Mdm2

Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an important negative regulator of the p53 tumor suppressor. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor and as an inhibitor of p53 transcriptional activation.

Cat. No.	Product name	CAS No.	Purity
T16771	RO-5963	1416663-77-8	98%
T16771	RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, respectively).
T11931	MA242	1049704-18-8	98%
T11931	MA242 is a nuclear factor of activated T cells 1 (NFAT1) for Pancreatic Cancer Therapy and dual inhibitor of murine double minute 2 (MDM2).
TN4341	IVHD-valtrate	28325-56-6	98%
TN4341	VHD-valtrate has anticancer effects against human ovarian cancer cells in vitro and in vivo, it is a potential therapeutic agent for ovarian cancer, providing a ...
T14203	AM-8735	1429386-01-5	98%
T14203	AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).
T12040	Milademetan	1398568-47-2	98%
T12040	Milademetan is a specific and oral inhibitor of MDM2.
T12027	MG-277	T12027	98%
T12027	MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.
TN4107	Ganoderic acid X	86377-53-9	98%
TN4107	Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
T12031	MI-1061	1410737-34-6	98%
T12031	MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4 nM).
T16888	SJ-172550	431979-47-4	98%
T16888	SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).
T67698	WAY-300374	350678-63-6	98%
T67698	WAY-300374 inhibits the p53-MDM2 protein-protein interaction.
T6254	Idasanutlin	1229705-06-9	98%
T6254	Idasanutlin (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).
T1919	Tenovin-1	380315-80-0	98%
T1919	Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
T3184	Kevetrin hydrochloride	66592-89-0	98%
T3184	Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
T21773	SP-141	1253491-42-7	98%
T21773	SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.
T6610	NSC-207895	58131-57-0	98%
T6610	NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
TQ0231	NVP-CGM097	1313363-54-0	98%
TQ0231	NVP-CGM097 is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).
T3517	RO8994	1309684-94-3	98%
T3517	RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding ...
TQ0127	Navtemadlin	1352066-68-2	98%
TQ0127	AMG 232 is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.
T6614	Nutlin-3b	675576-97-3	98%
T6614	Nutlin-3b is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nu...
T14303	Alrizomadlin	1818393-16-6	98%
T14303	Alrizomadlin is an orally active inhibitor of MDM2 with IC50 of 3.8 nM and Ki of 1 nM, respectively[1]. Alrizomadlin blocks the interaction of MDM2 and p53 and i...