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Metabolism

Acetyl-CoA Carboxylase

Amino Acids and Derivatives

Angiotensin-converting Enzyme (ACE)

Endogenous Metabolite

Glutathione Peroxidase

(40)

Glyoxalase

(2)

HIF/HIF Prolyl-Hydroxylase

Indoleamine 2,3-Dioxygenase (IDO)

(33)

Isocitrate Dehydrogenase (IDH)

Mitochondrial Metabolism

(94)

N-Acetylglucosaminyltransferase

Procollagen C Proteinase

(1)

Prolyl Endopeptidase (PREP)

Reactive Oxygen Species

Serine/threonin kinase

(46)

Stearoyl-CoA Desaturase (SCD)

Phosphorylase

Phosphorylases are enzymes that catalyze the addition of a phosphate group from an inorganic phosphate (phosphate+hydrogen) to an acceptor.They include allosteric enzymes that catalyze the production of glucose-1-phosphate from a glucan such as glycogen, starch or maltodextrin.

Filter HomeSignaling PathwaysMetabolismPhosphorylase

Ingliforib

T8493186392-65-4

Ingliforib (CP 368296) is a novel glycogen phosphorylase inhibitor with antihyperglycemic and cardioprotective properties.

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Glycogen phosphorylase-IN-1

T37577648926-15-2In house

Glycogen phosphorylase-IN-1 is a selective and potent inhibitor of human hepatic glycogen phosphorylase (hlGPa) with inhibitory effects on hlGPa activity and on hepatocyte glycogen-derived glucose production, and can be used in the study of type 2 diabetes mellitus and canine lupus.

$229

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Tracheloside

T385533464-71-0

Tracheloside significantly decreases the activity of alkaline phosphatase (IC50: 0.31 μg ml), a level of inhibition comparable to that of tamoxifen (IC50: 0.43 μg ml).

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AVE5688

T10421613260-13-2In house

AVE5688, an inhibitor of glycogen phosphorylase (GP), has IC50 values of 430 nM and 915 nM, and Kd values of 170 nM and 530 nM for rmGPb and rmGPa, respectively. It is suitable for research on type 2 diabetes.

$282

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Uric Acid

T062669-93-2

Uric Acid (Lithic acid) is an oxidation product of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.

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N6-Methyladenosine 5'-monophosphate disodium salt

T1216281921-35-9

N6-Methyladenosine 5'-monophosphate disodium salt is a glycogen phosphorylase b activator and an inhibitor of adenylate kinase II.

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CP-91149

T6455186392-40-5

CP-91149 is a selective glycogen phosphorylase (GP) inhibitor with IC50 of 0.13 μM in the presence of glucose, 5- to 10-fold less potent in the absence of glucose.

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L-Ascorbic acid 2-phosphate magnesium

T19389113170-55-1

L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) functions as an antioxidant and stimulates hepatocyte growth factor (HGF) production. This long-acting vitamin C derivative promotes collagen formation and expression.

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Disodium monofluorophosphate

T074510163-15-2

Disodium monofluorophosphate (NSC248) is a competitive inhibitor of pyruvate kinase and alkaline phosphatase, which also irreversibly inhibits phosphorylase phosphatase.

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H-HomoArg-OH.HCl

T39381483-01-8

H-HomoArg-OH.HCl (L-Homoarginine hydrochloride) is a specific inhibitor of liver-type alkaline phosphatase.

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H-HoArg-OH

T8103156-86-5

H-HoArg-OH (a homologue of arginine) is a potent inhibitor of human liver and bone alkaline phosphatase.

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Calcium glycerophosphate

T6025427214-00-2

Calcium glycerophosphate(CaGP) is an inhibitor of intestinal alkaline phosphatase F3. Calcium glycerophosphate can be a source of calcium and phosphorus in total parenteral nutrition solutions [1] [2].

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DIPQUO hydrochloride

T11048L In house

DIPQUO hydrochloride is an activator of the bone marker alkaline phosphatase (ALP), with an EC50 of 6.27 μM in C2C12 cells. DIPQUO hydrochloride promotes mouse and human osteoblast differentiation via activation of p38 MAPK-β.

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(-)-p-Bromotetramisole Oxalate

T635362284-79-1

(-)-p-Bromotetramisole Oxalate (6-Bromolevamisole oxalate) is a potent and non-specific inhibitor of alkaline phosphatase.

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Dipsacus saponin X

TN7352146100-01-8

Dipsacus saponin X is a triterpenoid saponin derived from Dipsacus asper. It stimulates the proliferation of UMR106 cells and increases alkaline phosphatase（ALP） activity. Additionally, it exhibits anti-acetylcholinesterase（AChE) activity, suggesting potential neuroprotective effects.

$273

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