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CFTR

CFTR, a 12TM, ABC transporter-type protein, is a cAMP-regulated epithelial cell membrane Cl- channel involved in normal fluid transport across various epithelia.
Cat No. product name
T2595 Lumacaftor VX-809 is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM).
T16681 Nesolicaftor PTI-428 is a specific amplifier of the cystic fibrosis transmembrane conductance regulator.
T2486 IOWH-032 IOWH032, a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.
T2451 GlyH-101 GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.
T2263 Tezacaftor VX-661 is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.
T20341 DNDS DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).
T2588 Ivacaftor Ivacaftor (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.
T3135 KM11060 KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma ...
T2355 CFTR(inh)-172 CFTRinh-172 is a voltage-independent, selective CFTR inhibitor.
T1805 Ataluren Ataluren is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Mu...
T9499 Icenticaftor Icenticaftor is an orally active potentiator of CFTR channel.
T0429 Glucosamine Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
T1874 PPQ-102 PPQ-102, an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).
T1634 Glibenclamide Glyburide is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T14935 Elexacaftor Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increa...
T5312 CFTR corrector 2 FDL-169 is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients who carry the F508d...
T7083 GLPG1837 GLPG1837 is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
T16516 PG01 PG01 is effective on ΔF508 (Ka of 0.3 μM). PG01 is also an effective CFTR Cl- channel potentiator. PG01 increases ΔF508-CFTR Cl- current after adding Forskolin. ...
Lumacaftor
T2595
VX-809 is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM).
Nesolicaftor
T16681
PTI-428 is a specific amplifier of the cystic fibrosis transmembrane conductance regulator.
IOWH-032
T2486
IOWH032, a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.
GlyH-101
T2451
GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.
Tezacaftor
T2263
VX-661 is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.
DNDS
T20341
DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).
Ivacaftor
T2588
Ivacaftor (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.
KM11060
T3135
KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma ...
CFTR(inh)-172
T2355
CFTRinh-172 is a voltage-independent, selective CFTR inhibitor.
Ataluren
T1805
Ataluren is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Mu...
Icenticaftor
T9499
Icenticaftor is an orally active potentiator of CFTR channel.
Glucosamine
T0429
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
PPQ-102
T1874
PPQ-102, an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).
Glibenclamide
T1634
Glyburide is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
Elexacaftor
T14935
Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increa...
CFTR corrector 2
T5312
FDL-169 is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients who carry the F508d...
GLPG1837
T7083
GLPG1837 is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
PG01
T16516
PG01 is effective on ΔF508 (Ka of 0.3 μM). PG01 is also an effective CFTR Cl- channel potentiator. PG01 increases ΔF508-CFTR Cl- current after adding Forskoli...