T29114 |
VRT-532
|
38214-71-0
|
98%
|
|
VRT-532 is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects. Arylsulfatase B (ARSB), which is necess...
|
T16516 |
PG01
|
853138-65-5
|
98%
|
|
PG01 is effective on ΔF508 (Ka of 0.3 μM). PG01 is also an effective CFTR Cl- channel potentiator. PG01 increases ΔF508-CFTR Cl- current after adding Forskolin. ...
|
T10591 |
BPO-27 racemate
|
1314873-02-3
|
98%
|
|
BPO-27 racemate is an effective inhibitor of CFTR (IC50: 8 nM).
|
T20341 |
DNDS
|
3709-43-1
|
98%
|
|
DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).
|
T2451 |
GlyH-101
|
328541-79-3
|
98.71%
|
|
GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.
|
T14935 |
Elexacaftor
|
2216712-66-0
|
98.87%
|
|
Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increa...
|
T2588 |
Ivacaftor
|
873054-44-5
|
99%
|
|
Ivacaftor (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.
|
T2263 |
Tezacaftor
|
1152311-62-0
|
99%
|
|
VX-661 is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.
|
T2486 |
IOWH-032
|
1191252-49-9
|
99%
|
|
IOWH032, a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.
|
T1874 |
PPQ-102
|
931706-15-9
|
99.17%
|
|
PPQ-102, an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).
|
T7083 |
GLPG1837
|
1654725-02-6
|
99.64%
|
|
GLPG1837 is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
|
T3135 |
KM11060
|
774549-97-2
|
99.67%
|
|
KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma ...
|
T0429 |
Glucosamine
|
3416-24-8
|
99.72%
|
|
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
|
T2595 |
Lumacaftor
|
936727-05-8
|
99.72%
|
|
VX-809 is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM).
|
T1634 |
Glibenclamide
|
10238-21-8
|
99.77%
|
|
Glyburide is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
|
T1805 |
Ataluren
|
775304-57-9
|
99.84%
|
|
Ataluren is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Mu...
|
T5312 |
CFTR corrector 2
|
1628416-28-3
|
99.88%
|
|
FDL-169 is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients who carry the F508d...
|
T2355 |
CFTR(inh)-172
|
307510-92-5
|
99.94%
|
|
CFTRinh-172 is a voltage-independent, selective CFTR inhibitor.
|
T9499 |
Icenticaftor
|
1334546-77-8
|
98%
|
|
Icenticaftor is an orally active potentiator of CFTR channel.
|
T16681 |
Nesolicaftor
|
1953130-87-4
|
98%
|
|
PTI-428 is a specific amplifier of the cystic fibrosis transmembrane conductance regulator.
|