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Chloride channel

Chloride channels are a superfamily of poorly understood ion channels specific for chloride. These channels may conduct many different ions, but are named for chloride because its concentration in vivo is much higher than other anions. Several families of voltage-gated channels and ligand-gated channels have been characterized in humans.
Cat No. product name
T0858 Flufenamic acid Flufenamic acid is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorder...
T4811 D-Alanine Alanine is a nonessential amino acid made in the body from the conversion of the carbohydrate pyruvate or the breakdown of DNA and the dipeptides carnosine and a...
T4059 Selamectin Selamectin is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. I...
T0051 Urethane Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
T5225 Hypotaurine Hypotaurine, an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor.
T0693 Niflumic acid Niflumic acid is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.
T0019 Betaine chloride Betaine hydrochloride is an acidic form of betaine, a vitamin-like substance observed in grains and other foods; gains the amplification of DNA by decreasing the...
T1125 Shikonin Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pathw...
T22330 Fenamic acid Fenamic acid is a chloride channel blocker that causes renal papillary necrosis in rats. Fenamic acid serves as a parent structure for several nonsteroidal anti-...
T50082 Org 25543 Org 25543 is the development of an N-Acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain.
T2498 Adjudin Adjudin is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.
T21615 Guanidinoethyl sulfonate Guanidinoethyl sulfonate is a competitive glycine receptor antagonist.
T8039 Brucine sulfate heptahydrate Brucine is an alkaloid that acts as an antagonist at glycine receptors and paralyzes inhibitory neurons.
T7638 NPPB NPPB is a chloride channel blocker with IC50 of 80 nM .
T8960 MONNA MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.
TN1035 Irisolidone Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
T0954 Halothane Halothane is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adeq...
T0275 Meticrane Meticrane is a sulphonamide-derivative with thiazide-like diuretic activity.
T10979 DCPIB DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM,...
T13059 T16Ainh-A01 T16Ainh-A01 is a potent inhibitor of TMEM16A Chloride channel, inhibiting TMEM16A-mediated chloride currents (IC50 of 1 µM),and functions as a calcium-activated ...
T4503 Talniflumate Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It poss...
T4330 CaCCinh-A01 CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).
T6307 Lubiprostone Lubiprostone, an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation.
T0052L Strychnine Sulfate In smaller doses, strychnine functions as a stimulant and an athletic performance-enhancer. The most common source is from the seeds of the Strychnos nux-vomica ...
T16346 NS1652 NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.
T13536 Afoxolaner Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA...
T15233 Endovion Endovion is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.
T15192 Eact Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception an...
Flufenamic acid
T0858
Flufenamic acid is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorder...
D-Alanine
T4811
Alanine is a nonessential amino acid made in the body from the conversion of the carbohydrate pyruvate or the breakdown of DNA and the dipeptides carnosine and a...
Selamectin
T4059
Selamectin is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. I...
Urethane
T0051
Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
Hypotaurine
T5225
Hypotaurine, an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor.
Niflumic acid
T0693
Niflumic acid is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.
Betaine chloride
T0019
Betaine hydrochloride is an acidic form of betaine, a vitamin-like substance observed in grains and other foods; gains the amplification of DNA by decreasing the...
Shikonin
T1125
Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pat...
Fenamic acid
T22330
Fenamic acid is a chloride channel blocker that causes renal papillary necrosis in rats. Fenamic acid serves as a parent structure for several nonsteroidal anti-...
Org 25543
T50082
Org 25543 is the development of an N-Acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain.
Adjudin
T2498
Adjudin is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.
Guanidinoethyl sulfonate
T21615
Guanidinoethyl sulfonate is a competitive glycine receptor antagonist.
Brucine sulfate heptahydrate
T8039
Brucine is an alkaloid that acts as an antagonist at glycine receptors and paralyzes inhibitory neurons.
NPPB
T7638
NPPB is a chloride channel blocker with IC50 of 80 nM .
MONNA
T8960
MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.
Irisolidone
TN1035
Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
Halothane
T0954
Halothane is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adeq...
Meticrane
T0275
Meticrane is a sulphonamide-derivative with thiazide-like diuretic activity.
DCPIB
T10979
DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM...
T16Ainh-A01
T13059
T16Ainh-A01 is a potent inhibitor of TMEM16A Chloride channel, inhibiting TMEM16A-mediated chloride currents (IC50 of 1 µM),and functions as a calcium-activated...
Talniflumate
T4503
Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It poss...
CaCCinh-A01
T4330
CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).
Lubiprostone
T6307
Lubiprostone, an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation.
Strychnine Sulfate
T0052L
In smaller doses, strychnine functions as a stimulant and an athletic performance-enhancer. The most common source is from the seeds of the Strychnos nux-vomica ...
NS1652
T16346
NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.
Afoxolaner
T13536
Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA...
Endovion
T15233
Endovion is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.
Eact
T15192
Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception an...