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FAK

Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is the first intracellular step in the signal transduction cascade initiated by the attachment of an integrin to the extracellular matrix at points known as focal adhesions. FAK has a key role in cellular migration and motility.
Cat No. product name
T24730 Roslin 2 bromide Roslin 2 bromide 是一种 p53 再激活剂,可破坏 FAK 和 p53 的结合。 Roslin 2 bromide 具有抗癌作用。
TN1433 Batatasin III Batatasin III 通过抑制上皮间质转化和 FAK-AKT 信号来抑制癌症迁移和侵袭,并具有抗癌活性。 Batatasin III对整株生长有长期抑制作用,显示出抑制萌发活性。
T6419 BMS-536924 BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2...
T1950 PND-1186 PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).
T9545 Compound 1T-0219 (SC) Compound 1T-0219 (SC) is a blocker of AKT1-FAK interaction reducing the stimulation of FAK phosphorylation in response to extracellular pressure in human SW620 c...
T2281 GSK2256098 GSK-2256098 is a small molecule FAK kinase inhibitor.
T10285 ALK inhibitor 1 ALK inhibitor 1 is a selective ALK kinase inhibitor.
T8544 Masitinib mesylate Masitinib mesylate is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;PDGFRα/β;LynB,respectivel...
T2001 PF-573228 PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM.
T0263 Chloropyramine hydrochloride Chloropyramine hydrochloride is a histamine receptor H1 antagonist.
T3391 Corosolic acid Corosolic acid contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts anticancer activities against H...
T9576 AMP-945 AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.
T3041 ALK inhibitor 2 ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.
T3122 Fangchinoline Fangchinoline is extracted from Stephania tetrandra S. Moore.
T6936 PF-03814735 PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and...
T6997 SU6656 SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.
T5S0761 Nitidine chloride 1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721...
T2809 (R)-Fangchinoline Fangchinoline is extracted from Stephania tetrandra S. Moore.
T13564 AZ7550 AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T1918 NVP-TAE 226 NVP-TAE226 is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, c-Met, and...
T21768 PF-562271 hydrochloride PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-f...
T2609 Masitinib Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has ...
T2314 PF-431396 PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).
T2655 CEP-37440 CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).
T2465 PF-562271 PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).
T1996 Defactinib Defactinib is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities.
T7119 Y15 Y15 is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth.
T11260 FAK inhibitor 2 FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM .
TN4046 Excisanin A ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
TN3139 5α-Hydroxycostic acid 5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
TQ0169 Inulicin Inulicin, an active compound isolated from Inula Britannica L, inhibits VEGF-mediated activation of Src and FAK.
T4606 2119738-71-3
T6177 PF-562271 besylate PF-562271 (besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectiv...
T5480 BI-4464 BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC
T15092 Defactinib hydrochloride Defactinib hydrochloride is a novel inhibitor of FAK which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.
T14997 Conteltinib Conteltinib is a multi-kinase inhibitor targeting FAK, Pyk2, and ALK. It has a significant inhibitory effect on FAK (IC50: 1.6 nM).
T9973 WAY-311677 WAY-311677 有潜在的抗增殖活性,是一种 FAK 抑制剂。
Roslin 2 bromide
T24730
Roslin 2 bromide 是一种 p53 再激活剂,可破坏 FAK 和 p53 的结合。 Roslin 2 bromide 具有抗癌作用。
Batatasin III
TN1433
BMS-536924
T6419
BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2...
PND-1186
T1950
PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).
Compound 1T-0219 (SC)
T9545
Compound 1T-0219 (SC) is a blocker of AKT1-FAK interaction reducing the stimulation of FAK phosphorylation in response to extracellular pressure in human SW620 c...
GSK2256098
T2281
GSK-2256098 is a small molecule FAK kinase inhibitor.
ALK inhibitor 1
T10285
ALK inhibitor 1 is a selective ALK kinase inhibitor.
Masitinib mesylate
T8544
Masitinib mesylate is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;PDGFRα/β;LynB,respectiv...
PF-573228
T2001
PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM.
Chloropyramine hydrochloride
T0263
Chloropyramine hydrochloride is a histamine receptor H1 antagonist.
Corosolic acid
T3391
Corosolic acid contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts anticancer activities against H...
AMP-945
T9576
AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.
ALK inhibitor 2
T3041
ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.
Fangchinoline
T3122
Fangchinoline is extracted from Stephania tetrandra S. Moore.
PF-03814735
T6936
PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and...
SU6656
T6997
SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.
Nitidine chloride
T5S0761
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721...
(R)-Fangchinoline
T2809
Fangchinoline is extracted from Stephania tetrandra S. Moore.
AZ7550
T13564
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
NVP-TAE 226
T1918
NVP-TAE226 is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, c-Met, and...
PF-562271 hydrochloride
T21768
PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-f...
Masitinib
T2609
Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has ...
PF-431396
T2314
PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).
CEP-37440
T2655
CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).
PF-562271
T2465
PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).
Defactinib
T1996
Defactinib is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities.
Y15
T7119
Y15 is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth.
FAK inhibitor 2
T11260
FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM .
Excisanin A
TN4046
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
5α-Hydroxycostic acid
TN3139
5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
Inulicin
TQ0169
Inulicin, an active compound isolated from Inula Britannica L, inhibits VEGF-mediated activation of Src and FAK.
2119738-71-3
T4606
PF-562271 besylate
T6177
PF-562271 (besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectiv...
BI-4464
T5480
BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC
Defactinib hydrochloride
T15092
Defactinib hydrochloride is a novel inhibitor of FAK which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.
Conteltinib
T14997
Conteltinib is a multi-kinase inhibitor targeting FAK, Pyk2, and ALK. It has a significant inhibitory effect on FAK (IC50: 1.6 nM).
WAY-311677
T9973
WAY-311677 有潜在的抗增殖活性,是一种 FAK 抑制剂。