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Membrane transporter/Ion channel CFTR

CFTR

CFTR, a 12TM, ABC transporter-type protein, is a cAMP-regulated epithelial cell membrane Cl- channel involved in normal fluid transport across various epithelia.
Cat No. product name
T0429 Glucosamine Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to r...
T1805 Ataluren Ataluren is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne M...
T1874 PPQ-102 PPQ-102, an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).
T2263 VX661 VX-661 is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.
T2355 CFTRinh-172 CFTRinh-172 is a voltage-independent, selective CFTR inhibitor.
T2451 GlyH-101 GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.
T2486 IOWH-032 IOWH032, a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.
T2588 IvacaftorHOT Ivacaftor (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.
T2595 LumacaftorHOT VX-809 is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM).
T3135 KM11060 KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasm...
T7083 GLPG1837 GLPG1837 is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
T5312 FDL169 FDL-169 is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients who carry the F50...
T14935 Elexacaftor Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and also facilitates the processing and trafficking of CFTR to increase...
T16516 PG01 PG01 is effective on ΔF508 (Ka of 0.3 μM). PG01 is also an effective CFTR Cl- channel potentiator. PG01 increases ΔF508-CFTR Cl- current after adding Forskol...
T16681 PTI-428 PTI-428 is a specific amplifier of the cystic fibrosis transmembrane conductance regulator.
Glucosamine
T0429CAS 3416-24-8
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to r...
Ataluren
T1805CAS 775304-57-9
Ataluren is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne M...
PPQ-102
T1874CAS 931706-15-9
PPQ-102, an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).
VX661
T2263CAS 1152311-62-0
VX-661 is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.
CFTRinh-172
T2355CAS 307510-92-5
CFTRinh-172 is a voltage-independent, selective CFTR inhibitor.
GlyH-101
T2451CAS 328541-79-3
GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.
IOWH-032
T2486CAS 1191252-49-9
IOWH032, a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.
Ivacaftor HOT
T2588CAS 873054-44-5
Ivacaftor (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.
Lumacaftor HOT
T2595CAS 936727-05-8
VX-809 is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM).
KM11060
T3135CAS 774549-97-2
KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasm...
GLPG1837
T7083CAS 1654725-02-6
GLPG1837 is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
FDL169
T5312CAS 1628416-28-3
FDL-169 is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients who carry the F50...
Elexacaftor
T14935CAS 2216712-66-0
Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and also facilitates the processing and trafficking of CFTR to increase...
PG01
T16516CAS 853138-65-5
PG01 is effective on ΔF508 (Ka of 0.3 μM). PG01 is also an effective CFTR Cl- channel potentiator. PG01 increases ΔF508-CFTR Cl- current after adding Forskol...
PTI-428
T16681CAS 1953130-87-4
PTI-428 is a specific amplifier of the cystic fibrosis transmembrane conductance regulator.