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Aryl Hydrocarbon Receptor

The aryl hydrocarbon receptor (also known as AhR, AHR, ahr, ahR, or dioxin receptor) is a protein that in humans is encoded by the AHR gene. The aryl hydrocarbon receptor is a transcription factor that regulates gene expression. It was originally thought to function primarily as a sensor of xenobiotic chemicals and also as the regulator of enzymes such as cytochrome P450s that metabolize these chemicals. The most notable of these xenobiotic chemicals are aromatic (aryl) hydrocarbons from which the receptor derives its name. More recently, it has been discovered that AhR is activated (or deactivated) by a number of endogenous indole derivatives such as kynurenine. In addition to regulating metabolism enzymes, the AhR has roles in regulating immunity, stem cell maintenance, and cellular differentiation.
Cat No. product name
T21966 MeBIO MeBIO 是一种芳烃受体激动剂,对 GSK-3 和 CDK1/CyclinB 的 IC50 分别为 44 和 55 μM。 MeBIO 不影响 GSK-3β。
T4928 L-Kynurenine L-Kynurenine is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppress...
T2448 CH-223191 CH-223191 is a potent and specific antagonist for aryl hydrocarbon receptor (AhR).
T6795 Carbidopa Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor (IC50: 29±2 μM). It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA.
T1831 StemRegenin 1 StemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor.
T4644 Tapinarof Tapinarof is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease.
T2623 PD98059 PD98059 is a non-ATP competitive MEK inhibitor (IC50: 2/50 μM for MEK1/MEK2).
T5281 Skatole Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.
T1960 YL-109 YL-109, a novel anticancer agent, can inhibit breast Y cell growth and invasiveness in vitro and in vivo.
T10270 BAY 2416964 BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1 (example 192, IC50: 341 nM). It has the...
T4608 PDM2 PDM 2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.
T2707 Pifithrin-α hydrobromide Pifithrin-α is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.
TN1451 Brevifolincarboxylic acid Brevifolincarboxylic acid is a natural product isolated from Polygonum capitatum, it has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarb...
T0878 Diosmin Diosmin is a bioflavonoid that strengthens vascular walls.
T13276 VAF347 VAF347 is a cell-permeable and highly affinity agonist of the aryl hydrocarbon receptor (AhR) with anti-inflammatory effects.
T2148 Carbidopa monohydrate Carbidopa Hydrate is an inhibitor of DOPA decarboxylase, preventing the conversion of levodopa to dopamine.
T5622 BAY-218 AHR antagonist 1 is an aryl hydrocarbon receptor (AHR) antagonist , has an IC50 of 39.9 nM in human cell line.
T4607 CAY 10465 CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).
T2947 Indole-3-carbinol Indole-3-carbinol, a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
T0640 Benzyl butyl phthalate Butyl benzyl phthalate is used as a plasticizer for PVC.
T7202 ITE ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) (Ki : 3 nM), has immunosuppressive activity.
T8980 SGA360 SGA360 is a selective aryl hydrocarbon (Ah) receptor modulator. It exhibits anti-inflammatory properties.
TQ0257 FICZ FICZ is a potent aryl agonist for the hydrocarbon receptor (AhR, Kd: 70 pM).
T15410 GNF351 GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal to...
MeBIO
T21966
MeBIO 是一种芳烃受体激动剂,对 GSK-3 和 CDK1/CyclinB 的 IC50 分别为 44 和 55 μM。 MeBIO 不影响 GSK-3β。
L-Kynurenine
T4928
L-Kynurenine is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppress...
CH-223191
T2448
CH-223191 is a potent and specific antagonist for aryl hydrocarbon receptor (AhR).
Carbidopa
T6795
Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor (IC50: 29±2 μM). It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA...
StemRegenin 1
T1831
StemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor.
Tapinarof
T4644
Tapinarof is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease.
PD98059
T2623
PD98059 is a non-ATP competitive MEK inhibitor (IC50: 2/50 μM for MEK1/MEK2).
Skatole
T5281
Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.
YL-109
T1960
YL-109, a novel anticancer agent, can inhibit breast Y cell growth and invasiveness in vitro and in vivo.
BAY 2416964
T10270
BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1 (example 192, IC50: 341 nM). It has the...
PDM2
T4608
PDM 2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.
Pifithrin-α hydrobromide
T2707
Pifithrin-α is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.
Brevifolincarboxylic acid
TN1451
Brevifolincarboxylic acid is a natural product isolated from Polygonum capitatum, it has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarb...
Diosmin
T0878
Diosmin is a bioflavonoid that strengthens vascular walls.
VAF347
T13276
VAF347 is a cell-permeable and highly affinity agonist of the aryl hydrocarbon receptor (AhR) with anti-inflammatory effects.
Carbidopa monohydrate
T2148
Carbidopa Hydrate is an inhibitor of DOPA decarboxylase, preventing the conversion of levodopa to dopamine.
BAY-218
T5622
AHR antagonist 1 is an aryl hydrocarbon receptor (AHR) antagonist , has an IC50 of 39.9 nM in human cell line.
CAY 10465
T4607
CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).
Indole-3-carbinol
T2947
Indole-3-carbinol, a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
Benzyl butyl phthalate
T0640
Butyl benzyl phthalate is used as a plasticizer for PVC.
ITE
T7202
ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) (Ki : 3 nM), has immunosuppressive activity.
SGA360
T8980
SGA360 is a selective aryl hydrocarbon (Ah) receptor modulator. It exhibits anti-inflammatory properties.
FICZ
TQ0257
FICZ is a potent aryl agonist for the hydrocarbon receptor (AhR, Kd: 70 pM).
GNF351
T15410
GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal to...