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CFTR

CFTR, a 12TM, ABC transporter-type protein, is a cAMP-regulated epithelial cell membrane Cl- channel involved in normal fluid transport across various epithelia.
Cat. No. Product name CAS No. Purity Chemical Structure
T29114 VRT-532 38214-71-0 98%
VRT-532 is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects. Arylsulfatase B (ARSB), which is necess...
T30293 Bamocaftor 2204245-48-5 98%
Bamocaftor is a CFTR channel (DeltaF508-CFTR mutation) corrector for CF transmembrane conductance regulators designed to restore F508del-CFTR protein function. C...
T63806 CFTR corrector 8 1918142-35-4 98%
CFTR corrector 8 is a highly effective modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). This compound is specifically designed for ut...
T10776 CFTR corrector 4 1918142-34-3 98%
CFTR corrector 4 is a potent and orally available transmembrane conductance regulator (CFTR) for cystic fibrosis and is a potent (R,R) type active enantiomer. C...
T2355 CFTR(inh)-172 307510-92-5 98%
CFTRinh-172 is a voltage-independent, selective CFTR inhibitor.
T20341 DNDS 3709-43-1 98%
DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).
T5312 CFTR corrector 2 1628416-28-3 98%
FDL-169 is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients who carry the F508d...
T16516 PG01 853138-65-5 98%
PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.22...
T1634 Glibenclamide 10238-21-8 98%
Glyburide is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T7083 GLPG1837 1654725-02-6 98%
GLPG1837 is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
T0429 Glucosamine 3416-24-8 98%
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
T3135 KM11060 774549-97-2 98%
KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma ...
T1805 Ataluren 775304-57-9 98%
Ataluren is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Mu...
T1874 PPQ-102 931706-15-9 98%
PPQ-102, an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).
T26955 Cavosonstat 1371587-51-7 98%
Cavosonstat is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor that promotes cystic fibrosis transmembrane conductance regulator (CFTR) maturat...
T2263 Tezacaftor 1152311-62-0 98%
VX-661 is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.
T16681 Nesolicaftor 1953130-87-4 98%
PTI-428 is a specific amplifier of the cystic fibrosis transmembrane conductance regulator.
T9499 Icenticaftor 1334546-77-8 98%
Icenticaftor is an orally active potentiator of CFTR channel.
T2588 Ivacaftor 873054-44-5 98%
Ivacaftor (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.
T2486 IOWH-032 1191252-49-9 98%
IOWH032, a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.
VRT-532
T29114
VRT-532 is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects. Arylsulfatase B (ARSB), which is necess...
Bamocaftor
T30293
Bamocaftor is a CFTR channel (DeltaF508-CFTR mutation) corrector for CF transmembrane conductance regulators designed to restore F508del-CFTR protein function. C...
CFTR corrector 8
T63806
CFTR corrector 8 is a highly effective modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). This compound is specifically designed for ut...
CFTR corrector 4
T10776
CFTR corrector 4 is a potent and orally available transmembrane conductance regulator (CFTR) for cystic fibrosis and is a potent (R,R) type active enantiomer. C...
CFTR(inh)-172
T2355
CFTRinh-172 is a voltage-independent, selective CFTR inhibitor.
DNDS
T20341
DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).
CFTR corrector 2
T5312
FDL-169 is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients who carry the F508d...
PG01
T16516
PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.22...
Glibenclamide
T1634
Glyburide is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
GLPG1837
T7083
GLPG1837 is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
Glucosamine
T0429
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
KM11060
T3135
KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma ...
Ataluren
T1805
Ataluren is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Mu...
PPQ-102
T1874
PPQ-102, an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).
Cavosonstat
T26955
Cavosonstat is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor that promotes cystic fibrosis transmembrane conductance regulator (CFTR) maturat...
Tezacaftor
T2263
VX-661 is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.
Nesolicaftor
T16681
PTI-428 is a specific amplifier of the cystic fibrosis transmembrane conductance regulator.
Icenticaftor
T9499
Icenticaftor is an orally active potentiator of CFTR channel.
Ivacaftor
T2588
Ivacaftor (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.
IOWH-032
T2486
IOWH032, a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.
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