Chloride channel

Chloride channels are a superfamily of poorly understood ion channels specific for chloride. These channels may conduct many different ions, but are named for chloride because its concentration in vivo is much higher than other anions. Several families of voltage-gated channels and ligand-gated channels have been characterized in humans.

Cat. No.	Product name	CAS No.	Purity
T16533	Picrotin	21416-53-5	98%
T16533	Picrotin is an inhibitor of glycine receptors. Picrotin blocks α2 GlyR, α1 GlyR, and α3 GlyR and can be used in studies about neurotransmission.
T16535	Picrotoxinin	17617-45-7	98%
T16535	Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 μM for α1β2γ2L GABAA. Picrotoxinin shows convulsant p...
T12788	R(+)-IAA-94	54197-31-8	98%
T12788	R(+)-IAA-94 is a potent indanyloxyacetic acid blocker of epithelial chloride channels. R(+)-IAA-94 inhibits Nef-sdAb19 (single-domain antibody) interaction and b...
T50082	Org 25543	363628-88-0
T50082	Org 25543 is the development of an N-Acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain.
T22330	Fenamic acid	91-40-7
T22330	Fenamic acid is a chloride channel blocker that causes renal papillary necrosis in rats. Fenamic acid serves as a parent structure for several nonsteroidal anti-...
TN1035	Irisolidone	2345-17-7
TN1035	Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
T0954	Halothane	151-67-7	100%
T0954	Halothane is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adeq...
T4059	Selamectin	220119-17-5	100%
T4059	Selamectin is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. I...
T13059	T16Ainh-A01	552309-42-9	98%
T13059	T16Ainh-A01 is a potent inhibitor of TMEM16A Chloride channel, inhibiting TMEM16A-mediated chloride currents (IC50 of 1 µM),and functions as a calcium-activated ...
T0019	Betaine chloride	590-46-5	98%
T0019	Betaine hydrochloride is an acidic form of betaine, a vitamin-like substance observed in grains and other foods; gains the amplification of DNA by decreasing the...
T2498	Adjudin	252025-52-8	98%
T2498	Adjudin is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.
T7638	NPPB	107254-86-4	98%
T7638	NPPB is a chloride channel blocker with IC50 of 80 nM .
T5225	Hypotaurine	300-84-5	98%
T5225	Hypotaurine, an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor.
T15233	Endovion	265646-85-3	98.31%
T15233	Endovion is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.
T6307	Lubiprostone	136790-76-6	98.54%
T6307	Lubiprostone, an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation.
T15192	Eact	461000-66-8	98.62%
T15192	Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception an...
T26630	Ani9	356102-14-2	98.72%
T26630	Ani9 is a high selective blocker of Anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A) with an IC50 of 77 nM and can be used in studies about ANO1 and the tre...
T0275	Meticrane	1084-65-7	98.74%
T0275	Meticrane is a sulphonamide-derivative with thiazide-like diuretic activity.
T21615	Guanidinoethyl sulfonate	543-18-0	98.9%
T21615	Guanidinoethyl sulfonate is a competitive glycine receptor antagonist.
T8960	MONNA	1572936-83-4	99.47%
T8960	MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.