonym: A 740003
Target: P2X Receptor
A-804598
T3639
Synonym: A 804598
Target: P2X Receptor
RO-3
T5513
Synonym:
Target: P2X Receptor
Indophagolin
T8946
Synonym:
Target: P2X Receptor, 5-HT Receptor, Autophagy
AZD9056 hydrochloride
T14385
Synonym:
Target: P2X Receptor
Eliapixant
T9519
Synonym: BAY 1817080
Target: P2X Receptor
AF-353
T2087
Synonym: Ro-4
Target: P2X Receptor
Sivopixant
T40045
Synonym: S-600918,Sivopixant
Target: P2X Receptor
PSB-12062
T12568
Synonym: N-(p-Methylphenylsulfonyl)phenoxazine
Target: P2X Receptor
JNJ-47965567
T4298
Synonym: JNJ-479655
Target: P2X Receptor
CE-224535
T14920
Synonym: PF-04905428
Target: P2X Receptor
A-317491
TQ0002
Synonym: ABT 202
Target: P2X Receptor
Lu AF27139
T9786
Synonym:
Target: P2X Receptor
KN-62
T2694
Synonym:
Target: CaMK, P2X Receptor, Autophagy
AZ10606120 dihydrochloride
T14366
Synonym:
Target: P2X Receptor
BAY-1797
T10466
Synonym:
Target: P2X Receptor
BX430
T14844
Synonym:
Target: P2X Receptor, Calcium Channel
Opiranserin hydrochloride
T9833
Synonym:
Target: P2X Receptor, GlyT, 5-HT Receptor
GW791343 dihydrochloride
T7805
Synonym: GW791343 (HCl)
Target: P2X Receptor
A 438079 hydrochloride
T2673
Synonym: A 438079 (hydrochloride),A-438079 hydrochloride,A-438079 HCl
Target: P2X Receptor
Gefapixant
T5099
Synonym: RO 4926219,AF219,MK-7264
Target: P2X Receptor
Aurintricarboxylic acid
T8333
Synonym: ATA,NSC-4056,NSC4056,NSC 4056
Target: Apoptosis, P2X Receptor, Influenza Virus, Topoisomerase
Opiranserin
T16399
Synonym:
Target: P2X Receptor, GlyT, 5-HT Receptor
GW791343 trihydrochloride
T6526
Synonym: GW791343 3HCl
Target: P2X Receptor
PPADS tetrasodium
T16564
Synonym:
Target: P2X Receptor, Na+/Ca2+ Exchanger
Cat No. Product Name Synonyms Targets
T4S0536 Bullatine A Apoptosis , P2X Receptor
1. Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects, may be used for the treatment of neurodegenerative diseases such as arthritis.

Natural Products

Bullatine A
T4S0536
Synonym:
Target: Apoptosis, P2X Receptor
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