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CFTR

CFTR, a 12TM, ABC transporter-type protein, is a cAMP-regulated epithelial cell membrane Cl- channel involved in normal fluid transport across various epithelia.
Cat. No. Product name CAS No. Purity Chemical Structure
T29114 VRT-532 38214-71-0 98%
VRT-532 is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects. Arylsulfatase B (ARSB), which is necess...
T16516 PG01 853138-65-5 98%
PG01 is effective on ΔF508 (Ka of 0.3 μM). PG01 is also an effective CFTR Cl- channel potentiator. PG01 increases ΔF508-CFTR Cl- current after adding Forskolin. ...
T10591 BPO-27 racemate 1314873-02-3 98%
BPO-27 racemate is an effective inhibitor of CFTR (IC50: 8 nM).
T20341 DNDS 3709-43-1 98%
DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).
T2451 GlyH-101 328541-79-3 98.71%
GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.
T14935 Elexacaftor 2216712-66-0 98.87%
Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increa...
T2588 Ivacaftor 873054-44-5 99%
Ivacaftor (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.
T2263 Tezacaftor 1152311-62-0 99%
VX-661 is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.
T2486 IOWH-032 1191252-49-9 99%
IOWH032, a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.
T1874 PPQ-102 931706-15-9 99.17%
PPQ-102, an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).
T7083 GLPG1837 1654725-02-6 99.64%
GLPG1837 is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
T3135 KM11060 774549-97-2 99.67%
KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma ...
T0429 Glucosamine 3416-24-8 99.72%
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
T2595 Lumacaftor 936727-05-8 99.72%
VX-809 is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM).
T1634 Glibenclamide 10238-21-8 99.77%
Glyburide is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T1805 Ataluren 775304-57-9 99.84%
Ataluren is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Mu...
T5312 CFTR corrector 2 1628416-28-3 99.88%
FDL-169 is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients who carry the F508d...
T2355 CFTR(inh)-172 307510-92-5 99.94%
CFTRinh-172 is a voltage-independent, selective CFTR inhibitor.
T9499 Icenticaftor 1334546-77-8 98%
Icenticaftor is an orally active potentiator of CFTR channel.
T16681 Nesolicaftor 1953130-87-4 98%
PTI-428 is a specific amplifier of the cystic fibrosis transmembrane conductance regulator.
VRT-532
T29114
VRT-532 is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects. Arylsulfatase B (ARSB), which is necess...
PG01
T16516
PG01 is effective on ΔF508 (Ka of 0.3 μM). PG01 is also an effective CFTR Cl- channel potentiator. PG01 increases ΔF508-CFTR Cl- current after adding Forskolin. ...
BPO-27 racemate
T10591
BPO-27 racemate is an effective inhibitor of CFTR (IC50: 8 nM).
DNDS
T20341
DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).
GlyH-101
T2451
GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.
Elexacaftor
T14935
Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increa...
Ivacaftor
T2588
Ivacaftor (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.
Tezacaftor
T2263
VX-661 is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.
IOWH-032
T2486
IOWH032, a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.
PPQ-102
T1874
PPQ-102, an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).
GLPG1837
T7083
GLPG1837 is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
KM11060
T3135
KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma ...
Glucosamine
T0429
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
Lumacaftor
T2595
VX-809 is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM).
Glibenclamide
T1634
Glyburide is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
Ataluren
T1805
Ataluren is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Mu...
CFTR corrector 2
T5312
FDL-169 is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients who carry the F508d...
CFTR(inh)-172
T2355
CFTRinh-172 is a voltage-independent, selective CFTR inhibitor.
Icenticaftor
T9499
Icenticaftor is an orally active potentiator of CFTR channel.
Nesolicaftor
T16681
PTI-428 is a specific amplifier of the cystic fibrosis transmembrane conductance regulator.