local anesthetic

Soquinolol (Soquinolol mucate) is a beta-adrenergic receptor antagonist with weak local anesthetic activity.Soquinolol has good enteral efficacy and a long duration of action.

Lidocaine hydrochloride (Lignocaine hydrochloride) is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.

Articaine hydrochloride (Hoe-045), a thiophene-containing local anesthetic, is pharmacologically similar to mepivacaine.

Hexylresorcinol (4-Hexylresorcinol) is a substituted dihydroxybenzene utilized topically as an antiseptic for minor skin infection treatment.

Dibucaine (Cinchocaine), a local anesthetic of the amide type, is now usually used for surface anesthesia.

Guaiacol (2-Methoxyphenol) is a precursor to various flavorants, such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic, and local anesthetic. It also can be used as an indicator in chemical reactions that produce oxygen. When oxygen binds to it, the complex turns yellowish brown and absorbs light maximally at about 470 nm.

Procaine (Vitamin H3) is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block.

Octodrine (2-Amino-6-methylheptane) is primarily used as a pharmaceutical intermediate for Octamylamine; it also functions as a local anesthetic and vasoconstrictor.

Prilocaine hydrochloride (Prilocaine HCl) is a local anesthetic of the amino amide type, binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions.

Bupivacaine hydrochloride (Vivacaine) is a long-acting, amide-type local anesthetic. Bupivacaine hydrochloride reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent membrane permeability to sodium ions and membrane stabilization; inhibition of depolarization and nerve impulse conduction; and a reversible loss of sensation.

Lidocaine (Alphacaine) is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellular adhesion molecule-1 (ICAM-1), pro-inflammatory cytokines, and reduction of neutrophils influx.

Ropivacaine hydrochloride (Ropivacaine monohydrochloride) is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity.

Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.

Procaine hydrochloride (Novocaine HCl) is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodiumchannels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.

Polidocanol (Polyoxyethylene lauryl ether) is an alkyl polyethylene glycol ether of lauryl alcohol, which is a derivative of natural fatty or alkyl alcohols in natural mineral oil and is a hardener. Polidocanol can be used as a local anesthetic, but in combination with other anesthetic drugs there is a risk of enhancing the effects of the anesthetic drugs on the cardiovascular system.

Dimethocaine (Larocaine) is a local anesthetic which also effects on the central nervous system acting as dopamine-reuptake-inhibitor.

Denatonium benzoate (THS-839) , a quaternary ammonium cation, is a compound of a salt with an inert anion like saccharide or benzoate. Its structure is involved in the local anesthetic lidocaine which difference only is the addition of a benzyl group to the amino nitrogen.

Prilocaine (NSC-40027) is a local anesthetic of the amino amide type, which acts on the sodium channel on the neuronal membrane and limits the spread of seizures.

Adiphenine hydrochloride (Patrovina), a nicotinic receptor inhibitor, can be used as an antispasmodic drug.

Cinchonine (LA40221), a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local narcotics and its parenteral use is restricted to spinal anesthesia.

Menthol (DL-Menthol) is an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties.

Dyclonine hydrochloride (Dyclonine HCl) , an over the counter throat lozenge, is found in Sucretswith local anesthetic effect .

Diperodon hydrochloride (Diperocaine) is a local anesthetic that can be broken down by serolytic enzymes to produce local anesthetic effects.

Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a reversible neuronal sodium channel inhibitor and the pure S(-)-enantiomer of bupivacaine, used as a long-acting local anesthetic.

(-)-Menthol (Levomenthol) is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. When added to pharmaceuticals and foods, menthol functions as a fortifier for peppermint flavors. It also has a counterirritant effect on skin and mucous membranes, thereby producing a local analgesic or anesthetic effect.

Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. Proparacaine hydrochloride (Proparacaine HCl) stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting sodium ion influx required for the initiation and conduction of impulses within the neuronal cell, and resulting in a loss of sensation.

Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.

Mepyramine maleate (Pyrilamine maleate) is a histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.

Etidocaine is an amino acidamide that acts as a local anesthetic with fast onset and long-acting properties.

Mepyramine is a histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies both parenterally and locally.

Trapencaine is a newly synthesized carbamate type local anesthetic that induces conformational changes in sodium channels on hypertrophic cell membranes.

Tolycaine is a compound of local anesthetic.

Chloroprocaine hydrochloride (Chloroprocaine HCl) is a local anesthetic during surgical procedures.

Secoverine is a selective muscarinic receptor antagonist that was studied as a neurotropic spasmolytic agent. It was shown that the drug had no nicotinolytic or antihistaminic activity, a moderate antisterotonic activity, an inhibiting effect on the noradrenaline uptake mechanism of the vas deferens and marked local anesthetic activity.

Phenacaine (Holocaine), a local anesthetic, suppresses the calmodulin-dependent activation of erythrocyte Ca2+-ATPase and inhibits cyclic nucleotide phosphodiesterases in the brain and heart, as evidenced by studies [1] [2].

Lorcainide hydrochloride is an antiarrhythmic drug with local anesthetic activity. The antiarrhythmic actions of lorcainide are mediated by an impairment of fast sodium conductance. Lorcainide appears effective in suppressing reentry phenomena and ectopic

Quatacaine is a local anesthetic.

GYKI-23107 is an antiarrhythmic agent with a local anesthetic activity.

Chlophedianol hydrochloride, a centrally acting cough suppressant, is used in the treatment of dry cough. It has antihistamine and local anesthetic properties, and may have anticholinergic effects at high doses.

BK 129 is a local anesthetic with relaxant properties. BK 129 inhibits Ca2+ entry into the smooth muscle cell and Ca2+ release from sarcoplasmic reticulum.

Pyrromecaine is a local anesthetic used for surface anesthesia. Pyromecaine has a wide spectrum of antiarrhythmic action, exerts a favorable effect on the contractility of the left ventricle, and on the myocardial blood flow following the ligation of the

Tetracaine-d6 is a deuterated compound of Tetracaine. Tetracaine has a CAS number of 94-24-6. Tetracaine is a powerful local anesthetic that alters the function of calcium releasing channels (lanine receptors) that control the release of calcium stored in cells.

Lidocaine-d10 (N,N-diethyl-d10) is a deuterated compound of Lidocaine. Lidocaine has a CAS number of 137-58-6. Lidocaine is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellular adhesion molecule-1 (ICAM-1), pro-inflammatory cytokines, and reduction of neutrophils influx.

Sameridine hydrochloride, a local anesthetic and local analgesic [1].

Ketocaine（Rec 7-0518） is a local anesthetic commonly used in animal experiments with potential antitumor activity for pain relief.

Bucumolol (Bucumarol) is a β-adrenergic blocking agent and a local anesthetic with antihypertensive activity and can be used to study myocardial infarction.

Oxybuprocaine hydrochloride (Oxybuprocaine HCl), a local anesthetic, is used especially in otolaryngology and ophthalmology.

Butopiprine is a cough suppressant with antispasmodic, local anesthetic and antitussive activity.