Stearoyl-CoA Desaturase (SCD)

Stearoyl-CoA desaturase (Δ-9-desaturase) is an endoplasmic reticulum enzyme that catalyzes the rate-limiting step in the formation of monounsaturated fatty acids (MUFAs), specifically oleate and palmitoleate from stearoyl-CoA and palmitoyl-CoA.[5] Oleate and palmitoleate are major components of membrane phospholipids, cholesterol esters and alkyl-diacylglycerol. In humans, the enzyme is encoded by the SCD gene.

Cat. No.	Product name	CAS No.	Purity
T6412	CVT-12012	1018675-35-8	98%
T6412	CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD; IC50 = 6.1 nM in HepG2 cells).
T16068	MF-438	921605-87-0	98%
T16068	MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1).
T1869	PluriSIn 1	91396-88-2	98%
T1869	PluriSln 1(NSC 14613) is an inhibitor of stearoyl-CoA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, revealing a unique role for lipid metabolism ...
T14878	CAY10566	944808-88-2	98%
T14878	CAY10566 shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 c...
T13356	XEN723	1072803-08-7	98%
T13356	XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).
T5427	GSK1940029	1150701-66-8	98%
T5427	GSK1940029 is a stearoyl-coa desaturase (SCD) inhibitor.
T10525	SCD1 inhibitor-4	1295541-87-5	98%
T10525	SCD1 inhibitor-4 is stearoylCoA desaturase-1 (SCD1) inhibitor. SCD1 inhibitor-4 can be used for the research of diabetes.
T4515	A939572	1032229-33-6	98%
T4515	A939572 is stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 values of <4 nM for mSCD1 and 37 nM for hSCD1.
T3341	Elemicin	487-11-6	98%
T3341	Elemicin is a constituent of several plant species' essential oils with anticholinergic effects in human.
T9722	YTX-465	2225824-53-1	98%
T9722	YTX-465 is an inhibitor of both stearoyl-CoA desaturase(IC50s = 39 nM) and Ole1 (IC50s = 30.4 μM).
T2650	MK-8245	1030612-90-8	98%
T2650	MK-8245 is a liver-targeting SCD inhibitor for human SCD1 (IC50: 1 nM) and for rat/mouse SCD1 (IC50: 3 nM), with anti-diabetic and anti-dyslipidemic function.
T12931	SLC13A5-IN-1	2227548-95-8	98%
T12931	SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5),completely blocks the uptake of 14C-citrate(IC50 : 0.022 μM in HepG2 cells).