T0263 |
Chloropyramine hydrochloride |
Chloropyramine hydrochloride is a histamine receptor H1 antagonist. |
T11260 |
FAK inhibitor 2 |
FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM . |
T14997 |
Conteltinib |
Conteltinib is a multi-kinase inhibitor targeting FAK, Pyk2, and ALK. It has a significant inhibitory effect on FAK (IC50: 1.6 nM). |
T15092 |
Defactinib hydrochloride |
Defactinib hydrochloride is a novel inhibitor of FAK which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner. |
T1918 |
TAE226 |
NVP-TAE226 is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, c-Met, an...
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T1950 |
PND-1186 |
PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM). |
T1996 |
Defactinib |
Defactinib is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. |
T2001 |
PF 573228 |
PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM. |
T21768 |
PF-562271 HCl |
PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-...
|
T2281 |
GSK-2256098 |
GSK-2256098 is a small molecule FAK kinase inhibitor. |
T2314 |
PF 431396 |
PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM). |
T2465 |
PF-562271 |
PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM). |
T2655 |
CEP37440 |
CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK). |
T2809 |
(+)-Thalrugosine |
Fangchinoline is extracted from Stephania tetrandra S. Moore. |
T3122 |
(+)-Fangchinoline |
Fangchinoline is extracted from Stephania tetrandra S. Moore. |
T3391 |
Corosolic acid |
Corosolic acid contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts anticancer activities against ...
|
T5480 |
BI-4464 |
BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC |
T6177 |
PF-562271 besylate |
PF-562271 (besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selecti...
|
T6419 |
BMS-536924 |
BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/...
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T7119 |
Y15 |
Y15 is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth. |
T8544 |
Masitinib mesylate |
Masitinib mesylate is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;PDGFRα/β;LynB,respecti...
|
TN3139 |
5alpha-Hydroxycostic acid |
5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate. |
TN4046 |
Excisanin A |
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pot...
|
TQ0169 |
Inulicin |
Inulicin, an active compound isolated from Inula Britannica L., inhibits VEGF-mediated activation of Src and FAK. |