mri

(R)-Monlunabant ((R)-MRI-1891) serves as a CB1 receptor antagonist utilized in obesity and metabolic disease research [1].

Zevaquenabant ((S)-MRI-1867), a dual cannabinoid CB1 receptor and inducible NOS (iNOS) antagonist, is orally bioavailable and peripherally restricted. It effectively mitigates obesity-induced chronic kidney disease (CKD).

Monlunabant ((S)-MRI-1891), a solid dispersion compound, functions as an inhibitor of the cannabinoid CB1 receptor [1].

AMRI-59 is a potent inhibitor of PrxI with anti-tumor activity.

(Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a potent and selective antagonist of the cannabinoid receptor type 1 (CB1R) and inducible nitric oxide synthase (iNOS), exhibiting a binding affinity (Ki) of 5.7 nM specifically for CB1R. Due to its characteristics, (Rac)-Zevaquenabant holds promise as an investigative tool in liver fibrosis research.

Emricasan (IDN-6556) is a pan-caspase inhibitor with irreversible properties. Emricasan has anti-inflammatory and anti-apoptotic activity and can be used in the treatment of infections and liver failure, etc. Emricasan also inhibits Zika virus infections.

Simlukafusp alfa (Simridarlimab) is a humanized immunoglobulin antibody that targets the CD274/PD-L1 and CD47 pathways.[1]

EOB-DTPA is a biochemical reagent that can be synthesized from other compounds and is commonly used in MRI.

Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.

α-Conotoxin MrIC is a biased agonist selective for the α7 nicotinic acetylcholine receptor (nAChR), with activation contingent upon the presence of type II positive allosteric modulators, such as PNU120596. It is utilized to investigate neurological disorders and delineate the pharmacological characteristics of the α7nAChR [1].

MMRi64 is a specific inhibitor of Mdm2-MdmX E3 ligase activity.MMRi64 potently induces p53 accumulation and apoptosis in the p53 pathway in leukemia/lymphoma cells, disrupts Mdm2-MdmX interactions, and downregulates Mdm2 and MdmX in leukemia cells.MMRi64 MMRi64 can be used in cancer research.

Inamrinone lactate is a positive inotropic cardiotonic with vasodilator properties, phosphodiesterase inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.

MRIA9, an ATP-competitive inhibitor targeting pan Salt-Inducible Kinases (SIK) and PAK2/3, demonstrates IC50 values of 516 nM, 180 nM, and 127 nM for SIK1, SIK2, and SIK3, respectively [1].

MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol), a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12.

Gadobutrol is a medicinal product used in diagnostic magnetic resonance imaging (MRI) in adults and children. It provides contrast enhancement during cranial, spinal, breast, or other investigations. In the central nervous system, Gadobutrol works by high

Gadopentetate dimeglumine is used in magnetic resonance imaging (MRI) to allow blood vessels, organs and other non-bone tissues to be visualized more clearly.Gadopentetate dimeglumine induces atrophy of spermatogonia.

Mangafodipir trisodium can enhance contrast in magnetic resonance imaging (MRI) of the liver, is a contrast agent delivered intravenously.

Gadodiamide is an MRI contrast agent, used in MR imaging procedures to assist in the visualization of blood vessels.

Super-chelating agent& MRI contrast agent

Mn(III) protoporphyrin IX chloride is a metalloporphyrin that, at a concentration of 10 µM, promotes mRNA expression of δ-aminolevulinate synthase and heme oxygenase (HO) in chick embryo liver cells, enzymes crucial for the initial steps in heme biosynthesis and breakdown, respectively. Additionally, this compound has been incorporated into nanobialys for magnetic resonance imaging (MRI) of fibrin clots in vitro and utilized in the creation of Mn(III) protoporphyrin IX-6(7)-glycyl-glycyl-L-histidine methyl ester (MnGGH), a metalloporphyrin conjugate exhibiting microperoxidase activity.

Gadopentetic acid (gadolinium complex) (Gd-DTPA) is an paramagnetic contrast agent commonly implemented by a bolus intravenous injection (i.v.) in Dynamic contrast-enhanced MRI (DCE-MRI) studies.

Gadoxetate Disodium is used to evaluate focal liver lesions, such as hepatocellular carcinoma or liver metastasis on T1-weighted imaging. It is a contrast agent in magnetic resonance imaging (MRI) of the hepatobiliary system. It accumulates in normal, fun

Gadobutrol is a nonionic, paramagnetic contrast agent developed for tissue contrast enhancement in magnetic resonance imaging (MRI)

Sprodiamide is a magnetic susceptibility-based MRI contrast agent.

Ethylene thiourea-d4 is a deuterated compound of Ethylene thiourea. Ethylene thiourea has a CAS number of 96-45-7. Ethylene thiourea is a pesticide used in fruit and vegetable production. Ethylene thiourea is also used as a novel contrast agent for MRI studies based on proton chemical exchange-dependent saturation transfer.

Super-chelating agent & MRI contrast agent

Gadoteridol (Gd-HP-DO3A) is a gadolinium-based MRI contrast agent that can be used for central nervous system imaging.

P 569 is an MRI contrast medium.

Gadodiamide Hydrate (Omniscan), a nonionic Gd3+ chelate, is frequently injected i.v. into magnetic resonance imaging (MRI) to enhance contrast.

DOTA-tri(t-butyl ester) is a versatile compound employed for the synthesis of third-generation (G3) nanoglobular magnetic resonance imaging (MRI) contrast agents. These contrast agents find application in the fields of MR angiography and tumor angiogenesis imaging.

Ethylene thiourea (NCIC03372) is a pesticide used in fruit and vegetable production. Ethylene thiourea is also used as a novel contrast agent for MRI studies based on proton chemical exchange-dependent saturation transfer.

Cyclen (1,4,7,10-tetraazacyclododecane) is a macrocycle capable of selectively binding cations that used as a ligand in chemistry for instance with chemicals used in MRI contrast agents.