Chloride channel

Chloride channels are a superfamily of poorly understood ion channels specific for chloride. These channels may conduct many different ions, but are named for chloride because its concentration in vivo is much higher than other anions. Several families of voltage-gated channels and ligand-gated channels have been characterized in humans.

Cat. No.	Product name	CAS No.	Purity
T61051	ANO1-IN-1	407587-01-3	98%
T61051	ANO1-IN-1, a selective ANO1 channel blocker, inhibited ANO1 and ANO2 with IC50 values of 2.56 μM and 15.43 μM, respectively.ANO1-IN-1 had a significant inhibitor...
T16346	NS1652	1566-81-0	98%
T16346	NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.
T13536	Afoxolaner	1093861-60-9	98%
T13536	Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA...
T4503	Talniflumate	66898-62-2	98%
T4503	Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It poss...
T4330	CaCCinh-A01	407587-33-1	98%
T4330	CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).
T0693	Niflumic acid	4394-00-7	98%
T0693	Niflumic acid is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.
T10979	DCPIB	82749-70-0	98%
T10979	DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM,...
T0858	Flufenamic acid	530-78-9	98%
T0858	Flufenamic acid is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorder...
T4059	Selamectin	220119-17-5	98%
T4059	Selamectin is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. I...
T0051	Urethane	51-79-6	98%
T0051	Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
T22330	Fenamic acid	91-40-7	98%
T22330	Fenamic acid is a chloride channel blocker that causes renal papillary necrosis in rats. Fenamic acid serves as a parent structure for several nonsteroidal anti-...
T8960	MONNA	1572936-83-4	98%
T8960	MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.
TN1035	Irisolidone	2345-17-7	98%
TN1035	Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
T12788	R(+)-IAA-94	54197-31-8	98%
T12788	R(+)-IAA-94 is a potent indanyloxyacetic acid blocker of epithelial chloride channels. R(+)-IAA-94 inhibits Nef-sdAb19 (single-domain antibody) interaction and b...
T21615	Guanidinoethyl sulfonate	543-18-0	98%
T21615	Guanidinoethyl sulfonate is a competitive glycine receptor antagonist.
T26630	Ani9	356102-14-2	98%
T26630	Ani9 is a high selective blocker of Anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A) with an IC50 of 77 nM and can be used in studies about ANO1 and the tre...
T15192	Eact	461000-66-8	98%
T15192	Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception an...
T15233	Endovion	265646-85-3	98%
T15233	Endovion is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.
T1125	Shikonin	517-89-5	98%
T1125	Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pathw...
T36585	Isodeoxycholic Acid	566-17-6	98%
T36585	Isodeoxycholic Acid is a bile acid that is formed via epimerization of deoxycholic acid by intestinal bacteria. It has a greater critical micelle concentration t...