T0830 |
Bithionol |
Bithionol, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause seri...
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T11234 |
ESI-08 |
ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation. ESI-08 is a potent and selective EPAC antagonist, ...
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T12616L |
CE3F4 |
CE3F4 is a selective antagonist of exchange protein directly activated by cAMP (Epac1) (IC50s: 10.7 μM and 66 μM for Epac1 and Epac2(B)). |
T15247 |
ESI-05 |
ESI-05 is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist (IC50: 0.4 µM). ESI-05 inhibits cAMP-mediated activation of EPAC2, as wel...
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T2244 |
ESI-09 |
ESI-09 is a new-typel noncyclic nucleotide EPAC antagonist.The IC50 values of ESI-09 for EPAC1 and EPAC2 is3.2 and 1.4 μM, respectively. |
T6536 |
HJC0350 |
HJC0350 is an effective and specific EPAC2 inhibitor (IC50: 0.3 μM), and no inhibition of Epac1. |
T7190 |
Actein |
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblas...
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TMA0003 |
Trans-caffeic acid |
Trans-caffeic acid stearyl ester is posited to inhibit melanogenesis signaling while suppressing cAMP levels and, subsequently, MC1R, MITF, tyrosinase, TRP-2 an...
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TMA1122 |
Moschamine |
Moschamine is a very potent compound that is able to inhibit COX-I by 58% and COX-II by 54%, at the concentration of 0.1 μmol L⁻1, it may suppress cAMP f...
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TMA1944 |
Protopine hydrochloride |
Protopine has antiplatelet effects,which is due to inhibition on thromboxane formation and phosphoinositides breakdown and then lead to the decrease of intracel...
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TMA2419 |
Catalponol |
Catalponol can enhance dopamine biosynthesis by inducing TH activity and protect against L-DOPA-induced cytotoxicity in PC12 cells, which was mediated by the in...
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TN1027 |
beta-Amyrin |
beta-Amyrin has antiviral, hepatoprotective, antinociceptive, anti-inflammatory, it retard acute inflammation in rat model of periodontitis. |
TN1121 |
Evocarpine |
Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels. |
TN1266 |
3-O-Methylquercetin |
3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value; it inhibits total cAMP- and cGMP-phos...
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TN1334 |
7-O-Methylrosmanol |
7-O-methylrosmanol can effectively suppress FSK-induced luciferase expression under the control of the CRE, PEPCK-C and G6Pase gene promoters, it may contribute...
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TN1420 |
Bacopaside I |
Bacopaside I is a modulator of Aquaporin-1 channel, has neuroprotective functions, it has anti-Alzheimer's disease, it ameliorates cognitive impairment in APP/P...
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TN1504 |
Citreorosein |
Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of bot...
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TN1620 |
Eriocalyxin B |
Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a can...
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TN1841 |
Kushenol A |
Kushenol A is a kind of Adenosine 3', 5'-cyclic monophosphate(cAMP)phosphodiesterase inhibitiors, it shows selective alpha-glucosidase inhibitory activity. Kush...
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TN2039 |
Panaxydol |
Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 M...
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TN2092 |
Polygalasaponin XXXI |
Onjisaponin F(Polygalasaponin XXXI) acts non-competitively against cyclic AMP phosphodiesterase, like papaverine; it also exhibits a prolongation effect on hexo...
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TN2230 |
Soyasaponin Ba |
Soyasaponins(Aa, Ab, Af, Ba, Bb, and Bb') together with their derivatives may represent viable candidates for effective vaccine adjuvants due to their higher an...
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TN2918 |
3-Acetoxy-8(17),13E-labdadien-15-oic acid |
ent-3-Acetoxy-labda-8(17),13-dien-15-oic acid have vasorelaxant and hypotensive actions, the mechanisms underlying the cardiovascular actions of the labdane inv...
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TN3013 |
4,5-Dimethoxycanthin-6-one |
4,5-Dimethoxycanthin-6-one has antibacterial actiyity, it exhibits inhibition against Staphylococcus aureus and its drug-resistant strains. 4,5-Dimethoxycanthin...
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TN3379 |
Allocryptopine |
Allocryptopine has certain effects on anti-injury for hepatocyte, ameliorating liver function, and prohibiting hepatic fibrosis; it increases mRNA levels of cyt...
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TN3466 |
Atherosperminine |
Atherosperminine shows cholinesterase inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Atherosperminine shows strong an...
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TN3607 |
Catalpalactone |
Catalpalactone exhibits high antitermitic, and cytotoxic activities, it exhibits potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264...
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TN3882 |
Dodoviscin A |
Dodoviscin A may be a new promising pigmentation-altering agent for cosmetic and therapeutic applications, it can inhibit melanin biosynthesis induced by 3-isob...
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TN4051 |
Fargesone B |
Fargesone B inhibits the vascular smooth muscle contraction by suppressing the voltage- and receptor-activated calcium influxes in a nonselective manner. |
TN4178 |
Gyrophoric acid |
Vulpinic and gyrophoric acids are known as ultraviolet filters for natural lichen populations, they can effectively prevent cytotoxic, apoptotic and cytoskeleto...
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TN4277 |
Isocupressic acid |
Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reprod...
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TN4317 |
Isopedicin |
Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA th...
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TN4433 |
Licoarylcoumarin |
Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE s...
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TN4489 |
Manassantin A |
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effe...
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TN4551 |
Methyl orsellinate |
Methyl orsellinate is a phytotoxic compound, it exhibits antifungal activity, it can cause significant inhibition of radicle growth of Amaranthus hypochondriacu...
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